Picroside II

製品コードS3765 バッチS376501

印刷

化学情報

Synonyms

6-Vanilloylcatalpol, Vanilloyl catalpol

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₃H₂₈O₁₃

分子量

512.46

CAS No.

39012-20-9

Solubility (25°C)*

体外

DMSO

100 mg/mL (195.13 mM)

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

5.0mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
in vitro	Picroside II can reduce H2O2-induced PC12 cell damage and improve cell survival^[3]. Picroside II effectively attenuates fatty acid accumulation by decreasing FFAs uptake and lipogenesis. Picroside II also decreases the expression of gluconeogenic genes^[4]. Picroside II significantly decreases the concentrations of TNF-α, IL-1β, and IL-6 in cells. It suppresses the activation of p65 NF-κB signaling pathway compared with LPS stimulation^[5].
in vivo	Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5^[1]. In the HDM-induced asthmatic model, picroside II significantly reduces inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), the levels of total immunoglobulin (Ig) E and HDM-specific IgE and IgG1 in serum, airway inflammation, and mucus hypersecretion in the lung tissues^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HepG2 cells
	濃度	0-300 μM
	反応時間	24 h
	実験の流れ	HepG2 cells are loaded with different concentrations of FFAs, picroside I, picroside II, and silibinin for 24 hours. Cytotoxicity is measured via MTT assay.
動物実験	動物モデル	adult male Wistar rats
	投薬量	20 mg/kg
	投与方法	i.p.

参考

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。