受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | PPLGM, Piplartine | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C17H19NO5 |
|||
分子量 | 317.34 | CAS No. | 20069-09-4 | |
Solubility (25°C)* | 体外 | DMSO | 63 mg/mL warmed with 50ºC water bath (198.52 mM) | |
Ethanol | 63 mg/mL warmed with 50ºC water bath (198.52 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. |
---|---|
in vitro | Piperlongumine is a known ROS inducer which could induce pancreatic cancer cell death in cell culture[1] As a thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation. [2] Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. [3] |
in vivo | Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells without leading to major changes in the biochemical, hematological and histopathological parameters. [4] |
細胞アッセイ | 細胞株 | MCF-7 and 786-O cells |
---|---|---|
濃度 | ~10 μM | |
反応時間 | 48 hours | |
実験の流れ | MCF-7 and 786-O cells are incubated with various PL concentrations for 48h. Cell proliferation is analysed by CellTiter Blue assay. Effective doses (ED) are calculated using XLift, Microsoft Excel add-in. |
|
動物実験 | 動物モデル | Mice transplanted with sarcoma 180 tumors |
投薬量 | ~50 mg/kg | |
投与方法 | i.p. |
Data from [Data independently produced by , , Oncotarget, 2016, 7(35):56933-56943]
Data from [Data independently produced by , , Oncotarget, 2016, 7(26):40531-40545]
Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity [ J Exp Clin Cancer Res, 2023, 42(1):118] | PubMed: 37161450 |
Identification of Piperlongumine as Potent Inhibitor of Necroptosis [ Drug Des Devel Ther, 2023, 17:1387-1394] | PubMed: 37188283 |
Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan [ Nat Commun, 2022, 13(1):107] | PubMed: 35013237 |
USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity [ Nat Commun, 2022, 13(1):7799] | PubMed: 36528652 |
Systematic identification of biomarker-driven drug combinations to overcome resistance [ Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7] | PubMed: 35332332 |
Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3 [ J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493] | PubMed: 34508571 |
A "Failed" Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage [ SLAS Discov, 2021, 24725552211020678] | PubMed: 34151632 |
MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her-2/PI3K/AKT Signaling [ Adv Sci (Weinh), 2020, 7(13):2000112] | PubMed: 32670759 |
Engineering Chromosome Region Maintenance 1 Fragments That Bind to Nuclear Export Signals [ Protein Sci, 2020, 29(6):1366-1372] | PubMed: 31495993 |
Inhibition of ERKs/Akt-Mediated c-Fos Expression Is Required for Piperlongumine-Induced Cyclin D1 Downregulation and Tumor Suppression in Colorectal Cancer Cells [ Onco Targets Ther, 2020, 13:5591-5603] | PubMed: 32606774 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。