受注:045-509-1970 |
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Synonyms | S-7701, AMR-69 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C12H11NO |
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分子量 | 185.22 | CAS No. | 53179-13-8 | |
Solubility (25°C)* | 体外 | DMSO | 37 mg/mL (199.76 mM) | |
Ethanol | 37 mg/mL (199.76 mM) | |||
Water | 16 mg/mL (86.38 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3. |
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in vitro | Pirfenidone (< 300 μg/mL) suppresses the proinflammatory cytokine tumor necrosis factor-α (TNF-α) by a translational mechanism in RAW264.7 cells, which is independent of activation of the mitogen-activated protain kinase (MAPK) 2, p38 MAP kinase, and c-Jun N-terminal kinase (JNK). [1] Pirfenidone (< 10 mM) leads to reduced glioma cell density in concentration-dependent manner in LN-18, T98G, LNT-229 and LN-308 cell lines. Pirfenidone (< 5 mM) reduces TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (< 8.3 mM) inhibits the activity of recombinant furin and downregulates the expression of MMP-11 in a dose-dependent manner in LN-308 cells. [2] |
in vivo | Pirfenidone (250 mg/kg) potently inhibits the production of the proinflammatory cytokines, TNF-alpha, interferon-gamma, and interleukin-6, but enhances the production of the anti-inflammatory cytokine, interleukin-10, in mice. [1] Pirfenidone (250 mg/kg/day) ameliorates cyclosporine-induced fibrosis by about 50% and decreases TGF-beta1 protein expression by 80% in Sprague-Dawley rats receiving a low-salt diet. [3] Pirfenidone (400 mg/kg/day) inhibits heat shock protein 47-positive cells and myofibroblasts, the principal cells responsible for the accumulation and deposition of extracellular matrix seen in pulmonary fibrosis in ICR mice intravenously injected with bleomycin. [4] Pirfenidone (0.5%, liquid diet) treatment reduces the degree of liver injury in rats, as determined by alanine aminotransferase values and necro-inflammatory score, which is associated with reduced hepatic stellate cells proliferation and collagen deposition. Pirfenidone (0.5%, liquid diet) administration downregulates dimethylnitrosamine induced transcripts levels of procollagen alpha1(I), TIMP-1 and MMP-2 by 50-60% in rats, and this is associated with a 70% reduction in collagen deposition. [5] |
細胞アッセイ | 細胞株 | ACHN cells |
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濃度 | 0.5 mg/ml | |
反応時間 | 12 h | |
実験の流れ | Cells were treated with various concentrations of drug. |
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動物実験 | 動物モデル | Sprague-Dawley rats receiving a low-salt diet |
投薬量 | 250 mg/kg | |
投与方法 | oral diet |
Data from [Data independently produced by Histochem Cell Biol, 2014, 142(4), 361-71]
, , Am J Respir Cell Mol Biol, 2017, 57(1):77-90
Data from [Data independently produced by , , Aging Cell, 2018, doi: 10.1111/acel.12788]
Repositioning of ezetimibe for the treatment of idiopathic pulmonary fibrosis [ Eur Respir J, 2024, 2300580] | PubMed: 38359963 |
Modulation of Extracellular Matrix Composition and Chronic Inflammation with Pirfenidone Promotes Scar Reduction in Retinal Wound Repair [ Cells, 2024, 13(2)164] | PubMed: 38247855 |
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis [ Acta Pharmacol Sin, 2023, 10.1038/s41401-023-01156-w] | PubMed: 37696989 |
Macrophage activity at the site of tumor ablation can promote murine urothelial cancer via transforming growth factor-β1 [ Front Immunol, 2023, 14:1070196] | PubMed: 36761730 |
Differences in Treatment Response in Bronchial Epithelial Cells from Idiopathic Pulmonary Fibrosis (IPF) Patients: A First Step towards Personalized Medicine [ Antioxidants (Basel), 2023, 12(2)443] | PubMed: 36830000 |
Differences in Treatment Response in Bronchial Epithelial Cells from Idiopathic Pulmonary Fibrosis -IPF) Patients: A First Step towards Personalized Medicine [ Antioxidants -Basel), 2023, 12(2)443] | PubMed: 36830000 |
Impact of in vitro HIV infection on human thymic regulatory T cell differentiation [ Front Microbiol, 2023, 14:1217801] | PubMed: 37547675 |
Establishment and characterization of immortalized sweat gland myoepithelial cells [ Sci Rep, 2022, 12(1):7] | PubMed: 34997030 |
The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β [ Cancer Biol Ther, 2022, 23(1):150-162] | PubMed: 35130111 |
Contracting scars from fibrin drops [ Integr Biol (Camb), 2022, 14(1):1-12] | PubMed: 35184163 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。