Pravastatin sodium

製品コードS3036 バッチS303606

化学情報

	Synonyms	CS-514 Sodium	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₃H₃₅O₇.Na
	分子量	446.51	CAS No.	81131-70-6
Solubility (25°C)*	体外	DMSO	89 mg/mL (199.32 mM)
		Water	89 mg/mL (199.32 mM)
		Ethanol	89 mg/mL (199.32 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
in vitro	Pravastatin-Na at 10 μM inhibits the sterol synthesis at a level greater than 50% in PBMC. ^[1] Pravastatin produces relaxation of isolated aortic rings, with maximum vasorelaxations of 62.8% at 10 μM and latency of ~8 min. Pravastatin (< 10 μM) stimulates NOS activity and NO release within 10 min in cultured bovine aortic endothelial cells. L-arginine potentiates NO production in response to Pravastatin (< 10 μM) in cultured bovine aortic endothelial cells. ^[2] Pravastatin results in a dose-dependent inhibition of macrophage cholesterol synthesis in human monocyte derived macrophages(HMDM), mouse peritoneal macrophages (MPM) and a J-774 A.1 macrophagelike cell lines. Small concentrations of pravastatin (< 0.19 μg/mL) increases the cellular cholesterol esterification rate after incubation with LDL, but higher concentrations (< 100 μg/mL) results in an inhibition of the esterification. ^[3] Pravastatin (< 0.5 mM) decreases Rho/ROCK pathway activity in human colon and ileum explants, which leads to decreased CCN2 mRNA levels. Pravastatin (<1 mM) also induces CCN2 inhibition in primary human smooth muscle cells. Pravastatin (< 0.5 mM) decreases type I collagen and fibronectin mRNA levels in both human colon and ileum explants and primary human smooth muscle cells. ^[4]
in vivo	Pravastatin (40 mg, single dose) causes a reduction in cholesterol synthesis in human monocyte derived macrophages by 62% in healthy subjects and 47% in hypercholesterolaemic patients. Pravastatin (40 mg/day, 8 weeks) results in a 55% inhibition of cholesterol synthesis and a 57% increase in LDL degradation in hypercholesterolaemic patients. ^[3] Pravastatin (30 mg/kg/d) results in decreased length of the dystrophic lesions by 34% and recovery of muscular structure in Male Wistar rats receiving irradiation, associated with decreased CCN2 level. ^[4]

プロトコル(参考用のみ)

動物実験	動物モデル	Male Wistar rats receiving irradiation for 5 weeks
	投薬量	30 mg/kg/day
	投与方法	Orally

参考

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カスタマーフィードバック

: , , JAMA Oncol, 2015, 1(4):495-504.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Effects of Mineralocorticoid Receptor Blockade and Statins on Kidney Injury Marker 1 (KIM-1) in Female Rats Receiving L-NAME and Angiotensin II [ Int J Mol Sci, 2023, 24(7)6500]	PubMed: 37047470
Simvastatin cream alleviates dermal fibrosis in a rabbit ear hypertrophic scar model [ J Cosmet Dermatol, 2022, 10.1111/jocd.15142]	PubMed: 35665590
Ultra-fast proteomics with Scanning SWATH [ Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4]	PubMed: 33767396
Classic and Targeted Anti-Leukaemic Agents Interfere With the Cholesterol Biogenesis Metagene in Acute Myeloid Leukaemia: Therapeutic Implications [ J Cell Mol Med, 2020, 25]	PubMed: 32450611
Simvastatin functions as a heat shock protein 90 inhibitor against triple-negative breast cancer [Kou X Cancer Sci, 2018, 109(10):3272-3284]	PubMed: 30039622
Vorinostat and Simvastatin have synergistic effects on triple-negative breast cancer cells via abrogating Rab7 prenylation [Kou X Eur J Pharmacol, 2017, 813:161-171]	PubMed: 28826913
The impact of statin use on the efficacy of abiraterone acetate in patients with castration-resistant prostate cancer [Harshman LC Prostate, 2017, 77(13):1303-1311]	PubMed: 28762529
Statin Use at the Time of Initiation of Androgen Deprivation Therapy and Time to Progression in Patients With Hormone-Sensitive Prostate Cancer. [Harshman LC, et al. JAMA Oncol, 2015, 10.1001/jamaoncol.2015.0829]

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。