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Synonyms | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C20H24ClN3S.C8H8O8 |
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分子量 | 606.09 | CAS No. | 84-02-6 | |
Solubility (25°C)* | 体外 | DMSO | 74 mg/mL warmed with 50ºC water bath (122.09 mM) | |
Ethanol | 2 mg/mL warmed with 50ºC water bath (3.29 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist. |
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in vitro | Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2]. |
in vivo | Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1]. |
細胞アッセイ | 細胞株 | BT474 cells |
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濃度 | 5 μM | |
反応時間 | 2 or 5 days | |
実験の流れ | Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR. | |
動物実験 | 動物モデル | Male Swiss albino mice, Wistar rats |
投薬量 | 1-2 mg/kg | |
投与方法 | i.p. |
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Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance [ Cancer Biol Ther, 2023, 24(1):2269637] | PubMed: 37878417 |
Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance [ Cancer Biol Ther, 2023, 10.1080/15384047.2023.2269637] | PubMed: 37878417 |
The Food and Drug Administration-approved antipsychotic drug trifluoperazine, a calmodulin antagonist, inhibits viral replication through PERK-eIF2α axis [ Front Microbiol, 2022, 13:979904] | PubMed: 36386620 |
Open drug discovery for the Zika virus. [ F1000Res, 2016, 5:150] | PubMed: 27134728 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。