受注:045-509-1970 |
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Synonyms | AY-64043, ICI-45520, NCS-91523 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C16H21NO2.HCl |
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分子量 | 295.8 | CAS No. | 318-98-9 | |
Solubility (25°C)* | 体外 | DMSO | 59 mg/mL (199.45 mM) | |
Water | 6 mg/mL (20.28 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor. |
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in vitro | Propranolol, a non-selective β1 and β2 adrenergic blocker, has no effect on the proliferation of neonatal mouse cardiac fibroblasts (NMCFs).[2] |
in vivo | Propranolol, an anti-arrhythmic drugs, consistently reduces the heart rates of adult mice by approximately 10%-20%, whereas isoproterenol has the opposite effect.[2] |
細胞アッセイ | 細胞株 | neonatal mice cardiomyocytes (NMCMs) |
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濃度 | 10, 20, 40, 50, and 100 μM | |
反応時間 | 6, 12, 18, and 24 h | |
実験の流れ | In vitro, the neonatal mice cardiomyocytes (NMCMs) are treated with different drugs of different concentration, including isoproterenol (0, 1, 2.5, 5, 10, 20, and 50 μM); amiodarone (0, 1, 2.5, 5, 10, 20, and 50 μM); metoprolol (0, 10, 20, 30, 50, 100, 150, and 200 μM); propranolol (0, 10, 20, 40, 50, and 100 μM); lidocaine (0, 1, 2.5, 5, 10, 20, and 50 μM); verapamil(0, 1, 2.5, 5, 10, 20, and 50 μM);ivabradine (0, 1, 2, 3, 5, 10, and 20 μM). And the concentrations of drugs that promote CMs proliferation most significantly are chosen for subsequent experiments, including isoproterenol (10 μM), amiodarone (5 μM), metoprolol (20 μM), propranolol (20 μM), lidocaine (5 μM), verapamil (2.5 μM), ivabradine (3 μM) for NMCMs, NMCFs, and hPSC-CM. |
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動物実験 | 動物モデル | 1-day-old neonatal mice; 12-week-old adult mice |
投薬量 | 10 mg/kg/d | |
投与方法 | s.c.; ALZET Osmotic Pumps |
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Multiple cancer cell types release LIF and Gal3 to hijack neural signals [ Cell Res, 2024, 10.1038/s41422-024-00946-z] | PubMed: 38467743 |
Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline [ Sci Rep, 2024, 14(1):4178] | PubMed: 38378892 |
Ketone bodies promote stroke recovery via GAT-1-dependent cortical network remodeling [ Cell Reports, 2023, 42(4)] | PubMed: None |
Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma [ EBioMedicine, 2022, 82:104149] | PubMed: 35816899 |
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch [ Cell Rep, 2022, 38(10):110468] | PubMed: 35263588 |
KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongation [ Stem Cell Res Ther, 2022, 13(1):287] | PubMed: 35765105 |
Targeting the β2 -adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism [ J Pathol, 2022, 10.1002/path.6020] | PubMed: 36245401 |
Targeting ADRB2 enhances sensitivity of non-small cell lung cancer to VEGFR2 tyrosine kinase inhibitors [ Cell Death Discov, 2022, 8(1):36] | PubMed: 35075132 |
LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy [ Front Endocrinol (Lausanne), 2022, 13:895360] | PubMed: 35813614 |
LPIN1 Induces Gefitinib Resistance in EGFR Inhibitor-Resistant Non-Small Cell Lung Cancer Cells [ Cancers (Basel), 2022, 14(9)2222] | PubMed: 35565351 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。