受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||||||
化学式 | C19H13F5N6
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分子量 | 420.34 | CAS No. | 1610964-64-1 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 84 mg/mL (199.83 mM) | ||||||||
Ethanol | 7 mg/mL (16.65 mM) | ||||||||||
Water | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines. |
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in vitro | PTC596 induces mitochondrial apoptosis in BMI-1-expressing MCL cells in a p53-independent manner. MCL SP cells were susceptible to PTC596-induced apoptosis[1]. |
in vivo | PTC596 inhibits myeloid leukemia cell growth in vivo while sparing normal hematopoietic cells[2]. |
細胞アッセイ | 細胞株 | Z-138 and REC-1 cells |
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濃度 | 300 nM | |
反応時間 | 24 h | |
実験の流れ | Z-138 and REC-1 cells were treated for 24 hours with 300 nM PTC596, after which BCL-2, BCL-XL and MCL-1 protein levels were determined. |
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動物実験 | 動物モデル | Non-obese diabetic-severe combined immunodeficiency (NOD-SCID)/IL2Rγ-KO (NSG) mice |
投薬量 | 5 mg/kg | |
投与方法 | by oral gavage |
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Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities [ NPJ Precis Oncol, 2024, 8(1):68] | PubMed: 38480868 |
Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas [ PLoS One, 2023, 18(2):e0277313] | PubMed: 36730269 |
PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion [ bioRxiv, 2023, 2023.01.23.525196] | PubMed: 36747762 |
BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions [ Cell Death Dis, 2021, 12(5):495] | PubMed: 33993198 |
Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization [ Int J Mol Sci, 2021, 22(18)10107] | PubMed: 34576269 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。