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Synonyms | 1,2,3-trihydroxybenzene | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C6H6O3 |
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分子量 | 126.11 | CAS No. | 87-66-1 | |
Solubility (25°C)* | 体外 | DMSO | 25 mg/mL (198.23 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. |
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in vitro | Pyrogallol (PG) inhibits the growth of human pulmonary A549 cells by inducing cell cycle arrest as well as triggering apoptosis. PG can disturb the natural oxidation and reduction equilibrium in cells. Oxidative stress by PG induces NF kappa B DNA binding and inducible NOS mRNA in cultured A549 lung epithelial cells, which may play a role in defending cells against PG-induced oxidative stress[1]. |
in vivo | Dermal administration of pyrogallol causes increased incidences of nonneoplastic lesions of the skin at the site of application in male and female rats and mice, skin adjacent to the site of application in male and female mice, and mammary gland in female mice[2]. |
細胞アッセイ | 細胞株 | A549 cells |
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濃度 | 0-100 μM | |
反応時間 | 72 h | |
実験の流れ | 1×106 cells are incubated with 0-100 μM of PG for 72 h. Cells are washed twice with cold PBS and then resuspended in 500 μl of binding buffer (10 mM HEPES/NaOH pH 7.4, 140 mM NaCl, 2.5 mM CaCl2) at 1×106 cells/ml. Then 5 μl of annexin V-FITC is added to these cells, which are analyzed with a FACStar flow cytometer. |
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動物実験 | 動物モデル | Male and female F344/N rats and B6C3F1/N mice |
投薬量 | 0, 9.5, 18.75, 37.5, 75, or 150 mg/kg (rats); 0, 38, 75, 150, 300, or 600 mg/kg (mice) | |
投与方法 | dermally |
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Ginsenoside Rg1 attenuates diabetic vascular endothelial dysfunction by inhibiting the calpain-1/ROS/PKC-β axis [ Life Sci, 2023, 329:121972] | PubMed: 37482213 |
ROS-mediated NLRP3 inflammasome activation participates in the response against Neospora caninum infection [ Parasit Vectors, 2020, 13(1):449] | PubMed: 32891167 |
ROS-mediated NLRP3 inflammasome activation participates in the response againstNeospora caninuminfection [ Parasites & Vectors, 2020, 449-2020)] | PubMed: None |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。