PDTC (Pyrrolidinedithiocarbamate ammonium)

製品コードS3633 バッチS363306

化学情報

	Synonyms	APDC, Pyrrolidine dithiocarbamic acid ammonium salt	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₅H₉NS₂.H₃N
	分子量	164.29	CAS No.	5108-96-3
Solubility (25°C)*	体外	DMSO	33 mg/mL (200.86 mM)
		Water	33 mg/mL (200.86 mM)
		Ethanol	8 mg/mL (48.69 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
in vitro	Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	Sprague-Dawley rats
	投薬量	50, 100, and 200 mg/kg
	投与方法	i.v.

参考

[1] Qin JD, et al. Pharm Biol. 2014, 52(11):1460-6.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling [ Mol Metab, 2023, 75:101766]	PubMed: 37406987
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release [ Oncogenesis, 2023, 12(1):18]	PubMed: 36990991
Telmisartan inhibits microglia-induced neurotoxic A1 astrocyte conversion via PPARγ-mediated NF-κB/p65 degradation [ Int Immunopharmacol, 2023, 123:110761]	PubMed: 37544025
Photobiomodulation reduces neuropathic pain after spinal cord injury by downregulating CXCL10 expression [ CNS Neurosci Ther, 2023, 10.1111/cns.14325]	PubMed: 37475184
A novel lncRNA DFRV plays a dual function in influenza A virus infection [ Front Microbiol, 2023, 14:1171423]	PubMed: 37303776
Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways [ Molecules, 2023, 28(4)1873]	PubMed: 36838858
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis [ J Diabetes Res, 2023, 2023:7423661]	PubMed: 37261217
GATA4 Forms a Positive Feedback Loop with CDX2 to Transactivate MUC2 in Bile Acids-Induced Gastric Intestinal Metaplasia [ Gut Liver, 2023, 10.5009/gnl220394]	PubMed: 36860162
Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials [ Int J Oral Sci, 2023, 15(1):31]	PubMed: 37532700
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma [ Signal Transduct Target Ther, 2022, 7(1):46]	PubMed: 35169126

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。