Rosavin

製品コードS3844 バッチS384401

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₀H₂₈O₁₀
	分子量	428.43	CAS No.	84954-92-7
Solubility (25°C)*	体外	DMSO	85 mg/mL (198.39 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities.
in vivo	Rosavin is eliminated in vivo quickly. T_1/2z for i.v. is 2.1 ± 0.5 h. T_max for p.o. is 0.9 ± 0.6 h, which indicates that the concentration of rosavin reached Cmax and it is fast absorbed in vivo ∼ 50 min after oral administration. Vz/F for i.v. is 17.6 ± 5.8 L/kg, which demonstrates that most of rosavin is distributed in extracellular fluid. CLz for p.o. is 93.8 ± 65.6 L/h/kg, which shows that rosavin experiences a slow elimination in vivo after oral administration. AUC_(0−∞) for p.o. is only 850.1 ± 766.1 μg/L h, and Vz/F for p.o. is much larger than that of i.v., which may be caused by highly water-soluble, polar and lower oil-water partition coefficient of rosavin, leading to the difficult absorption of the drug in vivo. Furthermore, rosavin is one of the glycoside compounds, which will be quiet easily hydrolyzed to aglycone in an acidic environment. The oral bioavailability is 4.7%. It may result from the poor membrane permeability, significant first-pass metabolism and efflux vector of small intestine and so on^[1].

製品説明

Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities.

in vivo

Rosavin is eliminated in vivo quickly. T_1/2z for i.v. is 2.1 ± 0.5 h. T_max for p.o. is 0.9 ± 0.6 h, which indicates that the concentration of rosavin reached Cmax and it is fast absorbed in vivo ∼ 50 min after oral administration. Vz/F for i.v. is 17.6 ± 5.8 L/kg, which demonstrates that most of rosavin is distributed in extracellular fluid. CLz for p.o. is 93.8 ± 65.6 L/h/kg, which shows that rosavin experiences a slow elimination in vivo after oral administration. AUC_(0−∞) for p.o. is only 850.1 ± 766.1 μg/L h, and Vz/F for p.o. is much larger than that of i.v., which may be caused by highly water-soluble, polar and lower oil-water partition coefficient of rosavin, leading to the difficult absorption of the drug in vivo. Furthermore, rosavin is one of the glycoside compounds, which will be quiet easily hydrolyzed to aglycone in an acidic environment. The oral bioavailability is 4.7%. It may result from the poor membrane permeability, significant first-pass metabolism and efflux vector of small intestine and so on^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	SD rats
	投薬量	10 mg/kg (i.v) and 50 mg/kg (oral administration)
	投与方法	i.v. and oral administration

参考

[1] Chen D, et al. J Chromatogr Sci. 2016, 54(7):1166-70.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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