受注:045-509-1970 |
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Synonyms | Barbasco, Dactinol, Paraderil, Rotenon, Rotocide | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C23H22O6 |
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分子量 | 394.42 | CAS No. | 83-79-4 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 79 mg/mL (200.29 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. |
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in vitro | Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase, and induces apoptosis through enhancing mitochondrial reactive oxygen species production.[1] |
in vivo | Rotenone, a mitochondrial toxin, induce the up-regulation of alpha-synuclein (alpha-syn) in PD models.[2] |
細胞アッセイ | 細胞株 | Naïve CD8+ T cells |
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濃度 | 0.1 µM | |
反応時間 | 1 day | |
実験の流れ | OCR of CD8+ T cells are analyzed under basal conditions and after sequential injections of 1 μM oligomycin A, 2 μM carbonyl cyanide p-trifluoromethoxyphenylhydrazone, and 0.1 μM rotenone with 1 μM antimycin A. ECAR is analyzed under basal conditions and after sequential injections of 10 mM glucose, 1 μM oligomycin A, and 50 mM 2-deoxyglucose. |
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動物実験 | 動物モデル | mice |
投薬量 | i.g. | |
投与方法 |
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SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization [ Redox Biol, 2024, 70:103039] | PubMed: 38241838 |
Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease [ Sci Rep, 2023, 13(1):16893] | PubMed: 37803093 |
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway [ J Ginseng Res, 2023, 47(1):144-154] | PubMed: 36644390 |
Copper induces cell death by targeting lipoylated TCA cycle proteins [ Science, 2022, 375(6586):1254-1261] | PubMed: 35298263 |
Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis [ Cell Death Dis, 2022, 13(5):436] | PubMed: 35508606 |
Themis is indispensable for IL-2 and IL-15 signaling in T cells [ Sci Signal, 2022, 15(721):eabi9983] | PubMed: 35167340 |
Reduction of ROS-HIF1α-driven glycolysis by taurine alleviates Streptococcus uberis infection [ Food Funct, 2022, 10.1039/d1fo03909a] | PubMed: 35112684 |
Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation [ Sci Rep, 2022, 12(1):11533] | PubMed: 35798783 |
Low glycaemic diets alter lipid metabolism to influence tumour growth [ Nature, 2021, 10.1038/s41586-021-04049-2] | PubMed: 34671163 |
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition [ Cancer Lett, 2021, S0304-3835(21)00167-1] | PubMed: 33872694 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。