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Synonyms | Rubraca, AG014699 Camsylate, PF01367338 Camsylate | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C29H34FN3O5S |
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分子量 | 555.66 | CAS No. | 1859053-21-6 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (179.96 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Rucaparib (Rubraca, AG014699, PF01367338) Camsylate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. |
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in vitro | Deletion of ATM does not impact sensitivity to PARP inhibition by rucaparib.[2] |
細胞アッセイ | 細胞株 | Human prostate cancer lines DU145, ATM-deficient isogenic DU145 cells |
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濃度 | 0-5 µM | |
反応時間 | 3-4 days | |
実験の流れ | Cells were seeded into 24-well plates (2,500–4000 cells/well) and treated with increasing concentrations of drug the following day. Cell viability was assessed after 72–96 hours by adding CellTiter-Glo reagent and measuring luminescence using a plate reader. For clonogenic survival assays, cells were seeded in 6-well plates (500–4000 cells/well) in triplicate. Cells were treated with drug 16 to 18 hours after plating and were allowed to grow for 14 days. |
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Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair [ Adv Sci (Weinh), 2022, 9(30):e2201210] | PubMed: 36047643 |
Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma [ Cell Death Dis, 2022, 13(6):558] | PubMed: 35725817 |
Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition [ Int J Mol Sci, 2022, 23(10)5770] | PubMed: 35628590 |
Combined inhibition of BADSer99 phosphorylation and PARP ablates models of recurrent ovarian carcinoma [ Commun Med (Lond), 2022, 2:82] | PubMed: 35791346 |
Chemoresistance is mediated by ovarian cancer leader cells in vitro [ J Exp Clin Cancer Res, 2021, 40(1):276] | PubMed: 34470672 |
BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair [ Cell Death Dis, 2021, 12(6):546] | PubMed: 34039959 |
Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages [ Front Immunol, 2021, 12:712021] | PubMed: 34899683 |
Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition [ NPJ Breast Cancer, 2021, 7(1):111] | PubMed: 34465787 |
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions [ Sci Rep, 2021, 11(1):18910] | PubMed: 34556698 |
Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide-Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C [ J Pharmacol Exp Ther, 2021, 377(3):385-397] | PubMed: 33820831 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。