SB-3CT

製品コードS7430 バッチS743002

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₅H₁₄O₃S₂
	分子量	306.40	CAS No.	292605-14-2
Solubility (25°C)*	体外	DMSO	61 mg/mL (199.08 mM)
		Ethanol	10 mg/mL warmed with 50ºC water bath (32.63 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	SB-3CT is an effective and selective gelatinase inhibitor with K_i of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.
in vitro	SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro. ^[3]
in vivo	In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. ^[2] SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. ^[3] In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion. ^[4]

製品説明

SB-3CT is an effective and selective gelatinase inhibitor with K_i of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.

in vitro

SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro. ^[3]

in vivo

In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. ^[2]

SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. ^[3]

In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion. ^[4]

プロトコル(参考用のみ)

キナーゼアッセイ	Fluorescence enzymatic activity assays
キナーゼアッセイ	The enzymatic activity of MMP-2, MMP-9 and MMP-7 is monitored with the fluorescence quenched substrate MOCAcPLGLA2pr(Dnp)-AR-NH2. Fluorescence is measure with a PTI spectrofluorometer. The cuvette compartment is thermostated at 25 ℃ 。
細胞アッセイ	細胞株	HCC cells
	濃度	0.1 μM
	反応時間	24 h
	実験の流れ	Cells were treated with indicated concentration of drug for 24 h.
動物実験	動物モデル	Mouse L-CI.5s T-cell lymphoma model
	投薬量	50 mg/kg/d
	投与方法	i.p.

参考

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カスタマーフィードバック

: Data from [Data independently produced by , , Cell Physiol Biochem, 2017, 44(6):2281-2295]

: Data from [Data independently produced by , , Mol Nutr Food Res, 2018, doi:10.1002/mnfr.201700969]

: Data from [Data independently produced by , , Neuropharmacology, 2017, 118:157-166]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity [ Pharmacol Res, 2023, 190:106720]	PubMed: 36893823
COL4A3 Mutation Induced Podocyte Apoptosis by Dysregulation of NADPH Oxidase 4 and MMP-2 [ Kidney Int Rep, 2023, 8(9):1864-1874]	PubMed: 37705901
Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice [ Brain Res Bull, 2023, 204:110810]	PubMed: 37939860
Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson's Disease Mouse Model [ Int J Mol Sci, 2022, 23(5)2793]	PubMed: 35269933
MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice [ J Neurosci, 2022, 42(1):16-32]	PubMed: 34764155
Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer-Targeted Therapies [ Cancers (Basel), 2022, 14(7)1630]	PubMed: 35406401
MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice [ BMC Pulm Med, 2022, 22(1):230]	PubMed: 35705936
Rotenone impairs learning and memory in mice through microglia-mediated blood brain barrier disruption and neuronal apoptosis [ Chemosphere, 2021, S0045-6535(21)03454-8]	PubMed: 34822863
GSK-3α/β Activity Negatively Regulates MMP-1/9 Expression to Suppress Mycobacterium tuberculosis Infection [ Front Immunol, 2021, 12:752466]	PubMed: 35095838
Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1 [ Genome Med, 2020, 12(1):83]	PubMed: 32988398

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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