Sinapinic Acid

製品コードS3981 バッチS398101

印刷

化学情報

Chemical Structure Synonyms Sinapic acid Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C11H12O5
 
分子量 224.21 CAS No. 530-59-6
Solubility (25°C)* 体外 DMSO 44 mg/mL (196.24 mM)
Ethanol 44 mg/mL (196.24 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.
in vitro

Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants). Sinapic acid shows antioxidant, antimicrobial, anti-inflammatory, anticancer, and anti-anxiety activity. Sinapic acid inhibits nuclear factor-kappa B (NF-κB) activation in macrophages. Via NF-κB inactivation sinapic acid suppresses the expression of proinflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, and interleukin-1β. Sinapic acid exerts an inhibitory effect against tumorigenic colon cells, but a low influence on breast cancer cells. It also shows antiproliferative action (ability to prevent, or retard, the spread of malignant cells into surrounding tissue) on the human breast cancer T47D cell line[1].
in vivo

Sinapic acid is an important anxiolytic (anti-anxiety) agent. Its anxiolytic-like effect is mediated by the γ-aminobutyric acid (GABA) neurotransmitter system. Sinapic acid might act like the agonist of a specific GABA receptor. Due to its metal-chelating ability, it has a protective effect against arsenic-induced toxicity in rats as measured by the activities of serum hepatospecific enzymes, together with lipid peroxidative markers[1]. SA inhibits lipopolysaccharide-induced NO, prostaglandin E2, tumor necrosis factor-α and interleukin-1β production in a dose-dependent manner through the suppression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, and proinflammatory cytokines expressions. In addition, SA exhibits cognitive-ameliorating effects in a CO2- or scopolamine-induced mouse amnesic model. It attenuates Aβ1-42 protein-induced hippocampal neuronal cell death and thus exhibits neuroprotection against Aβ protein-induced neuronal injuries[2].

プロトコル(参考用のみ)

動物実験 動物モデル Mouse model of amyloid β (Aβ)1-42 protein-induced Alzheimer
投薬量 10 mg/kg/day
投与方法 p.o.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。