Sodium Aescinate

製品コードS3770 バッチS377002

化学情報

	Synonyms	Escin sodium salt	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₅₄H₈₃NaO₂₃
	分子量	1123.21	CAS No.	20977-05-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (89.03 mM)
		Water	100 mg/mL (89.03 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.
in vivo	Sodium aescinate (SA) prevents and alleviates acute lung injury induced by oleic acid^[1]. It is used as a vasoactive drug in clinical treatment. Topical application of SA can accelerate wound healing significantly marked by compact collagen deposition and newly regenerated epithelial layer. Sodium aescinate (SA) may effectively control and improve wound healing in diabetic rats via its anti-inflammatory and antioxidant activities^[2].

製品説明

Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.

in vivo

Sodium aescinate (SA) prevents and alleviates acute lung injury induced by oleic acid^[1]. It is used as a vasoactive drug in clinical treatment. Topical application of SA can accelerate wound healing significantly marked by compact collagen deposition and newly regenerated epithelial layer. Sodium aescinate (SA) may effectively control and improve wound healing in diabetic rats via its anti-inflammatory and antioxidant activities^[2].

プロトコル(参考用のみ)

動物実験	動物モデル	Sprague-Dawley rats
	投薬量	1 mg/kg, 2 mg/kg and 6mg/kg
	投与方法	i.v.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Sodium aescinate inhibits microglia activation through NF-κB pathway and exerts neuroprotective effect [ Front Pharmacol, 2023, 14:1086429]	PubMed: 36778008

Sodium aescinate inhibits microglia activation through NF-κB pathway and exerts neuroprotective effect [ Front Pharmacol, 2023, 14:1086429]

PubMed: 36778008

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。