Sodium oxamate

製品コードS6871 バッチS687105

印刷

化学情報

Chemical Structure Synonyms SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C2H2NNaO3
分子量 111.03 CAS No. 565-73-1
Solubility (25°C)* 体外 Water 22 mg/mL (198.14 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
in vitro

Sodium oxamate, a specific inhibitor of LDH-A, enhances the suppressive effects of PARP inhibitors on ovarian cancer without BRCA mutations, remarkably promoting the inhibitory effects of PARP inhibitors on wild-type BRCA ovarian cancer cells.[3]
in vivo

Sodium oxamate reduces the growth of colorectal cancer in CRC mice, by restoring the down-regulated MMR functional proteins and attenuating chemotherapy resistance to caused by C. tropicalis.[4]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 wild-type BRCA ovarian cancer cells (A2780 and SKOV3)
濃度 50 nM
反応時間 24 h
実験の流れ

Cell proliferation is evaluated using a Cell Counting Kit-8 (CCK-8). SKOV3 cells and A2780 cells are seeded in a 96-well culture plates at a density of 2×105 cells/well and incubated with different concentrations of the drugs (oxamate, AG14361 and ) for different times. Detection reagent is added to the cells, and the luminescence signals are determined.
動物実験 動物モデル four-week-old male BALB/c nude mice of CRC xenograft
投薬量 500 mg/kg
投与方法 i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression [ J Exp Clin Cancer Res, 2024, 43(1):105] PubMed: 38576043
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis [ J Adv Res, 2024, S2090-1232(24)00025-0] PubMed: 38219869
IL-6-Derived Autocrine Lactate Promotes Immune Escape of Uveal Melanoma [ Invest Ophthalmol Vis Sci, 2024, 65(3):37] PubMed: 38551584
Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes [ Theranostics, 2023, 13(11):3856-3871] PubMed: 37441587
Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation [ Mol Cell Biol, 2023, 10.1080/10985549.2023.2253131] PubMed: 37807652
Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation [ Mol Cell Biol, 2023, 43(10):531-546] PubMed: 37807652
C. tropicalis promotes chemotherapy resistance in colon cancer through increasing lactate production to regulate the mismatch repair system [ Int J Biol Sci, 2021, 17(11):2756-2769] PubMed: 34345205
LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells [ Aging (Albany NY), 2021, 13(24):25920-25930] PubMed: 34919531

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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