受注:045-509-1970 |
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Synonyms | SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C2H2NNaO3 |
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分子量 | 111.03 | CAS No. | 565-73-1 | |
Solubility (25°C)* | 体外 | Water | 22 mg/mL (198.14 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation. |
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in vitro | Sodium oxamate, a specific inhibitor of LDH-A, enhances the suppressive effects of PARP inhibitors on ovarian cancer without BRCA mutations, remarkably promoting the inhibitory effects of PARP inhibitors on wild-type BRCA ovarian cancer cells.[3] |
in vivo | Sodium oxamate reduces the growth of colorectal cancer in CRC mice, by restoring the down-regulated MMR functional proteins and attenuating chemotherapy resistance to caused by C. tropicalis.[4] |
細胞アッセイ | 細胞株 | wild-type BRCA ovarian cancer cells (A2780 and SKOV3) |
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濃度 | 50 nM | |
反応時間 | 24 h | |
実験の流れ | Cell proliferation is evaluated using a Cell Counting Kit-8 (CCK-8). SKOV3 cells and A2780 cells are seeded in a 96-well culture plates at a density of 2×105 cells/well and incubated with different concentrations of the drugs (oxamate, AG14361 and ) for different times. Detection reagent is added to the cells, and the luminescence signals are determined. |
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動物実験 | 動物モデル | four-week-old male BALB/c nude mice of CRC xenograft |
投薬量 | 500 mg/kg | |
投与方法 | i.p. |
Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization [ Cancer Cell, 2024, S1535-6108(24)00119-3] | PubMed: 38640932 |
GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression [ J Exp Clin Cancer Res, 2024, 43(1):105] | PubMed: 38576043 |
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis [ J Adv Res, 2024, S2090-1232(24)00025-0] | PubMed: 38219869 |
IL-6-Derived Autocrine Lactate Promotes Immune Escape of Uveal Melanoma [ Invest Ophthalmol Vis Sci, 2024, 65(3):37] | PubMed: 38551584 |
Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes [ Theranostics, 2023, 13(11):3856-3871] | PubMed: 37441587 |
Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation [ Mol Cell Biol, 2023, 10.1080/10985549.2023.2253131] | PubMed: 37807652 |
Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation [ Mol Cell Biol, 2023, 43(10):531-546] | PubMed: 37807652 |
C. tropicalis promotes chemotherapy resistance in colon cancer through increasing lactate production to regulate the mismatch repair system [ Int J Biol Sci, 2021, 17(11):2756-2769] | PubMed: 34345205 |
LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells [ Aging (Albany NY), 2021, 13(24):25920-25930] | PubMed: 34919531 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
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