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Synonyms | 4-Azaoctamethylenediamine trihydrochloride | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C7H19N3.3HCl |
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分子量 | 254.63 | CAS No. | 334-50-9 | |
Solubility (25°C)* | 体外 | Water | 50 mg/mL (196.36 mM) | |
DMSO | 30 mg/mL (117.81 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA). |
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in vitro | Spermidine induces autophagy in cultured yeast and mammalian cells, as well as in nematodes and flies[1]. |
in vivo | Spermidine at 200 μg/mouse, intracerebellar injection (icb), does not alter basal cGMP levels. Spermidine attenuates responses mediated through the N-methyl-D-aspartate (NMDA), NMDA-associated glycine receptor and quisqualate receptors. Spermidine is widely distributed in neural and non-neural tissues and has been shown to play a key role in cell differentiation and growth[2]. |
動物実験 | 動物モデル | |
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投薬量 | ||
投与方法 | intracerebellar injection (icb) |
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Metabolic support by macrophages sustains colonic epithelial homeostasis [ Cell Metab, 2023, S1550-4131(23)00341-8] | PubMed: 37804836 |
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19)10255] | PubMed: 34638596 |
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19), 10255] | PubMed: None |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。