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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C16H11N3O3 |
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分子量 | 293.28 | CAS No. | 285986-31-4 | |
Solubility (25°C)* | 体外 | DMSO | 30 mg/mL (102.29 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform. |
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in vitro | STAT5-IN-1, the STAT5 phosphorylation specific inhibitor, selectively blocks the STAT5 signaling and decreases the percentage of CD4+CD25+Foxp3+ Tregs after SEC2 stimulation on murine splenocytes.[2] |
in vivo | STAT5-IN-1, a STAT5 inhibitor, significantly attenuates atherosclerosis in ApoE-/- mice induced by HFD via decreasing inflammation.[3] |
細胞アッセイ | 細胞株 | murine splenocytes |
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濃度 | 0.47 mM | |
反応時間 | 3 days | |
実験の流れ | Fresh murine splenocytes seeded in 24-well flat-bottom plates are treated with each inhibitor at final concentrations of 10 μM LY294002, 10 mM Trigonelline, 0.47 mM STAT5-IN-1, 50 μM SB431542, and 1 μM SIS3, or treated with 10 μg/mL anti-IL-2 neutralizing antibody, respectively, then cells are stimulated with 104 ng/mL SEC2 for 3 days in a humidified incubator at 37 ℃ with 5% CO2. |
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動物実験 | 動物モデル | ApoE-/- mice |
投薬量 | 10 mg/kg | |
投与方法 | p.o. |
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Sustained AhR activity programs memory fate of early effector CD8+ T cells [ Proc Natl Acad Sci U S A, 2024, 121(11):e2317658121] | PubMed: 38437537 |
Macrophage re-programming by JAK inhibitors relies on MAFB [ Cell Mol Life Sci, 2024, 81(1):152] | PubMed: 38528207 |
Hedgehog receptors exert immune-surveillance roles in the epidermis across species [ Cell Rep, 2023, 42(8):112929] | PubMed: 37527037 |
CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis [ Front Immunol, 2023, 14:1078958] | PubMed: 37025992 |
GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis [ Front Immunol, 2023, 10.3389/fimmu.2023.1165306] | PubMed: 37920458 |
Vitamin A- and D-Deficient Diets Disrupt Intestinal Antimicrobial Peptide Defense Involving Wnt and STAT5 Signaling Pathways in Mice [ Nutrients, 2023, 15(2)376] | PubMed: 36678247 |
Human α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet [ Int J Mol Sci, 2023, 24(18)13878] | PubMed: 37762180 |
BCL6 inhibition ameliorates ruxolitinib resistance in CRLF2-rearranged acute lymphoblastic leukemia [ Haematologica, 2022, 10.3324/haematol.2022.280879] | PubMed: 36005560 |
Regulation of Il-2 on the expression of granzyme B- and perforin-like genes and its functional implication in grass carp peripheral blood neutrophils [ Fish Shellfish Immunol, 2022, 124:472-479] | PubMed: 35483596 |
Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways [ Biomed Pharmacother, 2021, 143:112204] | PubMed: 34560552 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
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