受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C25H28N6O2 |
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分子量 | 444.53 | CAS No. | 2499663-01-1 | |
Solubility (25°C)* | 体外 | DMSO | 89 mg/mL (200.21 mM) | |
Ethanol | 89 mg/mL (200.21 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases. |
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in vitro | STM2457 has a highly efficient and selective catalytic inhibition on RNA methyltransferase METTL3, causing gene-expression defects consistent with an effect on the mRNA translational efficiency of m6A substrates.[1] |
in vivo | STM2457 prevents acute myeloid leukaemia (AML) expansion and reduces the number of key leukaemia stem cells in vivo.[1] |
細胞アッセイ | 細胞株 | MOLM-13 cells |
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濃度 | 0.1, 1, 5 and 10 μM | |
反応時間 | -- | |
実験の流れ | Western blot analysis |
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動物実験 | 動物モデル | AML PDX-1 mice (NPM1c cells), AML PDX-2 mice (MLL-AF6 cells), AML PDX-3 mice (MLL-AF10) |
投薬量 | 50 mg/kg | |
投与方法 | -- |
Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity [ Cell Rep, 2024, 43(2):113796] | PubMed: 38367240 |
M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy [ Int J Biol Sci, 2023, 19(5):1543-1563] | PubMed: 37056926 |
METTL3-mediated m6A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis [ Cell Rep, 2023, 42(6):112589] | PubMed: 37270777 |
m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus [ Mol Med, 2023, 29(1):46] | PubMed: 37013484 |
METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6 [ Nutr Metab (Lond), 2023, 20(1):40] | PubMed: 37710320 |
METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6 [ Nutr Metab (Lond), 2023, 20(1):40] | PubMed: 37710320 |
N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA [ Nat Commun, 2022, 13(1):7038] | PubMed: 36396934 |
METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice [ Cell Death Discov, 2022, 8(1):62] | PubMed: 35165276 |
METTL3 inhibition reduces N6 -methyladenosine levels and prevents allogeneic CD4+ T-cell responses [ Immunol Cell Biol, 2022, 100(9):718-730] | PubMed: 36005900 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。