Succinic acid

製品コードS3791 バッチS379102

化学情報

	Synonyms	1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₄H₆O₄
	分子量	118.09	CAS No.	110-15-6
Solubility (25°C)*	体外	DMSO	24 mg/mL (203.23 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.
in vivo	It has been reported that succinic acid had sedative effect (4000 mg/kg) and protective action against high pressure oxygen convulsion (1180 mg/kg). Succinic acid at dose of 1180 mg/kg produces significant decrease of the locomotor activity and hyperthermia and prolonged the pentobarbital sleeping time significantly in mice. Succinic acid is found to protect rats against audiogenic seizure and inhibit the electroshock seizure in mice, but not the convulsion induced by picrotoxin, strychnine and semicarbazide. Succinic acid (100-400 mg/kg) dose-dependently inhibits pentylenetetrazol chemical and amygdale kindled seizer. Succinic acid is widely distributed in the nervous systems. Succinic acid possesses anxiolytic effects in the elevated plus-maze, food neophobia and stress-induced hyperthermia models^[1].

製品説明

Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.

in vivo

It has been reported that succinic acid had sedative effect (4000 mg/kg) and protective action against high pressure oxygen convulsion (1180 mg/kg). Succinic acid at dose of 1180 mg/kg produces significant decrease of the locomotor activity and hyperthermia and prolonged the pentobarbital sleeping time significantly in mice. Succinic acid is found to protect rats against audiogenic seizure and inhibit the electroshock seizure in mice, but not the convulsion induced by picrotoxin, strychnine and semicarbazide. Succinic acid (100-400 mg/kg) dose-dependently inhibits pentylenetetrazol chemical and amygdale kindled seizer. Succinic acid is widely distributed in the nervous systems. Succinic acid possesses anxiolytic effects in the elevated plus-maze, food neophobia and stress-induced hyperthermia models^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	Male Swiss mice
	投薬量	3.0 or 6.0 mg/kg
	投与方法	p.o./i.p.

参考

[1] Chen SW, et al. Life Sci. 2003, 73(25):3257-64.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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