受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C237H370N66O69S |
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分子量 | 5279.94 | CAS No. | 1599441-71-0 | |
Solubility (25°C)* | 体外 | Water | 100 mg/mL (18.93 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction. |
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in vitro | Super-TDU reduced endogenous interaction between YAP and TEADs. It inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27, but not MKN-45. Moreover, the Super-TDU downregulated expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU significantly inhibited growth of HeLa, MGC-803, HCT116, A549, and MCF-7 cells, but only marginally inhibited growth of Jurkat and Raji cells, indicating a selectivity of the Super-TDU in inhibiting tumor cell growth. Super-TDU may specifically target tumor cells with an elevated YAP/VGLL4 ratio[1]. |
in vivo | Super-TDU has the potential in treating gastric cancer by directly targeting YAP-TEADs, and importantly, unlike the conventional drug compound 5-FU, its antitumor activity tends to be specific toward tumors with an elevated ratio of YAP to VGLL4[1]. |
細胞アッセイ | 細胞株 | HCT116 and SW480 cells |
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濃度 | 0-320 ng/ml | |
反応時間 | 72 h | |
実験の流れ | Cells are transfected with the indicated plasmids. An ATP-based cell viability assay is used for detecting cell proliferation. The ATP content is measured. Briefly, 100 μl of assay reagent is added to the wells, and mixed for 2 min at room temperature. After 10 min, intracellular ATP content is measured using a multilabel luminescence counter. Cell viability is calculated. |
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動物実験 | 動物モデル | BALB/cA nu/nu mice |
投薬量 | 50 or 500 μg/kg | |
投与方法 | tail vein injection |
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YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis [ Gut Microbes, 2023, 15(1):2192501] | PubMed: 36959122 |
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway [ Cell Death Discov, 2023, 9(1):424] | PubMed: 38001078 |
CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation [ Nat Commun, 2022, 13(1):3117] | PubMed: 35660741 |
Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2 [ JCI Insight, 2022, 7(14)e158207] | PubMed: 35708907 |
Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state [ Int J Mol Med, 2022, 49(6)84] | PubMed: 35514314 |
Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers [ Exp Dermatol, 2022, 31(10):1477-1499] | PubMed: 35913427 |
ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma [ J Exp Clin Cancer Res, 2021, 40(1):23] | PubMed: 33413564 |
Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway [ Front Cell Dev Biol, 2021, 9:741060] | PubMed: 34805150 |
Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway [ Front Cell Dev Biol, 2021, 9:741060] | PubMed: 34805150 |
Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading [ Biomaterials, 2019, 205:64-80] | PubMed: 30904599 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。