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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C26H37N5O5 |
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分子量 | 499.60 | CAS No. | 171235-71-5 | ||||
Solubility (25°C)* | 体外 | DMSO | 99 mg/mL (198.15 mM) | ||||
Water (warmed with 50ºC water bath) | 99 mg/mL (198.15 mM) | ||||||
Ethanol | 99 mg/mL (198.15 mM) | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP). |
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in vitro | TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. [1] TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). [2] TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. [3] TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. [4] |
in vivo | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors |
細胞アッセイ | 細胞株 | LI90 cells |
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濃度 | 20 μM | |
反応時間 | 60 hours | |
実験の流れ | Five thousand cells are seeded into each well of 96-well plates and their viability is assessed by CellTiter-Glo Luminescent Cell Viability assay. Upon serum deprivation for 24 h, the cells are treated with Ang II for 60 h with and without pretreatment with each inhibitor and antagonist. The assay substrates are then added to each well on the plate and the samples are evaluated using a luminometer. |
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動物実験 | 動物モデル | Male Sprague-Dawley rats |
投薬量 | 1 μg | |
投与方法 | i.c.v. |
Data from [Data independently produced by , , Sci Rep, 2017, 7:46315]
Data from [Data independently produced by , , Biochim Biophys Acta Gen Subj, 2018, 1862(9):1988-1994]
Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8+ T cell infiltration [ Br J Cancer, 2024, 10.1038/s41416-024-02576-z] | PubMed: 38291183 |
Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism [ PLoS Pathog, 2023, 19(9):e1011629] | PubMed: 37669308 |
Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis [ J Transl Med, 2023, 21(1):530] | PubMed: 37543570 |
Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis [ J Transl Med, 2023, 21(1):530] | PubMed: 37543570 |
Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism [ PLoS Pathog, 2023, 19(9):e1011629] | PubMed: 37669308 |
MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis [ Cell Death Discov, 2022, 8(1):197] | PubMed: 35418181 |
The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17 [ FASEB J, 2022, 36(3):e22234] | PubMed: 35199397 |
Targeting the EGFR-ERK axis using the compatible solute ectoine to stabilize CFTR mutant F508del [ FASEB J, 2022, 36(5):e22270] | PubMed: 35412656 |
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase : a novel approach in the prevention of osteoclastogenesis [ Bone Joint Res, 2022, 11(11):763-776] | PubMed: 36331083 |
Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer [ Ann Surg Oncol, 2022, 10.1245/s10434-022-12505-0] | PubMed: 36149610 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。