Tinidazole

製品コードS4068 バッチS406801

化学情報

	Synonyms	CP12574	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₈H₁₃N₃O₄S
	分子量	247.27	CAS No.	19387-91-8
Solubility (25°C)*	体外	DMSO	49 mg/mL (198.16 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Tinidazole (CP12574) is an anti-parasitic drug.
in vitro	Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. ^[1] Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. ^[2] Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. ^[3] Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. ^[4] Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL. ^[5]

製品説明

Tinidazole (CP12574) is an anti-parasitic drug.

in vitro

Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. ^[1] Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. ^[2] Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. ^[3] Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. ^[4] Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL. ^[5]

プロトコル(参考用のみ)

参考

[4] Meloni BP, et al. Trans R Soc Trop Med Hyg, 1990, 84(3), 375-379.

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Activity of Drug Combinations against Mycobacterium abscessus Grown in Aerobic and Hypoxic Conditions [ Microorganisms, 2022, 10(7)1421]	PubMed: 35889140

Activity of Drug Combinations against Mycobacterium abscessus Grown in Aerobic and Hypoxic Conditions [ Microorganisms, 2022, 10(7)1421]

PubMed: 35889140

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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