Tiopronin

製品コードS2062 バッチS206201

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C5H9NO3S
分子量 163.19 CAS No. 1953-02-2
Solubility (25°C)* 体外 DMSO 32 mg/mL (196.09 mM)
Water 32 mg/mL (196.09 mM)
Ethanol 32 mg/mL (196.09 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
in vitro Tiopronin is an antioxidant with a free thiol (sulfidryl) group that has been shown to protect against cisplatin nephrotoxicity both in vitro and in vivo. Tiopronin improves the defence of the cochlea and scavenge the reactive oxygen species, whereas vitamin E (a-tocopherol) and vitamin C act by inhibiting lipid peroxidation and preventing free radical formation. [1] Tiopronin (2 mM) completely prevents the Cisplatin-induced increase in enzyme leakage and substantially blocks the decrease of MTT reduction caused by Cisplatin. Tiopronin also significantly protects the renal slices from cisplatin-induced toxic effects. Tiopronin protects against cisplatin-induced nephrotoxicity by acting as an alternative target for Cisplatin both intra- and extracellularly and thus protects against cisplatin-induced depletion of glutathione in the kidney cell. [2] Tiopronin protects rat kidney slices in vitro from the nephrotoxic effects of Cisplatin and does not reduce the antitumour activity of Cisplatin. Tiopronin provides marked protection againstcisplatin-induced increases in urea and creatinine. [3] Tiopronin protects against Cisplatin-induced changes in the adenine nucleotides in rat renal cortical slices. [4]
in vivo Tiopronin significantly lowers both the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, while only the serum ALT level is lowered by ursodeoxycholic acid (UDCA) in rats. Tiopronin significantly decreases the serum and liver levels of triglyceride (TG), total cholesterol (TC) and free fatty acids (FFA) as well as the serum LDL-C level, and increases the serum HDL-C level. [5]

プロトコル(参考用のみ)

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。