Tocilizumab (anti-IL-6R)

製品コード：A2012         Batch: A201203

印刷

Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.

製品説明

CAS No. ‎375823-41-9
Formulation PBS buffer, pH 7.2
Isotype Human IgG1
Source CHO cells
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping Shipped under low temperature conditions
Purity 98.4%
Protein concentration 5 mg/ml
Endotoxin Level <1 EU/mg

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c+ B cells [ Nature, 2023, 615(7951):305-314] PubMed: 36813963
Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease [ Nat Commun, 2023, 14(1):6959] PubMed: 37907518
Anti-inflammatory effect of interleukin-6 highly enriched in secretome of two clinically relevant sources of mesenchymal stromal cells [ Front Cell Dev Biol, 2023, 11:1244120] PubMed: 37745306
Cancer-associated fibroblasts induce growth and radioresistance of breast cancer cells through paracrine IL-6 [ Cell Death Discov, 2023, 9(1):6] PubMed: 36635302
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury [ Int J Mol Sci, 2023, 24(11)9692] PubMed: 37298645
ENO1 Promotes OSCC Migration and Invasion by Orchestrating IL-6 Secretion from Macrophages via a Positive Feedback Loop [ Int J Mol Sci, 2023, 24(1)737] PubMed: 36614179
Anti-inflammatory effect of interleukin-6 highly enriched in secretome of two clinically relevant sources of mesenchymal stromal cells [ Front Cell Dev Biol, 2023, 11:1244120] PubMed: 37745306
IL-6 Plays a Critical Role in Stromal Fibroblast RANKL Induction and Consequent Osteoclastogenesis in Ameloblastoma Progression [ Lab Invest, 2023, 103(1):100023] PubMed: 36748192
Characterization of HZ0412a, a novel potent humanized anti-IL-6 receptor antibody that blocks IL-6R binding to gp130 [ Antib Ther, 2023, 6(2):119-126] PubMed: 37324549
Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway [ Signal Transduct Target Ther, 2022, 7(1):52] PubMed: 35194016

人間や獣医の診断であるか治療的な使用のためにでない。