Tranylcypromine HCl

製品コードS4246 バッチS424603

印刷

化学情報

Chemical Structure Synonyms 2-PCPA HCl, SKF-385 HCl Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H12ClN
分子量 169.65 CAS No. 1986-47-6
Solubility (25°C)* 体外 DMSO 33 mg/mL (194.51 mM)
Water 33 mg/mL (194.51 mM)
Ethanol 33 mg/mL (194.51 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.
in vitro R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(−)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. [1] Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. [2] Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes. [3]
in vivo Tranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats. [4]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Front Neurol, 2017, 8:626]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [ Cell Rep, 2023, 42(6):112566] PubMed: 37235474
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Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation [ Biomolecules, 2023, 13(3)521] PubMed: 36979456
Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer [ PLoS One, 2023, 18(1):e0279063] PubMed: 36595522
Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets [ Cell Stem Cell, 2022, 29(8):1229-1245.e7] PubMed: 35931032
Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules [ Int J Mol Sci, 2022, 23(8)4213] PubMed: 35457029
Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm [ Adv Sci (Weinh), 2021, e2100779] PubMed: 34363353
LSD1-mediated demethylation of OCT4 safeguards pluripotent stem cells by maintaining the transcription of PORE-motif-containing genes [ Sci Rep, 2021, 11(1):10285] PubMed: 33986438
Meltome atlas-thermal proteome stability across the tree of life. [ Nat Methods, 2020, 17(5):495-503] PubMed: 32284610
IGFBP7 activates retinoid acid-induced responses in acute myeloid leukemia stem and progenitor cells [ Blood Adv, 2020, 4(24):6368-6383] PubMed: 33351133

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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