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Synonyms | Tromethamine | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C4H11NO3 |
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分子量 | 121.14 | CAS No. | 77-86-1 | |
Solubility (25°C)* | 体外 | Water | 24 mg/mL (198.11 mM) | |
DMSO | 2 mg/mL (16.5 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Trometamol(Tromethamine) is a proton acceptor used to treat acidemia. |
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in vitro | Trometamol is a proton acceptor that generates NH3 +/HCO3 - without generating CO2, and the protonated R-NH3 + is eliminated by the kidneys. Trometamol is the buffer of choice in the situation where CO2 elimination is impaired (in which case NaHCO3 cannot correct acidemia), and to avoid a Na+ load. Even during short intervals of apneic oxygenation when CO2 elimination is curtailed, trometamol, but not bicarbonate, will maintain a normal arterial pH. Trometamol also acts as an osmotic diuretic, increasing urine flow, urinary pH, and excretion of fixed acids, carbon dioxide and electrolytes. A significant fraction of trometamol is not ionized and therefore is capable of reaching equilibrium in total body water. This portion may penetrate cells and may neutralize acidic ions of the intracellular fluid. [1] |
in vivo | The drug is rapidly eliminated by the kidney; 75% or more appears in the urine after eight hours. Urinary excretion continues over a period of three days. The maximum daily dose is 15 mmol/kg for an adult. In large doses, trometamol may induce respiratory depression and hypoglycemia. [1] |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。