Tyloxapol

化学情報

生物活性

プロトコル(参考用のみ)

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

製品コードS4578 バッチS457801

	Synonyms	Triton WR1339	Storage (From the date of receipt)	2 year -80°C liquid
	化学式	(C₁₄H₂₂O.C₂H₄O.CH₂O)x
	分子量		CAS No.	25301-02-4
Solubility (25°C)*	体外


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

細胞アッセイ	細胞株	HEK293 cells
	濃度	100 μg/ml
	反応時間	48 h
	実験の流れ	HEK293 cells growing at 40% confluency are exposed to different test dispersions of SLP or their individual components for 48 h and observed the alterations in cellular morphology.
動物実験	動物モデル	Albino (Wistar) male rats
	投薬量	400mg/kg
	投与方法	i.v.

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.

in vitro

Tyloxapol is generally regarded as a safe stabilizer. In some studies, it is reported to causes cytotoxicity in epithelial and red blood cells, induces lysis of human Jurkat T-lymphoblasts and the apoptosis in RAW 264.7 murine macrophage-like cells and NIH/3T3 mouse fibroblast cells. These indications of cytotoxicity, however, do not reflect the in vivo use of Tyloxapol, since it is rarely used alone in clinical applications^[3].

A single intravenous injection of tyloxapol at dose of 400mg/kg body weight shows three distinctive phases, sharp linear increment, slow linear increment and slow decrement of plasma lipids toward the basal levels^[1]. The treatment of tyloxapol enhannces the pulmonary absorption of rh-insulin and increases the absorption of inhaled insulin in diabetic rats. It might significantly increase the hypoglycemic effect of intratracheally administered insulin in diabetic rats but does not change the LDH activity^[2].

Deciphering COVID-19 host transcriptomic complexity and variations for therapeutic discovery against new variants [ iScience, 2022, 25(10):105068]	PubMed: 36093376
Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver [ Front Cell Dev Biol, 2022, 10:808140]	PubMed: 35372326
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734]	PubMed: 32511305

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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