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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C25H37N5O2S |
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分子量 | 471.66 | CAS No. | 2271358-64-4 | |
Solubility (25°C)* | 体外 | DMSO | 94 mg/mL (199.29 mM) | |
Ethanol | 94 mg/mL (199.29 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 Neuroblastoma Cells. |
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in vitro | UAMC-3203 has an impressive t1/2 when incubated with both human and rat microsomes (t1/2 = 20.5 h and t1/2 = 16.5 h respectively) but is found to be relatively less stable when incubated with murine microsomes (t1/2 = 3.46 h)[1]. |
in vivo | UAMC-3203 significantly lowers the plasma levels of lactate dehydrogenase (LDH) in mice. It is rapidly removed from the bloodstream and redistributed into various tissues, as can be expected for lipophilic basic compounds. Significant concentrations of UAMC-3203 are found in all analyzed tissues (liver, kidney, and lungs)[1]. |
細胞アッセイ | 細胞株 | IMR-32 Neuroblastoma Cells |
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濃度 | 10 nM | |
反応時間 | ||
実験の流れ | Cells were treated with various concentrations of drug. |
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動物実験 | 動物モデル | wild-type mice derived from a Gpx4 fl/fl breeding |
投薬量 | 20 μmol/kg | |
投与方法 | IV |
Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma [ Cell Death Differ, 2023, 30(8):1988-2004] | PubMed: 37479744 |
Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy [ Br J Cancer, 2023, 129(4):601-611] | PubMed: 37402867 |
Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy [ Br J Cancer, 2023, 129(4):601-611] | PubMed: 37402867 |
Ferroptosis signaling promotes the release of misfolded proteins via exosomes to rescue ER stress in hepatocellular carcinoma [ Free Radic Biol Med, 2023, 202:110-120] | PubMed: 36997100 |
p53 status modifies cytotoxic activity of lactoferrin under hypoxic conditions [ Front Pharmacol, 2022, 13:988335] | PubMed: 36199689 |
UAMC-3203 or/and Deferoxamine Improve Post-Resuscitation Myocardial Dysfunction Through Suppressing Ferroptosis in a Rat Model of Cardiac Arrest [ Shock, 2022, 57(3):344-350] | PubMed: 34618729 |
Myostatin/HIF2α-Mediated Ferroptosis is Involved in Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease [ Int J Chron Obstruct Pulmon Dis, 2022, 17:2383-2399] | PubMed: 36185172 |
HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes [ J Mol Cell Cardiol, 2021, 150:65-76] | PubMed: 33098823 |
HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes [ J Mol Cell Cardiol, 2021, 150:65-76] | PubMed: 33098823 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。