受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C22H16F4N4OS |
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分子量 | 460.45 | CAS No. | 2443816-45-1 | |
Solubility (25°C)* | 体外 | DMSO | 92 mg/mL (199.8 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. |
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in vitro | ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress[1]. |
細胞アッセイ | 細胞株 | U2OS cells |
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濃度 | 5 μM | |
反応時間 | 2.5 h | |
実験の流れ | U2OS cells stably expressing EGFP-DFCP1 are treated for 2.5 hr with vehicle control or 100 nM AZD8055 with or without 5 μM ULK-101 and imaged live by fluorescent microscopy. |
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks [ Immunity, 2024, 57(2):287-302.e12] | PubMed: 38354704 |
Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression [ Cell Rep, 2024, 43(1):113575] | PubMed: 38181788 |
Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia [ Sci Rep, 2024, 14(1):4000] | PubMed: 38369625 |
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response [ EMBO J, 2023, e113349.] | PubMed: 37306101 |
Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival [ Nat Commun, 2022, 13(1):6589] | PubMed: 36329028 |
Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth [ Cell Commun Signal, 2022, 20(1):93] | PubMed: 35715817 |
Autophagy regulates transforming growth factor β signaling and receptor trafficking [ Biochim Biophys Acta Mol Cell Res, 2022, S0167-4889(22)00076-3] | PubMed: 35605790 |
Regulation of IFNα-induced expression of the short ACE2 isoform by ULK1 [ Mol Immunol, 2022, 147:1-9] | PubMed: 35489289 |
TP53 loss-of-function causes vulnerability to autophagy inhibition in aggressive prostate cancer [ Int J Urol, 2022, 29(9):1085-1094] | PubMed: 35975690 |
Synergetic contributions of viral VP1, VP3, and 3C to activation of the AKT-AMPK-MAPK-MTOR signaling pathway for Seneca Valley virus-induced autophagy [ J Virol, 2021, JVI0155021] | PubMed: 34757844 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。