Urethane

製品コードS4544 バッチS454401

化学情報

	Synonyms	Carbamic acid ethyl ester, Ethyl carbamate, Ethylurethane	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₃H₇NO₂
	分子量	89.09	CAS No.	51-79-6
Solubility (25°C)*	体外	DMSO	17 mg/mL (190.81 mM)
		Water	17 mg/mL (190.81 mM)
		Ethanol	17 mg/mL (190.81 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Urethane (Carbamic acid ethyl ester, Ethyl carbamate, Ethylurethane) is a kind of antineoplastic agent that is also used as a veterinary anesthetic. It is a intermediate in organic synthesis.
in vitro	urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors^[3].
in vivo	Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems^[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics^[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	C57BL/6 mice
	投薬量	1.5 g/kg
	投与方法	i.p.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice [ DSpace, 2023, Volume 30 Issue 11]	PubMed: none

Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice [ DSpace, 2023, Volume 30 Issue 11]

PubMed: none

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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