Urolithin A

製品コードS5312 バッチS531203

印刷

化学情報

Synonyms

3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₃H₈O₄

分子量

228.20

CAS No.

1143-70-0

Solubility (25°C)*

体外

DMSO

46 mg/mL (201.57 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

	5% DMSO 1 95% Corn oil	0.56mg/ml
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	1.1mg/ml

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
in vitro	Urolithin A inhibits cell proliferation and reduces oxidative stress status in liver cancer.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HepG2 cells
	濃度	137 µM
	反応時間	24 h
	実験の流れ	Cells were treated with various concentrations of drug for 24 h.
動物実験	動物モデル	ICR Mice
	投薬量	50, 100, and 150 mg/kg
	投与方法	o.g. or s.c.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis [ Cell Commun Signal, 2023, 21(1):357]	PubMed: 38102662
Urolithin A's Antioxidative, Anti-Inflammatory, and Antiapoptotic Activities Mitigate Doxorubicin-Induced Liver Injury in Wistar Rats [ Biomedicines, 2023, 11(4), 1125]	PubMed: 37189743
Urolithin A's Antioxidative, Anti-Inflammatory, and Antiapoptotic Activities Mitigate Doxorubicin-Induced Liver Injury in Wistar Rats [ Biomedicines, 2023, 11(4)1125]	PubMed: 37189743
Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice [ Neural Regen Res, 2022, 17(9):2007-2013]	PubMed: 35142690
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway [ Food Funct, 2022, 13(1):375-385]	PubMed: 34905594
Effects of urolithin A on osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand via bone morphogenic protein 2 [ Bioengineered, 2022, 13(3):5064-5078]	PubMed: 35164658
Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model [ Neuropharmacology, 2022, 207:108963]	PubMed: 35065082
PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages [ Oral Dis, 2022, 10.1111/odi.14286]	PubMed: 35730318
Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival [ JCI Insight, 2021, 6(7)144255]	PubMed: 33621216
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection [ Neuropharmacology, 2021, 196:108360]	PubMed: 33122030

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。