Vincamine

製品コードS3891 バッチS389101

印刷

化学情報

Chemical Structure Synonyms Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H26N2O3
分子量 354.44 CAS No. 1617-90-9
Solubility (25°C)* 体外 DMSO 3 mg/mL (8.46 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.
in vitro Vincamine decreases amyloid-β 25-35 induced oxidative stress and reduces reactive oxygen species levels. It significantly reduces the rate of apoptosis in a dose-dependent manner. Vincamine could provide neuroprotection from Aβ25-35 induced PC12 apoptosis through the phosphatidylinositol-3 kinase/Akt signaling pathway[1].
in vivo Vincamine could cross the blood-brain barrier, and its antioxidant scavenging capacity to inactivate hydroxyl free radicals is actually ranked in part with Vitamin E[1]. Vincamine decreases the mean arterial blood pressure (by 5-35%), the cardial output and the heart rate. After oral application of 20 mg/kg vincamine in rats, vincamine is rapidly absorbed and eliminated. The apparent elimination half life is 1.71 h. The bioavailability of vincamine after oral administration is 58% suggesting a significant firstpass metabolism. Vincamine is taken up in a high concentration by the different organs, the maximal organ-plasma concentration ratio is 21 for lungs, 14.6 for brain, 14.3 for the kidneys, 8.9 for the liver and 7.6 for the heart. There is no steady-state between plasma and heart, lungs and brain, the elimination from these organs is significantly more rapid than from plasma[2]. Vincamine is mainly metabolized in the liver and excreted by the kidneys and it may also go through cerebral metabolism. In the pharmacokinetic profile of vincamine, the compound is about 64% bound to plasma proteins, and 6% bound to erythrocytes[3].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 PC12 cells
濃度 20, 40, 80 μM
反応時間 3 h
実験の流れ

PC12 cells cultured in 6-well plates (4 × 104 cells/well) for 24 h are treated with various concentrations of vincamine for 3 h before the addition of 30 μM Aβ25-35 and further 24 h incubation. Cells are then digested with trypsin and washed twice in phosphate buffered solution (PBS). Thereafter, cells are suspended in 500 μl of PBS and lysed by ultrasonication in the presence of protease inhibitor before centrifugation at 4000 rpm for 5 min. The supernatant is collected for analysis.
動物実験 動物モデル male Sprague-Dawley rats
投薬量 10 and 30 mg/kg
投与方法 i.v.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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