Vitamin E

製品コードS4686 バッチS468602

印刷

化学情報

Chemical Structure Synonyms Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol Storage
(From the date of receipt)		 2 years -80°C liquid
化学式

C29H50O2
分子量 430.71 CAS No. 59-02-9
Solubility (25°C)* 体外  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
in vitro

vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1].
in vivo

Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1].
密度 0.95 g/mL at 25 °C

プロトコル(参考用のみ)

細胞アッセイ 細胞株 TC-1 cells
濃度 0, 25, 50 μM
反応時間 18 h
実験の流れ

For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I.
動物実験 動物モデル C57BL/6 mice 
投薬量 2 mg/kg
投与方法 i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Folic acid prevents interferon-induced iron accumulation and ferroptosis and improves liver health in children with biliary atresia [ medRxiv, 2023, 10.1101/2023.12.01.23299102] PubMed: none
Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis [ Bone Res, 2022, 10(1):26] PubMed: 35260560
An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile [ J Exp Clin Cancer Res, 2022, 41(1):86] PubMed: 35260172
Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy [ EMBO Mol Med, 2022, 14(2):e14903] PubMed: 35023619
Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis-Induced Acute Lung Injury through GSK3β/Keap1-Nrf2-GPX4 Pathway [ Oxid Med Cell Longev, 2022, 2022:2405943] PubMed: 35910848
Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis [ Nutrients, 2022, 14(18)3791] PubMed: 36145170
Ferroptosis Is Involved in Alcohol-Induced Cell Death in vivo and in vitro [ Biosci Biotechnol Biochem, 2020, 18;1-8] PubMed: 32419644
R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells. [ Cell Death Dis, 2019, 10(5):358] PubMed: 31043589
PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism [ Dev Cell, 2018, 46(4):441-455.e8] PubMed: 30100261

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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