Tezacaftor (VX-661)

製品コードS7059 バッチS705902

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₆H₂₇F₃N₂O₆
	分子量	520.5	CAS No.	1152311-62-0
Solubility (25°C)*	体外	DMSO	100 mg/mL (192.12 mM)
		Ethanol	100 mg/mL (192.12 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
in vitro	VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Primary HBE cells
	濃度	5 μM
	反応時間	24 h
	実験の流れ	Cells were treated with indicated concentration of drug for 24 h.
動物実験	動物モデル	Male FVB/n mice
	投薬量	2 mg/kg
	投与方法	i.p.

参考

カスタマーフィードバック

: Data from [Data independently produced by Sci Transl Med, 2014, 6(246), 246ra96]

: Data from [Data independently produced by , , J Cyst Fibros, 2018, doi:10.1016/j.jcf.2018.07.001]

: Data from [Data independently produced by , , NPJ Genom Med. 2017, 2:12]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

PTI-801 (posenacaftor) shares a common mechanism with VX-445 (elexacaftor) to rescue p.Phe508del-CFTR [ Eur J Pharmacol, 2024, 967:176390]	PubMed: 38336013
CFTR function is impaired in a subset of patients with pancreatitis carrying rare CFTR variants [ Pancreatology, 2024, S1424-3903(24)00066-8]	PubMed: 38493004
A uniquely efficacious type of CFTR corrector with complementary mode of action [ Sci Adv, 2024, 10(9):eadk1814]	PubMed: 38427726
UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR [ Cells, 2023, 12(23)2741]	PubMed: 38067172
A Novel Co-Culture Model Reveals Enhanced CFTR Rescue in Primary Cystic Fibrosis Airway Epithelial Cultures with Persistent Pseudomonas aeruginosa Infection [ Cells, 2023, 10.3390/cells12222618]	PubMed: 37998353
Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium [ Front Pharmacol, 2023, 14:1293578]	PubMed: 38149052
Elexacaftor Mediates the Rescue of F508del CFTR Functional Expression Interacting with MSD2 [ Int J Mol Sci, 2023, 24(16)12838]	PubMed: 37629017
Theratyping of the Rare CFTR Genotype A559T in Rectal Organoids and Nasal Cells Reveals a Relevant Response to Elexacaftor (VX-445) and Tezacaftor (VX-661) Combination [ Int J Mol Sci, 2023, 24(12)10358]	PubMed: 37373505
CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes [ Int J Mol Sci, 2023, 24(19)14539]	PubMed: 37833986
Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction [ Int J Mol Sci, 2023, 24(4)3211]	PubMed: 36834620

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。