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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C16H24N2.HCl |
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分子量 | 280.84 | CAS No. | 1218-35-5 | |
Solubility (25°C)* | 体外 | Water | 56 mg/mL (199.4 mM) | |
Ethanol | 56 mg/mL (199.4 mM) | |||
DMSO | 27 mg/mL (96.14 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. |
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in vitro | Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively. [1] |
キナーゼアッセイ | Measurement of intracellular Ca2+ responses | |
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The measurement of intracellular Ca2+ responses is performed by using an aequorin-EGFP fusion protein according to the method of CRET. In brief, harvested cells are loaded with 5 μM coelenterazine h for 2.5 h at room temperature. Suspensions of cells in assay buffer containing NaCl 150 mM, CaCl2 1.8 mM, KCl 5.4 mM, Hepes 10 mM, D-glucose 20 mM (pH 7.4) are used for luminometric determination of intracellular Ca2+ transients in 96-well plates in a Berthold Centro LB 960 luminometer. In the case of recording Ca2+ responses induced by adrenaline and noradrenaline, 1 mM ascorbic acid is added. Light emission is recorded 5 s prior and 25–60 s upon autoinjection of the agonist dissolved in assay buffer at a sampling rate of 2 Hz. |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。