YAP-TEAD Inhibitor 1 (Peptide 17)

製品コードS8164 バッチS816403

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₉₃H₁₄₄ClN₂₃O₂₁S₂

分子量

2019.86

CAS No.

1659305-78-8

Solubility (25°C)*

体外

Water

40 mg/mL (19.8 mM)

体内（毎回新しく調製した物を用意してください）

Clear solution

5% H2O 1 40% PEG 300 2 5% Tween 80 3 ddH2O

2.0mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified H2O stock solution to 400 μL of PEG 300, mix evenly to clarify; add 50 μL of Tween 80 to the above system, mix evenly to clarify; Then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
in vitro	The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro^[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1^[2].

プロトコル(参考用のみ)

参考

カスタマーフィードバック

: Data from [Data independently produced by , , J Exp Clin Cancer Res. 2018, 37(1):228]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway [ J Cancer, 2023, 14(13):2562-2573]	PubMed: 37670970
NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway [ J Cancer, 2023, 14(13):2562-2573]	PubMed: 37670970
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N6-Methyladenosine-Modified Yap Expression [ Research (Wash D C), 2022, 2022:9825916]	PubMed: 35474903
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 [ J Med Chem, 2022, 65(13):9206-9229]	PubMed: 35763499
Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex [ PLoS One, 2022, 17(4):e0266143]	PubMed: 35417479
Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers [ Exp Dermatol, 2022, 31(10):1477-1499]	PubMed: 35913427
mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma [ Cancer Res, 2021, 81(22):5652-5665]	PubMed: 34429326
YAP signaling in preovulatory granulosa cells is critical for the functioning of the EGF network during ovulation [ Mol Cell Endocrinol, 2021, 541:111524]	PubMed: 34856345
YAP/TAZ transcriptional co-activators create therapeutic vulnerability to verteporfin in EGFR mutant glioblastoma [ Clin Cancer Res, 2020, clincanres.0018.2020]	PubMed: 33172899
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling [ Cell Rep, 2020, 31(12):107809]	PubMed: 32579935

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。