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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C31H39FN4O9 |
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分子量 | 630.66 | CAS No. | 210344-97-1 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (158.56 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Z-YVAD-FMK is a cell-permeable and irreversible caspase-1 specific inhibitor with anti-inflammatory and anti-tumor activities. |
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in vitro | Z-YVAD-FMK treatment significantly reduces the increased caspase-1 activity induced by LPS+Aβ. Z-YVAD-FMK remarkably suppresses the protein expressions of cleaved IL-1β, cleaved IL-18, and Iba-1.[1] |
in vivo | Z-YVAD-FMK is a cell-permeable caspase-6 inhibitor. |
細胞アッセイ | 細胞株 | BV2 cells |
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濃度 | 5 μM | |
反応時間 | 1 h | |
実験の流れ | BV2 cells are treated without or with EGCG (10 μM) or/and Z-YVAD-FMK (5 μM) for 1 h, followed by stimulationwith LPS (1 μg/mL) for 1 h and Aβ1-42 (10 μM) for 6 h. The cells are harvested at room temperature, and the protein concentration is determined by the Bradfordmethod. A calibration curve is constructed, and caspase-1 activity is calculated according to it. |
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動物実験 | 動物モデル | C57BL/6J mice |
投薬量 | 50 μM | |
投与方法 | i.v. |
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Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats [ Transl Psychiatry, 2024, 14(1):166] | PubMed: 38538614 |
ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 [ EMBO J, 2023, e113118.] | PubMed: 37646198 |
Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway [ J Nanobiotechnology, 2023, 21(1):426] | PubMed: 37968665 |
Toxoplasma gondii Rhoptry Protein 7 (ROP7) Interacts with NLRP3 and Promotes Inflammasome Hyperactivation in THP-1-Derived Macrophages [ Cells, 2022, 11(10)1630] | PubMed: 35626667 |
Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis [ Mediators Inflamm, 2022, 2022:8007078] | PubMed: 35497095 |
Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis [ Mediators Inflamm, 2022, 2022:8007078] | PubMed: 35497095 |
Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma [ Transl Oncol, 2021, 14(1):100982] | PubMed: 33395748 |
Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling [ Biomed Pharmacother, 2020, 127:110151] | PubMed: 32559840 |
Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury [ Biol Pharm Bull, 2020, 43(10):1481-1489] | PubMed: 32999158 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。