新製品

添加時期順序で新製品が表示されます。

PI3K/Akt/mTOR
製品コード 製品名称 製品説明 添加時期
S2811 Sapanisertib (INK 128, MLN0128) Sapanisertib (INK 128, MLN0128) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1. Feb 09 2018
S7682 SAR405 SAR405 is a low-molecular-mass kinase inhibitor of Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. Jan 25 2018
S1022 Ridaforolimus (Deforolimus, MK-8669) Ridaforolimus (Deforolimus, MK-8669) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3. Jan 18 2018
A5269 Tuberin Rabbit Recombinant mAb   Jan 17 2018
A5218 PI 3 Kinase p110 delta Rabbit Recombinant mAb   Jan 12 2018
A5153 PDK1 Rabbit Recombinant mAb   Jan 12 2018
A5161 PDK2 Rabbit Recombinant mAb   Jan 12 2018
A5164 PI3 Kinase p110 beta Rabbit Recombinant mAb   Jan 12 2018
A5194 Phospho-AMPK alpha 1 (S496) Rabbit Recombinant mAb   Jan 12 2018
S8335 PF-06409577 PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patchBclamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms. Dec 11 2017
JAK/STAT
製品コード 製品名称 製品説明 添加時期
S7951 STA-21 Ochromycinone (STA-21) is a selective STAT3 inhibitor. Feb 10 2018
S8541 FM-381   Jan 24 2018
S8605 C188-9   Jan 24 2018
S5001 Tofacitinib (CP-690550) Citrate Tofacitinib (CP-690550) Citrate is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Jan 16 2018
A5084 STAT6 Rabbit Recombinant mAb   Jan 16 2018
A5159 JAK1 Rabbit Recombinant mAb   Jan 12 2018
S2902 S-Ruxolitinib (INCB018424) S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3. Oct 27 2017
S8561 HJC0152 HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility. Sep 19 2017
A5042 STAT5a Rabbit Recombinant mAb   Sep 17 2017
A5044 STAT2 Rabbit Recombinant mAb   Sep 17 2017
Cell Cycle
製品コード 製品名称 製品説明 添加時期
S1525 Adavosertib (MK-1775) Adavosertib (MK-1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2. Feb 09 2018
S2626 Rabusertib (LY2603618) Rabusertib (LY2603618) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Feb 09 2018
S7684 Salirasib Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2. Feb 05 2018
A5129 Cdk6 Rabbit Recombinant mAb   Jan 29 2018
S2284 Colchicine Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM. Jan 23 2018
S8156 ARS-853 (ARS853) ARS-853 is a selective, covalent inhibitor of KRAS(G12C) that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation. Jan 22 2018
A5276 Chk2 Rabbit Recombinant mAb   Jan 18 2018
A5305 SOS1 Rabbit Recombinant mAb   Jan 18 2018
A5268 p57 Kip2 Rabbit Recombinant mAb   Jan 17 2018
A5200 Cdc37 Rabbit Recombinant mAb   Jan 12 2018
DNA Damage
製品コード 製品名称 製品説明 添加時期
S7048 Talazoparib (BMN 673) Talazoparib (BMN 673) is a novel PARP inhibitor with IC50 of 0.58 nM in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3. Jan 31 2018
S1782 Azacitidine Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Jan 26 2018
S8666 BAY 1895344 (BAY-1895344)   Jan 24 2018
S2057 Cyclophosphamide Monohydrate Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations. Jan 22 2018
A5274 MSI2 Rabbit Recombinant mAb   Jan 18 2018
A5275 hnRNP K Rabbit Recombinant mAb   Jan 18 2018
A5279 Ku80 Rabbit Recombinant mAb   Jan 18 2018
A5283 SMC3 Rabbit Recombinant mAb   Jan 18 2018
A5294 Mre11 Rabbit Recombinant mAb   Jan 18 2018
A5297 PABPN1 Rabbit Recombinant mAb   Jan 18 2018
TGF-beta/Smad
製品コード 製品名称 製品説明 添加時期
S7207 Bisindolylmaleimide IX (Ro 31-8220 Mesylate) Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1. Feb 10 2018
S7530 Vactosertib  (TEW-7197) EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1. Feb 10 2018
A5114 Bim Rabbit Recombinant mAb   Jan 12 2018
A5117 Smad2 Rabbit Recombinant mAb   Jan 12 2018
A5130 Smad4 Rabbit Recombinant mAb   Jan 12 2018
A5135 PKC delta Rabbit Recombinant mAb   Jan 12 2018
A5155 PKC epsilon Rabbit Recombinant mAb   Jan 12 2018
A5162 PKC alpha Rabbit Recombinant mAb   Jan 12 2018
A5192 Phospho-Smad2 (S250) Rabbit Recombinant mAb   Jan 12 2018
S7507 LDN-193189 HCl LDN193189 HCl is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cell lines, respectively, 200-fold selectivity for BMP versus TGF-β. Dec 25 2017
GPCR & G Protein
製品コード 製品名称 製品説明 添加時期
S7174 Opaganib (ABC294640) ABC294640 is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2. Feb 10 2018
S3734 Albiglutide   Jan 23 2018
A5270 GRK2 Rabbit Recombinant mAb   Jan 17 2018
S7177 PF-543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. Jan 16 2018
S1647 Adenosine Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Jan 08 2018
S3051 Bosentan Hydrate Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. Dec 05 2017
S8067 Vorapaxar Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM. Dec 05 2017
S8575 CPI-444 A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. Nov 29 2017
S8637 Ipragliflozin (ASP1941) Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1. Oct 26 2017
S8558 Tofogliflozin(CSG 452) Tofogliflozin is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and Hsglt1, respectively. Aug 29 2017
Protein Tyrosine Kinase
製品コード 製品名称 製品説明 添加時期
S3759 Norcantharidin   Feb 11 2018
S1361 Glesatinib (MGCD265) Glesatinib (MGCD265) is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2. Feb 10 2018
A5188 Insulin Receptor Rabbit Recombinant mAb   Jan 12 2018
S1068 Crizotinib (PF-02341066) Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. Jan 10 2018
S2475 Imatinib (STI571) Imatinib (STI571) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Jan 08 2018
S8553 Avapritinib (BLU-285) Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM). Jan 08 2018
S8583 TPX-0005 TPX-0005 is a novel ALK/ROS1/TRK inhibitor with the IC50 values of 1.01 nM for WT ALK, 1.26 nM for ALK(G1202R), and 1.08 nM for ALK(L1196M); also a potent SRC inhibitor (IC50 5.3 nM). Nov 07 2017
S7754 Gilteritinib (ASP2215) Gilteritinib(ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM). Oct 25 2017
S8511 Belizatinib (TSR-011) "Belizatinib (TSR-011) is a potent inhibitor of ALK (IC50=0.7 nM) and tropomyosin receptor kinase (TRK) (IC50 values less than 3 nM for TRK A, B, and C). " Sep 19 2017
A5006 Met (c-Met) Rabbit Recombinant mAb WB, IF Sep 11 2017
Epigenetics
製品コード 製品名称 製品説明 添加時期
S8071 UNC0638 UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. Feb 08 2018
S7574 GSK-LSD1 2HCl GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). Feb 02 2018
S3944 Valproic acid   Jan 25 2018
S1047 Vorinostat (SAHA, MK0683) Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Jan 24 2018
S8664 GSK3326595 (EPZ015938)   Jan 24 2018
S8567 Tucidinostat (Chidamide) Chidamide is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively. Jan 24 2018
S8648 ACY-738   Jan 24 2018
A5222 Histone H2A (acetyl K9) Rabbit Recombinant mAb   Jan 12 2018
A5223 Histone H3 (mono methyl K36) Rabbit Recombinant mAb   Jan 12 2018
A5240 ASH2L Rabbit Recombinant mAb   Jan 12 2018
NF-κB
製品コード 製品名称 製品説明 添加時期
A5168 p120 (Catenin Delta 1) Rabbit Recombinant mAb   Jan 12 2018
S3633 Pyrrolidinedithiocarbamate ammonium Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor-κB (NF-κB) that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines. Nov 29 2017
A5071 IKK beta Rabbit Recombinant mAb   Nov 08 2017
A5075 NF-kB p65 Rabbit Recombinant mAb   Nov 08 2017
S8261 GSK583 GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM. Feb 09 2017
S4712 Diethylmaleate Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. Oct 26 2016
S7948 MRT67307 HCl MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. Apr 25 2016
S7691 PS-1145 PS-1145 is a specific IKK inhibitor with IC50 of 88 nM. Mar 09 2016
S7851 AZD3264 AZD3264 is a novel IKK2 inhibitor. Nov 27 2015
S7672 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2. Sep 14 2015
Metabolism
製品コード 製品名称 製品説明 添加時期
S3945 L-Cycloserine   Feb 11 2018
A5260 Phospho-HSF1(S326) Rabbit Recombinant mAb   Feb 08 2018
A5119 FOXO3A Rabbit Recombinant mAb   Jan 29 2018
S5146 3-Methylpyrazole   Jan 24 2018
S8608 Adenosine Dialdehyde (ADOX)   Jan 24 2018
S8657 PF-06840003   Jan 24 2018
S3736 Fondaparinux Sodium   Jan 23 2018
A5277 PLCG1 Rabbit Recombinant mAb   Jan 18 2018
A5282 Aromatase Rabbit Recombinant mAb   Jan 18 2018
A5285 SDHA Rabbit Recombinant mAb   Jan 18 2018
Proteases
製品コード 製品名称 製品説明 添加時期
S3733 Boceprevir   Jan 23 2018
A5284 Cathepsin L/V/K/H Rabbit Recombinant mAb   Jan 18 2018
A5287 Cathepsin B Rabbit Recombinant mAb   Jan 18 2018
A5125 Glutaminase Rabbit Recombinant mAb   Jan 12 2018
A5176 Notch1 Rabbit Recombinant mAb   Jan 12 2018
S3728 Grazoprevir Grazoprevir anhydrous is a Hepatitis C Virus NS3/4A Protease inhibitor with IC50 values of 7pM, 4pM, and 62pM for HCV genotype 1a, 1B, and 4 respectively. Dec 06 2017
S3724 Velpatasvir Velpatasvir is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication. Dec 06 2017
S3692 N-Ethylmaleimide (NEM) N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. Nov 29 2017
S2619 MG-132 MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively. Nov 24 2017
S8565 Omarigliptin (MK-3102) Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5). Jul 11 2017
Microbiology
製品コード 製品名称 製品説明 添加時期
S4759 p-Coumaric Acid   Jan 24 2018
S3741 Benznidazole   Jan 23 2018
S1833 Butoconazole nitrate Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. Jan 04 2018
S1282 Artemisinin Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent. Dec 22 2017
S3695 Cystamine dihydrochloride Cystamine dihydrochloride acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes. Dec 06 2017
S3645 Kitasamycin Kitasamycin is a macrolide antibiotic. It has antimicrobial activity against a wide spectrum of pathogens. Dec 06 2017
S3644 Sulfamonomethoxine Sulfamonomethoxine is a long-acting sulfonamide antibacterial agent and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate. Dec 06 2017
S3646 Thimerosal Thimerosal is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. Dec 06 2017
S3649 Ceftazidime Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa. Dec 06 2017
S3655 Cefepime Dihydrochloride Monohydrate Cefepime is a cephalosporin antibacterial drug used to treat pneumonia, urinary tract, skin, and intra-abdominal infections. Dec 06 2017
Apoptosis
製品コード 製品名称 製品説明 添加時期
S7609 GW4869 GW4869 is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM. Feb 02 2018
S8580 COTI-2   Jan 24 2018
S8483 CBL0137 (CBL-0137)   Jan 24 2018
A5259 APAF1 Rabbit Recombinant mAb   Jan 18 2018
A5272 p73 Rabbit Recombinant mAb   Jan 18 2018
A5273 STK3 Rabbit Recombinant mAb   Jan 18 2018
A5293 Bid Rabbit Recombinant mAb   Jan 18 2018
A5074 cleaved Caspase-9 Rabbit Recombinant mAb   Jan 18 2018
A5262 Phospho-PAK1/2/3(S144/S141/S139) Rabbit Recombinant mAb   Jan 17 2018
A5264 Phospho-RSK1 (S380) Rabbit Recombinant mAb   Jan 17 2018
MAPK
製品コード 製品名称 製品説明 添加時期
S1494 Ralimetinib (LY2228820) Ralimetinib (LY2228820) is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, does not alter p38 MAPK activation. Phase 1/2. Feb 10 2018
S1008 Selumetinib (AZD6244) Selumetinib (AZD6244) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM in cell-free assays, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Phase 3. Jan 16 2018
A5124 MEKK2 Rabbit Recombinant mAb   Jan 12 2018
A5165 MEK3 Rabbit Recombinant mAb   Jan 12 2018
A5191 Phospho-MEK1 (S298) Rabbit Recombinant mAb   Jan 12 2018
S8534 LY3214996 LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. Nov 29 2017
S7926 Lifirafenib (BGB-283) Lifirafenib (BGB-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant. Sep 19 2017
A5043 Raf1 Rabbit Recombinant mAb   Sep 17 2017
A5050 MEK3/MEK6 Rabbit Recombinant mAb   Sep 17 2017
A5005 JNK1/2/3 Rabbit Recombinant mAb WB, IF Sep 11 2017
Angiogenesis
製品コード 製品名称 製品説明 添加時期
S7173 CC-292 (AVL-292) Spebrutinib (CC-292, AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1. Feb 10 2018
S7357 PF-562271 HCl PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1. Jan 16 2018
A2006 Bevacizumab Bevacizumab is a humanized anti-VEGF monoclonal antibody which binds to and neutralizes all human VEGF-A isoforms and bioactive proteolytic fragments, MW:149 KD. Dec 01 2017
A2007 Trastuzumab Trastuzumab is a humanized, recombinant monoclonal antibody that binds to the extracellular domain of HER2, MW:145.53 KD. Dec 01 2017
A2008 Pertuzumab Pertuzumab, a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors, impairs the ability of HER2 to bind to other members of the HER family, MW: 148 KD. Dec 01 2017
A5066 Src Rabbit Recombinant mAb   Nov 08 2017
A5078 Bcl10 Rabbit Recombinant mAb   Nov 08 2017
A5086 FGFR1 Rabbit Recombinant mAb   Nov 08 2017
A5094 EGF Rabbit Recombinant mAb   Nov 08 2017
S7309 BAY 87-2243 BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Phase 1. Nov 03 2017
Stem Cells & Wnt
製品コード 製品名称 製品説明 添加時期
S7169 Crenigacestat (LY3039478) Crenigacestat (LY3039478) is an oral Notch inhibitor with an IC50 of 0.41 nM. Feb 10 2018
S8129 Salinomycin (from Streptomyces albus) Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects. Feb 02 2018
S8597 LYN-1604   Jan 24 2018
S8647 iCRT3   Jan 24 2018
S8644 GNF-6231   Jan 24 2018
A5298 ADAM10 Rabbit Recombinant mAb   Jan 17 2018
A5208 ULK3 Rabbit Recombinant mAb   Jan 12 2018
A5115 Sonic Hedgehog Rabbit Recombinant mAb   Jan 12 2018
A5254 YAP1 Rabbit Recombinant mAb   Jan 12 2018
A5345 DKK1 Rabbit Recombinant mAb   Jan 09 2018
Neuronal Signaling
製品コード 製品名称 製品説明 添加時期
S8018 Nirogacestat (PF-03084014, PF-3084014) PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2. Feb 10 2018
A5210   Feb 10 2018
S3075 Dexmedetomidine Dexmedetomidine is a sedative medication used by intensive care units and anesthetists. Feb 07 2018
S4760 (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)   Jan 24 2018
S3664 Flupenthixol dihydrochloride   Jan 23 2018
S3643 Amitraz   Jan 23 2018
S3639 Tacrine hydrochloride hydrate   Jan 23 2018
S8564 Verubecestat Verubecestat (MK-8931) is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Jan 22 2018
S3202 Catharanthine Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM. Jan 18 2018
A5308 GDNF Rabbit Recombinant mAb   Jan 18 2018
その他
製品コード 製品名称 製品説明 添加時期
S8667 JPH203   Feb 11 2018
S8673 ONC212   Feb 11 2018
S3947 Hydroumbellic acid   Feb 11 2018
S3946 Mesterolone   Feb 11 2018
S8612 α-cyano-4-hydroxycinnamic acid(α-CHCA) 4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs. Feb 11 2018
S3933 10-deacetyl-paclitaxel   Feb 11 2018
S3918 4',7-Dimethoxy-5-Hydroxyflavone   Feb 11 2018
S7559 ODM-201 Darolutamide (ODM-201) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3. Feb 10 2018
S7678 LCZ696 Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3. Feb 10 2018
S5173 2'-Hydroxy-4'-methylacetophenone   Feb 01 2018