Tanespimycin (17-AAG)

製品コードS1141 別名:CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG)化学構造

分子量(MW):585.69

Tanespimycin (17-AAG)は一種の有効なHSP90阻害剤で、無細胞試験でIC50値が5 nMですが、腫瘍細胞からのHSP90に作用する結合親和力は正常な細胞からのHSP90に作用する結合親和力より100倍が高くなります。臨床2期。

サイズ 価格(税別) 在庫  
JPY 32370.00 あり
JPY 24900.00 あり
JPY 61420.00 あり

カスタマーフィードバック(9)

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

  • Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

    SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

  • Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Tanespimycin (17-AAG)は一種の有効なHSP90阻害剤で、無細胞試験でIC50値が5 nMですが、腫瘍細胞からのHSP90に作用する結合親和力は正常な細胞からのHSP90に作用する結合親和力より100倍が高くなります。臨床2期。
特性 Displays very low toxicity toward normal cells.
ターゲット
HSP90 [1]
(Cell-free assay)
5 nM
体外試験

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NIXoPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMECwN|A{KM7:TR?= MXjTRW5ITVJ?
IST-MEL1 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDpZYpOUUN3ME2wMlAxODRyNzFOwG0> NYXkV5RTW0GQR1XS
NCI-SNU-1 MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLTTWM2OD1yLkCwNlA4KM7:TR?= NUnkNGlHW0GQR1XS
FADU NYrFVFd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHUWJlKSzVyPUCuNFAzODlizszN NHmwfIZUSU6JRWK=
C32 M4q5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjMRnhKSzVyPUCuNFA{ODRizszN MXvTRW5ITVJ?
D-566MG M{fVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLpWVVKSzVyPUCuNFA{QSEQvF2= NHixcWlUSU6JRWK=
LXF-289 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILtVplKSzVyPUCuNFA1OTlizszN M2fYUnNCVkeHUh?=
HGC-27 NXHBc5p7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HObWlEPTB;MD6wNFUyKM7:TR?= Mmj3V2FPT0WU
RPMI-7951 NFfvcmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rqUGlEPTB;MD6wNFcyPyEQvF2= MlnXV2FPT0WU
HSC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO3SHNuUUN3ME2wMlAxQTJ7IN88US=> NHTQOZZUSU6JRWK=
MIA-PaCa-2 NIPKZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7YTWM2OD1yLkCxNFA6KM7:TR?= NIOz[3ZUSU6JRWK=
KS-1 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrzcHFKSzVyPUCuNFE{PTVizszN NIPZSWVUSU6JRWK=
CAL-51 NYj3UnZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfJNHVKSzVyPUCuNFE1ODVizszN NUXvdIs{W0GQR1XS
MDA-MB-361 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPMTWM2OD1yLkCxOFk2KM7:TR?= MnjMV2FPT0WU
TI-73 NFXPS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXraZmtYUUN3ME2wMlAyPzl4IN88US=> M3PMXHNCVkeHUh?=
AGS NEX2e49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEG5N|gh|ryP NEj2VohUSU6JRWK=
NCI-H460 M4nqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f1T2lEPTB;MD6wNVk4PCEQvF2= MnSwV2FPT0WU
A204 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;LZZd2UUN3ME2wMlAzOjR7IN88US=> M{ntO3NCVkeHUh?=
CHL-1 MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7KTWM2OD1yLkCyNlUyKM7:TR?= NVTPVoI5W0GQR1XS
DU-4475 NXPlbW5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTSTWM2OD1yLkCyNlYyKM7:TR?= MorVV2FPT0WU
CGTH-W-1 MleyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrWSXVKSzVyPUCuNFI{PDlizszN NXj3fGZrW0GQR1XS
HCC2218 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHNSGk2UUN3ME2wMlAzPDl2IN88US=> NInkS|dUSU6JRWK=
A2780 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXofJdKSzVyPUCuNFI2OzFizszN MX\TRW5ITVJ?
NCI-H720 NGD3dmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXMTWM2OD1yLkCyOVQ3KM7:TR?= M{nOTnNCVkeHUh?=
NCI-N87 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEK1PVMh|ryP M1j2S3NCVkeHUh?=
CHP-212 M{DDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HoRWlEPTB;MD6wNlYzQCEQvF2= NFLm[FhUSU6JRWK=
NCI-H23 NYHCcXpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPZbVJkUUN3ME2wMlAzPjZ3IN88US=> NHzGUo9USU6JRWK=
D-263MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEK3PFYh|ryP MXjTRW5ITVJ?
ME-180 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGniWpNKSzVyPUCuNFI5QTFizszN NFH0RnBUSU6JRWK=
SW982 MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX6[otOUUN3ME2wMlAzQTl7IN88US=> NGjJUZpUSU6JRWK=
OE19 Mn2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPGTWM2OD1yLkCzNFc4KM7:TR?= NEfDWHNUSU6JRWK=
SK-LU-1 NHvITYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrrTWM2OD1yLkCzNFgzKM7:TR?= NF;TNFRUSU6JRWK=
H4 NGjMXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEOwPUDPxE1? NVHTSnVkW0GQR1XS
HT-144 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nE[mlEPTB;MD6wN|A6OyEQvF2= NHnnT4VUSU6JRWK=
SK-UT-1 NWewbG1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnSTYtKSzVyPUCuNFMyPzhizszN NIPWOVRUSU6JRWK=
D-336MG NYP3S4xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\uN|hVUUN3ME2wMlA{OzB7IN88US=> MonBV2FPT0WU
MDA-MB-175-VII NEDmPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD5Oo1EUUN3ME2wMlA{OzV2IN88US=> M2m0NnNCVkeHUh?=
GAMG NH3GbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP4TWM2OD1yLkCzOFM2KM7:TR?= Moq0V2FPT0WU
CP50-MEL-B MnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkGxTWM2OD1yLkCzOFUh|ryP NVvZOXl1W0GQR1XS
OVCAR-5 NFzq[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17N[mlEPTB;MD6wN|Q5KM7:TR?= MkLwV2FPT0WU
SK-MES-1 NF7VOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HG[WlEPTB;MD6wN|YxPiEQvF2= NF\lbYFUSU6JRWK=
VM-CUB-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7CTWM2OD1yLkCzOlU4KM7:TR?= MnOyV2FPT0WU
WM-115 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEO3OlIh|ryP NV\ieVQyW0GQR1XS
DSH1 NWfGT3cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTVZotKSzVyPUCuNFM5ODdizszN M4rTV3NCVkeHUh?=
Becker MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqzVG1KSzVyPUCuNFM5QDVizszN MUTTRW5ITVJ?
SW962 M1myT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTGXnpUUUN3ME2wMlA{QTR3IN88US=> NYDkSY9yW0GQR1XS
TYK-nu NI\BXnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDsO3p6UUN3ME2wMlA{QTh3IN88US=> MYXTRW5ITVJ?
HO-1-N-1 MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rZ[GlEPTB;MD6wOFAzOSEQvF2= Mn\VV2FPT0WU
T98G NEXLXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIm3bmxKSzVyPUCuNFQyODNizszN NEjCTFRUSU6JRWK=
ACN MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS0PW5bUUN3ME2wMlA1OTZ{IN88US=> M4WyUXNCVkeHUh?=
SW780 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLtPWhZUUN3ME2wMlA1OjB|IN88US=> M1P0cHNCVkeHUh?=
Detroit562 NF6z[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnMXGRvUUN3ME2wMlA1OjN7IN88US=> NXjPZlR4W0GQR1XS
BB49-HNC NWrLdXRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMESyOFMh|ryP MX3TRW5ITVJ?
HN M3G3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXQTWM2OD1yLkC0NlczKM7:TR?= NXizN|VGW0GQR1XS
H9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXzTWM2OD1yLkC0N|cyKM7:TR?= MWHTRW5ITVJ?
VA-ES-BJ MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zR[WlEPTB;MD6wOFQ1PyEQvF2= M4C5fHNCVkeHUh?=
MEL-JUSO MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme1TWM2OD1yLkC0OFc2KM7:TR?= NWXS[5ZzW0GQR1XS
BT-474 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DYWGlEPTB;MD6wOFUh|ryP NFLZUppUSU6JRWK=
CaR-1 NHHxSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMES1OFkh|ryP NFXYe3lUSU6JRWK=
PSN1 NE[4OJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPaTWM2OD1yLkC0OlA{KM7:TR?= Mki4V2FPT0WU
KYSE-510 NFnXOItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[wSnpKSzVyPUCuNFQ3PDlizszN NEnSWIRUSU6JRWK=
KP-4 NXXRVFk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMES3OVMh|ryP M13qPHNCVkeHUh?=
KYSE-410 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf3PIRKSzVyPUCuNFQ4PzJizszN MmjMV2FPT0WU
G-402 NIDN[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMES3PFkh|ryP M4\CZnNCVkeHUh?=
DOK NX;kOIZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\Bd|lKSzVyPUCuNFQ6ODJizszN NF7PdW5USU6JRWK=
COR-L88 NUmzfoo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfCZpViUUN3ME2wMlA1QTF{IN88US=> NIHiWZpUSU6JRWK=
SKG-IIIa NVPPbYo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr3R3VWUUN3ME2wMlA1QTh4IN88US=> MlPlV2FPT0WU
AN3-CA M2D0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnhZXRKSzVyPUCuNFUh|ryP NYrKeI5RW0GQR1XS
SW48 MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\hUGpKSzVyPUCuNFUxOzlizszN NUjBW5BqW0GQR1XS
YKG-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEWwO|Eh|ryP Ml3rV2FPT0WU
KYSE-150 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjROWFKSzVyPUCuNFUzOzVizszN NYK4eXNFW0GQR1XS
HuO-3N1 MnvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEWyN|ch|ryP M1jEb3NCVkeHUh?=
LB1047-RCC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmOxTWM2OD1yLkC1Nlk3KM7:TR?= NVnPfoV7W0GQR1XS
NCI-H2030 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\jTVNQUUN3ME2wMlA2PDF2IN88US=> NWLEUXRNW0GQR1XS
YH-13 M3TwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTvVZFKSzVyPUCuNFU4OjJizszN M13oO3NCVkeHUh?=
5637 NXLYeFlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEW3OEDPxE1? NYHRWJlkW0GQR1XS
LOXIMVI NWLDb|RiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC3TWM2OD1yLkC1PFczKM7:TR?= M4\SW3NCVkeHUh?=
GT3TKB NEDGV3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7Q[|BvUUN3ME2wMlA2QTR{IN88US=> M1T6TXNCVkeHUh?=
TCCSUP M{DGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkm3TWM2OD1yLkC1PVY1KM7:TR?= MkfiV2FPT0WU
EPLC-272H NYXGNWFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjP[WVKSzVyPUCuNFYzODVizszN MnPSV2FPT0WU
LU-99A Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwME[yN|ch|ryP MmnFV2FPT0WU
NCI-H1755 NGWwRnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2C5UmlEPTB;MD6wOlM1OSEQvF2= MmrHV2FPT0WU
KM12 NEjOS4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjEe3VFUUN3ME2wMlA3OzR6IN88US=> MULTRW5ITVJ?
SF295 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXZTWM2OD1yLkC2OFUzKM7:TR?= MmjwV2FPT0WU
MZ2-MEL M{LNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SwfmlEPTB;MD6wOlU2OyEQvF2= MU\TRW5ITVJ?
HEC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrmOFJWUUN3ME2wMlA3PTh6IN88US=> MXfTRW5ITVJ?
SW684 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwME[1PVEh|ryP M3qzN3NCVkeHUh?=
SF539 NW[3PWJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwME[2PFEh|ryP MofpV2FPT0WU
GMS-10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTyfI1ZUUN3ME2wMlA3Pjl7IN88US=> M1jRSHNCVkeHUh?=
MV-4-11 M4D1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPhTWM2OD1yLkC2PFA{KM7:TR?= NXfzS|NqW0GQR1XS
HT-29 M4DQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz4UJNKSzVyPUCuNFY6OTlizszN NIHuV3VUSU6JRWK=
23132-87 NFXyeZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDh[XU6UUN3ME2wMlA3QTVizszN M1LKcXNCVkeHUh?=
SW620 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEewNlYh|ryP MWDTRW5ITVJ?
HCC1806 NWnPbYRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrBTWM2OD1yLkC3NVMyKM7:TR?= M3vB[3NCVkeHUh?=
Hs-578-T M2LLfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\wcmR2UUN3ME2wMlA4OjB6IN88US=> NUjEbZRpW0GQR1XS
A2058 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEeyNlgh|ryP NGL5N49USU6JRWK=
MEL-HO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XYXmlEPTB;MD6wO|I2PSEQvF2= NWq2RZlTW0GQR1XS
HCC2998 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnleoEzUUN3ME2wMlA4OzR5IN88US=> NIKwNo1USU6JRWK=
HuO9 M37DUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf3d|U6UUN3ME2wMlA4PTh7IN88US=> MX\TRW5ITVJ?
CAL-39 NGTRWmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUThN4xSUUN3ME2wMlA4PzZ4IN88US=> MVrTRW5ITVJ?
M14 NFXJemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL2TWM2OD1yLkC3PVE{KM7:TR?= MVjTRW5ITVJ?
BFTC-909 M{HUV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7mRXYzUUN3ME2wMlA4QTZ7IN88US=> MkPpV2FPT0WU
TE-11 M3LxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL3cIdsUUN3ME2wMlA4QTl4IN88US=> MX7TRW5ITVJ?
TGBC1TKB M3jUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEiwOFMh|ryP M2r1THNCVkeHUh?=
L-363 NGHHNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnSXpV7UUN3ME2wMlA5OjB4IN88US=> M3;mS3NCVkeHUh?=
A431 NXfp[XdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuzNYRqUUN3ME2wMlA5OjFizszN MmLWV2FPT0WU
MKN45 Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLHTWM2OD1yLkC4NlE6KM7:TR?= NIX2UFJUSU6JRWK=
HT-1080 NUDi[pZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPJWZRZUUN3ME2wMlA5PDN7IN88US=> MkfiV2FPT0WU
OVCAR-8 M3i1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\NTWM2OD1yLkC4OlIzKM7:TR?= NH\RRohUSU6JRWK=
LCLC-97TM1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX1TWM2OD1yLkC4O|I5KM7:TR?= MULTRW5ITVJ?
M059J NHPacIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfxNJN5UUN3ME2wMlA6ODJ5IN88US=> M{Dwc3NCVkeHUh?=
SK-MEL-2 NFrpb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEmwOkDPxE1? MojhV2FPT0WU
TE-1 M1XrUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G2Z2lEPTB;MD6wPVIxPCEQvF2= M3ixTHNCVkeHUh?=
KYSE-180 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q4VWlEPTB;MD6wPVI3OiEQvF2= Mm\YV2FPT0WU
D-247MG NIXGc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEm0OVUh|ryP NEfTb2dUSU6JRWK=
8-MG-BA MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlu2TWM2OD1yLkC5OFczKM7:TR?= NWP3eoo6W0GQR1XS
NCI-H1792 M1jPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK1XnVpUUN3ME2wMlA6PjF6IN88US=> MmXBV2FPT0WU
MCF7 NHHtNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7kTWM2OD1yLkC5Olc4KM7:TR?= M4Pwc3NCVkeHUh?=
NCI-H2122 M3XwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DkNGlEPTB;MD6wPVc1PSEQvF2= MkLaV2FPT0WU
EFO-27 Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEm5PVch|ryP MVTTRW5ITVJ?
LB2241-RCC NFXKXXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\neGlEPTB;MD6xNFA2PCEQvF2= M4TObHNCVkeHUh?=
SN12C MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMUCxNFch|ryP MVPTRW5ITVJ?
A498 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3O[npKSzVyPUCuNVAyQCEQvF2= NFvrcGFUSU6JRWK=
PANC-03-27 M1nIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\Zco8xUUN3ME2wMlExOjh4IN88US=> M3rrVXNCVkeHUh?=
NCI-H1581 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3nTWM2OD1yLkGwNlkh|ryP NHTnZpZUSU6JRWK=
U-87-MG NXPGVpczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMUCzNFch|ryP M1TGUHNCVkeHUh?=
G-401 M2q1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMUCzOVMh|ryP MUnTRW5ITVJ?
SiHa NHfGbYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rxR2lEPTB;MD6xNFQ5PiEQvF2= NXnPblcyW0GQR1XS
U251 Moi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KwZmlEPTB;MD6xNFUzPSEQvF2= NVjyVol4W0GQR1XS
MMAC-SF M1HzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMUC1N|Eh|ryP Mk\EV2FPT0WU
BB65-RCC NEfDNIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvyOWpKSzVyPUCuNVA2PTRizszN NIDnOm5USU6JRWK=
NKM-1 MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PQSWlEPTB;MD6xNFY3PiEQvF2= NFq1dIlUSU6JRWK=
HD-MY-Z MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rLUGlEPTB;MD6xNFg4OyEQvF2= MmGzV2FPT0WU
TGBC11TKB MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLv[WpKSzVyPUCuNVA6ODNizszN NGP0RoFUSU6JRWK=
COLO-679 M3u5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rWRWlEPTB;MD6xNVIyOSEQvF2= M3foXnNCVkeHUh?=
TE-8 NInH[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMUGyOlQh|ryP Mk\QV2FPT0WU
SK-MEL-28 M33nTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;aTWM2OD1yLkGxN|IyKM7:TR?= NIXVOo9USU6JRWK=
SH-4 NW\PS|RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMUGzOVYh|ryP NYCwV2Z1W0GQR1XS
KALS-1 NUnG[JpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnSxTWM2OD1yLkGxN|k{KM7:TR?= M{DBZnNCVkeHUh?=
RKO MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvENIRKSzVyPUCuNVE4PjRizszN NGTEe49USU6JRWK=
OMC-1 NWTMSnVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fvSWlEPTB;MD6xNVc6PyEQvF2= Ml\TV2FPT0WU
BT-549 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljmTWM2OD1yLkGxO|k6KM7:TR?= MULTRW5ITVJ?
NCI-H28 NUjHN5JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC1TWM2OD1yLkGxPFE4KM7:TR?= Mo\IV2FPT0WU
RXF393 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmewTWM2OD1yLkGxPVgzKM7:TR?= NIOzO5hUSU6JRWK=
COLO-829 MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmT5TWM2OD1yLkGyNFA2KM7:TR?= MXnTRW5ITVJ?
HMV-II NVjS[4d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITXV5pKSzVyPUCuNVIxOiEQvF2= NIjtdHlUSU6JRWK=
SW1990 MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMUKxOVch|ryP M3PxVHNCVkeHUh?=
NCI-H1437 M4HrSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMUKxOVch|ryP NF\qeGJUSU6JRWK=
SNB75 MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDOTWM2OD1yLkGyNVY6KM7:TR?= MYnTRW5ITVJ?
EW-3 M3jje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ETWM2OD1yLkGyOlYyKM7:TR?= NF7GfVFUSU6JRWK=
SAS NVLucXJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTubXRKSzVyPUCuNVI3QSEQvF2= NEXwVGZUSU6JRWK=
NCI-H1666 M3P0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvC[ZlYUUN3ME2wMlEzPzd2IN88US=> M4ryRXNCVkeHUh?=
A375 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMUK3O|gh|ryP MUfTRW5ITVJ?
CAMA-1 NWfSfm17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zkSmlEPTB;MD6xNlkzPCEQvF2= MYjTRW5ITVJ?
HuP-T4 NYO2dHRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;2TWM2OD1yLkGyPVQ{KM7:TR?= NYPq[2MzW0GQR1XS
NCI-H292 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjY[5BKSzVyPUCuNVMyOSEQvF2= M1r5OXNCVkeHUh?=
PC-14 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMUOyNVEh|ryP Mn\MV2FPT0WU
BPH-1 NU\hcok2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:2bGh3UUN3ME2wMlE{PDFizszN NV;3Tmx2W0GQR1XS
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SK-MEL-24 NUD6bpRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMUO4O{DPxE1? M2j2N3NCVkeHUh?=
LB831-BLC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq0[GdPUUN3ME2wMlE{QDh|IN88US=> Ml\vV2FPT0WU
NCI-H2452 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMUO5OVYh|ryP M4P4WHNCVkeHUh?=
RT-112 NFTPVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SxbWlEPTB;MD6xOFA{PSEQvF2= NVXRcW9zW0GQR1XS
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MPP-89 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMUSxNlUh|ryP NV\BfpV5W0GQR1XS
NUGC-3 M2DWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLJe2dKSzVyPUCuNVQ1PzhizszN MYrTRW5ITVJ?
GI-1 NHKydmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUS1OVgh|ryP M3vlO3NCVkeHUh?=
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AsPC-1 NVP6[IVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn1bYJ2UUN3ME2wMlE2OjJ3IN88US=> NYTNOI1UW0GQR1XS
NCI-H1648 NYP5WmlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rTNWlEPTB;MD6xOVI{OiEQvF2= NWKyRWRvW0GQR1XS
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BxPC-3 M2[zOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMUW5OlYh|ryP MYXTRW5ITVJ?
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NCI-H1299 NYPuOotZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMU[yPFUh|ryP NHqzb5VUSU6JRWK=
SW1088 NIDwUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\vd4drUUN3ME2wMlE3PDF|IN88US=> NEKzPWZUSU6JRWK=
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NCI-H2087 M1\NdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMUezOlgh|ryP MVrTRW5ITVJ?
NCI-H2170 NXjt[HBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2xPVVjUUN3ME2wMlE4PTN4IN88US=> MVzTRW5ITVJ?
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MZ7-mel NGPVfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUe2OFkh|ryP MnnuV2FPT0WU
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KOSC-2 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMUe3N|Qh|ryP MVnTRW5ITVJ?
SCC-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMUe3O|ch|ryP M3;EXnNCVkeHUh?=
MDA-MB-157 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zhUmlEPTB;MD6xPFA5OiEQvF2= M{XnOHNCVkeHUh?=
KYSE-520 M{nTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HkZWlEPTB;MD6xPFIh|ryP M2\nNnNCVkeHUh?=
LK-2 MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TzV2lEPTB;MD6xPFMxOyEQvF2= NGTP[llUSU6JRWK=
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DEL MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS1TWM2OD1yLkG4OFUh|ryP NGDTOplUSU6JRWK=
NCI-H1395 M2LzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2OyeGlEPTB;MD6xPFY5OiEQvF2= NXfU[ZZJW0GQR1XS
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BCPAP NYPUTIU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMUi4O|Ih|ryP MofMV2FPT0WU
CAL-27 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3flNGlEPTB;MD6xPVAzOiEQvF2= M2DnZ3NCVkeHUh?=
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COLO-680N MnXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HnOGlEPTB;MD6xPVM3PCEQvF2= M{DGNHNCVkeHUh?=
NCI-H1650 NGX0V5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\LTWM2OD1yLkKwNFU4KM7:TR?= MYrTRW5ITVJ?
SBC-5 NYDxbpJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[3OmI4UUN3ME2wMlIxOTF6IN88US=> M3TVVXNCVkeHUh?=
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AM-38 NEOx[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMkC4OFgh|ryP M{XXZ3NCVkeHUh?=
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K-562 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvuZ45KSzVyPUSuO|M5OTRizszN MXzTRW5ITVJ?
MHH-NB-11 NYnoZms3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH3S2pKSzVyPUSuO|U1PjFizszN NF:5e3ZUSU6JRWK=
Calu-3 M2S5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;6PWlEPTB;ND63PFU1QCEQvF2= MmfkV2FPT0WU
HT55 NYLGS5E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TMOGlEPTB;ND64OFU1PSEQvF2= MYLTRW5ITVJ?
SK-N-FI NX\3UJhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTRwOEWwNFkh|ryP NWW0dIZNW0GQR1XS
ES1 NWGz[YR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKxS|RKSzVyPUSuPFYxPTdizszN NHPuXVFUSU6JRWK=
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SNU-387 MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTVwM{KzN|kh|ryP MYfTRW5ITVJ?
C8166 Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTKTWM2OD13LkO2N|M6KM7:TR?= MW\TRW5ITVJ?
LS-1034 NHXLbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfpTWpKSzVyPUWuOFI{ODdizszN M{nmeHNCVkeHUh?=
GR-ST NYKzXZRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7zV|dKSzVyPUWuOVIzODFizszN NVPUVYw5W0GQR1XS
NCI-H1092 NIPXcGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrCXZdKSzVyPUWuO|I5PDNizszN M3LlZ3NCVkeHUh?=
647-V NGXWToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnraTWM2OD13Lke0O|A3KM7:TR?= MWLTRW5ITVJ?
EW-13 NIPsdIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTVwN{[2Nlch|ryP MVvTRW5ITVJ?
KGN NFfWUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnHTWM2OD14LkC5PVIyKM7:TR?= NVXkN4MyW0GQR1XS
D-423MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzCTWM2OD14LkSwNlg1KM7:TR?= MV7TRW5ITVJ?
ECC10 MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTGXm1rUUN3ME23MlExOTBzIN88US=> MXrTRW5ITVJ?
TE-5 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfiZVl7UUN3ME23MlQyOjl6IN88US=> MVPTRW5ITVJ?
P12-ICHIKAWA Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjvR4c2UUN3ME23MlQ2PTJ|IN88US=> NHvMOFZUSU6JRWK=
NCI-H82 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILB[VZKSzVyPUeuOFU4ODFizszN NXXR[otkW0GQR1XS
NCI-H1993 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j3S2lEPTB;Nz64N|A3OyEQvF2= NGXXNZNUSU6JRWK=
RH-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rtWWlEPTB;Nz64OVI1PCEQvF2= M2jaSXNCVkeHUh?=
SW948 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;NUGlEPTB;Nz65OlA1QSEQvF2= NFjBS4hUSU6JRWK=
CAL-33 MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrxTYdKSzVyPUeuPVk6OzhizszN M4W5Z3NCVkeHUh?=
U-266 NYX0Z45oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi2TWM2OD16LkG1O|c4KM7:TR?= MnP5V2FPT0WU
CAL-72 NHvQbHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jTRmlEPTB;OD6yNFMzKM7:TR?= MmC1V2FPT0WU
SNU-423 NX\oRmFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XNVGlEPTB;OT6zOlY3PiEQvF2= NGXU[2pUSU6JRWK=
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BE-13 NEC1WGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFyLki4PVIh|ryP Mk\GV2FPT0WU
MKN7 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTPTWM2OD1zMD65O|Y2KM7:TR?= MUDTRW5ITVJ?
697 Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e3emlEPTB;MUGuNVQ4OiEQvF2= NVy5clJTW0GQR1XS
LU-135 NIDFTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jGOmlEPTB;MUGuNlMxPyEQvF2= MWLTRW5ITVJ?
ES7 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\lT5Z1UUN3ME2xNU4{OzF|IN88US=> NG[zUHlUSU6JRWK=
SK-HEP-1 NWP0OWVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[4RWJ7UUN3ME2xNU44PjR4IN88US=> NXXMeo9jW0GQR1XS
BEN NWjOWnRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIWydVdKSzVyPUGxMlg2OSEQvF2= M1zhNXNCVkeHUh?=
NCI-H1770 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\HeoxlUUN3ME2xNk4yOjZizszN NFnMUXNUSU6JRWK=
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Mo-T NYPnbZJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfVeHBKSzVyPUGyMlc1OjFizszN M1;XNHNCVkeHUh?=
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RCC10RGB NHSyWGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF|Lk[3NUDPxE1? NYG1eXdHW0GQR1XS
COLO-320-HSR M2PKW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF|LkezPFEh|ryP NGflW49USU6JRWK=
BHT-101 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;lbVFPUUN3ME2xN{45OzR3IN88US=> NIXVOnFUSU6JRWK=
OCUB-M MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTtOGlKSzVyPUG0MlE3ODJizszN NXPu[FN{W0GQR1XS
MEG-01 NFT2bFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\2b41sUUN3ME2xOE4{PzB6IN88US=> NFOyb4VUSU6JRWK=
RS4-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLpOIg{UUN3ME2xOE44PDJizszN M4HpVnNCVkeHUh?=
MN-60 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33WcGlEPTB;MUSuO|g6PCEQvF2= M4L4UHNCVkeHUh?=
NCI-H1304 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Xve2lEPTB;MUWuNFQzPSEQvF2= M2e3d3NCVkeHUh?=
Ramos-2G6-4C10 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTF3LkC1PFEh|ryP NUfXSlBUW0GQR1XS
NCI-H2342 NIDx[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTa[nFKSzVyPUG1MlIxPDRizszN MVvTRW5ITVJ?
LAN-6 M1fPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXXTWM2OD1zNT60OFE1KM7:TR?= NXnHfHVvW0GQR1XS
JVM-2 NVX3R5lST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Xnc2lEPTB;MUWuOVc1QCEQvF2= NH;qfHNUSU6JRWK=
P30-OHK NH;Xd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnwTWM2OD1zNj6wOlE1KM7:TR?= NHrZU4dUSU6JRWK=
C-33-A M{i0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HyO2lEPTB;MU[uOlIyPCEQvF2= MX3TRW5ITVJ?
RPMI-8866 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jmR2lEPTB;MU[uPFQ6PiEQvF2= NHnRU5JUSU6JRWK=
NCI-H630 NHPLPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF4Lki1N|ch|ryP NVPZNmxXW0GQR1XS
KYSE-140 MmOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnabWEzUUN3ME2xO{4zODJ6IN88US=> MV\TRW5ITVJ?
T84 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPVTWM2OD1zOD64Olk2KM7:TR?= MYLTRW5ITVJ?
KU-19-19 M1TKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD6TWM2OD1zOD65OlA5KM7:TR?= M1zwUHNCVkeHUh?=
BALL-1 NVTEUZBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn4TWM2OD1zOT6zN|k6KM7:TR?= MofNV2FPT0WU
Calu-6 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF7LkS5NkDPxE1? MkTVV2FPT0WU
EGI-1 NX;WWJljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmflTWM2OD1zOT61PVgh|ryP MUHTRW5ITVJ?
MFH-ino Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\NTWM2OD1zOT63OFU1KM7:TR?= NXi2WJVlW0GQR1XS
GB-1 MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfjbGpKSzVyPUKwMlM2OzVizszN MoDzV2FPT0WU
NCI-H1693 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJyLk[1NFUh|ryP MVLTRW5ITVJ?
SW1116 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuwPGZQUUN3ME2yNE46OzZ{IN88US=> MnnuV2FPT0WU
H-EMC-SS M1TMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33UdGlEPTB;MkKuNFQ2KM7:TR?= M2G2S3NCVkeHUh?=
D-502MG NEHINHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ{LkiyOlEh|ryP M{HkWnNCVkeHUh?=
IA-LM NWrkco1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfuTWM2OD1{Mz6yOFk{KM7:TR?= Mnz3V2FPT0WU
SW1463 NWHwdVI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJ|Lke5JO69VQ>? MW\TRW5ITVJ?
JAR NWr4b2x4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17vdmlEPTB;MkSuN|I6OyEQvF2= NEXGTm1USU6JRWK=
HT M2r5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ2LkS3OVMh|ryP NEnERlNUSU6JRWK=
LCLC-103H MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ2Lki0OFkh|ryP NEHlOpRUSU6JRWK=
SNU-449 NHrIPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ2Lki3OFEh|ryP NX7zSXN4W0GQR1XS
KE-37 M{TEe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXjTWM2OD1{NT6wPVI5KM7:TR?= NVn2UJRQW0GQR1XS
NCI-H1623 NWXP[JR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jBT2lEPTB;MkeuNVMxOyEQvF2= NEf0R4VUSU6JRWK=
MOLT-13 M3vQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLiTWM2OD1{Nz6zOVE3KM7:TR?= NV7Re4dNW0GQR1XS
COLO-741 M1fVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r1dmlEPTB;M{GuN|M{OyEQvF2= M1rxbXNCVkeHUh?=
NB6 M2nGOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN{LkK4O|Yh|ryP MmLqV2FPT0WU
MOLT-16 M3zWZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjYTWM2OD1|Mz6wNFU2KM7:TR?= NFvqU5BUSU6JRWK=
IST-MES1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN2LkC1OFEh|ryP NGLQN4pUSU6JRWK=
A4-Fuk M1Oye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvkOYNOUUN3ME2zOU4xPjZizszN M3n6UHNCVkeHUh?=
CAL-85-1 M1jpemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u4fmlEPTB;M{WuNlgyPyEQvF2= NUjxTJBsW0GQR1XS
CCRF-CEM NUHQXXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zPTWlEPTB;M{euNVU{PiEQvF2= NWOyOXQzW0GQR1XS
HAL-01 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTN6LkS4PFkh|ryP MmfFV2FPT0WU
HEL NW\tNldFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:wW|E5UUN3ME20N{4{PDB7IN88US=> NIr4bm5USU6JRWK=
EW-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTMV|B{UUN3ME20N{41PzZ6IN88US=> MVnTRW5ITVJ?
MDA-MB-231 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn3PHlKSzVyPUS1MlEyQTlizszN NYDpUVRSW0GQR1XS
ABC-1 M1[2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPNTWM2OD12Nj64OVM5KM7:TR?= NHLNVINUSU6JRWK=
NCI-H446 MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjiV4FKSzVyPUS4MlUxPThizszN Mo\QV2FPT0WU
MHH-PREB-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTR7Lk[wNFch|ryP MWHTRW5ITVJ?
DOHH-2 M1GxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fFbmlEPTB;NEmuOlY2PiEQvF2= M4HjeXNCVkeHUh?=
GCT MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7RTVJKSzVyPUS5MlY6PzZizszN NX;EUHFSW0GQR1XS

多くの細胞株試験データを見る場合、クリックしてください

体内試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
細胞試験: [1]
+ 展開
  • 細胞株: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • 濃度: Dissolved in DMSO, final concentrations ~10 μM
  • 反応時間: 5 days
  • 実験の流れ: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (参考用のみ)
動物試験:[2]
+ 展開
  • 動物モデル: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • 製剤: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • 投薬量: ~50 mg/kg
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 順序で溶剤を入れること:
5%DMSO+corn oil
10mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管
別名 CP127374,NSC-330507, KOS 953

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

技術サポート

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Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

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よくある質問(FAQ)

  • 問題1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90)信号経路図

HSP (e.g. HSP90) Inhibitors with Unique Features

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID