Tanespimycin (17-AAG)

製品コードS1141 別名:CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG)化学構造

分子量(MW):585.69

Tanespimycin (17-AAG)は一種の有効なHSP90阻害剤で、無細胞試験でIC50値が5 nMですが、腫瘍細胞からのHSP90に作用する結合親和力は正常な細胞からのHSP90に作用する結合親和力より100倍が高くなります。臨床2期。

サイズ 価格 在庫  
USD 245 あり
USD 189 あり
USD 466 あり

カスタマーフィードバック(8)

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

  • Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

    Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Tanespimycin (17-AAG)は一種の有効なHSP90阻害剤で、無細胞試験でIC50値が5 nMですが、腫瘍細胞からのHSP90に作用する結合親和力は正常な細胞からのHSP90に作用する結合親和力より100倍が高くなります。臨床2期。
特性 Displays very low toxicity toward normal cells.
ターゲット
HSP90 [1]
(Cell-free assay)
5 nM
体外試験

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NGPRVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DDbmlEPTB;MD6wNFA{ODNizszN MnzEV2FPT0WU
IST-MEL1 MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\lNmh3UUN3ME2wMlAxODRyNzFOwG0> NFz6OVJUSU6JRWK=
NCI-SNU-1 NHjFd4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\4TWM2OD1yLkCwNlA4KM7:TR?= NYPSdZp{W0GQR1XS
FADU MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{KxeWlEPTB;MD6wNFIxQSEQvF2= M1SyUHNCVkeHUh?=
C32 M324Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfsbWh4UUN3ME2wMlAxOzB2IN88US=> Mlv5V2FPT0WU
D-566MG NGPoTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXyTWM2OD1yLkCwN|kh|ryP NHv3OXNUSU6JRWK=
LXF-289 Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEC0NVkh|ryP Mn24V2FPT0WU
HGC-27 NGHofFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPXTWM2OD1yLkCwOVEh|ryP NGexcmxUSU6JRWK=
RPMI-7951 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHZTWM2OD1yLkCwO|E4KM7:TR?= NYLnWYh6W0GQR1XS
HSC-3 M{XpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMEC5Nlkh|ryP MkLpV2FPT0WU
MIA-PaCa-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYq0bIw1UUN3ME2wMlAyODB7IN88US=> NVjDb3E{W0GQR1XS
KS-1 NHPKVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jTPGlEPTB;MD6wNVM2PSEQvF2= M4HVc3NCVkeHUh?=
CAL-51 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEG0NFUh|ryP MlPkV2FPT0WU
MDA-MB-361 NWDMeYJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W1VmlEPTB;MD6wNVQ6PSEQvF2= NE\Xem5USU6JRWK=
TI-73 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDLSItKSzVyPUCuNFE4QTZizszN MonsV2FPT0WU
AGS MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEG5N|gh|ryP NHTse5RUSU6JRWK=
NCI-H460 M13ndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLSdXQyUUN3ME2wMlAyQTd2IN88US=> M13XXXNCVkeHUh?=
A204 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF65fmVKSzVyPUCuNFIzPDlizszN MYLTRW5ITVJ?
CHL-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3pbpNPUUN3ME2wMlAzOjVzIN88US=> M4nseXNCVkeHUh?=
DU-4475 M37HWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEKyOlEh|ryP Mmf5V2FPT0WU
CGTH-W-1 NVrNRnNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzyTWM2OD1yLkCyN|Q6KM7:TR?= M17veXNCVkeHUh?=
HCC2218 M3Pqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEK0PVQh|ryP NVPzdpBNW0GQR1XS
A2780 NGTvfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zXeWlEPTB;MD6wNlU{OSEQvF2= NVX3XpNHW0GQR1XS
NCI-H720 NXTTfmZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXMOlFKSzVyPUCuNFI2PDZizszN MYPTRW5ITVJ?
NCI-N87 NGrTflRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L5NGlEPTB;MD6wNlU6OyEQvF2= Mk\yV2FPT0WU
CHP-212 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEK2Nlgh|ryP NVfCSG5OW0GQR1XS
NCI-H23 MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXiTWM2OD1yLkCyOlY2KM7:TR?= MmjXV2FPT0WU
D-263MG M{flVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTKVI5HUUN3ME2wMlAzPzh4IN88US=> MkTDV2FPT0WU
ME-180 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HWN2lEPTB;MD6wNlg6OSEQvF2= NXWyT3ZVW0GQR1XS
SW982 NHzrPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6zbmpKSzVyPUCuNFI6QTlizszN M2TCcXNCVkeHUh?=
OE19 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXob4tKSzVyPUCuNFMxPzdizszN NVPlRVZtW0GQR1XS
SK-LU-1 NH\yPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\nfJR4UUN3ME2wMlA{ODh{IN88US=> NXK2fXVzW0GQR1XS
H4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLhTWM2OD1yLkCzNFkh|ryP NW\PbJJqW0GQR1XS
HT-144 NX\ZOIkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETTcZRKSzVyPUCuNFMxQTNizszN MV7TRW5ITVJ?
SK-UT-1 NHWw[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn2eZo3UUN3ME2wMlA{OTd6IN88US=> M2rrTXNCVkeHUh?=
D-336MG MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDFTWM2OD1yLkCzN|A6KM7:TR?= NVPie4JOW0GQR1XS
MDA-MB-175-VII NFvJcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3KTWM2OD1yLkCzN|U1KM7:TR?= MmTKV2FPT0WU
GAMG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3FO2c6UUN3ME2wMlA{PDN3IN88US=> M1vDdnNCVkeHUh?=
CP50-MEL-B M1Pl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXDT285UUN3ME2wMlA{PDVizszN M1zvZXNCVkeHUh?=
OVCAR-5 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFSzVmdKSzVyPUCuNFM1QCEQvF2= NH3JZ2ZUSU6JRWK=
SK-MES-1 NYfER3NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGq2O25KSzVyPUCuNFM3ODZizszN NWfOd5lRW0GQR1XS
VM-CUB-1 MoW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[yd49KSzVyPUCuNFM3PTdizszN M3TGO3NCVkeHUh?=
WM-115 NYfZRXhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ftcWlEPTB;MD6wN|c3OiEQvF2= M323V3NCVkeHUh?=
DSH1 M{fUUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPpTWM2OD1yLkCzPFA4KM7:TR?= Mle0V2FPT0WU
Becker M3;JUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEO4PFUh|ryP NVT3WHdKW0GQR1XS
SW962 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\OR2lEPTB;MD6wN|k1PSEQvF2= MmX5V2FPT0WU
TYK-nu NEfZN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWqydZdYUUN3ME2wMlA{QTh3IN88US=> MVHTRW5ITVJ?
HO-1-N-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMESwNlEh|ryP NE\XXYhUSU6JRWK=
T98G NE[3bZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnSWJQ6UUN3ME2wMlA1OTB|IN88US=> NGLPPFZUSU6JRWK=
ACN MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HITmlEPTB;MD6wOFE3OiEQvF2= MlLGV2FPT0WU
SW780 NYHHeIlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\mSIdlUUN3ME2wMlA1OjB|IN88US=> MnLoV2FPT0WU
Detroit562 NIPUeWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m3PGlEPTB;MD6wOFI{QSEQvF2= MYPTRW5ITVJ?
BB49-HNC NFKwVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nmZWlEPTB;MD6wOFI1OyEQvF2= M3X1fXNCVkeHUh?=
HN M3r4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXxeIZCUUN3ME2wMlA1Ojd{IN88US=> MYfTRW5ITVJ?
H9 M4nQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTGR2JEUUN3ME2wMlA1OzdzIN88US=> Ml\SV2FPT0WU
VA-ES-BJ MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS5TWM2OD1yLkC0OFQ4KM7:TR?= NHu1d2hUSU6JRWK=
MEL-JUSO NF\sVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH0TWM2OD1yLkC0OFc2KM7:TR?= MYfTRW5ITVJ?
BT-474 NWDleIx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLIR5BvUUN3ME2wMlA1PSEQvF2= MlPnV2FPT0WU
CaR-1 M1G1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13ycWlEPTB;MD6wOFU1QSEQvF2= Mmn5V2FPT0WU
PSN1 NULIWGJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfpOWJKSzVyPUCuNFQ3ODNizszN M4TT[XNCVkeHUh?=
KYSE-510 MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTXOpZKSzVyPUCuNFQ3PDlizszN MnHvV2FPT0WU
KP-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H1SmlEPTB;MD6wOFc2OyEQvF2= MV7TRW5ITVJ?
KYSE-410 NIfIRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fEXGlEPTB;MD6wOFc4OiEQvF2= NFm2NpRUSU6JRWK=
G-402 M2DQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHW2OW5KSzVyPUCuNFQ4QDlizszN NFLUXIZUSU6JRWK=
DOK MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33xNWlEPTB;MD6wOFkxOiEQvF2= MXLTRW5ITVJ?
COR-L88 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3WTWM2OD1yLkC0PVEzKM7:TR?= NFT6dY5USU6JRWK=
SKG-IIIa NUKyVWJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj4TWM2OD1yLkC0PVg3KM7:TR?= MojCV2FPT0WU
AN3-CA M{TaTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEWg{txO NEXKe2xUSU6JRWK=
SW48 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEWwN|kh|ryP MmTPV2FPT0WU
YKG-1 NVi5[WE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof0TWM2OD1yLkC1NFcyKM7:TR?= M4rsU3NCVkeHUh?=
KYSE-150 MnLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEWyN|Uh|ryP MXPTRW5ITVJ?
HuO-3N1 NWjmTYgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHadZdOUUN3ME2wMlA2OjN5IN88US=> MYLTRW5ITVJ?
LB1047-RCC NETtcVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDYNYlKSzVyPUCuNFUzQTZizszN MlrvV2FPT0WU
NCI-H2030 NGH3RoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEW0NVQh|ryP NUixTlk4W0GQR1XS
YH-13 MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULvZnpWUUN3ME2wMlA2PzJ{IN88US=> MXnTRW5ITVJ?
5637 MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXhTWM2OD1yLkC1O|Qh|ryP NFLPb3NUSU6JRWK=
LOXIMVI M{\iW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEW4O|Ih|ryP MYHTRW5ITVJ?
GT3TKB NGW3SWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;WSGlEPTB;MD6wOVk1OiEQvF2= NXewfWpRW0GQR1XS
TCCSUP NGfQOlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPMVWhKSzVyPUCuNFU6PjRizszN Mlv0V2FPT0WU
EPLC-272H MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfFNJRKSzVyPUCuNFYzODVizszN MVXTRW5ITVJ?
LU-99A MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W4XmlEPTB;MD6wOlI{PyEQvF2= MoXaV2FPT0WU
NCI-H1755 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfITWM2OD1yLkC2N|QyKM7:TR?= MV3TRW5ITVJ?
KM12 M{TGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fhPGlEPTB;MD6wOlM1QCEQvF2= NIX2b3ZUSU6JRWK=
SF295 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfHTWM2OD1yLkC2OFUzKM7:TR?= NWLmfY11W0GQR1XS
MZ2-MEL MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKwSoNKSzVyPUCuNFY2PTNizszN MXrTRW5ITVJ?
HEC-1 NH;YNW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z3e2lEPTB;MD6wOlU5QCEQvF2= MYrTRW5ITVJ?
SW684 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwME[1PVEh|ryP M{nyTHNCVkeHUh?=
SF539 NETXT2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvY[3NKSzVyPUCuNFY3QDFizszN NGT4bZpUSU6JRWK=
GMS-10 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmwNlNKSzVyPUCuNFY3QTlizszN M1zCT3NCVkeHUh?=
MV-4-11 MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwME[4NFMh|ryP M4S5[XNCVkeHUh?=
HT-29 MoTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu0dpd5UUN3ME2wMlA3QTF7IN88US=> NGnP[VFUSU6JRWK=
23132-87 M3vKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwME[5OUDPxE1? M4W5SHNCVkeHUh?=
SW620 M{L4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\GXpVrUUN3ME2wMlA4ODJ4IN88US=> NHvlW|ZUSU6JRWK=
HCC1806 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvuTWM2OD1yLkC3NVMyKM7:TR?= M17hXHNCVkeHUh?=
Hs-578-T MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvZN3RCUUN3ME2wMlA4OjB6IN88US=> MonFV2FPT0WU
A2058 MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfHboFkUUN3ME2wMlA4OjJ6IN88US=> NIr2cmlUSU6JRWK=
MEL-HO NVzmPYc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjQTWM2OD1yLkC3NlU2KM7:TR?= NVPIO3hjW0GQR1XS
HCC2998 NHj6OHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGf4fIRKSzVyPUCuNFc{PDdizszN NW\rOWdxW0GQR1XS
HuO9 NWXPbZFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jiSGlEPTB;MD6wO|U5QSEQvF2= NEPlTHVUSU6JRWK=
CAL-39 NHL4eJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoewTWM2OD1yLkC3O|Y3KM7:TR?= M2j0dXNCVkeHUh?=
M14 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjRR2VKSzVyPUCuNFc6OTNizszN NE\x[o5USU6JRWK=
BFTC-909 NIG5bVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEe5Olkh|ryP NIL2fmdUSU6JRWK=
TE-11 NEfEOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nSe2lEPTB;MD6wO|k6PiEQvF2= NXHrcIszW0GQR1XS
TGBC1TKB NWLWR5NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[2TWM2OD1yLkC4NFQ{KM7:TR?= MVPTRW5ITVJ?
L-363 NYnHPYdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEiyNFYh|ryP NUDo[HlyW0GQR1XS
A431 M4jQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;YTXJKSzVyPUCuNFgzOSEQvF2= MX;TRW5ITVJ?
MKN45 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEiyNVkh|ryP NEPhem5USU6JRWK=
HT-1080 NUi2SmY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHse4t[UUN3ME2wMlA5PDN7IN88US=> NXzmO25zW0GQR1XS
OVCAR-8 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEi2NlIh|ryP M3rBfXNCVkeHUh?=
LCLC-97TM1 M3u5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXlVm1qUUN3ME2wMlA5PzJ6IN88US=> NUC2NlNSW0GQR1XS
M059J NYSyWVlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEmwNlch|ryP NWXPU4k6W0GQR1XS
SK-MEL-2 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LDPWlEPTB;MD6wPVA3KM7:TR?= Mln4V2FPT0WU
TE-1 NWfVc29ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfTOI1wUUN3ME2wMlA6OjB2IN88US=> NFrsPYdUSU6JRWK=
KYSE-180 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\JO2hVUUN3ME2wMlA6OjZ{IN88US=> MX7TRW5ITVJ?
D-247MG NEX0fXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEm0OVUh|ryP NUDWfoY6W0GQR1XS
8-MG-BA NVzPfIJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMEm0O|Ih|ryP M3;FNnNCVkeHUh?=
NCI-H1792 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDzSXFtUUN3ME2wMlA6PjF6IN88US=> NYDIVI9UW0GQR1XS
MCF7 MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz3TWM2OD1yLkC5Olc4KM7:TR?= MlTGV2FPT0WU
NCI-H2122 M1ywO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj4TWM2OD1yLkC5O|Q2KM7:TR?= MlTVV2FPT0WU
EFO-27 M4m3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nKe2lEPTB;MD6wPVk6PyEQvF2= MVjTRW5ITVJ?
LB2241-RCC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PlbWlEPTB;MD6xNFA2PCEQvF2= NYXBRox4W0GQR1XS
SN12C M4Pkfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu4TWM2OD1yLkGwNVA4KM7:TR?= M3L4ZXNCVkeHUh?=
A498 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjrcmtKSzVyPUCuNVAyQCEQvF2= NFPsU|VUSU6JRWK=
PANC-03-27 NFrFPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nZTWlEPTB;MD6xNFI5PiEQvF2= Mmi3V2FPT0WU
NCI-H1581 NXzBRXlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn64TWM2OD1yLkGwNlkh|ryP M2DibnNCVkeHUh?=
U-87-MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMUCzNFch|ryP NFe3[YlUSU6JRWK=
G-401 NV\WOVU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonrTWM2OD1yLkGwN|U{KM7:TR?= MYXTRW5ITVJ?
SiHa Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfyPHp{UUN3ME2wMlExPDh4IN88US=> MkHYV2FPT0WU
U251 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEGwNJhKSzVyPUCuNVA2OjVizszN NWjTPFJiW0GQR1XS
MMAC-SF NVfGZo5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrPc3VKSzVyPUCuNVA2OzFizszN M3W5eHNCVkeHUh?=
BB65-RCC NV3vXVJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHUXmpKSzVyPUCuNVA2PTRizszN MYTTRW5ITVJ?
NKM-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMUC2OlYh|ryP MkT5V2FPT0WU
HD-MY-Z MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMUC4O|Mh|ryP M{jvXnNCVkeHUh?=
TGBC11TKB NEjsTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf4bHZiUUN3ME2wMlExQTB|IN88US=> NXvEdJJmW0GQR1XS
COLO-679 NWnaT5M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PyNGlEPTB;MD6xNVIyOSEQvF2= NX\NN3Z{W0GQR1XS
TE-8 NV:1XVRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K3TWlEPTB;MD6xNVI3PCEQvF2= M1\PeXNCVkeHUh?=
SK-MEL-28 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3MOpRKSzVyPUCuNVE{OjFizszN NYmzZ2tNW0GQR1XS
SH-4 NWLJS2RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDmXWpKSzVyPUCuNVE{PTZizszN MkfFV2FPT0WU
KALS-1 M4fZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHJW4NKSzVyPUCuNVE{QTNizszN MonWV2FPT0WU
RKO NHfTW4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXuUoVKSzVyPUCuNVE4PjRizszN MUTTRW5ITVJ?
OMC-1 NIS5PYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnzfm5KSzVyPUCuNVE4QTdizszN M2rDSnNCVkeHUh?=
BT-549 NE\YSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMUG3PVkh|ryP NH\5NXZUSU6JRWK=
NCI-H28 NXiw[mdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILGWIpKSzVyPUCuNVE5OTdizszN MnfyV2FPT0WU
RXF393 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjvTWM2OD1yLkGxPVgzKM7:TR?= M4fGUnNCVkeHUh?=
COLO-829 NYHJUIFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXGO|REUUN3ME2wMlEzODB3IN88US=> NYq3b|VoW0GQR1XS
HMV-II MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnS2TWM2OD1yLkGyNFIh|ryP NYDyV2pSW0GQR1XS
SW1990 NHTuPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\UVGlEPTB;MD6xNlE2PyEQvF2= MU\TRW5ITVJ?
NCI-H1437 NX3YZWJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7mTWM2OD1yLkGyNVU4KM7:TR?= MnO1V2FPT0WU
SNB75 NHLwcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMUKxOlkh|ryP NEnvWGhUSU6JRWK=
EW-3 M1\uRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7hVWlMUUN3ME2wMlEzPjZzIN88US=> MXzTRW5ITVJ?
SAS NYG3[44xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfqTWM2OD1yLkGyOlkh|ryP MmG0V2FPT0WU
NCI-H1666 NIfZS4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzTbVlKSzVyPUCuNVI4PzRizszN NUHsXmpiW0GQR1XS
A375 NILvU2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TTVmlEPTB;MD6xNlc4QCEQvF2= NHHocVNUSU6JRWK=
CAMA-1 MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjCNIs6UUN3ME2wMlEzQTJ2IN88US=> MYDTRW5ITVJ?
HuP-T4 M4flVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki2TWM2OD1yLkGyPVQ{KM7:TR?= NVe0d3N[W0GQR1XS
NCI-H292 M{fTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7RTWM2OD1yLkGzNVEh|ryP NGnxcmFUSU6JRWK=
PC-14 M3XCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILKVpNKSzVyPUCuNVMzOTFizszN NGfjS5ZUSU6JRWK=
BPH-1 NX3UOppIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7ER|NKSzVyPUCuNVM1OSEQvF2= MoDkV2FPT0WU
GAK MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMUO1Olch|ryP MlXhV2FPT0WU
VMRC-RCZ MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMUO3OlIh|ryP NH;lSZhUSU6JRWK=
SK-MEL-24 NXTiZnRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2POTmlEPTB;MD6xN|g4KM7:TR?= MnnWV2FPT0WU
LB831-BLC MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfqS4FKSzVyPUCuNVM5QDNizszN NVjaR4lwW0GQR1XS
NCI-H2452 NG[xfWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrzcnhiUUN3ME2wMlE{QTV4IN88US=> NHPpPIJUSU6JRWK=
RT-112 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXtTWM2OD1yLkG0NFM2KM7:TR?= NY\QOW9mW0GQR1XS
GP5d NVvRfXRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zBOWlEPTB;MD6xOFExPCEQvF2= M2\SWHNCVkeHUh?=
LC-2-ad M2rDUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7XWZFQUUN3ME2wMlE1OTJzIN88US=> MmHjV2FPT0WU
MPP-89 NWHGNplkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMUSxNlUh|ryP NF;YV3FUSU6JRWK=
NUGC-3 M1nmeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjZTWM2OD1yLkG0OFc5KM7:TR?= MYTTRW5ITVJ?
GI-1 NGPhVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPsVlRNUUN3ME2wMlE1PTV6IN88US=> M{P3dXNCVkeHUh?=
HCC1419 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnidnRKSzVyPUCuNVQ2PzZizszN M36xZnNCVkeHUh?=
SW1573 NIDseHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jTO2lEPTB;MD6xOFc2QCEQvF2= MXvTRW5ITVJ?
NCI-H2347 MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnrXlFCUUN3ME2wMlE1QDN7IN88US=> MYLTRW5ITVJ?
Mewo NVm1fYoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn64TWM2OD1yLkG0PFg6KM7:TR?= NYDkVZRwW0GQR1XS
639-V NEn1R4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LsZ2lEPTB;MD6xOVAyOyEQvF2= NGfBRXZUSU6JRWK=
AsPC-1 Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrVN4tKSzVyPUCuNVUzOjVizszN MWnTRW5ITVJ?
NCI-H1648 M2H3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG4c|VKSzVyPUCuNVUzOzJizszN MY\TRW5ITVJ?
786-0 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPKNJNKSzVyPUCuNVU{QDFizszN NWKwUHB5W0GQR1XS
ETK-1 M2nFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMUW5JO69VQ>? M1LKOXNCVkeHUh?=
BxPC-3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{izeWlEPTB;MD6xOVk3PiEQvF2= MoHMV2FPT0WU
CAL-62 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMU[xOlkh|ryP NXi0Z2Z7W0GQR1XS
HCC1937 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHnNFVqUUN3ME2wMlE3Ojd3IN88US=> MUnTRW5ITVJ?
NCI-H1299 NGjycZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnzNnNKSzVyPUCuNVYzQDVizszN NGr4RWdUSU6JRWK=
SW1088 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMU[0NVMh|ryP NXLhWYVMW0GQR1XS
FTC-133 NEC5UYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jQUWlEPTB;MD6xOlU1KM7:TR?= M3H4d3NCVkeHUh?=
OC-314 M3zqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnNVHZKSzVyPUCuNVY3QSEQvF2= MX7TRW5ITVJ?
SCC-9 NVPRcGRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzKN|V4UUN3ME2wMlE3PzF4IN88US=> MXvTRW5ITVJ?
HT-1376 NWDYUZgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljpTWM2OD1yLkG2PVM3KM7:TR?= MnvqV2FPT0WU
U-2-OS M1TqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTBPXNEUUN3ME2wMlE4OTd|IN88US=> NFTGclJUSU6JRWK=
COLO-824 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMUeyPVQh|ryP NWKwfm9[W0GQR1XS
BB30-HNC M4jTfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17lWmlEPTB;MD6xO|M{KM7:TR?= NYrsNpRNW0GQR1XS
NCI-H2087 NHPIUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:yZ2dzUUN3ME2wMlE4OzZ6IN88US=> MorlV2FPT0WU
NCI-H2170 NFrhTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnXNI9KSzVyPUCuNVc2OzZizszN NXX4eFg3W0GQR1XS
SK-OV-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkmxTWM2OD1yLkG3OVcyKM7:TR?= NVn1fpJGW0GQR1XS
MZ7-mel MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMUe2OFkh|ryP MUnTRW5ITVJ?
NCI-H650 NXnuSZpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XKdmlEPTB;MD6xO|Y5OiEQvF2= MUTTRW5ITVJ?
KOSC-2 NF65cVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3YTWM2OD1yLkG3O|M1KM7:TR?= NGnVbYZUSU6JRWK=
SCC-4 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXlSXpKUUN3ME2wMlE4Pzd5IN88US=> M3XSenNCVkeHUh?=
MDA-MB-157 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLyTWM2OD1yLkG4NFgzKM7:TR?= NGCxdYxUSU6JRWK=
KYSE-520 MnXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm1VYp3UUN3ME2wMlE5OiEQvF2= NHjQd2pUSU6JRWK=
LK-2 NEXySo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInFfppKSzVyPUCuNVg{ODNizszN MYrTRW5ITVJ?
KNS-81-FD MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTmO2o2UUN3ME2wMlE5Ozl2IN88US=> NWLoZmZzW0GQR1XS
IGROV-1 NG\kVnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMUi0OFMh|ryP MkHkV2FPT0WU
DEL NUP3bY13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Lsd2lEPTB;MD6xPFQ2KM7:TR?= MYfTRW5ITVJ?
NCI-H1395 Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMUi2PFIh|ryP NXzmcWg5W0GQR1XS
JEG-3 M1TWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HifGlEPTB;MD6xPFcxPSEQvF2= NGC5OmJUSU6JRWK=
BCPAP Ml65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMUi4O|Ih|ryP MWfTRW5ITVJ?
CAL-27 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LGN2lEPTB;MD6xPVAzOiEQvF2= NUXVeXlNW0GQR1XS
RD Mm\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Trc2lEPTB;MD6xPVEyOyEQvF2= M3jQSHNCVkeHUh?=
RVH-421 NIXWN|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmwSJpnUUN3ME2wMlE6OTF4IN88US=> M4H4d3NCVkeHUh?=
Capan-2 NXrXcoxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ZUlllUUN3ME2wMlE6OjV4IN88US=> MWjTRW5ITVJ?
COLO-680N NY\meWQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmryTWM2OD1yLkG5N|Y1KM7:TR?= NGH4fGhUSU6JRWK=
NCI-H1650 M{XUdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMkCwOVch|ryP MV3TRW5ITVJ?
SBC-5 MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljjTWM2OD1yLkKwNVE5KM7:TR?= MUnTRW5ITVJ?
U031 M2K1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\1UWlEPTB;MD6yNFU1PyEQvF2= M4nPOHNCVkeHUh?=
S-117 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMkC1OlQh|ryP NHTQTZBUSU6JRWK=
DoTc2-4510 MkmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DTdWlEPTB;MD6yNFc3QSEQvF2= MoDqV2FPT0WU
AM-38 NF;zUXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPLXIRKSzVyPUCuNlA5PDhizszN MXzTRW5ITVJ?
A172 NGLrTIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnlTWM2OD1yLkKxNFIzKM7:TR?= NWfpZ2VGW0GQR1XS
HPAF-II Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LWR2lEPTB;MD6yNVI3PCEQvF2= MXrTRW5ITVJ?
769-P M2rG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMkGyPEDPxE1? M{LRUHNCVkeHUh?=
MFE-280 M{nNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW1Vm14UUN3ME2wMlIyOjl6IN88US=> M362dXNCVkeHUh?=
TE-9 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vydmlEPTB;MD6yNVc5PiEQvF2= MnPBV2FPT0WU
C2BBe1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMkKxPUDPxE1? MnLPV2FPT0WU
EoL-1-cell MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMkKyNFMh|ryP MmDmV2FPT0WU
G-361 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMkK2PFIh|ryP NEfxPHdUSU6JRWK=
KYSE-270 M1XQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMkOwPFQh|ryP NEHBeJFUSU6JRWK=
TK10 M4jjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTwbIZKSzVyPUCuNlMyOTdizszN MnjuV2FPT0WU
ML-2 NF3DNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HXVmlEPTB;MD6yN|EyQSEQvF2= NUD6N|FpW0GQR1XS
MHH-ES-1 M1XobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj3fY9KSzVyPUCuNlM3QDFizszN MorHV2FPT0WU
BHY NIXBO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LlSGlEPTB;MD6yN|Y6OSEQvF2= MULTRW5ITVJ?
LS-513 NILhSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP6SVdMUUN3ME2wMlI{QTZzIN88US=> Ml7nV2FPT0WU
COLO-678 NVO5U5VZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITCbZdKSzVyPUCuNlQxPDRizszN Mkn3V2FPT0WU
NCI-H747 NIfkUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW4dZN6UUN3ME2wMlI1OTZ7IN88US=> MoC0V2FPT0WU
K5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fTb2lEPTB;MD6yOFM5KM7:TR?= NGjDc4hUSU6JRWK=
OS-RC-2 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjhZoRyUUN3ME2wMlI1PTB7IN88US=> M17VNHNCVkeHUh?=
KINGS-1 NVHFVWZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMkS1Nlkh|ryP M1\WPXNCVkeHUh?=
SCC-25 NXfwbm95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXv[GZKSzVyPUCuNlQ2PjNizszN NHO3T2ZUSU6JRWK=
CAPAN-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXwTWM2OD1yLkK0O|g{KM7:TR?= NHfM[IpUSU6JRWK=
ESS-1 Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPOTWM2OD1yLkK0PFA2KM7:TR?= NXvi[ZgxW0GQR1XS
TE-6 MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3pVotEUUN3ME2wMlI2PzVizszN NEOwVWZUSU6JRWK=
LB2518-MEL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHXTWM2OD1yLkK1O|c4KM7:TR?= MnHaV2FPT0WU
COLO-800 MnHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzOZZB[UUN3ME2wMlI2QDF{IN88US=> Ml3wV2FPT0WU
LU-134-A NUjOeFV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3TNZlyUUN3ME2wMlI3OTN4IN88US=> MV7TRW5ITVJ?
NCI-H1155 NFXVeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMk[xOlIh|ryP MYDTRW5ITVJ?
MFM-223 NX\re20yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPQUGJKSzVyPUCuNlY{PjNizszN NFTNOI1USU6JRWK=
HTC-C3 MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnKV|dKSzVyPUCuNlY2ODZizszN M2LxZnNCVkeHUh?=
HCT-116 M1Hhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4npNWlEPTB;MD6yOlU6QSEQvF2= NVfYOHRtW0GQR1XS
Ca-Ski NFHyTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfiOG1KSzVyPUCuNlY3PzhizszN NXLhc494W0GQR1XS
SBC-1 M1TNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMk[3OFIh|ryP MVjTRW5ITVJ?
NB69 NVrRcIlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXZfJdNUUN3ME2wMlI4ODh5IN88US=> NV3md45UW0GQR1XS
J82 NWTUSXZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMkeyOlUh|ryP NITHNm5USU6JRWK=
U-118-MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnWTWM2OD1yLkK3OVc6KM7:TR?= NIDNOVVUSU6JRWK=
NCI-H1355 NXewS4dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rydGlEPTB;MD6yPFA4PCEQvF2= NX60VIVsW0GQR1XS
NCI-H1048 NITocGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMki5OVYh|ryP MofwV2FPT0WU
SW954 NYHUfI1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMkmyNlch|ryP NYf3eHptW0GQR1XS
NMC-G1 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33POGlEPTB;MD6yPVI4PyEQvF2= MkLyV2FPT0WU
SW1710 NFn1b|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\kTpZKSzVyPUCuNlk1QTRizszN M2rvTnNCVkeHUh?=
KY821 M3rhc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj0T3dKUUN3ME2wMlI6QDd{IN88US=> NFnGdJpUSU6JRWK=
HCC38 NIXnWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPLdWZKSzVyPUCuN|AxPzhizszN NFXzbWFUSU6JRWK=
NCI-SNU-5 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwM{C1OEDPxE1? NUnDdJUzW0GQR1XS
ES8 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\PSGRKSzVyPUCuN|A4QDRizszN M3HGcXNCVkeHUh?=
COLO-792 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwM{GyOVEh|ryP NIK1OZdUSU6JRWK=
BFTC-905 MljmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\mTWM2OD1yLkOxOVIyKM7:TR?= MkHOV2FPT0WU
ChaGo-K-1 NEO0[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHweYhEUUN3ME2wMlMyPzF3IN88US=> NXTTPVJ7W0GQR1XS
Daoy NH:1flJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwM{G3NlMh|ryP M2P6T3NCVkeHUh?=
SJSA-1 MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDBTWM2OD1yLkOxPFQ4KM7:TR?= MnnVV2FPT0WU
KNS-62 NFHlXYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\J[2lEPTB;MD6zNlA5QCEQvF2= M1jmSHNCVkeHUh?=
CAKI-1 MlPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjkUZJGUUN3ME2wMlMzOTFzIN88US=> MmSyV2FPT0WU
UACC-62 NGXhWmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\3eolKSzVyPUCuN|IzOjdizszN NIezcVRUSU6JRWK=
HuCCT1 NETxTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwM{KyPFMh|ryP MkHTV2FPT0WU
CTB-1 NIOxXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwM{K3OVMh|ryP NVn5[ohUW0GQR1XS
NTERA-S-cl-D1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTMN|lOUUN3ME2wMlMzQDN4IN88US=> MXXTRW5ITVJ?
T-24 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD4TWM2OD1yLkOzNVU6KM7:TR?= MoftV2FPT0WU
KYSE-70 Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;tTWM2OD1yLkOzNlg{KM7:TR?= M37uRnNCVkeHUh?=
SW626 NYrSOWx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwM{O1N|Ih|ryP M1nHVHNCVkeHUh?=
LB996-RCC MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrnXHdKSzVyPUCuN|M3OTlizszN NULQR2JyW0GQR1XS
DMS-273 NXv4cYhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\WRmlEPTB;MD6zN|kyPiEQvF2= M{nIRXNCVkeHUh?=
SW1783 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7kTWM2OD1yLkOzPVk4KM7:TR?= NYXOPIV6W0GQR1XS
KU812 NInDRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC1Rld3UUN3ME2wMlM1ODN6IN88US=> M2P5XXNCVkeHUh?=
HSC-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT2NJF6UUN3ME2wMlM1ODV|IN88US=> MoPIV2FPT0WU
A3-KAW MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjMSllKSzVyPUCuN|QyPjJizszN MkDvV2FPT0WU
COLO-684 NVfIRVRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzGXnhKSzVyPUCuN|Q2ODFizszN NWrNRlUxW0GQR1XS
NCI-H2405 NWHnZZZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXlTWM2OD1yLkO0OlMyKM7:TR?= NXrWUJFHW0GQR1XS
NCI-H2228 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLURYhKSzVyPUCuN|U{PTdizszN M4n4WnNCVkeHUh?=
NB13 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwM{[4Nlkh|ryP M4n3SHNCVkeHUh?=
no-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq5TWM2OD1yLkO2PVUh|ryP M1nJUXNCVkeHUh?=
DK-MG NIq2eYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LMbmlEPTB;MD6zO|E5QCEQvF2= MXvTRW5ITVJ?
NBsusSR NEPGfFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO0emZKSzVyPUCuN|czQDVizszN NYDOfG0zW0GQR1XS
KP-N-YS NXzKVpZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwM{e0OlMh|ryP NUL1WmRRW0GQR1XS
CFPAC-1 NEXGfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT1TWM2OD1yLkO3OVE5KM7:TR?= NIe4TWtUSU6JRWK=
KARPAS-45 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwM{e4OlIh|ryP NGPPXYJUSU6JRWK=
NCI-H1793 MkfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD1[4tUUUN3ME2wMlM5PTFizszN MoPsV2FPT0WU
HCE-T NV[1cXNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nEPGlEPTB;MD6zPFYxOyEQvF2= MXzTRW5ITVJ?
NCI-H520 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjOcVBXUUN3ME2wMlM5PzB|IN88US=> NVrtVFB2W0GQR1XS
HCC2157 M4W1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;tTWM2OD1yLkO4O|gyKM7:TR?= MWHTRW5ITVJ?
EW-18 NVHGN|BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fxNGlEPTB;MD6zPFk1OSEQvF2= M{i2THNCVkeHUh?=
RO82-W-1 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof4TWM2OD1yLkO5Olk6KM7:TR?= NGH0c3pUSU6JRWK=
HuP-T3 NIroUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwNECxOFMh|ryP M3HIc3NCVkeHUh?=
PANC-10-05 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXqT25PUUN3ME2wMlQyOTdizszN Mk\kV2FPT0WU
NCI-H1703 NX7FZ41CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHYTWM2OD1yLkSxOFQ3KM7:TR?= MYTTRW5ITVJ?
TE-10 NXTsdY9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fYT2lEPTB;MD60NVQ1PyEQvF2= MU\TRW5ITVJ?
HOS MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnOTWM2OD1yLkSxOlgzKM7:TR?= NWTjTldkW0GQR1XS
LN-405 Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDZTWM2OD1yLkSxOlg4KM7:TR?= NHrQVVhUSU6JRWK=
A427 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHyTWM2OD1yLkSxPVgyKM7:TR?= NFrqVJFUSU6JRWK=
CAL-12T M2\FcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnKPFFKSzVyPUCuOFI4QCEQvF2= NIT1d4ZUSU6JRWK=
SW756 M4TudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nmXmlEPTB;MD60OFE5OyEQvF2= MWTTRW5ITVJ?
YAPC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;VWVFMUUN3ME2wMlQ2ODhizszN NVizfVQ2W0GQR1XS
GOTO MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm4dnN6UUN3ME2wMlQ2OTZizszN NIDEeoFUSU6JRWK=
C3A MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;G[oFKSzVyPUCuOFU1OzdizszN Mo\wV2FPT0WU
UM-UC-3 NVPW[phKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPucplKSzVyPUCuOFU1PyEQvF2= NHvzToxUSU6JRWK=
NCI-H1573 NUflOndQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPITWM2OD1yLkS1OVY6KM7:TR?= Mn;vV2FPT0WU
LS-411N MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHZZ5BXUUN3ME2wMlQ3PTJ5IN88US=> NV3KfndoW0GQR1XS
COR-L23 NWDMXYNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDzVGhKSzVyPUCuOFY4PjRizszN M4X3TnNCVkeHUh?=
HCE-4 NYDDR5hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwNEe0OFYh|ryP NXTOc|Z4W0GQR1XS
NCI-H2291 MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;0RWlKSzVyPUCuOFc5QTZizszN Mlv0V2FPT0WU
A101D MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVyyVWYzUUN3ME2wMlQ5ODV|IN88US=> NXXFUIpZW0GQR1XS
HT-3 NFnuNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:0eFBKSzVyPUCuOFgzOTdizszN MknlV2FPT0WU
HOP-62 MonXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrScpJKSzVyPUCuOFk5PjVizszN MmHMV2FPT0WU
PC-3 NYHwN2F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3JNHlZUUN3ME2wMlUyPTB5IN88US=> Mn\nV2FPT0WU
CTV-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXVTWM2OD1yLkWyOlY6KM7:TR?= M3HOe3NCVkeHUh?=
PANC-08-13 NVnPUXdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPjUVVKSzVyPUCuOVMyPzdizszN NWjhVoxmW0GQR1XS
CAL-120 NWmzcoN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwNUOzPVkh|ryP NIGwU|lUSU6JRWK=
UMC-11 M1XVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonxTWM2OD1yLkW1NlM1KM7:TR?= NYHhU2pjW0GQR1XS
MSTO-211H M33WW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP1dGlKSzVyPUCuOVU4PjJizszN NWi0XGRpW0GQR1XS
NCI-H2126 NV3MbFR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f6[WlEPTB;MD61OlgyPSEQvF2= MVrTRW5ITVJ?
SNU-C2B NYfuNnFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwNUe5O|ch|ryP MVHTRW5ITVJ?
DBTRG-05MG NHLMUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLvTHJKSzVyPUCuOVgxPTNizszN MWTTRW5ITVJ?
MKN1 M4CxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzROHVKSzVyPUCuOVg4QDNizszN NUH1UGQ5W0GQR1XS
ES3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDFTWM2OD1yLkW5NVI1KM7:TR?= M1nHZ3NCVkeHUh?=
OVCAR-3 NEfZe|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwNUmzOFEh|ryP MlrzV2FPT0WU
ACHN M4Doe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml34TWM2OD1yLk[wOVY6KM7:TR?= NF\kOnpUSU6JRWK=
SW872 Ml3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHCTWM2OD1yLk[wO|Y{KM7:TR?= M1fGTnNCVkeHUh?=
CP66-MEL NIrPSJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrxS4RKSzVyPUCuOlA6PjlizszN NUXEdFF7W0GQR1XS
NCI-H661 NX\qb4JyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X1dWlEPTB;MD62NVExPCEQvF2= NXXqVoNxW0GQR1XS
UACC-893 NFrU[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz6dWhKSzVyPUCuOlM3QDFizszN NGL4eXRUSU6JRWK=
JVM-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwNkO4NFQh|ryP MVHTRW5ITVJ?
SF268 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLETWM2OD1yLk[0N|Q6KM7:TR?= MnvpV2FPT0WU
OCI-AML2 NIfac3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7Sb5J2UUN3ME2wMlY2Ozl5IN88US=> Mn\WV2FPT0WU
RPMI-8226 MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm5WpFKSzVyPUCuOlY{OjNizszN M1[2fHNCVkeHUh?=
MKN28 NHTje2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqwNHBKSzVyPUCuOlY3OjRizszN MmPkV2FPT0WU
MDA-MB-453 NE\HV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwNkexPEDPxE1? M4nWPHNCVkeHUh?=
BV-173 MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLpbmxKSzVyPUCuOlg3PzlizszN NFG2d4tUSU6JRWK=
NCI-H358 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rRUWlEPTB;MD62PFczPiEQvF2= M4S4bnNCVkeHUh?=
NCI-H1651 NYTOPW5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwNzFOwG0> MYDTRW5ITVJ?
MDA-MB-415 NUTxTlVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHyTWM2OD1yLkewPFI6KM7:TR?= MVXTRW5ITVJ?
8305C NVjjflZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;PWmlEPTB;MD63NlQ6QCEQvF2= MYDTRW5ITVJ?
EFM-19 NHqyVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\hfVZKSzVyPUCuO|M3PzFizszN NXrPO4xRW0GQR1XS
RERF-LC-MS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwN{S2NVMh|ryP Mln1V2FPT0WU
A388 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfF[I5KSzVyPUCuO|Y1PjdizszN NUD4cHdmW0GQR1XS
GI-ME-N M4LjUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL4bZJKUUN3ME2wMlc4OjN3IN88US=> NG\3bYpUSU6JRWK=
IGR-1 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXab3FGUUN3ME2wMlc6ODR|IN88US=> M2e1TXNCVkeHUh?=
LNCaP-Clone-FGC NUPTeJBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zBN2lEPTB;MD64NFAxPCEQvF2= NX[4ZYplW0GQR1XS
SK-MEL-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLIeZo3UUN3ME2wMlgyPTB6IN88US=> NF\1TItUSU6JRWK=
UACC-257 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwOEKyN|Eh|ryP MUDTRW5ITVJ?
OE33 NInB[WhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwOEWxNFEh|ryP NUjhUXJnW0GQR1XS
QIMR-WIL MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwOEWxOFEh|ryP NGTsO3dUSU6JRWK=
NCI-H2009 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfBTWM2OD1yLki1N|EyKM7:TR?= M3u1d3NCVkeHUh?=
NCI-H522 NUDaUIFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rWbWlEPTB;MD64O|c5OyEQvF2= M1\MbXNCVkeHUh?=
Saos-2 NU\s[lNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X2OWlEPTB;MD64O|g4OSEQvF2= M3T5SHNCVkeHUh?=
NB17 NHfPUFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy1fIZKSzVyPUCuPFgxOjVizszN NWHKe5g3W0GQR1XS
D-392MG NUCwe2ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmwTlZKSzVyPUCuPFk{PTZizszN NWLRdGN4W0GQR1XS
SHP-77 NFvF[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\vVmlEPTB;MD65NFQ5PSEQvF2= NYj6TJFGW0GQR1XS
SK-MEL-30 NI\zWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\ZTWM2OD1yLkmxNVg2KM7:TR?= NUnxUYlGW0GQR1XS
GCIY NUTBeXFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvRbYZ6UUN3ME2wMlkyQDR|IN88US=> NF3pXW1USU6JRWK=
HCC70 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPYZmRKSzVyPUCuPVIxPTlizszN NX\CWWpzW0GQR1XS
LU-65 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwOUK1PVEh|ryP NVLBRXdDW0GQR1XS
NCI-H1563 NETUN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwOUS4OlUh|ryP MY\TRW5ITVJ?
KURAMOCHI MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTMTWM2OD1yLkm1NVkzKM7:TR?= M{jnbnNCVkeHUh?=
PA-1 M4jMbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HCfmlEPTB;MD65OVQzPCEQvF2= MmjiV2FPT0WU
NOS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WxSWlEPTB;MD65O|Q5QSEQvF2= NWDp[VRIW0GQR1XS
NCI-H69 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DKVmlEPTB;MD65O|Y{PCEQvF2= NIL0O2dUSU6JRWK=
KYSE-450 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fTWWlEPTB;MD65PFYzPiEQvF2= NGfRRoZUSU6JRWK=
8505C M{SydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vqNmlEPTB;MD65PVk5OiEQvF2= MV\TRW5ITVJ?
TGBC24TKB NE\pSHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzKTWM2OD1zLkCwNFg1KM7:TR?= NHHvdnBUSU6JRWK=
PFSK-1 M{TXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;oTWM2OD1zLkCxOFI5KM7:TR?= NHm4SVBUSU6JRWK=
EKVX NHnHOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XwcmlEPTB;MT6wN|EzOSEQvF2= NVzvZZZoW0GQR1XS
RCM-1 NGLOfJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTtTWM2OD1zLkC1OVA4KM7:TR?= M13ueHNCVkeHUh?=
SW900 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;nV2VsUUN3ME2xMlA4QDNizszN MUHTRW5ITVJ?
D-542MG MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33Fd2lEPTB;MT6wO|g2PSEQvF2= NVfWc5d2W0GQR1XS
SK-PN-DW M4e4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXQTXViUUN3ME2xMlExODV4IN88US=> MlLCV2FPT0WU
NCI-H727 NEHK[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfzTWM2OD1zLkGwNVU1KM7:TR?= NIXUdmNUSU6JRWK=
SW837 NW\qWXBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3WTWM2OD1zLkGwPVU1KM7:TR?= NUf4eZVbW0GQR1XS
BT-20 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGxTGdvUUN3ME2xMlEyOjB2IN88US=> MYjTRW5ITVJ?
RH-18 NEG3ZWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXDTWM2OD1zLkGzNVA{KM7:TR?= MYfTRW5ITVJ?
TE-12 NH7ielhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7hTWM2OD1zLkGzN|M{KM7:TR?= NYrrZ5J3W0GQR1XS
NB10 MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDTN5M{UUN3ME2xMlE{OzR2IN88US=> NWjGT3VxW0GQR1XS
AU565 M3vGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELjRXNKSzVyPUGuNVU6PzNizszN MoLuV2FPT0WU
OAW-42 NYriOGVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwMUizNFYh|ryP MoriV2FPT0WU
DJM-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\u[|NKSzVyPUGuNVk5QDFizszN NFXwfYFUSU6JRWK=
HH MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrMTGlKSzVyPUGuNlM5OzFizszN NYqyOJVCW0GQR1XS
LAMA-84 NGHKV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHIN3NKSzVyPUGuNlc{QTRizszN Mme3V2FPT0WU
KNS-42 NFPmXIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;RUXVKSzVyPUGuN|AzQTZizszN NEjE[5FUSU6JRWK=
NCI-H2052 M1\Vemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\iTWM2OD1zLkOwOVA4KM7:TR?= M{\zfHNCVkeHUh?=
MLMA MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K2O2lEPTB;MT6zNlQxPyEQvF2= MnLpV2FPT0WU
NB12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3vTWM2OD1zLkO1OlM3KM7:TR?= MXzTRW5ITVJ?
NCI-H1838 M2DSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPzc2V4UUN3ME2xMlM3OzB4IN88US=> MVLTRW5ITVJ?
NCI-H526 M3\K[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnLXWh6UUN3ME2xMlM4QDV|IN88US=> MUfTRW5ITVJ?
LS-123 M3fSWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHJRoFKSzVyPUGuN|kxQTRizszN MlHXV2FPT0WU
HDLM-2 NFnMb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwM{myO|Eh|ryP NXHkS2VvW0GQR1XS
MC-IXC M1X4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j2O2lEPTB;MT60NlM4OSEQvF2= NFjvOoVUSU6JRWK=
HCT-15 MmTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwNEOwOlgh|ryP MmjuV2FPT0WU
NCI-H596 NYm5ellCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHDd3NKSzVyPUGuOFUxPjFizszN NHy3UolUSU6JRWK=
ZR-75-30 NYrQSXBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L5[WlEPTB;MT60O|A5OiEQvF2= NWPnNYxCW0GQR1XS
A704 NHfVWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\VVWFKSzVyPUGuOlY2PjNizszN NGLBU|JUSU6JRWK=
OVCAR-4 M1;zWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;K[4tKSzVyPUGuOlk3ODdizszN NUKwd5UyW0GQR1XS
SW1417 NHHObY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFwN{K4OFkh|ryP MlvXV2FPT0WU
CAS-1 NIDMU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFwN{O5N|Yh|ryP NWj2bnFtW0GQR1XS
IST-SL1 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1yyfmlEPTB;MT63PVc2QSEQvF2= M3mzcnNCVkeHUh?=
A253 MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7TTlY1UUN3ME2xMlgzOjN7IN88US=> M2DXeXNCVkeHUh?=
EW-16 NF\DcYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17pemlEPTB;MT64Nlg4PSEQvF2= NVPE[mxGW0GQR1XS
SK-NEP-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXFTWM2OD1zLki2PVg5KM7:TR?= MmXJV2FPT0WU
NCI-H226 Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjZdYdwUUN3ME2xMlg6OzV7IN88US=> NWq0XIl7W0GQR1XS
HOP-92 MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXLTWM2OD1zLkm2NFk6KM7:TR?= Mlf1V2FPT0WU
NCI-H441 NI\teW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPMTWM2OD1{LkCyN|M4KM7:TR?= MYHTRW5ITVJ?
LU-139 NXLxXnRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjPc5BrUUN3ME2yMlA{OTF2IN88US=> NU\oUG0{W0GQR1XS
SJRH30 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnjdFFKSzVyPUKuNFQzPTNizszN NUT4dGZ5W0GQR1XS
MG-63 NF;ZTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq2TWM2OD1{LkG0NVEyKM7:TR?= MWHTRW5ITVJ?
NH-12 NFXqSFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJwMUWwNFYh|ryP NVnwbZVjW0GQR1XS
NB7 NV3hOm1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrLTWM2OD1{LkG5Olc{KM7:TR?= NUPXWXBLW0GQR1XS
LB771-HNC NGDuWllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwMkC1PVUh|ryP M1O1OHNCVkeHUh?=
HCC1569 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPUTWM2OD1{LkK0OVg{KM7:TR?= NX7QeJlxW0GQR1XS
D-283MED Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLMTWM2OD1{LkK0O|gzKM7:TR?= MkT2V2FPT0WU
J-RT3-T3-5 MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDWWlRKSzVyPUKuNlU{PTFizszN M4PBZXNCVkeHUh?=
ATN-1 M4q4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn2wTWM2OD1{LkOzNFgzKM7:TR?= NUjSVpRTW0GQR1XS
HCC1954 MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYiwZXJmUUN3ME2yMlM1PDB6IN88US=> MWXTRW5ITVJ?
SCC-15 NE\D[3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXwdo5XUUN3ME2yMlM6OzF{IN88US=> M2i3W3NCVkeHUh?=
COLO-668 M4L1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJwNEOyJO69VQ>? M3WwNXNCVkeHUh?=
LB373-MEL-D NF7YS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlz4TWM2OD1{LkW0Olc4KM7:TR?= M3jZeHNCVkeHUh?=
no-10 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwNUS5OFch|ryP NW\VWndYW0GQR1XS
HT-1197 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHeydpNKSzVyPUKuOlMyQDhizszN MXPTRW5ITVJ?
DU-145 NFLaSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonNTWM2OD1{Lke5NVYzKM7:TR?= NXfqXHJIW0GQR1XS
SK-N-AS M{i0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjRXlBSUUN3ME2yMlg1Pjl{IN88US=> NHnZfHJUSU6JRWK=
MOLT-4 M4\Jbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXNenhKSzVyPUKuPFU{OjJizszN MmTDV2FPT0WU
EW-22 NF3NS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXrSoJxUUN3ME2yMlkzQDRzIN88US=> M2LOV3NCVkeHUh?=
DB MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq3TWM2OD1{Lkm3O|U6KM7:TR?= Mke5V2FPT0WU
HL-60 MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTNwMESzO|Yh|ryP NWDZN3RzW0GQR1XS
SK-N-DZ MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPoeVFzUUN3ME2zMlA2ODd3IN88US=> M3LlR3NCVkeHUh?=
NY MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK1UIRKSzVyPUOuNFg2PDJizszN Ml\6V2FPT0WU
T47D NY\o[Y1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLTTWM2OD1|LkGwOVU5KM7:TR?= M1TwRXNCVkeHUh?=
NCI-H2029 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNwMkK0O|ch|ryP MVXTRW5ITVJ?
KARPAS-299 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGK2UoNKSzVyPUOuNlYxOjdizszN NWDrNJFLW0GQR1XS
KM-H2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jvNWlEPTB;Mz6zNFY5KM7:TR?= MWTTRW5ITVJ?
CHP-134 NWPZXJhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnviTWM2OD1|LkS3N|kh|ryP NXizfXVIW0GQR1XS
22RV1 NIPDU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\HTWM2OD1|LkS5NVY5KM7:TR?= MknEV2FPT0WU
NB5 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX5SW84UUN3ME2zMlUxPjh7IN88US=> M3XlW3NCVkeHUh?=
CW-2 M1\KWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzKTWM2OD1|LkW1N|E1KM7:TR?= M2LwVnNCVkeHUh?=
EFO-21 M4DueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HMTGlEPTB;Mz61Olk1KM7:TR?= M2SxZ3NCVkeHUh?=
HuH-7 M3zXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvhV29YUUN3ME2zMlU5PDF2IN88US=> MVjTRW5ITVJ?
ALL-PO M2flfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnyxTWM2OD1|Lk[yN|M2KM7:TR?= MXXTRW5ITVJ?
EM-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrBPYZKSzVyPUOuOlkxOTFizszN NFGzNW9USU6JRWK=
KLE MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTNwN{OwNlkh|ryP NVyzWHpPW0GQR1XS
NEC8 M376c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTEdVVKSzVyPUOuPVE5ODhizszN NX20[|cyW0GQR1XS
KP-N-YN NH7LWmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq0TWM2OD1|LkmzOFc3KM7:TR?= MWHTRW5ITVJ?
SK-MEL-1 NWWyTHRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HBNWlEPTB;ND6wN|UyQCEQvF2= MlPrV2FPT0WU
CAL-54 MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnqWFFKSzVyPUSuNFU6OSEQvF2= NVrpd3dZW0GQR1XS
MS-1 NVrHcoc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LJfGlEPTB;ND6xOlE2PSEQvF2= NG\BcVZUSU6JRWK=
NCI-H209 M1;zV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\YNWlEPTB;ND6yPVk6QSEQvF2= NGS2PHdUSU6JRWK=
NOMO-1 NIDRRWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3PTWM2OD12LkOyNVMyKM7:TR?= NHfMU3ZUSU6JRWK=
RPMI-2650 M3;BVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[zcVY{UUN3ME20MlM3OzJ5IN88US=> NXezfpp1W0GQR1XS
NCI-H810 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zBPGlEPTB;ND6zPVc{PiEQvF2= MVvTRW5ITVJ?
Ca9-22 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmOwTWM2OD12LkS1OlkyKM7:TR?= MoTGV2FPT0WU
ES4 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nETGlEPTB;ND60O|A6PSEQvF2= MorSV2FPT0WU
ES6 MnzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\C[oRKSzVyPUSuOFk3PTdizszN NEfERW5USU6JRWK=
DMS-114 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\XXmlEPTB;ND61OFY6OSEQvF2= MoPOV2FPT0WU
ONS-76 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vqTWlEPTB;ND61O|k2KM7:TR?= MVPTRW5ITVJ?
K-562 NFfFN5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTKTWM2OD12LkezPFE1KM7:TR?= NHq5WVZUSU6JRWK=
MHH-NB-11 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHZeZc{UUN3ME20Mlc2PDZzIN88US=> NFPXTndUSU6JRWK=
Calu-3 NX7QcJl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjqc|hKSzVyPUSuO|g2PDhizszN MljEV2FPT0WU
HT55 NGDYenBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTqeolDUUN3ME20Mlg1PTR3IN88US=> NE\HVmZUSU6JRWK=
SK-N-FI MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlztTWM2OD12Lki1NFA6KM7:TR?= MXXTRW5ITVJ?
ES1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTRwOE[wOVch|ryP NInxW|RUSU6JRWK=
SF126 NX\YOnZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTRwOUOxPFQh|ryP NVyybG5WW0GQR1XS
ES5 M33rZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;zVYNKSzVyPUWuNVI1OjdizszN Mo\RV2FPT0WU
LoVo MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrJO4I{UUN3ME21MlE2QDdzIN88US=> NVLS[GRmW0GQR1XS
SNU-387 M4DyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTVwM{KzN|kh|ryP MV3TRW5ITVJ?
C8166 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT4TWM2OD13LkO2N|M6KM7:TR?= MWPTRW5ITVJ?
LS-1034 M4TiOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTFemRUUUN3ME21MlQzOzB5IN88US=> MUXTRW5ITVJ?
GR-ST MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTVwNUKyNFEh|ryP NE\GbmtUSU6JRWK=
NCI-H1092 M3e3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPKN5Z3UUN3ME21MlczQDR|IN88US=> M3X3SXNCVkeHUh?=
647-V NHrF[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;HV2lEPTB;NT63OFcxPiEQvF2= Mn;MV2FPT0WU
EW-13 NEjrUHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvjVlJKSzVyPUWuO|Y3OjdizszN NGrxcYpUSU6JRWK=
KGN M1j4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXR[nNkUUN3ME22MlA6QTJzIN88US=> MULTRW5ITVJ?
D-423MG M4G2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfXTWM2OD14LkSwNlg1KM7:TR?= NUm4R4luW0GQR1XS
ECC10 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInzN2tKSzVyPUeuNVAyODFizszN NIPMZo1USU6JRWK=
TE-5 NWr0W|RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfiOpg5UUN3ME23MlQyOjl6IN88US=> Mn23V2FPT0WU
P12-ICHIKAWA M3q1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT1NlFjUUN3ME23MlQ2PTJ|IN88US=> M3XSOnNCVkeHUh?=
NCI-H82 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\YZ2lEPTB;Nz60OVcxOSEQvF2= NYTNXGxzW0GQR1XS
NCI-H1993 M32zXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfLTWM2OD15LkizNFY{KM7:TR?= MoTtV2FPT0WU
RH-1 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvWTWM2OD15Lki1NlQ1KM7:TR?= NWD1bnlHW0GQR1XS
SW948 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTdwOU[wOFkh|ryP M1;EWnNCVkeHUh?=
CAL-33 NYfkSlVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTdwOUm5N|gh|ryP M1vNfnNCVkeHUh?=
U-266 NYS1U|Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\MTWM2OD16LkG1O|c4KM7:TR?= M{\jUnNCVkeHUh?=
CAL-72 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXtTlltUUN3ME24MlIxOzJizszN NY\vTVNyW0GQR1XS
SNU-423 NW[1bYp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnPTWM2OD17LkO2OlY3KM7:TR?= M1;RZ3NCVkeHUh?=
KG-1 NFjxV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moi0TWM2OD17LkW4OFU3KM7:TR?= M3TOVnNCVkeHUh?=
HCC1395 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHkTWM2OD17LkmyN|UzKM7:TR?= MYHTRW5ITVJ?
BE-13 NXO3VFd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[zTWM2OD1zMD64PFkzKM7:TR?= M4TZcHNCVkeHUh?=
MKN7 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonETWM2OD1zMD65O|Y2KM7:TR?= NHT3[lhUSU6JRWK=
697 M3v0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jzO2lEPTB;MUGuNVQ4OiEQvF2= MYPTRW5ITVJ?
LU-135 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fWVGlEPTB;MUGuNlMxPyEQvF2= NVTucI11W0GQR1XS
ES7 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELnR3dKSzVyPUGxMlM{OTNizszN NHrpUYJUSU6JRWK=
SK-HEP-1 Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[0WHk1UUN3ME2xNU44PjR4IN88US=> NFvFVodUSU6JRWK=
BEN MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqwNWRUUUN3ME2xNU45PTFizszN MXvTRW5ITVJ?
NCI-H1770 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTF{LkGyOkDPxE1? NHTSNnVUSU6JRWK=
SW13 NEe2WGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX2TWM2OD1zMj6xOVQyKM7:TR?= NVfQSlhZW0GQR1XS
MZ1-PC M1zN[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF{LkW0OVIh|ryP MoO4V2FPT0WU
Mo-T MnTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XWb2lEPTB;MUKuO|QzOSEQvF2= M{jTSXNCVkeHUh?=
HLE M174[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nUdGlEPTB;MUKuPFIyPSEQvF2= M2HJb3NCVkeHUh?=
RCC10RGB NFzsc4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF|Lk[3NUDPxE1? MlzDV2FPT0WU
COLO-320-HSR NH3sU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3Wc5gxUUN3ME2xN{44OzhzIN88US=> MU\TRW5ITVJ?
BHT-101 M{P2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PTT2lEPTB;MUOuPFM1PSEQvF2= NFvxfnFUSU6JRWK=
OCUB-M NVeyWpAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;wTWM2OD1zND6xOlAzKM7:TR?= MnXtV2FPT0WU
MEG-01 NEnuTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\KRYdKSzVyPUG0MlM4ODhizszN MnLHV2FPT0WU
RS4-11 NFKwWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCyTWM2OD1zND63OFIh|ryP NE\tcolUSU6JRWK=
MN-60 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkSzTWM2OD1zND63PFk1KM7:TR?= NFzLXolUSU6JRWK=
NCI-H1304 MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjXcnl5UUN3ME2xOU4xPDJ3IN88US=> NGS2cotUSU6JRWK=
Ramos-2G6-4C10 NGDlcpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF3LkC1PFEh|ryP NFHIbGFUSU6JRWK=
NCI-H2342 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\wfnBiUUN3ME2xOU4zODR2IN88US=> NWftPHIzW0GQR1XS
LAN-6 NHnacnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTv[nVKSzVyPUG1MlQ1OTRizszN Ml3vV2FPT0WU
JVM-2 NFXsWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF3LkW3OFgh|ryP MnftV2FPT0WU
P30-OHK MnvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;HTWM2OD1zNj6wOlE1KM7:TR?= NIWxVWdUSU6JRWK=
C-33-A MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHTXFRKSzVyPUG2MlYzOTRizszN MWfTRW5ITVJ?
RPMI-8866 NInPfpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\CTWM2OD1zNj64OFk3KM7:TR?= NUnO[pM1W0GQR1XS
NCI-H630 M2CwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTF4Lki1N|ch|ryP NVv4WWFiW0GQR1XS
KYSE-140 NX75UotQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnjcJNPUUN3ME2xO{4zODJ6IN88US=> NX2xcVBUW0GQR1XS
T84 MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTXd3dKSzVyPUG4Mlg3QTVizszN NXn0XW1iW0GQR1XS
KU-19-19 NWnHVGI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTmTWM2OD1zOD65OlA5KM7:TR?= Mo\4V2FPT0WU
BALL-1 NUS5T3ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHGUFN{UUN3ME2xPU4{Ozl7IN88US=> MVXTRW5ITVJ?
Calu-6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\hVIlKSzVyPUG5MlQ6OiEQvF2= NWLNbnhFW0GQR1XS
EGI-1 M2fZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;qTWM2OD1zOT61PVgh|ryP NUCwWIZXW0GQR1XS
MFH-ino MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTF7Lke0OVQh|ryP MnS2V2FPT0WU
GB-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PaXWlEPTB;MkCuN|U{PSEQvF2= NHjGWnFUSU6JRWK=
NCI-H1693 MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjSV2tuUUN3ME2yNE43PTB3IN88US=> NVXPXnlHW0GQR1XS
SW1116 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4iyPGlEPTB;MkCuPVM3OiEQvF2= M3TRbXNCVkeHUh?=
H-EMC-SS MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJ{LkC0OUDPxE1? Mk\SV2FPT0WU
D-502MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDkSpFKSzVyPUKyMlgzPjFizszN MYfTRW5ITVJ?
IA-LM MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr5d|ZKSzVyPUKzMlI1QTNizszN MlHBV2FPT0WU
SW1463 NV7nb4VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlznTWM2OD1{Mz63PUDPxE1? MmjGV2FPT0WU
JAR NYHTc3p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLwTWM2OD1{ND6zNlk{KM7:TR?= MWLTRW5ITVJ?
HT M1XMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjjTWM2OD1{ND60O|U{KM7:TR?= NHj3eVdUSU6JRWK=
LCLC-103H M4e2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH4TWM2OD1{ND64OFQ6KM7:TR?= MVzTRW5ITVJ?
SNU-449 NFnSR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nTR2lEPTB;MkSuPFc1OSEQvF2= MoXUV2FPT0WU
KE-37 MkfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVyzdnRRUUN3ME2yOU4xQTJ6IN88US=> MXfTRW5ITVJ?
NCI-H1623 NXHDWm5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnkTWM2OD1{Nz6xN|A{KM7:TR?= MoDaV2FPT0WU
MOLT-13 MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHUTWM2OD1{Nz6zOVE3KM7:TR?= NYTBRnB2W0GQR1XS
COLO-741 M4fVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTNzLkOzN|Mh|ryP NVf0bYl2W0GQR1XS
NB6 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD0TWM2OD1|Mj6yPFc3KM7:TR?= NWDDZY5GW0GQR1XS
MOLT-16 M3f5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTN|LkCwOVUh|ryP MmT5V2FPT0WU
IST-MES1 M{Hzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jSbWlEPTB;M{SuNFU1OSEQvF2= MmLTV2FPT0WU
A4-Fuk NULEboJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rXRWlEPTB;M{WuNFY3KM7:TR?= NH[5UlZUSU6JRWK=
CAL-85-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTN3LkK4NVch|ryP NWLNPZJjW0GQR1XS
CCRF-CEM NHnNXJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP2cFFKSzVyPUO3MlE2OzZizszN M3zTO3NCVkeHUh?=
HAL-01 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\ydmlEPTB;M{iuOFg5QSEQvF2= NHTUbFdUSU6JRWK=
HEL NX\mcW9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\SRWlEPTB;NEOuN|QxQSEQvF2= MlLxV2FPT0WU
EW-1 M2jsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L6T2lEPTB;NEOuOFc3QCEQvF2= NVTGd5FMW0GQR1XS
MDA-MB-231 NXfOdWp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTR3LkGxPVkh|ryP MlO0V2FPT0WU
ABC-1 NVjWPVVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPVXYpKSzVyPUS2Mlg2OzhizszN MUnTRW5ITVJ?
NCI-H446 NV7CR45pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvZRpBKSzVyPUS4MlUxPThizszN M4XacHNCVkeHUh?=
MHH-PREB-1 M3zi[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTR7Lk[wNFch|ryP M3nYNnNCVkeHUh?=
DOHH-2 NWC3bmtET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTR7Lk[2OVYh|ryP NFHUTGRUSU6JRWK=
GCT MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPDVGJKSzVyPUS5MlY6PzZizszN NYH2OWZLW0GQR1XS

多くの細胞株試験データを見る場合、クリックしてください

体内試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
細胞試験: [1]
+ 展開
  • 細胞株: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • 濃度: Dissolved in DMSO, final concentrations ~10 μM
  • 反応時間: 5 days
  • 実験の流れ: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (参考用のみ)
動物試験:[2]
+ 展開
  • 動物モデル: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • 製剤: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • 投薬量: ~50 mg/kg
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water slightly soluble or insoluble
体内 順序で溶剤を入れること:
5%DMSO+corn oil
10mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管
in solvent
別名 CP127374,NSC-330507, KOS 953

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90)信号経路図

HSP (e.g. HSP90) Inhibitors with Unique Features

相関HSP (e.g. HSP90)製品

Tags: Tanespimycin (17-AAG)を買う | Tanespimycin (17-AAG) ic50 | Tanespimycin (17-AAG)供給者 | Tanespimycin (17-AAG)を購入する | Tanespimycin (17-AAG)費用 | Tanespimycin (17-AAG)生産者 | オーダーTanespimycin (17-AAG) | Tanespimycin (17-AAG)化学構造 | Tanespimycin (17-AAG)分子量 | Tanespimycin (17-AAG)代理店
×
細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID