BI 2536

製品コードS1109

BI 2536化学構造

分子量(MW):521.66

BI2536は一種の有効なPlk1阻害剤で、無細胞試験でIC50値が0.83nMですが、Plk1に作用する選択性はPlk2とPlk3に作用する選択性より4倍と11倍がそれぞれ高くなります、臨床2期。

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文献中の引用(53)

カスタマーフィードバック(11)

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

製品安全説明書

PLK阻害剤の選択性比較

生物活性

製品説明 BI2536は一種の有効なPlk1阻害剤で、無細胞試験でIC50値が0.83nMですが、Plk1に作用する選択性はPlk2とPlk3に作用する選択性より4倍と11倍がそれぞれ高くなります、臨床2期。
特性 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
ターゲット
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
PI3Kα [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 2.407 μM 4.754 μM
体外試験

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NHjs[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHMXnRKSzVyPUCuNFA4PzZizszN NGjuTndUSU6JRWK=
ACN NFHTPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\OTWM2OD1yLkCwPFQ{KM7:TR?= NHewc4hUSU6JRWK=
TE-8 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGyXWxKSzVyPUCuNFA6PDFizszN M{fH[HNCVkeHUh?=
LC-2-ad MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7STWM2OD1yLkCxNFk{KM7:TR?= NVvvRnc6W0GQR1XS
ALL-PO M{XkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEGzJO69VQ>? NGXX[oVUSU6JRWK=
EW-16 M2TsbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP5TWM2OD1yLkCxN|M3KM7:TR?= M3XWVHNCVkeHUh?=
KM12 NVS3PIcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHudodFUUN3ME2wMlAyOzR6IN88US=> NYrnPVJOW0GQR1XS
GI-1 NH\NSW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTXTWM2OD1yLkCxN|g{KM7:TR?= NGrBVGxUSU6JRWK=
LS-411N M33DXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWewcnZkUUN3ME2wMlAyPDB5IN88US=> NFzyR3JUSU6JRWK=
ES8 M2jPd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvWZ5FKSzVyPUCuNFE1QTRizszN NGP3c3pUSU6JRWK=
SNU-C2B M2fhT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH4WmlkUUN3ME2wMlAyPTJ4IN88US=> MX\TRW5ITVJ?
CESS NHfKZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e5WmlEPTB;MD6wNVYxOiEQvF2= MV3TRW5ITVJ?
697 M1y1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLTS2tsUUN3ME2wMlAyPjZ6IN88US=> M4K4cnNCVkeHUh?=
NCI-H1963 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT1V2pJUUN3ME2wMlAyPjd|IN88US=> M2[ybnNCVkeHUh?=
IA-LM NXvPV297T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PUS2lEPTB;MD6wNVY5QCEQvF2= MkTXV2FPT0WU
SW954 NF3i[pNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPlW2hKSzVyPUCuNFE4ODVizszN NID4OVVUSU6JRWK=
RL95-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEG3N|gh|ryP MmfZV2FPT0WU
LXF-289 NXTFO3FVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEG3O{DPxE1? NF3mS|lUSU6JRWK=
OCUB-M MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfKTWM2OD1yLkCxPFI3KM7:TR?= MknNV2FPT0WU
RKO NWrLTYZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEG5PFch|ryP M4jvW3NCVkeHUh?=
LOUCY MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fPdGlEPTB;MD6wNlA2KM7:TR?= NV7HUYVjW0GQR1XS
NOS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPCd29KSzVyPUCuNFIxQTNizszN NUHObIpNW0GQR1XS
A4-Fuk M2PnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zEPWlEPTB;MD6wNlIyQCEQvF2= MmrZV2FPT0WU
A388 NXXMRVJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W2ZWlEPTB;MD6wNlIzPyEQvF2= MkLmV2FPT0WU
TE-9 NXzNWYluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLEZZJwUUN3ME2wMlAzOjZzIN88US=> MmfCV2FPT0WU
KURAMOCHI M37yO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPiXXFrUUN3ME2wMlAzOjh3IN88US=> NGf4[VhUSU6JRWK=
KALS-1 NGfvb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fjS2lEPTB;MD6wNlM{QCEQvF2= MYnTRW5ITVJ?
HOP-62 Ml:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjvS2ZKSzVyPUCuNFI1OiEQvF2= MVLTRW5ITVJ?
RPMI-8402 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEK1NFgh|ryP MWPTRW5ITVJ?
TE-1 M3;CWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEK1NVIh|ryP NU\Veo91W0GQR1XS
CCRF-CEM M1r3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3Nd5ZKSzVyPUCuNFI2PDNizszN NGHwOVJUSU6JRWK=
HUTU-80 M4fKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnniTWM2OD1yLkCyOlI1KM7:TR?= NYT3[3Y2W0GQR1XS
NCI-H1648 NGjHUWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HiSWlEPTB;MD6wNlY1PyEQvF2= NXvVXFNxW0GQR1XS
HCE-4 M3XNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojNTWM2OD1yLkCyOlgzKM7:TR?= NH\2bY9USU6JRWK=
ETK-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37pOmlEPTB;MD6wNlc{PiEQvF2= M3SzcnNCVkeHUh?=
TE-15 M37Sd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEK3N|gh|ryP NHrv[pZUSU6JRWK=
BE-13 MlfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlftTWM2OD1yLkCyO|Qh|ryP NX7Hc2pxW0GQR1XS
KE-37 NVL0empMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPkTGV[UUN3ME2wMlAzPzRzIN88US=> MlHNV2FPT0WU
NCI-H1355 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXBeZNoUUN3ME2wMlAzPzh|IN88US=> MmTYV2FPT0WU
TE-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDITWM2OD1yLkCyPFA6KM7:TR?= NGHvVFlUSU6JRWK=
BL-70 NWXNTod2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXXbGxKSzVyPUCuNFI5PTdizszN NYrs[2tVW0GQR1XS
ES6 NYDEcpd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf4TWM2OD1yLkCyPFgyKM7:TR?= MmrWV2FPT0WU
GT3TKB M2qwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ftVGlEPTB;MD6wNlk2OyEQvF2= NVjadm9TW0GQR1XS
LB647-SCLC NGfLclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2zTWM2OD1yLkCzNVk2KM7:TR?= M3XTfnNCVkeHUh?=
NB13 MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfqT2hKSzVyPUCuNFM{OTZizszN NV[1dG12W0GQR1XS
ST486 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\IfINpUUN3ME2wMlA{OzN5IN88US=> MnTLV2FPT0WU
NCI-H82 M3KyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEOzOFMh|ryP MXzTRW5ITVJ?
NTERA-S-cl-D1 NFTjU3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\iXWlEPTB;MD6wN|M6QSEQvF2= MX3TRW5ITVJ?
ES4 NXK2bZhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEO0OlMh|ryP NYnER5JoW0GQR1XS
SK-NEP-1 M2H4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEO0PVkh|ryP MYnTRW5ITVJ?
Becker NYXnS5NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEO1OVUh|ryP NVKzfXk{W0GQR1XS
A101D Mnv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO5ZmJKSzVyPUCuNFM4PDhizszN MV7TRW5ITVJ?
SK-UT-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLGTWM2OD1yLkCzO|c1KM7:TR?= MVvTRW5ITVJ?
SW982 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDMTWM2OD1yLkCzO|kh|ryP NF7tflNUSU6JRWK=
TE-10 M{PhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHyTWM2OD1yLkC0NFQ3KM7:TR?= Mn;IV2FPT0WU
OVCAR-4 M1fMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ez[mlEPTB;MD6wOFA2QSEQvF2= MXTTRW5ITVJ?
KP-N-YS NHrsN5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTCbVFnUUN3ME2wMlA1ODh3IN88US=> Mn;iV2FPT0WU
BL-41 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[ySGlEPTB;MD6wOFEzPSEQvF2= M{TidHNCVkeHUh?=
MZ1-PC NIPtbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMESxNlch|ryP MojaV2FPT0WU
PF-382 MljmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP4TWM2OD1yLkC0NVk5KM7:TR?= MY\TRW5ITVJ?
MOLT-13 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMESyN|gh|ryP MorGV2FPT0WU
HCC1599 NGPMd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T5RmlEPTB;MD6wOFI2QCEQvF2= NX2wdpZwW0GQR1XS
IST-MEL1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\EdWlEPTB;MD6wOFQ1OiEQvF2= NUXncnlpW0GQR1XS
LU-139 NYewO|E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITaO3dKSzVyPUCuNFQ1PDJizszN M1PaTHNCVkeHUh?=
MS-1 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nKVWlEPTB;MD6wOFcxOSEQvF2= MmfaV2FPT0WU
MFH-ino NFTP[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPlOXFYUUN3ME2wMlA2ODB|IN88US=> MmDtV2FPT0WU
IMR-5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLnTWM2OD1yLkC1NFIyKM7:TR?= NV3VVHRiW0GQR1XS
TE-5 NFjWZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEWwOlMh|ryP M4[2ZXNCVkeHUh?=
DJM-1 MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInOeHBKSzVyPUCuNFUyPDJizszN M1:2TXNCVkeHUh?=
NB17 NH20dJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W0SWlEPTB;MD6wOVIxPyEQvF2= M4THfnNCVkeHUh?=
KARPAS-45 NF[yNGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn1[5dzUUN3ME2wMlA2OzV6IN88US=> NVTGZWh2W0GQR1XS
TGBC1TKB M4PueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXnc4xWUUN3ME2wMlA2PDB3IN88US=> MX\TRW5ITVJ?
ML-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEW0NVQh|ryP NFfsVFhUSU6JRWK=
no-10 NIHpe2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEW0O|Qh|ryP MV7TRW5ITVJ?
CTV-1 NXjWN5B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XLXGlEPTB;MD6wOVUxOiEQvF2= NVjoRpNSW0GQR1XS
SJSA-1 NVLQNYtWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LlW2lEPTB;MD6wOVUzKM7:TR?= NGrXdHRUSU6JRWK=
HC-1 NGCyXmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHRTWM2OD1yLkC1OVk4KM7:TR?= NWDIb49OW0GQR1XS
TE-12 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnuTWM2OD1yLkC1OlE{KM7:TR?= M{Lie3NCVkeHUh?=
KY821 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMEW2N|Ih|ryP MUjTRW5ITVJ?
TALL-1 NWDRW5gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\xTWM2OD1yLkC1O|A5KM7:TR?= NGPCeFZUSU6JRWK=
DEL NE\0fYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEW3NFkh|ryP NV;lcHJRW0GQR1XS
TE-6 NH\yTmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEW3NlIh|ryP Mm\2V2FPT0WU
SK-LMS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjsNFRKSzVyPUCuNFU5ODVizszN M162T3NCVkeHUh?=
EW-1 NH\mbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET6eFRKSzVyPUCuNFU5OzdizszN NFS3WWxUSU6JRWK=
8-MG-BA M2\h[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjWemdKSzVyPUCuNFU5PTFizszN NFvJUXFUSU6JRWK=
NALM-6 NGXGZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[4eINPUUN3ME2wMlA2QTd|IN88US=> MnfWV2FPT0WU
LB771-HNC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEW5O|kh|ryP NYPDXW1GW0GQR1XS
HT-144 NHPKR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrE[G5KSzVyPUCuNFYyOyEQvF2= MnXGV2FPT0WU
KM-H2 NX2yfnR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXUToplUUN3ME2wMlA3OjJzIN88US=> MY\TRW5ITVJ?
SF268 NHTPd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvITWM2OD1yLkC2Nlg3KM7:TR?= MWHTRW5ITVJ?
RS4-11 NV\NeZNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe4RoRuUUN3ME2wMlA3OzB2IN88US=> MmfyV2FPT0WU
MHH-PREB-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnicYFwUUN3ME2wMlA3OzF7IN88US=> MV7TRW5ITVJ?
ATN-1 NVvqeZBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwME[zOFUh|ryP MUfTRW5ITVJ?
BB30-HNC NUXNSW92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X1dGlEPTB;MD6wOlQ{PiEQvF2= NUnOb4x5W0GQR1XS
CPC-N M1LpW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHLdGkzUUN3ME2wMlA3PTJ2IN88US=> M36zUXNCVkeHUh?=
NB1 NWLMTJBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DSb2lEPTB;MD6wOlYyOyEQvF2= NGHWW|FUSU6JRWK=
KS-1 NYXqVFlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnuxTWM2OD1yLkC2O|Q5KM7:TR?= NXTHemVsW0GQR1XS
RXF393 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHCTWM2OD1yLkC2O|Y1KM7:TR?= NFrlO|BUSU6JRWK=
IST-SL2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Tpe2lEPTB;MD6wO|AxPCEQvF2= MYPTRW5ITVJ?
GI-ME-N M3TxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEeyPFYh|ryP NFfxd|BUSU6JRWK=
VA-ES-BJ MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHPTWM2OD1yLkC3OFc2KM7:TR?= Mm\3V2FPT0WU
NCI-H1581 M2Pyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHWTWM2OD1yLkC3OFc5KM7:TR?= MoG1V2FPT0WU
U-266 M1;heGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTuZpBKSzVyPUCuNFc1QTdizszN MVjTRW5ITVJ?
DMS-114 M4e3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDIVmFQUUN3ME2wMlA4PTJ6IN88US=> M1O4b3NCVkeHUh?=
NCI-H187 M1;ObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEe3NlYh|ryP MUDTRW5ITVJ?
SW962 NVjQOogxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDXTWM2OD1yLkC3PFM6KM7:TR?= MX3TRW5ITVJ?
MONO-MAC-6 M4\hfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{iyd2lEPTB;MD6wO|k5PiEQvF2= MWHTRW5ITVJ?
MOLT-16 NHnnVWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLaTWM2OD1yLkC4NVIyKM7:TR?= MXnTRW5ITVJ?
KNS-42 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEixOlEh|ryP M{PyOHNCVkeHUh?=
CMK MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEiyNlUh|ryP MX7TRW5ITVJ?
Ramos-2G6-4C10 NIrMfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vYdmlEPTB;MD6wPFIzPSEQvF2= M{nnenNCVkeHUh?=
Daudi NHfjeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEiyOVYh|ryP MW\TRW5ITVJ?
NCI-H510A NXjtXZVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEizN|Yh|ryP MoS0V2FPT0WU
LB831-BLC NG\xO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXmUmJKSzVyPUCuNFg2PjFizszN NF:zTVRUSU6JRWK=
HEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEi2Olgh|ryP M2jPeHNCVkeHUh?=
LU-134-A MoDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;4TWM2OD1yLkC4O|A5KM7:TR?= MX;TRW5ITVJ?
NCI-H1694 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEi3OFQh|ryP MVXTRW5ITVJ?
KGN M3zROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEi3OVkh|ryP MlHPV2FPT0WU
A253 M{\ZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEi4NlIh|ryP M1Xm[3NCVkeHUh?=
DG-75 NX\wWZRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEi5NlIh|ryP MkOyV2FPT0WU
MOLT-4 NF33UGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEi5PFMh|ryP M13IeXNCVkeHUh?=
NCI-SNU-5 NWnyc|lTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3zSZBKSzVyPUCuNFkzPThizszN MVPTRW5ITVJ?
ONS-76 Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD6cHVKSzVyPUCuNFkzPzZizszN NUTuUlN2W0GQR1XS
NCI-H446 NGrzVZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\KXnMyUUN3ME2wMlA6PDZ{IN88US=> MVPTRW5ITVJ?
COR-L279 NGPke2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7QTWM2OD1yLkC5OVU3KM7:TR?= MnLnV2FPT0WU
Calu-6 M1fsXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fNVmlEPTB;MD6wPVU6QCEQvF2= MV;TRW5ITVJ?
BC-3 M3[1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEftZ4JKSzVyPUCuNFk3PjJizszN M1;TTXNCVkeHUh?=
NCI-H2126 NF7IN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nlT2lEPTB;MD6wPVc6OSEQvF2= MXXTRW5ITVJ?
NCI-H1882 NHPxNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv6fGRKSzVyPUCuNFk5ODlizszN NXTQe5E5W0GQR1XS
BB65-RCC NXf3N|hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMUCyPVQh|ryP MVLTRW5ITVJ?
DU-4475 NX\YR4RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fhPGlEPTB;MD6xNFQxPyEQvF2= Mo[yV2FPT0WU
NCI-H526 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHBXodjUUN3ME2wMlExPDRizszN M2DtU3NCVkeHUh?=
NEC8 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\0PYtKSzVyPUCuNVA2OjVizszN MXTTRW5ITVJ?
NCI-H1304 M1nEe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT3T|FKSzVyPUCuNVA2QTRizszN NYHOdJBRW0GQR1XS
L-540 NEe2bXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECyXotKSzVyPUCuNVA4ODhizszN MoXYV2FPT0WU
NCI-SNU-16 NHXC[HFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ywS2lEPTB;MD6xNFc1OiEQvF2= M{Dmd3NCVkeHUh?=
HD-MY-Z MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TUZmlEPTB;MD6xNFg2PiEQvF2= MVzTRW5ITVJ?
K-562 M1r2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFv1fmdKSzVyPUCuNVA5PThizszN MlP6V2FPT0WU
JAR NGDLT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DWdGlEPTB;MD6xNFkzPSEQvF2= MWfTRW5ITVJ?
MZ2-MEL NWn4dHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMUGwOUDPxE1? M{[2XHNCVkeHUh?=
L-363 NHm5XGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMUGwO|kh|ryP MVjTRW5ITVJ?
BV-173 M1v6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTZSoNOUUN3ME2wMlEyOjR|IN88US=> NHzRW4RUSU6JRWK=
NCI-H524 MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETqbmRKSzVyPUCuNVEzPzRizszN NXrVV2MxW0GQR1XS
EoL-1-cell NXLHW2NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTsOnQ2UUN3ME2wMlEyPjd{IN88US=> MkW0V2FPT0WU
K052 NX33T3FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMUG3NVIh|ryP NXnpNlc5W0GQR1XS
TK10 MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjrVGtpUUN3ME2wMlEyPzJ6IN88US=> NUnYbnVJW0GQR1XS
KU812 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\Ld3JKSzVyPUCuNVIxPDRizszN MorKV2FPT0WU
RPMI-8226 M{PUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnCTWM2OD1yLkGyNFUzKM7:TR?= MkTRV2FPT0WU
MZ7-mel NVfsU4J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPxZYVPUUN3ME2wMlEzOjN5IN88US=> NIq1cFNUSU6JRWK=
SK-PN-DW Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvDOpJNUUN3ME2wMlEzOjh5IN88US=> MU\TRW5ITVJ?
SR NVvldppNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{iy[WlEPTB;MD6xNlQ1OSEQvF2= MX;TRW5ITVJ?
RPMI-6666 NIKxfXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMUK3OFMh|ryP M1XMVXNCVkeHUh?=
no-11 NET0WotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfLTWM2OD1yLkGyPFY6KM7:TR?= MnX2V2FPT0WU
EW-3 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuydFJKSzVyPUCuNVI5QTNizszN NEHYPHRUSU6JRWK=
LAMA-84 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMUOxPFch|ryP MVzTRW5ITVJ?
HT M4XBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y2WmlEPTB;MD6xN|U4PCEQvF2= NEH2O5FUSU6JRWK=
KP-N-RT-BM-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfHWHMzUUN3ME2wMlE{PjF{IN88US=> NEf0fWRUSU6JRWK=
NCI-H747 NYOwT5dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMUO3JO69VQ>? MUXTRW5ITVJ?
NCCIT MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUO5N|kh|ryP M1:yTHNCVkeHUh?=
MLMA MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDxVGNWUUN3ME2wMlE1OTZ5IN88US=> MXzTRW5ITVJ?
LP-1 NIPsdW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMUSyOEDPxE1? MVnTRW5ITVJ?
CAL-148 M1HUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3GwXGlEPTB;MD6xOFQ5OyEQvF2= MVrTRW5ITVJ?
GB-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe0NnNKSzVyPUCuNVQ2OjZizszN MkTMV2FPT0WU
COR-L88 MkfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMUS4NFIh|ryP NGHMXW5USU6JRWK=
NKM-1 NWnKW2ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfycZZmUUN3ME2wMlE1QTB4IN88US=> MljnV2FPT0WU
NB5 NVLrR41PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y2UWlEPTB;MD6xOVQ3OiEQvF2= M{[zNXNCVkeHUh?=
SH-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvVSJVNUUN3ME2wMlE2PDZ4IN88US=> NVHwO4xbW0GQR1XS
EM-2 NV3hd3J3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vqNmlEPTB;MD6xOVQ3PyEQvF2= NUDGWVlMW0GQR1XS
TGBC24TKB NEXWfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7nc29KSzVyPUCuNVU3PTlizszN NI[5d49USU6JRWK=
SCLC-21H NYPaZ4Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLuTWM2OD1yLkG1O|AzKM7:TR?= M1TmXnNCVkeHUh?=
COLO-684 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLaTWM2OD1yLkG1O|IyKM7:TR?= NFXISY9USU6JRWK=
KINGS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f3cmlEPTB;MD6xOVkyKM7:TR?= M{ToU3NCVkeHUh?=
LS-123 NGC5SXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37yd2lEPTB;MD6xOVkyPyEQvF2= NX;VXIp{W0GQR1XS
MC116 NH\CSmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DrZWlEPTB;MD6xOlE2QCEQvF2= MXjTRW5ITVJ?
SU-DHL-1 NH\XVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLNUGFKSzVyPUCuNVYzODZizszN NFrESHFUSU6JRWK=
NCI-H64 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PHWGlEPTB;MD6xOlM1PyEQvF2= NIXqRlBUSU6JRWK=
HCE-T M2naUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDHR3A2UUN3ME2wMlE3PTB2IN88US=> M1LzSHNCVkeHUh?=
LOXIMVI NXn3T3ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PNTGlEPTB;MD6xOlk1QSEQvF2= MkDBV2FPT0WU
ARH-77 NWrWOFZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMUezO|kh|ryP NH\JclJUSU6JRWK=
DOHH-2 NHjzOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1KxO2lEPTB;MD6xO|Y4OiEQvF2= NFfRTlNUSU6JRWK=
COLO-320-HSR NV3XRWNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn6NG1KSzVyPUCuNVgyPTRizszN MVfTRW5ITVJ?
NB6 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVixZllSUUN3ME2wMlE5PTZ4IN88US=> NYDXe|Y4W0GQR1XS
L-428 MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMUi4NVMh|ryP NHjXZVdUSU6JRWK=
SNB75 NVnV[I5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf4eoJxUUN3ME2wMlE5QDJ2IN88US=> M17tTnNCVkeHUh?=
NCI-H2141 NVWzXmU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMUmwNVEh|ryP NXT4OIRrW0GQR1XS
KARPAS-299 NEC5NFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHrUWNYUUN3ME2wMlE6OjRzIN88US=> MULTRW5ITVJ?
LC4-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrld4JiUUN3ME2wMlE6PTB{IN88US=> MkKzV2FPT0WU
UACC-257 NGfEOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Czb2lEPTB;MD6xPVk1PyEQvF2= NEjHPHlUSU6JRWK=
EVSA-T M3\W[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrETVdKSzVyPUCuNlA{OTJizszN M3TUb3NCVkeHUh?=
JiyoyeP-2003 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjZe|cxUUN3ME2wMlIxPDd5IN88US=> MYfTRW5ITVJ?
NCI-H720 MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfueHpKSzVyPUCuNlA2OjVizszN MUjTRW5ITVJ?
GAK M2TmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvGVHBKSzVyPUCuNlEyQDlizszN M3S2PHNCVkeHUh?=
HH Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLsTWM2OD1yLkKxOFA2KM7:TR?= M4HaUnNCVkeHUh?=
NCI-H1436 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMkG0OlQh|ryP M4D0THNCVkeHUh?=
GR-ST M4jremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILKS4hKSzVyPUCuNlE1QDhizszN MnzqV2FPT0WU
BC-1 NVGzdW16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMkK2NVYh|ryP NEfpOHFUSU6JRWK=
SIG-M5 M2X6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMkK3Nlch|ryP MWfTRW5ITVJ?
NCI-H345 NHy2dJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHqTnM2UUN3ME2wMlI{QDB3IN88US=> MnOyV2FPT0WU
OPM-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fpUWlEPTB;MD6yN|g5OiEQvF2= M1\mTnNCVkeHUh?=
LB1047-RCC M2LW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX24R5F7UUN3ME2wMlI1PDFizszN M3fiXHNCVkeHUh?=
CTB-1 MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K5[2lEPTB;MD6yOFQ6OyEQvF2= MnLQV2FPT0WU
A3-KAW NHTOTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHQTWM2OD1yLkK1N|QyKM7:TR?= MUfTRW5ITVJ?
SF126 M{fzbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXCR45KSzVyPUCuNlU{QDNizszN MnvsV2FPT0WU
KARPAS-422 NXnheXd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7vTWM2OD1yLkK1OFM2KM7:TR?= NUHhNHRGW0GQR1XS
MEG-01 M3u0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nSVGlEPTB;MD6yOVY4OyEQvF2= MVvTRW5ITVJ?
NCI-H209 M1fSUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XFOGlEPTB;MD6yOlM4PCEQvF2= Moe0V2FPT0WU
SBC-1 M3rz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMk[1JO69VQ>? NVPDWXA4W0GQR1XS
K5 MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMk[5PFQh|ryP M3Xp[nNCVkeHUh?=
QIMR-WIL MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTFTm9TUUN3ME2wMlI4OTV3IN88US=> M{nnRnNCVkeHUh?=
NMC-G1 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLwTWM2OD1yLkK4NlE4KM7:TR?= MYPTRW5ITVJ?
IST-MES1 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjoTWM2OD1yLkK5NlM5KM7:TR?= MlG4V2FPT0WU
SW684 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPBTWM2OD1yLkOwNFQ4KM7:TR?= MkHDV2FPT0WU
MV-4-11 NH25RnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvRR5FJUUN3ME2wMlMxPzh6IN88US=> MVvTRW5ITVJ?
LAN-6 NXK1NJVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwM{G1O|Ih|ryP M{n1XnNCVkeHUh?=
RH-1 NWHhSIEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwM{G4O|Eh|ryP M4rkbnNCVkeHUh?=
CP66-MEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzVTWM2OD1yLkOxPFc5KM7:TR?= NGftTZFUSU6JRWK=
EC-GI-10 M2PKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3voNmlEPTB;MD6zNlk5PyEQvF2= NVfyZnJSW0GQR1XS
GDM-1 NX7mO3p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\1R5N2UUN3ME2wMlM{ODV7IN88US=> NVnQXmlkW0GQR1XS
IST-SL1 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTuTWM2OD1yLkO0PVE1KM7:TR?= M2L0XnNCVkeHUh?=
KMOE-2 NGnPXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTBV5NKSzVyPUCuN|UyPzVizszN M1XSWHNCVkeHUh?=
OS-RC-2 M33KTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzXTWM2OD1yLkO1OVQ1KM7:TR?= MUXTRW5ITVJ?
HDLM-2 NXWyUFUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK5OWVFUUN3ME2wMlM4QDF2IN88US=> NIjlPI5USU6JRWK=
DSH1 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{POZWlEPTB;MD6zPFY{OSEQvF2= M4S4[HNCVkeHUh?=
LS-1034 M{WzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzlcIZYUUN3ME2wMlM5QTV2IN88US=> NIHJV4hUSU6JRWK=
LB373-MEL-D M4Twbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7vTWM2OD1yLkO5NVk4KM7:TR?= MmH2V2FPT0WU
GOTO NFPMWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z5ZWlEPTB;MD60NlEyQCEQvF2= NFvPRVdUSU6JRWK=
MRK-nu-1 MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;CZ5JYUUN3ME2wMlQzOjB3IN88US=> M1flOnNCVkeHUh?=
SK-MM-2 NH\lOWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIftVpRKSzVyPUCuOFM1PDJizszN MVXTRW5ITVJ?
BOKU NIf3PZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHMTWM2OD1yLkSzO|kzKM7:TR?= MmXhV2FPT0WU
NOMO-1 MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ewTWlEPTB;MD60N|g3KM7:TR?= NVHUR4pUW0GQR1XS
J-RT3-T3-5 NXP6dXN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Pn[GlEPTB;MD60OFg4QCEQvF2= MVzTRW5ITVJ?
COLO-668 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTuTWM2OD1yLkS1OlY5KM7:TR?= M4nKS3NCVkeHUh?=
SF539 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDuTWM2OD1yLkS4Olg1KM7:TR?= NXPG[GF5W0GQR1XS
LB2518-MEL M2\0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfRR4dKSzVyPUCuOFk4ODNizszN NXftNZR4W0GQR1XS
TE-441-T NWLQXod7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwNUCxNkDPxE1? NFmw[JNUSU6JRWK=
MDA-MB-134-VI Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH3N2lKSzVyPUCuOVA6OjFizszN M1S5eHNCVkeHUh?=
SCC-3 NUXxeVVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSyUIJzUUN3ME2wMlUyQDd|IN88US=> MYHTRW5ITVJ?
KLE MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwNUKxO|Eh|ryP MV\TRW5ITVJ?
LB2241-RCC NHuxbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTlTWM2OD1yLkWyOVI2KM7:TR?= M3r6PXNCVkeHUh?=
NCI-H1417 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrxTWM2OD1yLkWzOFM2KM7:TR?= NXu0U411W0GQR1XS
NCI-H2081 M4HH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XYcmlEPTB;MD61PFYyOSEQvF2= NIPnRXpUSU6JRWK=
NCI-H1522 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjsdm1KSzVyPUCuOVk{QDNizszN MkTMV2FPT0WU
NCI-H889 M3vl[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPrcpdKSzVyPUCuOVk5PDRizszN NWTQZoYzW0GQR1XS
CGTH-W-1 NHXsdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwNkC3OVUh|ryP NGnTV4ZUSU6JRWK=
EB-3 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPPTWM2OD1yLk[xNVU{KM7:TR?= M33BNXNCVkeHUh?=
D-336MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHGTWM2OD1yLk[xO|kyKM7:TR?= M4rHZXNCVkeHUh?=
LC-1F NHP4W4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPScHdlUUN3ME2wMlYzPTl{IN88US=> NXrsS4FtW0GQR1XS
MHH-NB-11 M3rORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwNkO4NFEh|ryP NV:1dIdFW0GQR1XS
SK-N-FI MmjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNkO5NUDPxE1? MmXhV2FPT0WU
NCI-H69 NGLEPGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLxdFNKSzVyPUCuOlQ5PzlizszN NH\pcIdUSU6JRWK=
SCH MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nmNGlEPTB;MD62OlAzOyEQvF2= NFrZdZJUSU6JRWK=
LS-513 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwNkeyOVkh|ryP MYnTRW5ITVJ?
CP67-MEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HK[2lEPTB;MD62O|U6PiEQvF2= M{nMUnNCVkeHUh?=
GCIY NWD1dplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rWPGlEPTB;MD63NFM3OyEQvF2= MkDqV2FPT0WU
SHP-77 NELxbo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlflTWM2OD1yLkewO|M1KM7:TR?= MWnTRW5ITVJ?
EHEB MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjie5ZKSzVyPUCuO|E5PTRizszN MUjTRW5ITVJ?
D-247MG NUCyXmI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXIU4xUUUN3ME2wMlc{OjN{IN88US=> M2fqPHNCVkeHUh?=
Raji NWDLS5dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPkfmpKSzVyPUCuO|Q6QDlizszN M{nDPHNCVkeHUh?=
MPP-89 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwN{W5O|gh|ryP NE[0dnZUSU6JRWK=
EKVX NGizUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3uWJgzUUN3ME2wMlc6ODd|IN88US=> MnPEV2FPT0WU
HCC2218 NGHLSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwN{mxN|Eh|ryP M3\Fc3NCVkeHUh?=
KNS-81-FD NHXHO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\HTWlEPTB;MD64NVAyOSEQvF2= M1P1OXNCVkeHUh?=
HCC2157 MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvITWM2OD1yLki0PVUyKM7:TR?= NXLHWY9qW0GQR1XS
BT-474 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwOEi4OVQh|ryP M3faNHNCVkeHUh?=
NCI-H748 NFvTOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\r[|hoUUN3ME2wMlkyOiEQvF2= MnznV2FPT0WU
EW-24 NFHxUHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnCfFJxUUN3ME2wMlkzODB{IN88US=> M3y2e3NCVkeHUh?=
D-263MG NIrwbZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF74VnBKSzVyPUCuPVQ2OTJizszN NHTZSJJUSU6JRWK=
OMC-1 NGnNSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjwU|dKSzVyPUCuPVY{PzNizszN MV;TRW5ITVJ?
NCI-H2196 NV7JU5hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwOUe3O|ch|ryP MknmV2FPT0WU
HAL-01 M{\STGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDPW2NKSzVyPUCuPVk5PzJizszN MXXTRW5ITVJ?
NCI-H2107 NYTPNlU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjsUFRLUUN3ME2xMlAyQDV2IN88US=> MXnTRW5ITVJ?
LB996-RCC NVjjO21qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFwMEiwOVEh|ryP MWPTRW5ITVJ?
NCI-H1395 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXITWM2OD1zLkGwOlch|ryP NXywe3NrW0GQR1XS
CHP-126 NWTR[W9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f3T2lEPTB;MT6xOlE6QSEQvF2= M1\4UnNCVkeHUh?=
NB69 NYTJSopOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Wx[WlEPTB;MT6yOlE1QCEQvF2= MnjVV2FPT0WU
CAS-1 MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ThXGlEPTB;MT6zOFI{OSEQvF2= NYiwTnFEW0GQR1XS
JVM-3 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXHSpZLUUN3ME2xMlQ4QDV3IN88US=> NVqyUIxqW0GQR1XS
DMS-153 NI\icItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W4bGlEPTB;MT61O|Y4PCEQvF2= MkS2V2FPT0WU
SK-MEL-2 M3iyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q4TGlEPTB;MT63NVc5QSEQvF2= M2K5WHNCVkeHUh?=
NCI-H1155 MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHSSI1KSzVyPUGuO|M3PzZizszN MonOV2FPT0WU
NCI-H1092 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXLPI9ZUUN3ME2xMlc3OTh{IN88US=> NEPVW3NUSU6JRWK=
LU-165 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPmWHpKSzVyPUGuPFY1PzZizszN M2fIfHNCVkeHUh?=
HL-60 NGXk[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPKV5ZKSzVyPUGuPVk6ODhizszN MX7TRW5ITVJ?
REH MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPJO3VKSzVyPUKuNFA2QDJizszN NH\mbIhUSU6JRWK=
JVM-2 M2rVUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT4SlVJUUN3ME2yMlA3OTN3IN88US=> MXTTRW5ITVJ?
MN-60 NFHISIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjObmVKSzVyPUKuNVc{ODhizszN M1PjS3NCVkeHUh?=
SCC-15 NUWwe3N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJwMkCyO{DPxE1? M1;NTXNCVkeHUh?=
SNU-C1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXPfmVtUUN3ME2yMlIyOzR|IN88US=> MUDTRW5ITVJ?
SK-MEL-1 M3zLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7EeoFKSzVyPUKuN|IxPDdizszN M{XJdXNCVkeHUh?=
TGW MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3eWlEPTB;Mj6zOVAzPyEQvF2= NHT5dHZUSU6JRWK=
CA46 NHy4[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT1TWM2OD1{Lke1PVY4KM7:TR?= M{nyOHNCVkeHUh?=
NCI-H23 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXLbXpKSzVyPUKuPFA4QTFizszN NIT3coRUSU6JRWK=
MMAC-SF M1HaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvtbpNKSzVyPUKuPFY3OjhizszN NVzKVmZlW0GQR1XS
NCI-H2171 MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNwMEO0OFgh|ryP NWTuNFJPW0GQR1XS
A704 NIjNNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPxTWM2OD1|LkG0NVk1KM7:TR?= MV\TRW5ITVJ?
DB NFPqR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTNwMkW1O|Yh|ryP NHi0THFUSU6JRWK=
NCI-H719 Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknETWM2OD1|LkOwN|g1KM7:TR?= MlTCV2FPT0WU
MC-CAR Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LFTGlEPTB;Mz61OFgyPyEQvF2= MYDTRW5ITVJ?
SIMA MknwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rmTWlEPTB;Mz61PFQyPiEQvF2= MnGxV2FPT0WU
SW872 NGH0RllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTNwN{ixNFEh|ryP MVTTRW5ITVJ?
HCC1187 NILBXlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnZTWM2OD1|Lke4N|E2KM7:TR?= NXO5XnQ2W0GQR1XS
EW-13 M2TMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4POUGlEPTB;Mz64N|QyPyEQvF2= NXjxcmVDW0GQR1XS
NCI-SNU-1 NGXTVY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTVWnJKSzVyPUSuNlE6QTlizszN NGfwfJVUSU6JRWK=
NCI-H226 MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TGSWlEPTB;ND6zN|YxPiEQvF2= MkfzV2FPT0WU
RPMI-8866 M4nKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW0TWM2OD12LkO2NFI6KM7:TR?= Ml3FV2FPT0WU
OCI-AML2 M2XvbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnScItjUUN3ME20MlU2OjNizszN MYTTRW5ITVJ?
LU-65 M1f5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7oTWM2OD12LkmzNFM{KM7:TR?= Ml\OV2FPT0WU
SK-N-DZ NV;GUY5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\iTWM2OD13Lk[zOFY2KM7:TR?= M{Lzd3NCVkeHUh?=
NB14 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[0b4ZKSzVyPUWuPVcyOzVizszN NH:3SlZUSU6JRWK=
COLO-829 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\uV3lHUUN3ME22MlM{OzV7IN88US=> NGXTSmhUSU6JRWK=
MHH-CALL-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HRZ2lEPTB;Nj61NVUxQCEQvF2= MVvTRW5ITVJ?
NCI-H1770 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MluyTWM2OD14Lk[2PVA1KM7:TR?= MV\TRW5ITVJ?
ECC4 M2PreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfDNZVKSzVyPU[uPFIyPzlizszN M1naPHNCVkeHUh?=
A498 M{D0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTZwOEexPVIh|ryP NFj1SZhUSU6JRWK=
DMS-79 MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vzd2lEPTB;Nz6wOFUyOiEQvF2= MnToV2FPT0WU
P30-OHK NWe2W2RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTdwMkG5NFYh|ryP M1;NTHNCVkeHUh?=
D-502MG NXztdJhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP5c3hwUUN3ME23Mlk5OzZizszN MWPTRW5ITVJ?
RCC10RGB NGjkSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX1eHBtUUN3ME24MlA3OjhizszN NVLxdllPW0GQR1XS
U-698-M Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNSW5KSzVyPUiuNlkzOjZizszN MkTQV2FPT0WU
BB49-HNC Ml76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIi2XFJKSzVyPUmuOFIzPjVizszN NYjVNIZ6W0GQR1XS
ES1 NIq2dYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nmWGlEPTB;OT62PFk2PiEQvF2= NXXubm5LW0GQR1XS
MFM-223 NUD0TWRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHLb4lpUUN3ME2xNE46QTJ5IN88US=> M3XL[3NCVkeHUh?=
C2BBe1 NH;xNYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vqd2lEPTB;MUGuN|UzOyEQvF2= M1jDN3NCVkeHUh?=
EB2 NYG1fXNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzCTnFKSzVyPUGyMlY5QDFizszN MWPTRW5ITVJ?
C8166 MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF|LkizNFMh|ryP MXrTRW5ITVJ?
ES3 NYrvb2dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzqTHY3UUN3ME2xN{46QTd5IN88US=> NFTFSZRUSU6JRWK=
NCI-H1650 NF;EcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\TZ2lEPTB;MU[uN|c3PSEQvF2= Mm\TV2FPT0WU
Mo-T NGq1OZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF5LkSwNlkh|ryP M1PmSnNCVkeHUh?=
NB7 NUjFZmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTF5Lke0Olch|ryP MWHTRW5ITVJ?
ES7 MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF7LkW1NFch|ryP M4XVeXNCVkeHUh?=
ES5 NUPPOlhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJzLke2O|Eh|ryP MX7TRW5ITVJ?
MSTO-211H NYD5dXZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJzLki4OVgh|ryP M3rqc3NCVkeHUh?=
U-87-MG Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr1UnhKSzVyPUK1MlE6PjZizszN NHT1b3pUSU6JRWK=
THP-1 NH;mS4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETUOJhKSzVyPUK5MlczODFizszN NETPe4JUSU6JRWK=
NB10 NGLKRopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHUVYtKSzVyPUOwMlI3QTRizszN M372OHNCVkeHUh?=
NH-12 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTN|LkKwNVch|ryP NWXQU5d2W0GQR1XS
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Wittier MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi0O|IhcA>? NF72cVlKSzVyPUOuNlYhdk1? NGG4dpgzOTl4NUezPS=>
H-1 MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W2e|czKGh? MnK2TWM2OD17LkW0JI5O MUWyNVk3PTd|OR?=
HuH-28 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvBO|IhcA>? NYTpUoIxUUN3ME2xNU4yQSCwTR?= MXWyNVk3PTd|OR?=
NEC NU\QSW11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7o[5c4OiCq MY\JR|UxRTlwOUigcm0> M2D2SFIyQTZ3N{O5
REB NUjFUWV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\YO|IhcA>? MULJR|UxRTF|LkWxJI5O NUTWOYNuOjF7NkW3N|k>
CC-LP-1 NVfm[5RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K3N|czKGh? MYfJR|UxRTVwOESgcm0> Mo[5NlE6PjV5M{m=
CC-SW-1 M1zsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnMS4lqPzJiaB?= NXTLRmtWUUN3ME25MlU2KG6P NHXpPGszOTl4NUezPS=>
EGI-1 NH;QeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHRcIY4OiCq M4DMT2lEPTB;MUCuO|Ihdk1? MXmyNVk3PTd|OR?=
Sk-ChA-1 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi2fIU4OiCq MYLJR|UxRTF5LkKgcm0> NXHPeWdiOjF7NkW3N|k>
TFK-1 NUDZPFFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T2dVczKGh? NEDnOldKSzVyPUGzMlQ2KG6P M4Ozb|IyQTZ3N{O5
786-O NWXLd|B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\LOU05OCCwTR?= MkHlPVYhcA>? MmDUTGNt NEfKdWt{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= MkDkNlE3PDJ|N{S=
A498 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUG1MVgxKG6P MnSyPVYhcA>? NWXXTVlRUEOu NUj5eZpKe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N NELt[JMzOTZ2MkO3OC=>
ACHN NUTxPIF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfueIJHPS16MDDuUS=> NV\oN3hxQTZiaB?= M1q5UmhEdA>? NYjM[Jhbe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N MVeyNVY1OjN5NB?=
Caki-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGCzXpI2NThyIH7N NW[5OZpkQTZiaB?= MVnIR4w> Ml;Sd5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P MYiyNVY1OjN5NB?=
SN12C NFfTTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTndXVJPS16MDDuUS=> NETCSIY6PiCq NWnPdVFuUEOu M1zQN5N2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MnfHNlE3PDJ|N{S=
HMC-1.1 M37FfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYexMVExODBibl2= M4XhcVczKGh? MVPpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NVryVG15OjF{NEKxPFk>
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C2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWWxMVExODBibl2= NVzrOWFxPzJiaB?= MXnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> MXmyNVI1OjF6OR?=
CHP-212 MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfm[ZNUOS1zMkWgcm0> M1zoblI1NTF{MDDo NFzMU4ZqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NWjXW29mOjFzNkmyOFI>
IMR-32 Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWOxMVEzPSCwTR?= MWSyOE0yOjBiaB?= NYq5N|RlcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NYKzO3lvOjFzNkmyOFI>
Kelly NEjiS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PKPFEuOTJ3IH7N NIjK[VIzPC1zMkCgbC=> Mm\tbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NIXweIEzOTF4OUK0Ni=>
SH-EP MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInscY4yNTF{NTDuUS=> MkPHNlQuOTJyIHi= Mly4bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NWXXO2hLOjFzNkmyOFI>
SH-SY5Y NFW3cI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUWxMVEzPSCwTR?= NH;n[|QzPC1zMkCgbC=> Mm\abY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NFvkNnAzOTF4OUK0Ni=>
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U937 MoP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXGxM|ExNzFyMDDuUS=> NF\XWGw4OiCq NWLQepVDTE2VTx?= NYDCWXUycW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M2PUTVE6PDV6M{W4
CAL62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXUb4luOC5zLUGwNEBvVQ>? MV:3NkBp M2H1V2ROW09? Mn32SWM2OD1zLkSgcm0> NYfrO5c6OTl{MkO1OVM>
OCUT-1 NWj4Z3dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz2WZMxNjFvMUCwJI5O NFH1Wog4OiCq MVzEUXNQ MULFR|UxRTJwMzDuUS=> MkLHNVkzOjN3NUO=
8505C NH;wUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPtNE4yNTFyMDDuUS=> Mme3O|IhcA>? Mn;kSG1UVw>? MlnqSWM2OD1|LkKgcm0> MnPWNVkzOjN3NUO=
ACT-1 MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSwMlEuOTByIH7N Mn:zO|IhcA>? M1rjU2ROW09? NEHvfGFGSzVyPUWuOEBvVQ>? MWKxPVIzOzV3Mx?=
SW1736 NUG1NHI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXpNE4yNTFyMDDuUS=> MorKO|IhcA>? MkLnSG1UVw>? MYrFR|UxRTVwNjDuUS=> MmP6NVkzOjN3NUO=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
細胞試験: [1]
+ 展開
  • 細胞株: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • 濃度: Dissolved in DMSO, final concentrations ~1 μM
  • 反応時間: 24 and 72 hours
  • 実験の流れ: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • 製剤: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • 投薬量: ~50 mg/kg
  • 投与方法: Injection i.v. once or twice per week
    (参考用のみ)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 順序で溶剤を入れること:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK信号経路図

PLK Inhibitors with Unique Features

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Tags: BI 2536を買う | BI 2536 ic50 | BI 2536供給者 | BI 2536を購入する | BI 2536費用 | BI 2536生産者 | オーダーBI 2536 | BI 2536化学構造 | BI 2536分子量 | BI 2536代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID