BI 2536

製品コードS1109

BI 2536化学構造

分子量(MW):521.66

BI2536は一種の有効なPlk1阻害剤で、無細胞試験でIC50値が0.83nMですが、Plk1に作用する選択性はPlk2とPlk3に作用する選択性より4倍と11倍がそれぞれ高くなります、臨床2期。

サイズ 価格(税別)  
JPY 39840.00
JPY 19920.00
JPY 34860.00
JPY 111220.00
JPY 165502.00

文献中の使用例(53)

カスタマーフィードバック(11)

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

製品安全説明書

PLK阻害剤の選択性比較

生物活性

製品説明 BI2536は一種の有効なPlk1阻害剤で、無細胞試験でIC50値が0.83nMですが、Plk1に作用する選択性はPlk2とPlk3に作用する選択性より4倍と11倍がそれぞれ高くなります、臨床2期。
特性 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
ターゲット
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外試験

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvsb|U3UUN3ME2wMlAxPzd4IN88US=> NIDSNJpUSU6JRWK=
ACN NWXUWXVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6XGlEPTB;MD6wNFg1OyEQvF2= NXHGboJyW0GQR1XS
TE-8 M2PCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTKTWM2OD1yLkCwPVQyKM7:TR?= MVHTRW5ITVJ?
LC-2-ad NEDkc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnOyTWM2OD1yLkCxNFk{KM7:TR?= MmnwV2FPT0WU
ALL-PO MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z6TWlEPTB;MD6wNVMh|ryP NGXZT|dUSU6JRWK=
EW-16 MmDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT4TWM2OD1yLkCxN|M3KM7:TR?= M2\idHNCVkeHUh?=
KM12 MojZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEGzOFgh|ryP MUfTRW5ITVJ?
GI-1 NWTSUpM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEGzPFMh|ryP M3\kXXNCVkeHUh?=
LS-411N NWTBZ2FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1THOGlEPTB;MD6wNVQxPyEQvF2= MmPrV2FPT0WU
ES8 MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;R[opKSzVyPUCuNFE1QTRizszN NGLmNZVUSU6JRWK=
SNU-C2B NX;2[YZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEG1NlYh|ryP Mon6V2FPT0WU
CESS MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfOOFR2UUN3ME2wMlAyPjB{IN88US=> MUXTRW5ITVJ?
697 NEPtSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEG2Olgh|ryP MX\TRW5ITVJ?
NCI-H1963 Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK5TWM2OD1yLkCxOlc{KM7:TR?= MXPTRW5ITVJ?
IA-LM MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojaTWM2OD1yLkCxOlg5KM7:TR?= NYj6V3ptW0GQR1XS
SW954 M4raNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELETFVKSzVyPUCuNFE4ODVizszN MXfTRW5ITVJ?
RL95-2 NWO1ZWNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMEG3N|gh|ryP MYPTRW5ITVJ?
LXF-289 NHnWW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvDWphKSzVyPUCuNFE4PyEQvF2= NVyyN4FOW0GQR1XS
OCUB-M Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEG4NlYh|ryP MnTxV2FPT0WU
RKO MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPiTWM2OD1yLkCxPVg4KM7:TR?= NVTxOoVOW0GQR1XS
LOUCY NWnrWopMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\0[WlEPTB;MD6wNlA2KM7:TR?= M{DjPHNCVkeHUh?=
NOS-1 NIjoeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPDfGdKSzVyPUCuNFIxQTNizszN NXvofVBiW0GQR1XS
A4-Fuk M2jiT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4SwcmlEPTB;MD6wNlIyQCEQvF2= NUHwNFlWW0GQR1XS
A388 NVLzOYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPnSW9KSzVyPUCuNFIzOjdizszN M{PjVXNCVkeHUh?=
TE-9 M37pSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLxTWM2OD1yLkCyNlYyKM7:TR?= NH\n[npUSU6JRWK=
KURAMOCHI MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEKyPFUh|ryP MXnTRW5ITVJ?
KALS-1 Mk\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrZOWJKSzVyPUCuNFI{OzhizszN NXX0[nFCW0GQR1XS
HOP-62 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEK0NkDPxE1? NV7Eb3h1W0GQR1XS
RPMI-8402 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPZTWM2OD1yLkCyOVA5KM7:TR?= MYPTRW5ITVJ?
TE-1 NG\FU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHtTWM2OD1yLkCyOVEzKM7:TR?= MlrYV2FPT0WU
CCRF-CEM MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEK1OFMh|ryP MWfTRW5ITVJ?
HUTU-80 M4jCbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nkTGlEPTB;MD6wNlYzPCEQvF2= M2e1R3NCVkeHUh?=
NCI-H1648 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz5U2tKSzVyPUCuNFI3PDdizszN NFLaOI1USU6JRWK=
HCE-4 NV3jbGVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEK2PFIh|ryP M3LwZXNCVkeHUh?=
ETK-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnu[JpKSzVyPUCuNFI4OzZizszN Mm\6V2FPT0WU
TE-15 NVGy[HR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFywRXVKSzVyPUCuNFI4OzhizszN NVTJfXA5W0GQR1XS
BE-13 NV73RYhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoeyTWM2OD1yLkCyO|Qh|ryP M1i5XnNCVkeHUh?=
KE-37 NXPxRlNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEK3OFEh|ryP NVfyVFNqW0GQR1XS
NCI-H1355 MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV20RW96UUN3ME2wMlAzPzh|IN88US=> MVvTRW5ITVJ?
TE-11 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEK4NFkh|ryP MULTRW5ITVJ?
BL-70 MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rseWlEPTB;MD6wNlg2PyEQvF2= M17PXXNCVkeHUh?=
ES6 Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPvUFlqUUN3ME2wMlAzQDhzIN88US=> NVroUmZ{W0GQR1XS
GT3TKB M1Hzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCyXo9PUUN3ME2wMlAzQTV|IN88US=> NYjR[5ZrW0GQR1XS
LB647-SCLC NF7QfphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;4TWM2OD1yLkCzNVk2KM7:TR?= M2fqTnNCVkeHUh?=
NB13 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEOzNVYh|ryP MmP2V2FPT0WU
ST486 NVHRS3lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LoZ2lEPTB;MD6wN|M{PyEQvF2= NViwSZNmW0GQR1XS
NCI-H82 NGS1[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHyeWtKSzVyPUCuNFM{PDNizszN MnnnV2FPT0WU
NTERA-S-cl-D1 MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojRTWM2OD1yLkCzN|k6KM7:TR?= NUD1TpdGW0GQR1XS
ES4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEO0OlMh|ryP MojoV2FPT0WU
SK-NEP-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXuzVHJIUUN3ME2wMlA{PDl7IN88US=> NFHvVXZUSU6JRWK=
Becker Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv1TWM2OD1yLkCzOVU2KM7:TR?= MoD4V2FPT0WU
A101D MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvCNGFKSzVyPUCuNFM4PDhizszN NF3YN|VUSU6JRWK=
SK-UT-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYSyZ|JlUUN3ME2wMlA{Pzd2IN88US=> NXjM[IhyW0GQR1XS
SW982 NWTyN3dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMEO3PUDPxE1? NF;C[I5USU6JRWK=
TE-10 NUfyVHFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7nNXZKSzVyPUCuNFQxPDZizszN NEDhe5NUSU6JRWK=
OVCAR-4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:1VGlEPTB;MD6wOFA2QSEQvF2= M37QN3NCVkeHUh?=
KP-N-YS Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TK[GlEPTB;MD6wOFA5PSEQvF2= M3;E[nNCVkeHUh?=
BL-41 NX\LR5dYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rifWlEPTB;MD6wOFEzPSEQvF2= MmP1V2FPT0WU
MZ1-PC NHTmSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PZNGlEPTB;MD6wOFEzPyEQvF2= NV;oR2ZwW0GQR1XS
PF-382 NUXib5FvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzhWZlnUUN3ME2wMlA1OTl6IN88US=> M2\kTnNCVkeHUh?=
MOLT-13 NHLzV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TUW2lEPTB;MD6wOFI{QCEQvF2= NICwbY1USU6JRWK=
HCC1599 M3TNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLSZo1YUUN3ME2wMlA1OjV6IN88US=> MV;TRW5ITVJ?
IST-MEL1 NUfYNWxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT3O5JWUUN3ME2wMlA1PDR{IN88US=> M4fDfHNCVkeHUh?=
LU-139 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMES0OFIh|ryP NWfqUHpwW0GQR1XS
MS-1 NHnXeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMES3NFEh|ryP Mnj5V2FPT0WU
MFH-ino MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LuVWlEPTB;MD6wOVAxOyEQvF2= MnzUV2FPT0WU
IMR-5 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[0WGJKSzVyPUCuNFUxOjFizszN MXLTRW5ITVJ?
TE-5 M4LwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEWwOlMh|ryP MVTTRW5ITVJ?
DJM-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILHbJRKSzVyPUCuNFUyPDJizszN MkHOV2FPT0WU
NB17 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml76TWM2OD1yLkC1NlA4KM7:TR?= M3TJS3NCVkeHUh?=
KARPAS-45 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEWzOVgh|ryP MmLaV2FPT0WU
TGBC1TKB NHzwRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEW0NFUh|ryP Mo\DV2FPT0WU
ML-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEW0NVQh|ryP MYrTRW5ITVJ?
no-10 M1H4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEW0O|Qh|ryP MW\TRW5ITVJ?
CTV-1 NEHpdY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\DTWM2OD1yLkC1OVAzKM7:TR?= M3GwVnNCVkeHUh?=
SJSA-1 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrt[5VKSzVyPUCuNFU2OiEQvF2= MnLaV2FPT0WU
HC-1 NX7hVnZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlqyTWM2OD1yLkC1OVk4KM7:TR?= NULBd5dTW0GQR1XS
TE-12 NYPWdGlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTmcXBZUUN3ME2wMlA2PjF|IN88US=> M{n6dHNCVkeHUh?=
KY821 NUnxfIlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XVfmlEPTB;MD6wOVY{OiEQvF2= Ml\uV2FPT0WU
TALL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37QVGlEPTB;MD6wOVcxQCEQvF2= M{HBWnNCVkeHUh?=
DEL M17zb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHOOVRKSzVyPUCuNFU4ODlizszN MYrTRW5ITVJ?
TE-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj1Z2pGUUN3ME2wMlA2PzJ{IN88US=> NIThUIFUSU6JRWK=
SK-LMS-1 M4nLfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEW4NFUh|ryP MWLTRW5ITVJ?
EW-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEW4N|ch|ryP MlPEV2FPT0WU
8-MG-BA MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf1TWM2OD1yLkC1PFUyKM7:TR?= MUfTRW5ITVJ?
NALM-6 M{fkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\zTmlEPTB;MD6wOVk4OyEQvF2= MULTRW5ITVJ?
LB771-HNC MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3kOW9GUUN3ME2wMlA2QTd7IN88US=> M3;IZXNCVkeHUh?=
HT-144 M4m2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlznTWM2OD1yLkC2NVMh|ryP MXnTRW5ITVJ?
KM-H2 M37qNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwME[yNlEh|ryP NWr2bm1RW0GQR1XS
SF268 NFvhW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17jUmlEPTB;MD6wOlI5PiEQvF2= NUDQU2NYW0GQR1XS
RS4-11 NXy3c3RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPZfoI6UUN3ME2wMlA3OzB2IN88US=> Mm\zV2FPT0WU
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NCI-H1694 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK4[4lTUUN3ME2wMlA5PzR2IN88US=> NVOzVpNmW0GQR1XS
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LAMA-84 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\IbGlYUUN3ME2wMlE{OTh5IN88US=> MUPTRW5ITVJ?
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SCLC-21H NWrKZoZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrFTWM2OD1yLkG1O|AzKM7:TR?= NX3rbW01W0GQR1XS
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HCE-T MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vLfGlEPTB;MD6xOlUxPCEQvF2= NXWwPJgxW0GQR1XS
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NB6 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMUi1OlYh|ryP NFruVJVUSU6JRWK=
L-428 NEXJbYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLCTWM2OD1yLkG4PFE{KM7:TR?= MmjTV2FPT0WU
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NCI-H2141 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTTTWM2OD1yLkG5NFEyKM7:TR?= NXiy[VhQW0GQR1XS
KARPAS-299 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M160RmlEPTB;MD6xPVI1OSEQvF2= NVXjUo5KW0GQR1XS
LC4-1 M{HmeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXV[GFKSzVyPUCuNVk2ODJizszN MX3TRW5ITVJ?
UACC-257 Mly1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[0TWM2OD1yLkG5PVQ4KM7:TR?= MYjTRW5ITVJ?
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JiyoyeP-2003 NED6VmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVny[5hzUUN3ME2wMlIxPDd5IN88US=> M4rBWHNCVkeHUh?=
NCI-H720 M4jqc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMkC1NlUh|ryP Mmj3V2FPT0WU
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NCI-H1436 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HMcGlEPTB;MD6yNVQ3PCEQvF2= NFrOdnhUSU6JRWK=
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BC-1 MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmntTWM2OD1yLkKyOlE3KM7:TR?= MnnKV2FPT0WU
SIG-M5 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMkK3Nlch|ryP Mmq0V2FPT0WU
NCI-H345 M1T5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jk[2lEPTB;MD6yN|gxPSEQvF2= MWLTRW5ITVJ?
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LB1047-RCC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjqWYxsUUN3ME2wMlI1PDFizszN NGjRblBUSU6JRWK=
CTB-1 NHnDWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMkS0PVMh|ryP M4HtRXNCVkeHUh?=
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KARPAS-422 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMkW0N|Uh|ryP NIW1RYxUSU6JRWK=
MEG-01 MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X6fmlEPTB;MD6yOVY4OyEQvF2= MmjRV2FPT0WU
NCI-H209 NYLLWnZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXixWId{UUN3ME2wMlI3Ozd2IN88US=> NV[wfIdZW0GQR1XS
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QIMR-WIL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPjVIxRUUN3ME2wMlI4OTV3IN88US=> NGrJ[XZUSU6JRWK=
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IST-MES1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMkmyN|gh|ryP NXTXSlBGW0GQR1XS
SW684 NWXGU45nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33OTmlEPTB;MD6zNFA1PyEQvF2= MX;TRW5ITVJ?
MV-4-11 NWS4eo5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwM{C3PFgh|ryP MX3TRW5ITVJ?
LAN-6 NXjubnZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[0TWM2OD1yLkOxOVczKM7:TR?= MlPCV2FPT0WU
RH-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Tyc2lEPTB;MD6zNVg4OSEQvF2= NWLXe2JlW0GQR1XS
CP66-MEL MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1m3eWlEPTB;MD6zNVg4QCEQvF2= NEjK[YpUSU6JRWK=
EC-GI-10 NXnYbJZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwM{K5PFch|ryP NH3oVmNUSU6JRWK=
GDM-1 MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLFPVk2UUN3ME2wMlM{ODV7IN88US=> MXfTRW5ITVJ?
IST-SL1 MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;XOWlEPTB;MD6zOFkyPCEQvF2= NVTmXXRNW0GQR1XS
KMOE-2 M{iyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLNTWM2OD1yLkO1NVc2KM7:TR?= MUfTRW5ITVJ?
OS-RC-2 NIjI[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwM{W1OFQh|ryP NWDWPVFkW0GQR1XS
HDLM-2 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLlbnN1UUN3ME2wMlM4QDF2IN88US=> MWnTRW5ITVJ?
DSH1 NF[2SWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwM{i2N|Eh|ryP MnvOV2FPT0WU
LS-1034 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fTVmlEPTB;MD6zPFk2PCEQvF2= NUXDcI9xW0GQR1XS
LB373-MEL-D NYOyNIdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmzTWM2OD1yLkO5NVk4KM7:TR?= MWLTRW5ITVJ?
GOTO NHPkdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlGyTWM2OD1yLkSyNVE5KM7:TR?= NETaephUSU6JRWK=
MRK-nu-1 M2rvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwNEKyNFUh|ryP M1zqPXNCVkeHUh?=
SK-MM-2 NXHjWmg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTCTWM2OD1yLkSzOFQzKM7:TR?= NVPOfFBnW0GQR1XS
BOKU M{L4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7aTWM2OD1yLkSzO|kzKM7:TR?= MortV2FPT0WU
NOMO-1 NUS0N|Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;XO|FIUUN3ME2wMlQ{QDZizszN MYjTRW5ITVJ?
J-RT3-T3-5 MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL0eJlKSzVyPUCuOFQ5PzhizszN NGnOUoNUSU6JRWK=
COLO-668 NFzmfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz3TWM2OD1yLkS1OlY5KM7:TR?= M3LuZXNCVkeHUh?=
SF539 NEPwW5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHTTWM2OD1yLkS4Olg1KM7:TR?= MUXTRW5ITVJ?
LB2518-MEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwNEm3NFMh|ryP NXvCTmxJW0GQR1XS
TE-441-T MoHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwNUCxNkDPxE1? M1m1dXNCVkeHUh?=
MDA-MB-134-VI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H6dGlEPTB;MD61NFkzOSEQvF2= NF;YRpVUSU6JRWK=
SCC-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3KTWM2OD1yLkWxPFc{KM7:TR?= MlXUV2FPT0WU
KLE MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfETWM2OD1yLkWyNVcyKM7:TR?= MUfTRW5ITVJ?
LB2241-RCC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\PTWM2OD1yLkWyOVI2KM7:TR?= NF:0TWJUSU6JRWK=
NCI-H1417 M3\WWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYriSGg6UUN3ME2wMlU{PDN3IN88US=> NXr0VFJOW0GQR1XS
NCI-H2081 MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H4fmlEPTB;MD61PFYyOSEQvF2= NFvGXnVUSU6JRWK=
NCI-H1522 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4O1bmlEPTB;MD61PVM5OyEQvF2= MlGzV2FPT0WU
NCI-H889 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwNUm4OFQh|ryP NVnLV2gxW0GQR1XS
CGTH-W-1 NHTlU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LNdWlEPTB;MD62NFc2PSEQvF2= NGXCcldUSU6JRWK=
EB-3 M1;hWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT3fYJKSzVyPUCuOlEyPTNizszN MmTDV2FPT0WU
D-336MG MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLNTWM2OD1yLk[xO|kyKM7:TR?= MlvuV2FPT0WU
LC-1F Mnu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DuTmlEPTB;MD62NlU6OiEQvF2= M1LHRXNCVkeHUh?=
MHH-NB-11 M2PKWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KxXmlEPTB;MD62N|gxOSEQvF2= Ml;2V2FPT0WU
SK-N-FI NFLYXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXpbpdOUUN3ME2wMlY{QTFizszN NWXOTXlrW0GQR1XS
NCI-H69 M2\LXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHQTWM2OD1yLk[0PFc6KM7:TR?= NEfDeWlUSU6JRWK=
SCH NHjIWYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK4bnN{UUN3ME2wMlY3ODJ|IN88US=> MlrjV2FPT0WU
LS-513 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwNkeyOVkh|ryP M3PrNHNCVkeHUh?=
CP67-MEL NHfDPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LPemlEPTB;MD62O|U6PiEQvF2= NGLOe5pUSU6JRWK=
GCIY MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33VdWlEPTB;MD63NFM3OyEQvF2= NHvvNItUSU6JRWK=
SHP-77 NGHqVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILRUXpKSzVyPUCuO|A4OzRizszN MlPFV2FPT0WU
EHEB NWi1OXdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwN{G4OVQh|ryP MnixV2FPT0WU
D-247MG MmnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXNZ3RKSzVyPUCuO|MzOzJizszN MknsV2FPT0WU
Raji MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm3TWM2OD1yLke0PVg6KM7:TR?= MVXTRW5ITVJ?
MPP-89 MmnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwN{W5O|gh|ryP NFvR[nlUSU6JRWK=
EKVX MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rZeWlEPTB;MD63PVA4OyEQvF2= MkXTV2FPT0WU
HCC2218 M135Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz2TWM2OD1yLke5NVMyKM7:TR?= Mk\xV2FPT0WU
KNS-81-FD NWnOe3NxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvh[otKSzVyPUCuPFExOTFizszN Mo\ZV2FPT0WU
HCC2157 M2XnfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3MUWl1UUN3ME2wMlg1QTVzIN88US=> NYfuSpZNW0GQR1XS
BT-474 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwOEi4OVQh|ryP MkH4V2FPT0WU
NCI-H748 NFq3TZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHTcJQxUUN3ME2wMlkyOiEQvF2= NXrTTIZQW0GQR1XS
EW-24 NGPoZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MneyTWM2OD1yLkmyNFAzKM7:TR?= NHXEbW1USU6JRWK=
D-263MG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLHTWM2OD1yLkm0OVEzKM7:TR?= MnexV2FPT0WU
OMC-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7ETHJKSzVyPUCuPVY{PzNizszN Mn32V2FPT0WU
NCI-H2196 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUGzRWpsUUN3ME2wMlk4Pzd5IN88US=> M1r5fXNCVkeHUh?=
HAL-01 Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrVbJNxUUN3ME2wMlk6QDd{IN88US=> MVfTRW5ITVJ?
NCI-H2107 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fISmlEPTB;MT6wNVg2PCEQvF2= Ml;GV2FPT0WU
LB996-RCC NX\KSm9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLOWFFvUUN3ME2xMlA5ODVzIN88US=> MoTvV2FPT0WU
NCI-H1395 NWD3R25ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzBSGNRUUN3ME2xMlExPjdizszN NVPwbG5KW0GQR1XS
CHP-126 NF;COWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwMU[xPVkh|ryP NYniNnJUW0GQR1XS
NB69 M1SyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m2WmlEPTB;MT6yOlE1QCEQvF2= M2PZXnNCVkeHUh?=
CAS-1 NYC5bpZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTFwM{SyN|Eh|ryP MVvTRW5ITVJ?
JVM-3 NGDRbZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jLW2lEPTB;MT60O|g2PSEQvF2= M1L3WnNCVkeHUh?=
DMS-153 M1v6cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTFwNUe2O|Qh|ryP NVS4VmloW0GQR1XS
SK-MEL-2 M3PpV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHK[GtJUUN3ME2xMlcyPzh7IN88US=> M2HyRXNCVkeHUh?=
NCI-H1155 NEfqNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f1emlEPTB;MT63N|Y4PiEQvF2= NIToS3FUSU6JRWK=
NCI-H1092 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnJTWM2OD1zLke2NVgzKM7:TR?= MmLaV2FPT0WU
LU-165 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHKTmpqUUN3ME2xMlg3PDd4IN88US=> Mk\aV2FPT0WU
HL-60 MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmzZo5IUUN3ME2xMlk6QTB6IN88US=> MkXPV2FPT0WU
REH MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DoPGlEPTB;Mj6wNFU5OiEQvF2= NE\BU25USU6JRWK=
JVM-2 M1juSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\sTWM2OD1{LkC2NVM2KM7:TR?= Mo\iV2FPT0WU
MN-60 NHT3ZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7WfoNKSzVyPUKuNVc{ODhizszN NWnLNmRoW0GQR1XS
SCC-15 NHPySoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;Nd2tKSzVyPUKuNlAzPyEQvF2= Ml;BV2FPT0WU
SNU-C1 M4ezeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTnTWM2OD1{LkKxN|Q{KM7:TR?= M3zSRXNCVkeHUh?=
SK-MEL-1 MkLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:5NphkUUN3ME2yMlMzODR5IN88US=> MXrTRW5ITVJ?
TGW MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ftZ2lEPTB;Mj6zOVAzPyEQvF2= M4\yWHNCVkeHUh?=
CA46 NXzXVodvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS3TWM2OD1{Lke1PVY4KM7:TR?= MXjTRW5ITVJ?
NCI-H23 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXMTWM2OD1{LkiwO|kyKM7:TR?= MmnWV2FPT0WU
MMAC-SF MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzKTWM2OD1{Lki2OlI5KM7:TR?= NF3ZbWNUSU6JRWK=
NCI-H2171 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfVfYF[UUN3ME2zMlA{PDR6IN88US=> MXvTRW5ITVJ?
A704 NH7CXmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P3ZWlEPTB;Mz6xOFE6PCEQvF2= M1mzUHNCVkeHUh?=
DB MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m3WWlEPTB;Mz6yOVU4PiEQvF2= MUnTRW5ITVJ?
NCI-H719 NVO2TVAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTNwM{CzPFQh|ryP NF\ZSodUSU6JRWK=
MC-CAR NYLuSnhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3MVZd{UUN3ME2zMlU1QDF5IN88US=> M1PUeHNCVkeHUh?=
SIMA NGi0WGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjPTWM2OD1|LkW4OFE3KM7:TR?= MoKxV2FPT0WU
SW872 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7p[HJKSzVyPUOuO|gyODFizszN NILpW3hUSU6JRWK=
HCC1187 NV;RS29UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTNwN{izNVUh|ryP MX\TRW5ITVJ?
EW-13 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLkcZJ1UUN3ME2zMlg{PDF5IN88US=> M1u5UXNCVkeHUh?=
NCI-SNU-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTRwMkG5PVkh|ryP NHPQS5lUSU6JRWK=
NCI-H226 NGfmUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO1TWM2OD12LkOzOlA3KM7:TR?= NFryTVNUSU6JRWK=
RPMI-8866 MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHSUJdKSzVyPUSuN|YxOjlizszN M4XiVnNCVkeHUh?=
OCI-AML2 M4L4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTRTWM2OD12LkW1NlMh|ryP MnX3V2FPT0WU
LU-65 NIHuN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[xOZBRUUN3ME20Mlk{ODN|IN88US=> NV3S[|Z[W0GQR1XS
SK-N-DZ NFqwV4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTVwNkO0OlUh|ryP M2rCZnNCVkeHUh?=
NB14 NYrsOVZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDETotUUUN3ME21Mlk4OTN3IN88US=> NV;JOGp5W0GQR1XS
COLO-829 M2S5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrUTWM2OD14LkOzN|U6KM7:TR?= MmjLV2FPT0WU
MHH-CALL-2 NVXOUWVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLzNpFKSzVyPU[uOVE2ODhizszN MkXMV2FPT0WU
NCI-H1770 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;5NIh{UUN3ME22MlY3QTB2IN88US=> M{C1XHNCVkeHUh?=
ECC4 NIK0W21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTZwOEKxO|kh|ryP MUfTRW5ITVJ?
A498 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX36Z203UUN3ME22Mlg4OTl{IN88US=> MVnTRW5ITVJ?
DMS-79 NFv5SFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjJNXlQUUN3ME23MlA1PTF{IN88US=> NEjXPYNUSU6JRWK=
P30-OHK M{XSSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;B[2pKSzVyPUeuNlE6ODZizszN NGi3RpFUSU6JRWK=
D-502MG MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnOXmdQUUN3ME23Mlk5OzZizszN MY\TRW5ITVJ?
RCC10RGB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRThwME[yPEDPxE1? NGHMWGVUSU6JRWK=
U-698-M MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorSTWM2OD16LkK5NlI3KM7:TR?= M{L0V3NCVkeHUh?=
BB49-HNC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFToV5JKSzVyPUmuOFIzPjVizszN NUjNdHI5W0GQR1XS
ES1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITTNIFKSzVyPUmuOlg6PTZizszN MX\TRW5ITVJ?
MFM-223 M4Dke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i2PGlEPTB;MUCuPVkzPyEQvF2= M2ewNHNCVkeHUh?=
C2BBe1 M4XPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:3TWM2OD1zMT6zOVI{KM7:TR?= M1TicnNCVkeHUh?=
EB2 NGfHUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17tN2lEPTB;MUKuOlg5OSEQvF2= MXXTRW5ITVJ?
C8166 M17BSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTmTWM2OD1zMz64N|A{KM7:TR?= NFq0RnBUSU6JRWK=
ES3 NF;D[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjsOYZKSzVyPUGzMlk6PzdizszN NWPnNJIzW0GQR1XS
NCI-H1650 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnlTFBKSzVyPUG2MlM4PjVizszN NFXwXFBUSU6JRWK=
Mo-T NIr6UnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DjbWlEPTB;MUeuOFAzQSEQvF2= M4fRU3NCVkeHUh?=
NB7 M3qyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF5Lke0Olch|ryP M3mxOHNCVkeHUh?=
ES7 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDwVoVKSzVyPUG5MlU2ODdizszN MX3TRW5ITVJ?
ES5 NG\DZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn2Z4JKSzVyPUKxMlc3PzFizszN NGrP[4xUSU6JRWK=
MSTO-211H M4fDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nyWmlEPTB;MkGuPFg2QCEQvF2= MoXBV2FPT0WU
U-87-MG NHXDbXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vzdWlEPTB;MkWuNVk3PiEQvF2= M2XmW3NCVkeHUh?=
THP-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJ7LkeyNFEh|ryP MmD4V2FPT0WU
NB10 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHjcG86UUN3ME2zNE4zPjl2IN88US=> MnyyV2FPT0WU
NH-12 M2ix[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqxZZF6UUN3ME2zN{4zODF5IN88US=> MXTTRW5ITVJ?
COLO-824 MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2raXGlEPTB;M{SuNVAxPiEQvF2= M2rVS3NCVkeHUh?=
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NCI-H1838 NWe5fXplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjvdIRXUUN3ME2zPE4{Pzl5IN88US=> NWDkNIZlW0GQR1XS
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KG-1 NXvkbW1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnvcmVCUUN3ME20NE45QTV3IN88US=> MkOwV2FPT0WU
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NCI-H322M M4PjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR{LkW5PFQh|ryP NH7NXGFUSU6JRWK=
LNCaP  Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUixdYYyUUN3ME25NU4{KG6P MXiyOVUxPTF5NB?=
C4-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLv[|VKSzVyPUigcm0> NXPpWnA{OjV3MEWxO|Q>
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MOLT-4 NYfNSoloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\qN|I1KGh? NUC4[FU3UUN3ME2yPFU{NjVibl2= MU[yOFUyQTl7NR?=
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NALM-6 NUL3UnhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\t[WJGOjRiaB?= MX;JR|UxRTN2M{OwJI5O NX62eoJXOjR3MUm5PVU>
RS 4;11 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK0Z29xOjRiaB?= MVvJR|UxRTVzOT6wOUBvVQ>? M1nsdVI1PTF7OUm1
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SIL-ALL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPFNlQhcA>? NVvVO4V{UUN3ME2xPVkvPzdibl2= NEnKSnEzPDVzOUm5OS=>
CEM Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX0NlQhcA>? NUCxUFhCUUN3ME21Nk4yQCCwTR?= NH3NSlYzPDVzOUm5OS=>
P12 NUj6[mZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS2NlQhcA>? Mn;lTWM2OD1|OT6yO{BvVQ>? NEHGRYMzPDVzOUm5OS=>
NALM-16 Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXleHZyOjRiaB?= MVnJR|UxRTl4LkK4JI5O MV[yOFUyQTl7NR?=
JURKAT MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTkWpg1QCCq M3TiTmlEPTB;MUSuPFQhdk1? MUOyOFUyQTl7NR?=
MOLT-4 NGLPW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu5VlU1QCCq M{DkW2lEPTB;Mk[uOkBvVQ>? MXKyOFUyQTl7NR?=
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NALM-6 MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLrOFghcA>? MVjJR|UxRTJ|LkK2JI5O MYOyOFUyQTl7NR?=
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697 NGK4XXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHSWHA1QCCq MWXJR|UxRTNyNT6zJI5O MnnmNlQ2OTl7OUW=
SIL-ALL MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXy0PEBp M4nReWlEPTB;N{SuOlIhdk1? NVLkUIl3OjR3MUm5PVU>
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NALM-16 NWe2dFNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV[0PEBp MYnJR|UxRTZ|LkK0JI5O MVWyOFUyQTl7NR?=
JURKAT NGPUfodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorqO|IhcA>? NF3STHJKSzVyPUOuOlUhdk1? MoizNlQ2OTl7OUW=
MOLT-4 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjDc5ZOPzJiaB?= M4faOWlEPTB;Nz6zPUBvVQ>? MVSyOFUyQTl7NR?=
REH MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37QSFczKGh? NXi4T5RsUUN3ME2xOk4xOSCwTR?= NFrGdlkzPDVzOUm5OS=>
NALM-6 M1;TXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHsR3M4OiCq M{nqcGlEPTB;MT63PEBvVQ>? Mm\TNlQ2OTl7OUW=
RS 4;11 NHO4TJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXMO|IhcA>? MmDBTWM2OD12LkO4JI5O Mn3TNlQ2OTl7OUW=
697 MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfL[|A4OiCq MkjPTWM2OD15ND6yPEBvVQ>? NI\ZSGIzPDVzOUm5OS=>
SIL-ALL M3foWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTLO|IhcA>? NFj4PVZKSzVyPUeuNkBvVQ>? NFLzfmUzPDVzOUm5OS=>
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P12 M1vzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfBN4NGPzJiaB?= M17mSWlEPTB;Nj6zO{BvVQ>? MYSyOFUyQTl7NR?=
NALM-16 MoHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe0WIpGPzJiaB?= M3;3V2lEPTB;N{euO|Mhdk1? M4nLdFI1PTF7OUm1
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WER-Rb-1 MWfBdI9xfG:|aYOgRZN{[Xl? MWixMVUxKG6P NHXsbY4yOi9{NDDo M2XU[WROW09? M3vwSolv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=> Mom3NlQ{PjZ4NkW=
G7 MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\zTWM2OD1|LkOgcm0> NI\hbIczPDJyNEezNy=>
G166 M4rudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jqW2lEPTB;Nz6wJI5O NHPQUJAzPDJyNEezNy=>
CB660 NGfZVJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTLZ2tKSzVyPU[uOEBvVQ>? Mn3nNlQzODR5M{O=
CB1117 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH1TWM2OD1zNT62JI5O M3\M[lI1OjB2N{Oz
KB-3-1 NYTDN|NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwNEigxtEhOC53MzDuUS=> M2flcFI{QTZ{NES1
KB-8-5-11 M2jTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjiTWM2OD13LkCxJOKyKDJwMEGgcm0> NYfuOGZHOjN7NkK0OFU>
KB-C-1 NYjNRYhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfRO|hUUUN3ME2xOk44PiEEsTC0MlUyKG6P MV[yN|k3OjR2NR?=
KB-V-1 NXTSW3RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q1PGlEPTB;MkixMlI1KMLzIEOxMlU4KG6P NFW5d5UzOzl4MkS0OS=>
OVCAR-8 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX5[Y5xUUN3ME23MlE6KMLzIEOuOlAhdk1? NFuwPYQzOzl4MkS0OS=>
NCI-ADR-RES NUCyO5loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjrWnpKSzVyPUGyO|MvOzBiwsGgNVkyNjJyIH7N MmnvNlM6PjJ2NEW=
MCF7 M2XQZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jsPGlEPTB;NT6xNUDDuSBzLkS3JI5O NHLtUo4zOzl4MkS0OS=>
MCF7-FLV1000 M{XwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\VRmlEPTB;M{mzMlE5KMLzIEe0Mlg{KG6P Mo[yNlM6PjJ2NEW=
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CORL-23/P MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\GTWM2OD12LkO4JOKyKDFwMkWgcm0> MUKyN|k3OjR2NR?=
CORL-23/R M4exXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXEcGV5UUN3ME21MlE3KMLzIEGuPFMhdk1? M{C4OlI{QTZ{NES1
NIH3T3 NGjFfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\3NZBvUUN3ME20NE43OCEEsTC0Mlk4KG6P NV;wVHhKOjN7NkK0OFU>
NIH3T3-G185 Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L0SGlEPTB;MkSxN{41OCEEsTC0NlMvPjZibl2= NWi2[GNlOjN7NkK0OFU>
pcDNA-HEK293 NIDNNG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrkTJI2UUN3ME2yMlc2KMLzIECuOlchdk1? M1HN[lI{QTZ{NES1
MDR19-HEK293 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HRbmlEPTB;OEWuOVAhyrFiMUOuOlchdk1? MWqyN|k3OjR2NR?=
R482-HEK293 NITJTGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT0[mxKSzVyPUK1Mlk4KMLzIESuPVUhdk1? NE\VZpQzOzl4MkS0OS=>
MRP1-HEK293 NYLYeXdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJwOUmgxtEhOS52OTDuUS=> NF;qfWIzOzl4MkS0OS=>
SF188 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HmV|ExNTFyMDDuUS=> M4HCOlI1NTl4IHi= MnvOSG1UVw>? MVHpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? M{frSlI{QDh5NkS1
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DU145 NV3tRpVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfEUXNQ Mof1TWM2OOLKvE[wJI5O NFLIU4EzOzh6NESyPC=>
LNCaP  NHW4eXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nHRmROW09? MX7JR|Ux6oj:N{Wgcm0> MlKwNlM5QDR2Mki=
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5637 MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13ib2lEPTB;NEWuOFchdk1? MnHYNlM4QTJ4M{m=
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MCF7  NYjHdpU3TnWwY4Tpc44hSXO|YYm= NGjHeYwyODBibl2= M4nrWVEhcA>? NYnucZhxTE2VTx?= Ml34doVlfWOnczD0bIUhcW6mdXP0bY9vKG:owrDHdoVjOS{EoGPnb|EtyqCSc{KsxsBU\XKyaX7hN{wh[W6mwrDXbZNxOg>? Ml7QNlM4PzB{NES=
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Hec50co NXrWRo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFOx[HBKSzVyPUWgcm0> NXy5cmFVOjNzNE[2PFc>
MDA-MB-468 MYfBdI9xfG:|aYOgRZN{[Xl? MWOxM|UwOTBibl2= M3LpT|I1NzR6L{eyJIg> NYTrT|l[TE2VTx?= NVrzOpRwcW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M1rkWVI{OTR2Mkm0
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MDA-MB-231 M3\XfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSwMVExOCCwTR?= NV3BWFdFPzJiaB?= Mlq1bY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy MWOyNlMxQTl|OR?=
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Caki-1 NFThV29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjm[pZFPS16MDDuUS=> NFL0RVE6PiCq NUPv[mZQUEOu NEC4PJl{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= M2jMZVIyPjR{M{e0
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多くの細胞株試験データを見る場合、クリックしてください

体内試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
細胞試験: [1]
+ 展開
  • 細胞株: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • 濃度: Dissolved in DMSO, final concentrations ~1 μM
  • 反応時間: 24 and 72 hours
  • 実験の流れ: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • 製剤: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • 投薬量: ~50 mg/kg
  • 投与方法: Injection i.v. once or twice per week
    (参考用のみ)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 順序で溶剤を入れること:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Tags: BI 2536を買う | BI 2536 ic50 | BI 2536供給者 | BI 2536を購入する | BI 2536費用 | BI 2536生産者 | オーダーBI 2536 | BI 2536化学構造 | BI 2536分子量 | BI 2536代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID