Adalimumab (anti-TNF-alpha)

製品コードA2010 別名: LU200134, D2E7

製品コード：A2010 純度：99.23%

Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.

サイズ	価格(税別)	在庫状況
1mg	JPY 44500	国内在庫あり
1mg*5	JPY 146500	お問い合わせ
5mg	JPY 146500	国内在庫あり
1mg*25	JPY 445500	お問い合わせ

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

文献中Selleckの製品使用例（10）

質量管理及び製品安全説明書

現在のバッチを見る：純度： 99.23% タンパク質濃度： 5.00 mg/ml 内毒素： ≤1 EU/mg

99.23

TNF-alpha阻害剤の選択性比較

生物活性

製品説明

Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.

同型

Human IgG1

Targets

TNF-α ^[1]

In Vitro
In Vitro	Adalimumab treatment alters the secretion of cytokines.^[1]
細胞実験	Fa2N-4 cells were co-cultivated (CC) with monocyte derived macrophages (MDMs) for 24 h. Physiological (15%) and pro-inflammatory (50%) MDM-to-Fa2N-4 ratios were used. All measured cytokine concentrations were related to the corresponding control (fold change) to analyse (A) the IL-8 neutralising antibody (αIL-8, 100 ng/ml) specific effect and (B) the TNF-α neutralising effect of Adalimumab.

In Vivo
In Vivo	We injected adalimumab intraductally into the MG of adult mice;this was found to stimulate BSC multipotency.^[2]
動物試験	Animal Models: K5CreER, K8rtTA, TetO-DTA mice Dosages: 0.15 mg Administration: i.d. Reference:^[2]

参考
[1] Padberg F, et al. 2021 Jun;73:105134. [2] Centonze A, et al. Nature. 2020 Aug;584(7822):608-613.

参考

製品説明

CAS No.	331731-18-1
Formulation	PBS buffer, pH 7.2
Isotype	Human IgG1
Source	CHO cells
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping	Shipped under low temperature conditions
Sterility	5.00mg/ml

技術サポート

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Handling Instructions

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* 必須

よくある質問（FAQ）

質問：1：
How to store the antibody?

回答：
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.