Regorafenib (BAY 73-4506)

製品コードS1178 別名:Fluoro-Sorafenib

Regorafenib (BAY 73-4506)化学構造

分子量(MW):482.82

Regorafenib (BAY 73-4506)は一種の多ターゲット阻害剤で、無細胞試験でVEGFR1、VEGFR2、VEGFR3、PDGFR-β、Kit、RETとRaf-1に作用する時のIC50値が13 nM、4.2 nM、46 nM、22 nM、7 nM、1.5 nMと2.5 nMにそれぞれ分かれることです。

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JPY 24189.98 あり
JPY 17278.56 あり
JPY 30237.48 あり
JPY 67674.36 あり
JPY 139668.35 あり

製品安全説明書

VEGFR阻害剤の選択性比較

生物活性

製品説明 Regorafenib (BAY 73-4506)は一種の多ターゲット阻害剤で、無細胞試験でVEGFR1、VEGFR2、VEGFR3、PDGFR-β、Kit、RETとRaf-1に作用する時のIC50値が13 nM、4.2 nM、46 nM、22 nM、7 nM、1.5 nMと2.5 nMにそれぞれ分かれることです。
ターゲット
RET [1]
(Cell-free assay)
Raf-1 [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
Kit [1]
(Cell-free assay)
VEGFR1 [1]
(Cell-free assay)
1.5 nM 2.5 nM 4.2 nM 7 nM 13 nM
体外試験

Regorafenib strongly prevents VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with IC50 of 3 nM. In HAoSMCs, regorafenib suppress PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib also inhibits FGFR signaling in MCF-7 breast cancer (BC) cells stimulated with FGF10. Regorafenib very potently inhibited the mutant receptors KITK642E and RETC634W, with IC50 of approximately 20 nM and 10 nM, respectively. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of approximately 3 nM. Regorafenib prevents the proliferation of FGF2-stimulated HUVECs and of PDGF-BB-stimulated HAoSMCs with IC50 of 127 nM and 146 nM, respectively. [1] Regorafenib targets both tumor cell proliferation and tumor vasculature through inhibition of receptors of tyrosine kinases (VEGFR, KIT, RET, FGFR, and PDGFR) and serine/threonine kinases (Raf and p38MAPK). [2] Regorafenib suppresses growth of human Hep3B, PLC/PRF/5 and HepG2 cells in a concentration- and time-dependent manner. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Hep3B NHn3O4FCeG:ydH;zbZMhSXO|YYm= M3vJbVHjiJN3wrFOwG0> NXztd3d6PDhiaB?= MX3pcohq[mm2czDj[YxtKGe{b4f0bC=> MkXWNlY{Ojl4MEi=
PLC/PRF/5  Mo\MRZBweHSxc3nzJGF{e2G7 MnKzNgKBmzYEoN88US=> M{fCb|Q5KGh? NFrYRY9qdmirYnn0d{Bk\WyuIHfyc5d1cA>? NVPTcm9IOjZ|Mkm2NFg>
HepG2  MX\BdI9xfG:|aYOgRZN{[Xl? NVLrclZ6OeLCk{ZCpO69VQ>? Mkn4OFghcA>? NGLtfWFqdmirYnn0d{Bk\WyuIHfyc5d1cA>? NFH0cJYzPjN{OU[wPC=>
HEK293 NFLWRY9HfW6ldHnvckBCe3OjeR?= NX:wOmRzOC534pEJ{txO MoHYNk81NzZiaB?= MnjXdoVlfWOnczDHVnA4QCCneIDy[ZN{cW:w M37EbFI2QDV6MEOy
GEO M3qxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfReooxNjBzLUKwJO69VQ>? M3\Dc|k3KGh? NFjzfWVFVVOR Ml\5bY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M4iw[FI2QDN6M{mx
SW48 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXINE4xOS1{MDFOwG0> M2LhUVk3KGh? MnuxSG1UVw>? NY[4eVRbcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MmqwNlU5Ozh|OUG=
HT29 NFrlb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG5NE4xOS1{MDFOwG0> NIT5fnI6PiCq M4\aPGROW09? MUnpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MWWyOVg{QDN7MR?=
SW480 NH\BXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXVR21TOC5yMT2yNEDPxE1? M4\H[Vk3KGh? M3\MRmROW09? NHj4bm1qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MoPZNlU5Ozh|OUG=
SW620 M4T0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWyd49MOC5yMT2yNEDPxE1? M2ftdVk3KGh? M3L3V2ROW09? MYDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M4T2dFI2QDN6M{mx
HCT116 NEOye2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDMS|MxNjBzLUKwJO69VQ>? NIHrdHo6PiCq MUjEUXNQ NXj1b2ZPcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NVexT3BXOjV6M{izPVE>
LOVO NF7UTIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DxVFAvODFvMkCg{txO Mk\OPVYhcA>? NEOwNlNFVVOR MX\pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NVHEWYF{OjV6M{izPVE>
HCT150 M{\jRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq1fZl[OC5yMT2yNEDPxE1? MUK5OkBp MonPSG1UVw>? MlPlbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MUCyOVg{QDN7MR?=
SW48-CR NYTxTYxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H1UVAvODFvMkCg{txO NVfF[3FpQTZiaB?= NEPQXGZFVVOR NVOyVWdHcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MYSyOVg{QDN7MR?=
GEO-CR M{HVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUewMlAyNTJyIN88US=> MV[5OkBp M{LCbGROW09? MkLybY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MWeyOVg{QDN7MR?=
KB-31 NY\GdWFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DzfWlEPTB;NT61xtExNjNibl2= NVPSOVN3OjV5NUOzOlE>
KB-G2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7xTWM2OD17LkJCtVAvOSCwTR?= MnnLNlU4PTN|NkG=
LLC-PK1 M{\FWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTR{LkFCtVMvOiCwTR?= MWCyOVc2OzN4MR?=
LLC-PK1/MRP2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLzVIxKSzVyPUiyMlTDuTJwNzDuUS=> NEHzXGczPTd3M{O2NS=>
HEK293 M3LYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTFzLkFCtVEvOiCwTR?= Mn7JNlU4PTN|NkG=
HEK293/OATP1B1 M3fmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XSc2lEPTB;Nj6yxtExNjNibl2= MnPQNlU4PTN|NkG=
HROC18 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTRTWM2OD1zLkOg{txO NVP5ZVZiOjV|MEm5NVQ>
HROC24 M1vtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXTc5RJUUN3ME20MlYh|ryP M3fm[FI2OzB7OUG0
HROC43 NV6xfYNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rCXmlEPTB;NT6zJO69VQ>? MkDONlU{ODl7MUS=
HROC46 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\jTWM2OD1{LkSg{txO NGr4TFQzPTNyOUmxOC=>
RJ345 MV;GeY5kfGmxbjDBd5NigQ>? MmjONE42NzVizszN NV34RodCOjRiaB?= MUjEUXNQ MorLbY5pcWKrdIOgeIhmKGOnbHygcYloemG2aX;u M3nYeVI2OjV|OUm0
RJ348 MYLGeY5kfGmxbjDBd5NigQ>? MYiwMlUwPSEQvF2= NFjtWI8zPCCq Mn7nSG1UVw>? MUnpcohq[mm2czD0bIUh[2WubDDtbYdz[XSrb36= MX2yOVI2Ozl7NB?=
MCF-7 MUHGeY5kfGmxbjDBd5NigQ>? MUWwMlUwPSEQvF2= Mn;mNlQhcA>? NXzwRnR4TE2VTx?= NHW2bXJqdmirYnn0d{B1cGViY3XscEBucWe{YYTpc44> M4fPdlI2OjV|OUm0
MDA-MB-231 NYnPd3R2TnWwY4Tpc44hSXO|YYm= MVOwMlUwPSEQvF2= M3fYPFI1KGh? M3jYdGROW09? NY\OT4dWcW6qaXLpeJMhfGinIHPlcIwhdWmpcnH0bY9v M{jITlI2OjV|OUm0
HT15 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvHOlIyNTJyIN88US=> MmG2OFghcA>? MYTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MWOyOVA4OTBzOB?=
DLD1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnOzNU0zOCEQvF2= MmnvOFghcA>? NETLVIZqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MnnqNlUxPzFyMUi=
HT-29 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjyWFJbOS1{MDFOwG0> M3;mblQ5KGh? NETCfYhqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NYGweo0zOjVyN{GwNVg>
Hct-116 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojyNU0zOCEQvF2= MojuOFghcA>? NXfpV4lxcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MWmyOVA4OTBzOB?=
HT15 NF;BV|FCeG:ydH;zbZMhSXO|YYm= NIPrc40yNTFyIN88US=> Ml\1OFghcA>? NYflVJBCcW6mdXPld{Bk\WyuIHTlZZRpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M17YOVI2ODdzMEG4
DLD1 MWLBdI9xfG:|aYOgRZN{[Xl? M3izZVEuOTBizszN NYPhZlJOPDhiaB?= NGTjS49qdmS3Y3XzJINmdGxiZHXheIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NIO3SWgzPTB5MUCxPC=>
HT-29 NXTMXG06SXCxcITvd4l{KEG|c3H5 MofNNU0yOCEQvF2= M2HifFQ5KGh? NYHtOnV3cW6mdXPld{Bk\WyuIHTlZZRpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NHzNdngzPTB5MUCxPC=>
Hct-116 MXnBdI9xfG:|aYOgRZN{[Xl? NVfXRYFNOS1zMDFOwG0> NGjGXlg1QCCq Mn\0bY5lfWOnczDj[YxtKGSnYYToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MYKyOVA4OTBzOB?=
GBM5 NVnlN4tvSXCxcITvd4l{KEG|c3H5 NV;XZWY6OC534pETNU4x6oDLzszN M3TWd|I1KGh? NYfFeVd4TE2VTx?= MkPLbY51\XKjY4TzJJdqfGhibHHwZZRqdmmkIITvJIlv\HWlZTDj[YxtKGSnYYTo MmHHNlQ6OTF{MUW=
GBM6 M1TteGFxd3C2b4Ppd{BCe3OjeR?= M2e3O|AvPeLCk{GuNQKBkc7:TR?= NEDmNGgzPCCq NVrrU2VWTE2VTx?= NYX0fIdYcW62ZYLhZ5R{KHerdHigcIFx[XSrbnniJJRwKGmwZIXj[UBk\WyuIHTlZZRp M3fIVlI1QTFzMkG1
GBM12 MmXURZBweHSxc3nzJGF{e2G7 NXnZPXhTOC534pETNU4x6oDLzszN Ml:0NlQhcA>? NFm3PWdFVVOR M{jrUYlvfGW{YXP0d{B4cXSqIHzhdIF1cW6rYjD0c{BqdmS3Y3WgZ4VtdCCmZXH0bC=> M4jOR|I1QTFzMkG1
GBM14  MnfQRZBweHSxc3nzJGF{e2G7 M3LldlAvPeLCk{GuNQKBkc7:TR?= M13oWVI1KGh? NYnqc2JwTE2VTx?= NWHWO4VCcW62ZYLhZ5R{KHerdHigcIFx[XSrbnniJJRwKGmwZIXj[UBk\WyuIHTlZZRp NV3sUmZZOjR7MUGyNVU>
Hep3B MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnGyNgKBmzJwNdMg{txO Ml\PNlQwPDhxN{KgbC=> NHLUeGRqdmirYnn0d{Bk\WyuIHfyc5d1cA>? NVvkSoV{OjR6OEW4PVA>
PLC/PRF/5  MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrpNgKBmzJwNdMg{txO NU[yNFl5OjRxNEivO|IhcA>? NEDEZoZqdmirYnn0d{Bk\WyuIHfyc5d1cA>? NELQZngzPDh6NUi5NC=>
HepG2  M3PDfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYex5qCUOi53wrFOwG0> NHrLTG0zPC92OD:3NkBp MULpcohq[mm2czDj[YxtKGe{b4f0bC=> NGToV2EzPDh6NUi5NC=>
HCT116  NXTEWIw1TnWwY4Tpc44hSXO|YYm= NXzIeGVYOTBxMkCvOFAh|ryP M2jGT|I1KGh? NIXoS5hqdmS3Y3XzJHBWVUFicILveIVqdiCjbnSgcXJPSSCneIDy[ZN{cW:wIHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= MlLvNlQ4PjN4MUG=
Lim2405 MVjGeY5kfGmxbjDBd5NigQ>? M17jSVQxKM7:TR?= NV7o[2VkOjRiaB?= NFjSdo5qdmS3Y3XzJHBWVUFicILveIVqdiCjbnSgZ4VtdCCjcH;weI9{cXN? MWqyOFc3OzZzMR?=
LoVo NUm2fIlkTnWwY4Tpc44hSXO|YYm= NGLmfpQ1OCEQvF2= MVuyOEBp MUXpcoR2[2W|IGDVUWEheHKxdHXpckBidmRiY3XscEBieG:ydH;zbZM> MXqyOFc3OzZzMR?=
Lim1215 MYfGeY5kfGmxbjDBd5NigQ>? NYTQXmVDPDBizszN MkTRNlQhcA>? MVvpcoR2[2W|IGDVUWEheHKxdHXpckBidmRiY3XscEBieG:ydH;zbZM> NGPjVG8zPDd4M{[xNS=>
SW48 NIPUeppHfW6ldHnvckBCe3OjeR?= NF\LV5Y1OCEQvF2= Mo[4NlQhcA>? NEiyOJpqdmS3Y3XzJHBWVUFicILveIVqdiCjbnSgZ4VtdCCjcH;weI9{cXN? M{mzdVI1PzZ|NkGx
RKO  NXjmU3RKTnWwY4Tpc44hSXO|YYm= NXH3[W1XPDBizszN NV7OZYp{OjRiaB?= M2ThT4lv\HWlZYOgVHVOSSCycn;0[YlvKGGwZDDj[YxtKGGyb4D0c5Nqew>? NHHC[G8zPDd4M{[xNS=>
SW837 NGTU[ZpHfW6ldHnvckBCe3OjeR?= MmPOOFAh|ryP NUW1Z|R2OjRiaB?= NIiwdmpqdmS3Y3XzJHBWVUFicILveIVqdiCjbnSgZ4VtdCCjcH;weI9{cXN? NVjiN5lDOjR5NkO2NVE>
SW1463 NVHSVohlTnWwY4Tpc44hSXO|YYm= NVqyVWxqPDBizszN NWrzcJZ{OjRiaB?= NECyPZFqdmS3Y3XzJHBWVUFicILveIVqdiCjbnSgZ4VtdCCjcH;weI9{cXN? M3XSUlI1PzZ|NkGx
SW480 NIXucVFHfW6ldHnvckBCe3OjeR?= MUO0NEDPxE1? NWPMSHdTOjRiaB?= NFnaWGJqdmS3Y3XzJHBWVUFicILveIVqdiCjbnSgZ4VtdCCjcH;weI9{cXN? M1L4O|I1PzZ|NkGx
Vaco432 NVvidWhlTnWwY4Tpc44hSXO|YYm= NEnrZoM1OCEQvF2= NHzIVXYzPCCq M4HUc4lv\HWlZYOgVHVOSSCycn;0[YlvKGGwZDDj[YxtKGGyb4D0c5Nqew>? MVWyOFc3OzZzMR?=
Vaco400 NIDPdHVHfW6ldHnvckBCe3OjeR?= NH3jcIM1OCEQvF2= NUTN[Hh6OjRiaB?= NWHyOpFUcW6mdXPld{BRXU2DIIDyc5RmcW5iYX7kJINmdGxiYYDvdJRwe2m| M1[2e|I1PzZ|NkGx
DLD1 Mnn4SpVv[3Srb36gRZN{[Xl? M3rFZ|QxKM7:TR?= MVSyOEBp NYWyUWFEcW6mdXPld{BRXU2DIIDyc5RmcW5iYX7kJINmdGxiYYDvdJRwe2m| M{PIOlI1PzZ|NkGx
HT29  M4LkT2Z2dmO2aX;uJGF{e2G7 MXS0NEDPxE1? NG\YUJMzPCCq MWXpcoR2[2W|IGDVUWEheHKxdHXpckBidmRiY3XscEBieG:ydH;zbZM> MYGyOFc3OzZzMR?=
PLC/PRF/5  NHnqOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPVUYhYOeLCk{ZCuW0> NWTkenBlOjRxNEivO|IhcA>? NX;3WmJ4cW6qaXLpeJMh[2WubDDndo94fGh? MUOyN|E3QTF2OB?=
HepG2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPEcYFIOeLCk{ZCuW0> MXuyOE81QC95MjDo MXzpcohq[mm2czDj[YxtKGe{b4f0bC=> NVfwVWpDOjNzNkmxOFg>
Hep3B  NVj2S5UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSx5qCUPcL3TR?= M{O1VVI1NzR6L{eyJIg> NEDlNZFqdmirYnn0d{Bk\WyuIHfyc5d1cA>? MoCxNlMyPjlzNEi=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Regorafenib reveals potent dose-dependent TGI in various preclinical human xenograft models in mice, with tumor shrinkages in breast MDA-MB-231 and renal 786-O carcinoma models. Regorafenib prevents not only the growth of syngeneic primary 4T1 breast tumors growing orthotopically in the fat pad, but also suppresses the formation of tumor metastasis in the lung. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Kinase assays:

In vitro assays using recombinant VEGFR2 (murine aa785–aa1367), VEGFR3 (murine aa818–aa1363), PDGFRβ (aa561–aa1106), Raf-1 (aa305–aa648) and BRafV600E (aa409–aa765) kinase domains are performed. Initial in vitro kinase inhibition profiling is performed at a fixed 1 μM Regorafenib concentration. Inhibitory concentration of 50% (IC50) values are determined from selected responding kinases, e.g., VEGFR1 and RET. TIE2 kinase inhibition is measured with a homogeneous time-resolved fluorescence (HTRF) assay using a recombinant fusion protein of glutathione-S-transferase, the intracellular domain of TIE2 and the peptide biotin-Ahx-EPKDDAYPLYSDFG as substrate.
細胞試験: [1]
+ 展開
  • 細胞株: GIST 882 and TT cells
  • 濃度: 5 nM-10 μM
  • 反応時間: 96 hours
  • 実験の流れ: For proliferation assays, GIST 882 and TT cells are grown in RPMI medium containing L-glutamine, and MDA-MB-231, HepG2 and A375 cells in DMEM always containing 10% hiFBS. Cells are trypsinized, plated at 5×104 cells/well in 96-well plates in complete media containing 10% FBS and grown overnight at 37 °C. The next day, vehicle or Regorafenib serially diluted in complete growth media to between 10 μM and 5 nM final concentrations, and 0.2% DMSO, is added and incubation is continued for 96 hours. Cell proliferation is quantified.
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Female athymic NCr nu/nu mice with Colo-205, MDA-MB-231 or 786-O
  • 製剤: PEG400/125 mM aqueous methanesulfonic acid (80/20) or polypropylene glycol/PEG400/Pluronic F68 (42.5/42.5/15 + 20% Aqua)
  • 投薬量: 3 mg/kg, 10 mg/kg, 30 mg/kg, 100 mg/kg
  • 投与方法: Orally
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (200.9 mM)
Water Insoluble
Ethanol Insoluble
体内 順序で溶剤を入れること:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL (suspension)

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 482.82
化学式

C21H15ClF4N4O3

CAS No. 755037-03-7
保管
in solvent
別名 Fluoro-Sorafenib

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03042689 Not yet recruiting Acute Myeloid Leukemia Massachusetts General Hospital|Bayer January 2017 Phase 1
NCT02910843 Not yet recruiting Rectal Cancer Swiss Group for Clinical Cancer Research December 2016 Phase 1
NCT02940223 Not yet recruiting Malignant Neoplasms of Independent (Primary) Multiple Sites|Metastatic Colorectal Cancer M.D. Anderson Cancer Center|Bayer December 2016 Phase 2
NCT02955940 Enrolling by invitation Pancreatic Cancer|Colorectal Cancer|Breastcancer|Lung Cancer Non-Small Cell Incyte Corporation November 2016 Phase 2
NCT02889328 Recruiting Gastrointestinal Stromal Tumors (GISTs) Asan Medical Center September 2016 Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

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VEGFR Inhibitors with Unique Features

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID