Dabrafenib (GSK2118436)

製品コードS2807

Dabrafenib (GSK2118436)化学構造

分子量(MW):519.56

Dabrafenib (GSK2118436)は一種の突然変異型BRAFV600の特異性的な阻害剤で、無細胞試験でIC50値が0.8nMですが、BRAFV600に作用する効果はB-Raf(wt)とc-Rafに作用する効果より4倍と6倍がそれぞれ高くなります。

サイズ 価格(税別)  
JPY 29880.00
JPY 14940.00
JPY 21580.00
JPY 28220.00
JPY 44820.00
JPY 66400.00

カスタマーフィードバック(5)

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

製品安全説明書

Raf阻害剤の選択性比較

生物活性

製品説明 Dabrafenib (GSK2118436)は一種の突然変異型BRAFV600の特異性的な阻害剤で、無細胞試験でIC50値が0.8nMですが、BRAFV600に作用する効果はB-Raf(wt)とc-Rafに作用する効果より4倍と6倍がそれぞれ高くなります。
ターゲット
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
体外試験

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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SK-MEL-28 M1rFZ2tqdmG|ZTDBd5NigQ>? MUOxJIg> NIjaTXRKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN MnnTNlQ6ODB4N{O=
HepG2 MmHzT4lv[XOnIFHzd4F6 Mm\iTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iRWLLJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMESg{txO Ml;tNlQ6ODB4N{O=
COLO205 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj5cmZKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:yNFUh[2WubDDwdo9tcW[ncnH0bY9vKHerdHigTWM2OCCxZjCwMlAxPyEQvF2= NXrPOpdbOjR7MEC2O|M>
HepG2 M{PZWGZ2dmO2aX;uJGF{e2G7 MWi0OUBucW5? NG\pSFlFVVOR M4XxfmlvcGmkaYTpc44hd2ZiQXzrOUBqdiCWR1[tZoV1[S2|dHnteYxifGWmIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOvYXSyJJBpd3OyaH;yfYxifGmxbjD0doVifGWmIH\vdkA1PSCvaX7zJJBzcW:{IITvJHRITi2kZYThJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFYxKG2rboOgZpkhd2S7c4PlfUBjdG:2IIPjZY5v\XJiYX7hcJl{cXNid3n0bEBKSzVyIH;mJFMvPyEQvF2= NFjvTHYzPDlyME[3Ny=>
HFF MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXOxNEDPxE1? MlTjO|IhcA>? NYXXPVhZTE2VTx?= MWTJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhcHWvYX6gTGZHKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSi2UYX[ge4l1cCCLQ{WwJI9nKDNizszN NFTuSGYzOzh2NECzPC=>
SK-MEL-28 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XSTlExKM7:TR?= MX[3NkBp MoLWSG1UVw>? Ml3iTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> NGCyeZgzOzh2NECzPC=>
A375P-F11 NVraXYNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvHVpEyOCEQvF2= NF\FepU4OiCq M2LxN2ROW09? MU\Jcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hSTN5NWCtSlEyKGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPzFizszN NHTG[5ozOzh2NECzPC=>
MALME-3M MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXQc|VPOTBizszN M37RclczKGh? NWDKXZZbTE2VTx?= NWrMXWNoUUN3ME2xJI5O MkLTNlM5PDRyM{i=
UACC-62 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDaNVAh|ryP NXjoR4x[PzJiaB?= M2jIS2ROW09? M2XSXGlEPTB;MTDuUS=> Moe4NlM5PDRyM{i=
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SK-MEL-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTqfoVkOTBizszN M{Sxc|czKGh? NXz0[2o3TE2VTx?= MnzkTWM2OD1{IH7N MlvUNlM5PDRyM{i=
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SK-MEL-28 NX\kOFM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13UPFExKM7:TR?= NX3CUmlUPzJiaB?= M4XKPGROW09? Mn7iTWM2OD1|IH7N MlPGNlM5PDRyM{i=
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SW1417 NWfpOFZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnPbHQyOCEQvF2= M17qflczKGh? MUXEUXNQ MXnJR|UxRTF3ODDuUS=> NVLvV3p7OjN6NESwN|g>
SW872 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPYNVAh|ryP MX23NkBp MXfEUXNQ NHSyWJJKSzVyPUO3O{BvVQ>? NV76R|hWOjN6NESwN|g>
RKO NFPseldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fRVFExKM7:TR?= NIjoTlU4OiCq M1X6WmROW09? NFnLSmZKSzVyPUKuOVIzKM7:TR?= NITtd3EzOzh2NECzPC=>
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GCT MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVixNEDPxE1? M1q5eVczKGh? MWnEUXNQ MX\JR|UxRTFyIN88US=> MUSyN|g1PDB|OB?=
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NCI-H508 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYSxNEDPxE1? MUC3NkBp MWDEUXNQ MnvZTWM2OD1zMDFOwG0> MX[yN|g1PDB|OB?=
MDA-MB-231 MlnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P2dVExKM7:TR?= MU[3NkBp MUHEUXNQ NXXIS4RTUUN3ME2xNEDPxE1? MnzKNlM5PDRyM{i=
SW756 M1HRR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrQepMyOCEQvF2= MV23NkBp M33DVGROW09? MoTNTWM2OD1zMDFOwG0> NULSSWl[OjN6NESwN|g>
SW-837 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? Mn;WO|IhcA>? NUn2N2NbTE2VTx?= NH7XWXZKSzVyPUGwJO69VQ>? MX:yN|g1PDB|OB?=
UMUC-3 NGHpN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnhNVAh|ryP NGmzXYk4OiCq M4m5NmROW09? NFW5UodKSzVyPUGwJO69VQ>? MnHyNlM5PDRyM{i=
LS-174T NV\sPVEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H5eFExKM7:TR?= NI[wW2M4OiCq MoK1SG1UVw>? NWDuWno5UUN3ME2xNEDPxE1? MnzQNlM5PDRyM{i=
A549 NVX4fmdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\aNVAh|ryP NHruXVk4OiCq M2PqNWROW09? MUTJR|UxRTFyIN88US=> MVuyN|g1PDB|OB?=
SHP-77 M1\kXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmThNVAh|ryP MXG3NkBp MWjEUXNQ NYHDNJZRUUN3ME2xNEDPxE1? NVrpU5ZpOjN6NESwN|g>
SW480 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrUeHk4OTBizszN M1PxRVczKGh? Ml7zSG1UVw>? NHrFUJBKSzVyPUGwJO69VQ>? MoK3NlM5PDRyM{i=
DLD-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[xXYgyOCEQvF2= MkXGO|IhcA>? NIfPeGFFVVOR NYrRVldUUUN3ME2xNEDPxE1? NIPjSVczOzh2NECzPC=>
HCT-116 NEKzPXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL0d4oyOCEQvF2= MVK3NkBp M1KxdWROW09? Mk\6TWM2OD1zMDFOwG0> NIThUowzOzh2NECzPC=>
NCI-H747 NYX1[mhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2xNEDPxE1? NXPnV3dzPzJiaB?= NX\RcYdHTE2VTx?= MUjJR|UxRTFyIN88US=> NHHlTZYzOzh2NECzPC=>
T-84 M2\LUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvCR4RlOTBizszN M33GRVczKGh? M3rQb2ROW09? NIfINW9KSzVyPUGwJO69VQ>? MV2yN|g1PDB|OB?=
NCI-H460 NUTUVZA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFq1WFYyOCEQvF2= NUfHUVNjPzJiaB?= MVLEUXNQ M3zHR2lEPTB;MUCg{txO M4fVbVI{QDR2MEO4
Calu-6 M{PRPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXs[XdnOTBizszN NWr5UpZzPzJiaB?= NUTrO5FxTE2VTx?= MoLITWM2OD1zMDFOwG0> M{jKd|I{QDR2MEO4
HCC-2998 Mk\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWqxNEDPxE1? NV7OV2J4PzJiaB?= NYj2T4lETE2VTx?= MV7JR|UxRTFyIN88US=> NIjsZ3EzOzh2NECzPC=>
LS1034 NH6xWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HTT|ExKM7:TR?= NUe1UVZlPzJiaB?= M3rNN2ROW09? MoHFTWM2OD1zMDFOwG0> M{jhSFI{QDR2MEO4
CHP-212 NEHsPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PLTlExKM7:TR?= M2rEdlczKGh? NYjvWmZNTE2VTx?= MYXJR|UxRTFyIN88US=> NVr6ZoVyOjN6NESwN|g>
SK-N-AS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLKNVAh|ryP NXrXdpFwPzJiaB?= Ml;FSG1UVw>? MXvJR|UxRTFyIN88US=> NGLjTpYzOzh2NECzPC=>
BFTC-905 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYexNEDPxE1? MWq3NkBp NYG1O3drTE2VTx?= NX;WfXN[UUN3ME2xNEDPxE1? MoXxNlM5PDRyM{i=
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RPMI-8226 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvLNVAh|ryP MlXtO|IhcA>? NX6ydFR5TE2VTx?= M3XXdmlEPTB;Mk[zJI5O NVHRcmVLOjN6NESwN|g>
BC-3 MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXixNEDPxE1? NWLOeWRLPzJiaB?= MnruSG1UVw>? MWTJR|UxRTJ5NzDuUS=> MlHwNlM5PDRyM{i=
ACHN Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PmSFExKM7:TR?= MkW3O|IhcA>? NULO[GdsTE2VTx?= NHLyb45KSzVyPUK5OEBvVQ>? NFr0[VczOzh2NECzPC=>
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SK-MES-1 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T0WVExKM7:TR?= NGD3OIY4OiCq NXXrWGVCTE2VTx?= MoexTWM2OD1|Mkmgcm0> NFzyZWMzOzh2NECzPC=>
CESS NVH3XVRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPOWFAyOCEQvF2= NH62ZZo4OiCq M2XzOWROW09? M3HNbmlEPTB;NEm3JI5O MViyN|g1PDB|OB?=
H4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\COXFsOTBizszN MmnYO|IhcA>? NIj6SGJFVVOR MWDJR|UxRTZzOTDuUS=> MXqyN|g1PDB|OB?=
BC-1 M3jpV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxNEDPxE1? MnuyO|IhcA>? M2nrRmROW09? M{jsfmlEPTB;N{C0JI5O M3LMVlI{QDR2MEO4
DB NVvDcG9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfpWlQyOCEQvF2= Mnz4O|IhcA>? M4nHVmROW09? Mn3xTWM2OD16N{Ogcm0> NEfORXgzOzh2NECzPC=>
RPMI-6666 M1TVWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXybYwyOCEQvF2= MYe3NkBp NVzl[IZQTE2VTx?= MVvJR|UxRTl{ODDuUS=> NIDJb5czOzh2NECzPC=>
MC/CAR Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qyV|ExKM7:TR?= MVy3NkBp NWjpdXBTTE2VTx?= NFrQTItKSzVyPUGuNFAzKM7:TR?= MYeyN|g1PDB|OB?=
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CEM/C1 NFLVO5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHpNVAh|ryP MlXCO|IhcA>? MkDySG1UVw>? MVvJR|UxRTFwN{ezJO69VQ>? MWqyN|g1PDB|OB?=
GDM-1 M2nwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvwbIMyOCEQvF2= NWjLVXJ7PzJiaB?= NUfIVlY3TE2VTx?= M4\tWGlEPTB;MT65PVch|ryP MUiyN|g1PDB|OB?=
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NCI-H2228 NYjSbJBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\SXVExKM7:TR?= MmnmO|IhcA>? MWLEUXNQ MWPJR|UxRTFyIN88US=> NF3RO3ozOzh2NECzPC=>
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OE-21 NV3Ec5kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfhbnIyOCEQvF2= MWK3NkBp NXTme5BJTE2VTx?= M{DX[GlEPTB;MUCg{txO MYmyN|g1PDB|OB?=
OE-33 NV3lTGhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWCxNEDPxE1? MXi3NkBp Ml7KSG1UVw>? MVLJR|UxRTFyIN88US=> MUeyN|g1PDB|OB?=
OVCAR-3 M3nCXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK3ZpgxOTBizszN NH35NmM4OiCq MnfhSG1UVw>? MmPDTWM2OD1zMDFOwG0> MVSyN|g1PDB|OB?=
OVCAR-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n3[|ExKM7:TR?= MmTrO|IhcA>? NXPpc4dTTE2VTx?= NVKzOHZiUUN3ME2xNEDPxE1? Mlf4NlM5PDRyM{i=
OVCAR-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nUWlExKM7:TR?= NHeyeWE4OiCq NWfCVldSTE2VTx?= NGDWWFlKSzVyPUGwJO69VQ>? NVHNcFZ[OjN6NESwN|g>
P3HR-1 NFy4e2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXKxNEDPxE1? NHzBU5U4OiCq NWnqT3RkTE2VTx?= NHLKNFBKSzVyPUGwJO69VQ>? NFLFRYczOzh2NECzPC=>
PC-3 NYK3XJVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\VcFcyOCEQvF2= M4m2ZVczKGh? M{nxVmROW09? NYr3XFB[UUN3ME2xNEDPxE1? MkfsNlM5PDRyM{i=
Raji M3;ER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PtfFExKM7:TR?= NGP0NXA4OiCq NXn3bpFHTE2VTx?= NIj3OWdKSzVyPUGwJO69VQ>? MV6yN|g1PDB|OB?=
RD NIX6eINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;ISW56OTBizszN NEPhWFI4OiCq NFnH[HRFVVOR NInGV5RKSzVyPUGwJO69VQ>? NIDqbHYzOzh2NECzPC=>
RD-ES M1;WSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;qb3kyOCEQvF2= M{S0XlczKGh? NIXncGVFVVOR NFn3PXZKSzVyPUGwJO69VQ>? NXf0OmZ4OjN6NESwN|g>
RL NIHoNnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVmxNEDPxE1? MWe3NkBp MYHEUXNQ NX;UT29qUUN3ME2xNEDPxE1? NGjUZVMzOzh2NECzPC=>
SaOS2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF70T4QyOCEQvF2= MkPuO|IhcA>? M1TlTGROW09? MonNTWM2OD1zMDFOwG0> MUmyN|g1PDB|OB?=
SCC-9 NFnBTm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf6VFgyOCEQvF2= MkjGO|IhcA>? NGPLWG5FVVOR M2\kTGlEPTB;MUCg{txO NYPmZ|VGOjN6NESwN|g>
SCC-12 MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXNdIliOTBizszN NVrsPZFIPzJiaB?= NX3KfHpCTE2VTx?= NXrXXmFkUUN3ME2xNEDPxE1? Mn;jNlM5PDRyM{i=
SCC-13 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln5NVAh|ryP NIfYd|U4OiCq NWL2PVRzTE2VTx?= M2fy[mlEPTB;MUCg{txO MUKyN|g1PDB|OB?=
SCC-15 M{LYdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVKxNEDPxE1? NUTtO4x4PzJiaB?= M{\kWGROW09? MWHJR|UxRTFyIN88US=> MWSyN|g1PDB|OB?=
SCC-25 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTEc|BxOTBizszN MmG1O|IhcA>? MlrJSG1UVw>? Mnf0TWM2OD1zMDFOwG0> NWGzdJdQOjN6NESwN|g>
SCLC-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1m4XlExKM7:TR?= NUHJN2dYPzJiaB?= MmW3SG1UVw>? MY\JR|UxRTFyIN88US=> Ml;6NlM5PDRyM{i=
SF-268 MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNEDPxE1? MoTQO|IhcA>? Mn3jSG1UVw>? MVzJR|UxRTFyIN88US=> MWiyN|g1PDB|OB?=
SF-295 M{XP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\QflExKM7:TR?= M1XpS|czKGh? MYLEUXNQ NInnOZVKSzVyPUGwJO69VQ>? Mnu5NlM5PDRyM{i=
SJRH30 NY\iW2hrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? NXTSPI92PzJiaB?= NFHzcGNFVVOR MlXDTWM2OD1zMDFOwG0> MmnYNlM5PDRyM{i=
SK-BR-3 NFXucZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxNEDPxE1? MlXmO|IhcA>? NGPscJpFVVOR MUTJR|UxRTFyIN88US=> MmnmNlM5PDRyM{i=
SK-LMS-1 NFfv[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYGxNEDPxE1? MXe3NkBp NH:0SpVFVVOR NYO5c5JLUUN3ME2xNEDPxE1? M1Lqc|I{QDR2MEO4
SK-N-DZ NUXPPI5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[xNEDPxE1? NUTwcGNLPzJiaB?= NVPC[3BzTE2VTx?= NVvBZYxWUUN3ME2xNEDPxE1? NYjNfZFoOjN6NESwN|g>
SK-N-F1 NF;iRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3yw[lExKM7:TR?= NWriZ41EPzJiaB?= NFHnTJdFVVOR NF\EXmRKSzVyPUGwJO69VQ>? M4mxZlI{QDR2MEO4
SKOV-3 MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPWUFdCOTBizszN MVK3NkBp M{TsT2ROW09? Mlf6TWM2OD1zMDFOwG0> MX2yN|g1PDB|OB?=
SK-UT-1 NUn6b|VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV6xNEDPxE1? NFnDbY04OiCq MVvEUXNQ MVHJR|UxRTFyIN88US=> NV[3fGlGOjN6NESwN|g>
SN12C M4e5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUGzWHNJOTBizszN M3;HcFczKGh? NUHwTm9zTE2VTx?= MnTLTWM2OD1zMDFOwG0> M{XtWFI{QDR2MEO4
SNB-19 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvwNVAh|ryP NHSzU5Q4OiCq NWHEZYw4TE2VTx?= NFX4U3lKSzVyPUGwJO69VQ>? NX;ZTXBCOjN6NESwN|g>
SNU-5 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\UdFRrOTBizszN M{TWUlczKGh? MYrEUXNQ NXrLZWtrUUN3ME2xNEDPxE1? M4rsdlI{QDR2MEO4
SNU-16 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDZNVAh|ryP Ml;IO|IhcA>? NIPRV|lFVVOR NGXNU2xKSzVyPUGwJO69VQ>? NHnhTWczOzh2NECzPC=>
SNU-398 M1[0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDjNVAh|ryP MoPiO|IhcA>? MmO3SG1UVw>? M1rKSGlEPTB;MUCg{txO MlfKNlM5PDRyM{i=
SNU-449 NWK0SVdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnqVlcyOCEQvF2= NEL1V|A4OiCq M3TEPGROW09? M3Tq[mlEPTB;MUCg{txO NIX6O5EzOzh2NECzPC=>
SR NWrPSmg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\BUGdUOTBizszN NEnjVpU4OiCq MWfEUXNQ NULKUmF4UUN3ME2xNEDPxE1? MWSyN|g1PDB|OB?=
ST486 M1\hXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXexNEDPxE1? MV:3NkBp MmHpSG1UVw>? MWjJR|UxRTFyIN88US=> NVzQOWoyOjN6NESwN|g>
SW579 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13ad|ExKM7:TR?= MkPGO|IhcA>? NFLkOWFFVVOR M4LVR2lEPTB;MUCg{txO NGj4R|UzOzh2NECzPC=>
SW684 NEXPdmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLFNVAh|ryP NIrZWGY4OiCq NUn5emRCTE2VTx?= MV;JR|UxRTFyIN88US=> NULyZo1bOjN6NESwN|g>
SW-780 MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3CeFQyOCEQvF2= M4fTXFczKGh? MVzEUXNQ NW[yemtYUUN3ME2xNEDPxE1? MlnnNlM5PDRyM{i=
SW900 NED5NpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjxTog{OTBizszN M4jLfFczKGh? NUP5OHdYTE2VTx?= MUXJR|UxRTFyIN88US=> MlHhNlM5PDRyM{i=
SW1088 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUixNEDPxE1? NXPtOmdWPzJiaB?= NYDSWG9iTE2VTx?= MnXiTWM2OD1zMDFOwG0> Mk\qNlM5PDRyM{i=
SW1463 NFvPWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPicGwyOCEQvF2= MYq3NkBp NYPXOIE6TE2VTx?= MUPJR|UxRTFyIN88US=> M37jTFI{QDR2MEO4
SW1990 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfyNVAh|ryP MlzFO|IhcA>? NUPFUWI4TE2VTx?= MkL2TWM2OD1zMDFOwG0> MWeyN|g1PDB|OB?=
T47D NEjxboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GwclExKM7:TR?= M4PDVlczKGh? NXeydG5uTE2VTx?= MWTJR|UxRTFyIN88US=> Mnz3NlM5PDRyM{i=
TE381.T M3ziNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;Zb|ExKM7:TR?= MoH6O|IhcA>? M2CyU2ROW09? M3HLcWlEPTB;MUCg{txO M1SyeFI{QDR2MEO4
TK-10 NFH5O2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy5V4xOOTBizszN MYq3NkBp NHrmR2dFVVOR MYfJR|UxRTFyIN88US=> MVKyN|g1PDB|OB?=
U2OS NWfGVIRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNEDPxE1? Mn7kO|IhcA>? NWPmcmVtTE2VTx?= NYHxWJBlUUN3ME2xNEDPxE1? MUCyN|g1PDB|OB?=
U251 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHmbVBpOTBizszN MmTwO|IhcA>? Mme2SG1UVw>? NHLBXVVKSzVyPUGwJO69VQ>? Mk\mNlM5PDRyM{i=
UACC-812 NYnDOY9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP3WFIyOCEQvF2= NYCwdXJXPzJiaB?= MVnEUXNQ M1e3RWlEPTB;MUCg{txO MkH4NlM5PDRyM{i=
YAPC M1flfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXBNVAh|ryP NIHVRVc4OiCq M3KwbmROW09? NIHZ[pVKSzVyPUGwJO69VQ>? NXXzUGtCOjN6NESwN|g>
ZR-75-1 M4r5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYKxNEDPxE1? NIS2[Wg4OiCq MlzPSG1UVw>? MofzTWM2OD1zMDFOwG0> M1v0T|I{QDR2MEO4
A375 NI\2W3JHfW6ldHnvckBie3OjeR?= MnTFNU4zKM7:TR?= M4faSFQhcA>? NGLwU2FFVVOR MX3Jcohq[mm2aX;uJI9nKHCqb4PwbI9zgWyjdHnvckBw\iCPRVusJGVTUyxiYX7kJHM3WA>? NXGxeYNkOjJ|OEm0O|E>
YUSIT1 Mo\pSpVv[3Srb36gZZN{[Xl? NXX5UmY5TE2VTx?= M4\FN5Jm\HWlZXSgd4Vve2m2aY\peJkhf2m2aDDJR|UxKD5iMD61JO69VQ>? MmPINlI{QDl2N{G=
MeWo NGLEUmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrEUXNQ NVqwfm9RUUN3MDC9JFk5PyCwTR?= MYCyOlAyQDV{NB?=
WiDr MnriS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV;vVW5xTE2VTx?= MVLJR|UxKD1iN{[gcm0> NV[wXIw6OjZyMUi1NlQ>
Colo-205 M3LyWWZ2dmO2aX;uJIF{e2G7 M2flflEh|ryP MVe0JIQ> NIPNWXZFVVOR MUnJcoR2[2WmIHGgbIlocGy7IHPvcZBiemGkbHWgZ49ueGGldHnvckBxcGWwb4T5dIU> Mlv3NlU{QDFzNUK=
RBW-1 NHjP[otHfW6ldHnvckBie3OjeR?= NVPrXVVXOSEQvF2= M1HpSGROW09? NYPN[GM5Vm9icnXkeYN1cW:wIH;mJG1mcyBzL{KgdIhwe3Cqb4L5cIF1cW:w NX34OJRQOjR6OEW2PVA>
RBO-1 NFzuNINHfW6ldHnvckBie3OjeR?= M{nQXlEh|ryP MYjEUXNQ M13qRWlvcGmkaYTpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> NE\BeoUzPDh6NU[5NC=>
RBO-2 MXTGeY5kfGmxbjDhd5NigQ>? MX:xJO69VQ>? MlHkSG1UVw>? M{LJeWlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v M{DnR|I1QDh3Nkmw
RBOW NX\GSFF4TnWwY4Tpc44h[XO|YYm= NFzSVVYyKM7:TR?= MljESG1UVw>? NGXYcYNKdmirYnn0bY9vKG:oIDDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? MoPjNlQ5QDV4OUC=
M257 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPO[4UyODBibl2= NUT2RlRHPzJiaB?= M2fWfWRw\XNibn;0JIlvcGmkaYSgdJJwdGmoZYLheIlwdiCxZjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= NHXvbZIzOzNzN{S0Oi=>
LCP Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvHbWxLOTByIH7N NYW2WnhVPzJiaB?= NYLZd|VRUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? MlHZNlM{OTd2NE[=
WM266 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ldHIyOTByIH7N MWi3NkBp NGe1R3FKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiV12yOlYh[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNWQhdXW2YX70ZZRqd25? MWSyN|MyPzR2Nh?=
M257 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSxNFAhdk1? M4PPdlczKGh? MlrNSI9meyCwb4SgbY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI M4LVb|I{OzF5NES2
LCP M17aRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLKNVAxKG6P M4jwclczKGh? M3zvRWlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDMR3Ah[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNHIhdXW2YX70ZZRqd25? NXnPR3I5OjN|MUe0OFY>
WM266 MmrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYGxNFAhdk1? NXLPO|BQPzJiaB?= NF7OcYNKdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gW20zPjZiY3XscEBp[XKkb4XybY5oKEKUQV[gWlYxOERibYX0ZY51[XSrb36= NEjr[5YzOzNzN{S0Oi=>

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
体内 順序で溶剤を入れること:
30% PEG400+0.5% Tween80+5% propylene glycol
8 mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 519.56
化学式

C23H20F3N5O2S2

CAS No. 1195765-45-7
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

Related Antibodies

Raf信号経路図

Raf Inhibitors with Unique Features

相関Raf製品

Tags: Dabrafenib (GSK2118436)を買う | Dabrafenib (GSK2118436) ic50 | Dabrafenib (GSK2118436)供給者 | Dabrafenib (GSK2118436)を購入する | Dabrafenib (GSK2118436)費用 | Dabrafenib (GSK2118436)生産者 | オーダーDabrafenib (GSK2118436) | Dabrafenib (GSK2118436)化学構造 | Dabrafenib (GSK2118436)分子量 | Dabrafenib (GSK2118436)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID