Fenoprofen calcium hydrate

別名:Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate

Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).

Fenoprofen calcium hydrate化学構造

CAS No. 71720-56-4, 53746-45-5

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 103200 国内在庫あり
JPY 18100 国内在庫あり

代表番号: 045-509-1970|電子メール:[email protected]
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文献中Selleckの製品使用例(1)

製品安全説明書

現在のバッチを見る: S302701 DMSO] 48 mg/mL] false] Ethanol] 18 mg/mL] false] Water] Insoluble] false 純度: 99.29%
99.29

Fenoprofen calcium hydrate関連製品

Immunology & Inflammation related阻害剤の選択性比較

生物活性

製品説明 Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).
In Vitro
In vitro

Fenoprofen is a more potent inhibitor of collagen-induced platelet aggregation than either aspirin or phenylbutazone. [1] Fenoprofen inhibits the formation of palmitoyl-CoA in both microsomal and peroxisomal fractions, and inhibits the beta-oxidation of lignoceric acid and cerotic acid in rat hepatocytes. [5] Fenoprofen exhibits modest antiproliferative activity against HT-29, DID-1, and SW480 cells with IC50 of 240 μM, 300 μM, and 360 μM, respectively. [6] Fenoprofen (0.1 mM) is an efficient activator of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to a degree comparable to that obtained with the PPARγ ligands BRL49653 and 15-deoxy-D12,14-PGJ2 and the peroxisome proliferator Wy14643. Fenoprofen is also an efficacious activator of PPARα, activating the receptor to a degree comparable to that obtained with the strong peroxisome proliferator Wy14643. Consistently, Fenoprofen treatment promotes lipogenesis in C3H10T1/2 cells. [7] Although Fenoprofen displays only modest antiproliferative activity, Fenoprofen amides can potently induce cell cycle arrest at the G1 phase, as well as apoptosis, probably because of a greater lipophilicity and/or better cell uptake. [9]

細胞実験 細胞株 HT-29, DID-1, and SW480
濃度 Dissolved in DMSO, final concentrations ~1 mM
反応時間 6 days
実験の流れ

Cells are exposed to various concentrations of Fenoprofen for 6 days. Cell number is determined using the SRB colonimetnic protein stain assay. After 6 days of culture, cells are fixed by the addition of cold trichloroacetic acid to a final concentration of 10%. Plates are incubated at 4 °C for 1 hour, then the supernatant is aspirated and the plates are washed with deionized water. SRB solution is formulated to 0.4% w/v in 1% acetic acid; 100 μL is added to each well and the plates are incubated for 10 minutes at room temperature. Unbound SRB is removed by washing with 1% acetic acid followed by air drying. Bound stain is solubilized with 50 mM unbuffered Tris and absorbance is read by an automated spectrophotometer at a single wavelength of 540 nm.

In Vivo
In Vivo

Oral administration of Fenoprofen at 50 mg/kg potently inhibits thrombus formation by 47%, whereas a dose of 200 mg/kg of aspirin is required to reduce thrombus formation 21 %. [1] Similar to indomethacin, adminstration of Fenoprofen inhibits prostaglandin synthesis. [2] In rats with type II collagen-induced arthritis, Fenoprofen treatment at 40 mg/kg/day partially suppresses the paw swelling, but has no significant effect on humoral and cellular responses. [3] Administration of Fenoprofen depresses the rebound contraction, thus transforming the brisk relaxant response, elicited by vagal stimulation or ATP, into long-lasting relaxation. [4] Administration of Fenoprofen causes a strong and dose-related induction of peroxisomal palmitoyl-CoA oxidase, and of carnitine acyltransferase and acyl-CoA hydrolase activities in liver homogenates of mice fed diets. Hepatic catalase activity is significantly increased in mice fed the diet with 0.05 and 0.1% fenoprofen but not the 1% fenoprofen-containing diet. [8]

動物実験 動物モデル Guinea pigs with induced thrombus formation
投与量 ~200 mg/kg
投与経路 Orally

化学情報

分子量 558.63 化学式

C30H30CaO8

CAS No. 71720-56-4, 53746-45-5 SDF Download Fenoprofen calcium hydrate SDFをダウンロードする
Smiles CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)[O-].CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)[O-].O.O.[Ca+2]
保管

In vitro
Batch:

DMSO : 48 mg/mL ( (85.92 mM); 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : 18 mg/mL

Water : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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