Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839)は一種のEGFR阻害剤で、NR6wtEGFRとNR6Wの細胞中のTyr1173、Tyr992、Tyr1173とTyr992に作用する時のIC50値が37 nM、37nM、26 nMと57 nMにそれぞれ分かれることです。

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JPY 31706.00
JPY 24402.00
JPY 44820.00

文献中の使用例(91)

カスタマーフィードバック(12)

  • Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

    Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

  • (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

    LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

  • Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839)は一種のEGFR阻害剤で、NR6wtEGFRとNR6Wの細胞中のTyr1173、Tyr992、Tyr1173とTyr992に作用する時のIC50値が37 nM、37nM、26 nMと57 nMにそれぞれ分かれることです。
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB NIexUIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETlUWlKSzVyPUCuNFU1KM7:TR?= MoHmNVY2OTZ2N{O=
NIH3T3 MUTGeY5kfGmxbjDBd5NigQ>? M1GxSVAvOiEQvF2= MVOyJIg> MlzFSG1UVw>? NH3ueohKdmirYnn0bY9vKG:oIFXHSkB{fGmvdXzheIVlKGi3bXHuJIVz[kJzIHH1eI9xcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEG0OEDPxE1? MVqxOlQ5ODJ6NB?=
COS7 NIjWN4NHfW6ldHnvckBCe3OjeR?= MVO5OkDPxE1? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzJiVk[xO2YhdXW2YX70JIV5eHKnc4Pl[C=> NFvke4IyPzF5OEeyNi=>
A549 NETKWWtEgXSxdH;4bYMhSXO|YYm= M3n5dFk3KGh? Mnf2SG1UVw>? M4jySGlEPTB;MUOuOVkh|ryP NWL5T2Z[OTh|MUO4NFc>
K562 NHzFcYpEgXSxdH;4bYMhSXO|YYm= MkKzPVYhcA>? MX\EUXNQ MULJR|UxRTlwM{[g{txO MWmxPFMyOzhyNx?=
MDA-MB-231 MXrDfZRwfG:6aXOgRZN{[Xl? M3u4N|k3KGh? NITofmxFVVOR NYnXO|JzUUN3ME2zOk43OSEQvF2= M2XyeFE5OzF|OEC3
MOLT4 Ml6wR5l1d3SxeHnjJGF{e2G7 NIn6SXk6PiCq Mk\rSG1UVw>? MojFTWM2OD1zNT6wNkDPxE1? M1zUXFE5OzF|OEC3
MCF7 M{LNeGN6fG:2b4jpZ{BCe3OjeR?= NETNelc2OCEQvF2= MUe3NkBp M2PyXWlEPTB;MUKuNFUh|ryP NXrhVZN3OTh5N{G4NVk>
BT474 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPwfpk4OiCq NEfHSGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOFc1KGOnbHzzJI93\XKneIDy[ZN{cW6pIFXSRoIzKHerdHigSWM2OCCxZjCwMlMh|ryP MnyzNVkxOjh2MkS=
HN5 M{nz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Q[GtqPzJiaB?= MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiQNTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghTUN3MDDv[kAxNjBzIN88US=> MmDENVkxOjh2MkS=
BA/F3 M3LoemN6fG:2b4jpZ{BCe3OjeR?= MUC3NkBp NF74SHNEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFXHSnIhVDh3OGKgcZV1[W62IIfpeIghUUN3MDDv[kAxNjBzMEig{txO MVKxPVI{QTJ{OR?=
NIH3T3 NUK4R4pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjvO|IhcA>? Ml7hS5Jwf3SqIHnubIljcXSrb36gc4YhdW:3c3WgUmlJNzOWMzDj[YxteyCneIDy[ZN{cW6pIHXyRlIh\2WwZTD3bZRpKEmFNUCgc4YhOC53NDFOwG0> NUTIUYdsOTl4NkWzO|c>
MCF7 MX MWfGeY5kfGmxbjDBd5NigQ>? MVmzNEBucW5? MVvJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJJdqfGhiSVO1NEBw\iBzLkGg{txO NULWSYd6OTl7M{K5OlA>
A431 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYO0fVdoOTBizszN MWS3NkBp M2G0T2dKPTB;MD61NVQh|ryP MmTuNVk6Pjl2NkW=
A431 NFfwcWZMcW6jc3WgRZN{[Xl? MoXYNE4yKM7:TR?= NXL3Z|FPOSCq MkLtTY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> MXuxPVk3QTR4NR?=
A431 MknVT4lv[XOnIFHzd4F6 Mm[5NVAxKM7:TR?= MkP3NVAhdWmw MWnQdo9td26pZXSgbY5pcWKrdH;yfUBi[3Srdnn0fUBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> Mn3CNVk6Pjl2NkW=
Sf9 MnL2T4lv[XOnIFHzd4F6 MmrENVAhdWmw NXPmRW1ZTE2VTx?= MXvJcohq[mm2aX;uJI9nKEWJRmKg[ZhxemW|c3XkJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdoVk\XC2b4KgZZV1d3Cqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wN|Mh|ryP NIfFOGgzODB3NkSyOS=>
NCI-H1975 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjQVXRGPSEQvF2= NWT5Wnp1PzJiaB?= MnfBTWM2OD16LkK2JO69VQ>? NEnTSZQzODF3MU[3NC=>
NCI-H1975 MUnLbY5ie2ViQYPzZZk> MnzKNVAh|ryP NYOwbXpQUW6qaXLpeIlwdiCxZjDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25? MlLLNlAyPTF4N{C=
NCI-H1975 M1HQemZ2dmO2aX;uJGF{e2G7 M2roWFExKM7:TR?= M{XFVGlvcGmkaYTpc44hd2ZiRWLCRlIh[XW2b4Doc5NxcG:{eXzheIlwdg>? MlX3NlAyPTF4N{C=
NCI-H1975 M3X3bWZ2dmO2aX;uJGF{e2G7 MmPOOUDPxE1? NYH3ZnBmPDhiaB?= NGrzcZBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHHzd4V{e2WmIHHzJIFkfGm4YYTpc44hd2ZiY3HzdIF{\S1| NUDTcWJSOjBzNUG2O|A>
A375 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYG0PEBp MUDJR|UxRTJyLkW1JO69VQ>? NIL3e3kzODNyNEWzOy=>
SMMC7721 NYn6dYRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHzOFghcA>? NUPCTVhpUUN3ME2zN{4yOiEQvF2= MXWyNFMxPDV|Nx?=
DU145 Mnn6R5l1d3SxeHnjJGF{e2G7 Mmn5OUBl NH;Qe4RFVVOR NYTt[pF3UUN3ME20Nk4yPyEQvF2= MoK0NlA1PjZ3NUW=
MIAPaCa2 MmfxR5l1d3SxeHnjJGF{e2G7 NX;jSW5[PSCm NXHH[FZsTE2VTx?= NX\CTm1nUUN3ME21NE43OiEQvF2= NEXtWYMzODR4NkW1OS=>
PANC1 NGG3XlZEgXSxdH;4bYMhSXO|YYm= MVi1JIQ> MVTEUXNQ NUC4O|hTUUN3ME20NE41OiEQvF2= NEG2SJUzODR4NkW1OS=>
PC9 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj6WFhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGVITlJvZHXmbYNq\W62IHj1cYFvKFCFOTDj[YxteyC5aYToJGVEPTBib3[gNE4xOTdizszN MnqyNlEzODh6MEK=
PC9 NV\0fZJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDndo94fGhvcnXzbZN1[W62IHj1cYFvKFCFOTDj[YxteyCneIDy[ZN{cW6pIFXHSnIhTTd2Nm;BO|UxN1R5OUDNJI12fGGwdDD3bZRpKEWFNUCgc4YhPyEQvF2= NXrmeXh7OjF{MEi4NFI>
PC3 Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjSNVAh|ryP MofXO|IhcA>? MXLEUXNQ NV7DPIU1UUN3ME23MlQh|ryP Ml\XNlE{PTN3NE[=
MDA-MB-468 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7VPXgyODBizszN NXzrVGZRPDhiaB?= MUfEUXNQ NGnXfZlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fS=> MVKyNVQzQTZ|Mh?=
Plasmodium falciparum NFnwWWdyUFSVIIDyc4ZqdGmwZzDmc5IhcW6qaXLpeI9zeyCxZjDQcIF{dW:maYXtJIZidGOrcHHyeY0heHKxbHnm[ZJifGmxbh?= NXrNZZB7OjF6MUewOFU>
NCI-H1993 NUXXVoh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHjVXo4OiCq MWfEUXNQ NWPZPW03UUN3ME2wMlEh|ryP MXGyNVkyPjR|Mx?=
NCI-H292 NYPqfZo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\lO|IhcA>? MmP2SG1UVw>? M2DhV2lEPTB;MD6wNkDPxE1? Mn3iNlE6OTZ2M{O=
A431 M4rqUGtqdmG|ZTDBd5NigQ>? MXOyJIg> NHLxWopFVVOR NHu3O4JKdmirYnn0bY9vKG:oIFXHSnIheGixc4Doc5J6dGG2aX;uJIlvKEWJRj3zeIlufWyjdHXkJIh2dWGwIFG0N|Ehf2m2aDDJR|UxKG:oIECuNFAyKM7:TR?= MlvyNlIyODFzM{K=
MCF7 MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe3TVIyODEEoN88[{9uVA>? MnHGOFghcA>? M331dWROW09? NIXaNVFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgc5ZmemW6cILld5NqdmdiRVfGVkBo\W6nIIfpeIghUUN3MDDv[kAyOi5yNTFOwG0> NUf2SI9XOjJzMUmxN|A>
BT474 NYi2[41CS3m2b4TvfIlkKEG|c3H5 NWPDcIdLOTBizszN NUC2SJNGPDhiaB?= NWXnPYNFS3m2b4TvfIlkcXS7IHHnZYlve3Ric3XyeY0ue3Sjco\l[EBpfW2jbjDCWFQ4PCClZXzsdy=> NYLN[odVOjJzM{izNFg>
MCF7 NGTlW2NEgXSxdH;4bYMhSXO|YYm= MlfqNVAh|ryP NEThUXY1QCCq Ml7jR5l1d3SxeHnjbZR6KGGpYXnud5Qhe2W{dX2td5Rien[nZDDoeY1idiCPQ1[3JINmdGy|IH;2[ZIu\XiycnXzd4lv\yCHcnLCNkBk\Wyucx?= NYPRRY1UOjJzM{izNFg>
HCC827 NHzwPHVMcW6jc3WgRZN{[Xl? NVz0Rm1VOC5zMkWg{txO M3;6TVI1KGh? M{LEd2ROW09? MXLJcohq[mm2aX;uJI9nKEWJRmKg[IVtKEV5NE[tRVc2OCCvdYThcpQhYTFyNkigZZV1d3Cqb4PwbI9zgWyjdHnvci=> NFzZ[GEzOjN|OUO0Ni=>
HCC827 MljrT4lv[XOnIFHzd4F6 MV6wMlEzPSEQvF2= MYWyOEBp MWPEUXNQ M3rWdmlvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfC2vZXTpZZRm\CCHcnugdIhwe3Cqb4L5cIF1cW:w MV2yNlM{QTN2Mh?=
HCC827 Mme5T4lv[XOnIFHzd4F6 MWCwMlEzPSEQvF2= M2TwS|I1KGh? NYixeGhSTE2VTx?= NHnQSnNKdmirYnn0bY9vKG:oIFXHSnIh\GWuIFW3OFYuSTd3MDDteZRidnRvbXXkbYF1\WRiQXv0JJBpd3OyaH;yfYxifGmxbh?= NWnTb|dLOjJ|M{mzOFI>
A431 NGHBNnFMcW6jc3WgRZN{[Xl? MYexNFAh|ryP M{HJdFMxKG2rbh?= MkjyTY5pcWKrdHnvckBw\iCHR1\SJIRmemm4ZXSg[pJwdSCqdX3hckBCPDNzIHPlcIwhdWWvYoLhcoUh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxd2y7LVfseU1VgXJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCxMlA5KM7:TR?= NGrk[2MzOjZ7OEe4Ni=>
H460 MVnDfZRwfG:6aXOgRZN{[Xl? M{KxdVczKGh? NX:yU3ZyUUN3ME21MlU6KM7:TR?= NYX1cFdiOjJ5Mke0OFk>
HT-29 MUPDfZRwfG:6aXOgRZN{[Xl? MWm3NkBp M1vBPGlEPTB;Mz6zOkDPxE1? MXiyNlczPzR2OR?=
SGC7901 MnK4R5l1d3SxeHnjJGF{e2G7 MkjCO|IhcA>? M3zq[2lEPTB;MUCuNlYh|ryP NYnEbWpoOjJ5Mke0OFk>
A498 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2OUigZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKGGwZDDTVmMhf2m2aDDJR|UxKG:oIEiuOkDPxE1? M3n2bVIzQDF6OES4
Calu3 MlvVR5l1d3SxeHnjJGF{e2G7 MlK4NVAh|rypL33M MX[3NkBp NIDwfZVKSzVyPUGuOkDPxE1? M4j4TlI{OTF4MU[4
FADU NUnWZVFqS3m2b4TvfIlkKEG|c3H5 M{HZd|ExKM7:Zz;tUC=> NG\sSmU4OiCq NHTZOndKSzVyPUCuNFUh|ryP MkLVNlMyOTZzNki=
HCC827 MXjDfZRwfG:6aXOgRZN{[Xl? M1zjNlExKM7:Zz;tUC=> M1HyflczKGh? M37KPWlEPTB;MD6wNFE2KM7:TR?= NFG2d4wzOzFzNkG2PC=>
PC9 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jBdVExKM7:Zz;tUC=> MofKO|IhcA>? NUjJeXR7UUN3ME2wMlAxOTRizszN NH\MfJIzOzFzNkG2PC=>
Sf9 NWTy[|FZU2mwYYPlJGF{e2G7 M{LTSVEhcA>? M3zDbGROW09? NWrPVG9EUW6qaXLpeIlwdiCxZjDoeY1idiCJU2SteIFo\2WmIFXHSnIhVDh|NGKgcZV1[W62IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOC5yMUWg{txO NHzxb2gzOzZzMU[5NS=>
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SW620 MWHDfZRwfG:6aXOgRZN{[Xl? NHnDSGs1QCCq MVLEUXNQ NYX6SYFFUUN3ME2yPE4zKM7:TR?= NFv4TIozPDlyMEW5OC=>
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HCC827 MlPiSpVv[3Srb36gRZN{[Xl? M1nNPFAvPSEQvF2= MWmyJIg> MWDEUXNQ Mn[0[I9meyCwb4SgbY5pcWKrdDDjMW1mfCCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHB2ND:0NkBxcG:|cHjvdplt[XSrb36= Ml\wNlM6QTN|Mki=
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LB2241-RCC MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF7ND65N{BvVQ>? NUL4W2JFW0GQR1XS
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BT-20 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7ncnlJUUN3ME2yMlI3PzR2IN88US=> NVz5[ng2W0GQR1XS
A498 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfXU2hKSzVyPUKuNlk1OTVizszN M4\DXHNCVkeHUh?=
IGROV-1 NX3yeWF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLoUHNKSzVyPUKuN|EzOzdizszN MnroV2FPT0WU
JVM-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfJb5JuUUN3ME2yMlM1PjR|IN88US=> M1qxe3NCVkeHUh?=
NCI-H2170 M1:4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHS[ZVKSzVyPUKuN|Q4QDNizszN MnntV2FPT0WU
EW-18 NEfmWVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXBOJhLUUN3ME2yMlM2PDdzIN88US=> MkPSV2FPT0WU
KU812 M2PnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf6VJh3UUN3ME2yMlM3Pzd7IN88US=> MlfRV2FPT0WU
NY NGS3[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTJwM{eyO{DPxE1? M{fze3NCVkeHUh?=
HTC-C3 MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXadGxKSzVyPUKuOFIzPjdizszN MV;TRW5ITVJ?
CFPAC-1 NEWxeYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XKcGlEPTB;Mj60N|g3PCEQvF2= NHTQO5JUSU6JRWK=
HH MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:4UnlSUUN3ME2yMlQ6QDV2IN88US=> MkjBV2FPT0WU
MKN7 M4TkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nBV2lEPTB;Mj62Nlc1QCEQvF2= MVLTRW5ITVJ?
TE-8 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJwNkO2OVMh|ryP NF\OcHBUSU6JRWK=
MC-IXC NF;1[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzyTWM2OD1{Lk[0OFU{KM7:TR?= NX7HPVN{W0GQR1XS
DMS-79 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r0UWlEPTB;Mj62PVI5PCEQvF2= MmnlV2FPT0WU
Detroit562 M3TEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJwNkm4OFUh|ryP MlT5V2FPT0WU
HuP-T4 NIXPUHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPXTWM2OD1{LkeyPFE5KM7:TR?= M4TNR3NCVkeHUh?=
QIMR-WIL NHfGW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3HS5loUUN3ME2yMlc2QTV{IN88US=> NXPUc|FOW0GQR1XS
BB65-RCC MnjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPjRWtOUUN3ME2yMlgxPzF|IN88US=> NF7td3NUSU6JRWK=
PC-3 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjDOWVKUUN3ME2yMlg{OzF5IN88US=> MmXwV2FPT0WU
OVCAR-3 NFPvVmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXryVpM2UUN3ME2yMlg2PTl2IN88US=> NWXrbYd5W0GQR1XS
KYSE-510 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XIPWlEPTB;Mj64Olc5PiEQvF2= M1LRTnNCVkeHUh?=
HC-1 NXL1cGM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTrdllYUUN3ME2yMlk1ODF{IN88US=> M4npZnNCVkeHUh?=
NCI-H1693 M4LWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHMZ2l1UUN3ME2yMlk2QDl5IN88US=> M2DEWXNCVkeHUh?=
DU-4475 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwOUmwOVIh|ryP MlnkV2FPT0WU
COLO-680N NEXDdmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjNTWM2OD1|LkCwOFk2KM7:TR?= M4e4TnNCVkeHUh?=
MN-60 M{KyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknlTWM2OD1|LkC0PVc1KM7:TR?= MmXPV2FPT0WU
BCPAP MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17hb2lEPTB;Mz6wPFI6PSEQvF2= MoH1V2FPT0WU
647-V NHr2NVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H6SmlEPTB;Mz6xOlIzKM7:TR?= M1HxbHNCVkeHUh?=
HT-1376 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfhTWM2OD1|LkKwOVA3KM7:TR?= NF;LPHFUSU6JRWK=
NCI-H1793 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfmTWR3UUN3ME2zMlIyODl6IN88US=> MX3TRW5ITVJ?
SW1463 M2C0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnwNpRHUUN3ME2zMlI3OTl{IN88US=> NGn3O|FUSU6JRWK=
NCI-H727 NH3UW5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLYZmxKSzVyPUOuN|g2QDRizszN NYnKV|RMW0GQR1XS
LB771-HNC NX;iVmpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKybYdGUUN3ME2zMlM6OTJ4IN88US=> Ml3HV2FPT0WU
D-542MG NV;DcZViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nPU2lEPTB;Mz60OFIzOiEQvF2= NUf3cmpUW0GQR1XS
NTERA-S-cl-D1 NHrIbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTNwNES5OVch|ryP NYr6WIV{W0GQR1XS
C8166 M4j4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTNwNE[1NlEh|ryP MmfMV2FPT0WU
639-V MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P0eWlEPTB;Mz61O|c6OiEQvF2= M3z3dXNCVkeHUh?=
TE-1 M17U[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XWT2lEPTB;Mz61PVE3QSEQvF2= NGTyOlJUSU6JRWK=
OAW-28 NV3ab4FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnPTWM2OD1|LkW5OFI3KM7:TR?= MX7TRW5ITVJ?
SK-LU-1 NHnScmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTNwNkC2OFUh|ryP NUDmZotKW0GQR1XS
CaR-1 M{LYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTNwNkGwOFgh|ryP M3jlfnNCVkeHUh?=
A2780 NVPRd5p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTNwNkSwPFkh|ryP NX;WU41UW0GQR1XS
C2BBe1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO4PI93UUN3ME2zMlY1PDB5IN88US=> M{[3eXNCVkeHUh?=
SK-MES-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3ISoRsUUN3ME2zMlY1PjF2IN88US=> M33kS3NCVkeHUh?=
PANC-10-05 NELTbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfVT4VQUUN3ME2zMlczODd{IN88US=> NW\OO5VsW0GQR1XS
J-RT3-T3-5 M4[1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i1[2lEPTB;Mz63OVQxPiEQvF2= NVf0RXhXW0GQR1XS
ES4 NIT3cGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTNwOEKyPFYh|ryP Ml\TV2FPT0WU
NCI-H28 MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfiUY5MUUN3ME2zMlgzQTZzIN88US=> MnnsV2FPT0WU
NCI-H1155 M3zBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjNfYw6UUN3ME2zMlg1OTV7IN88US=> MoD1V2FPT0WU
KURAMOCHI MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;UTWM2OD1|Lki2NFU3KM7:TR?= MVvTRW5ITVJ?
NCI-H69 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTNwOUCxO|gh|ryP NV3yTnFWW0GQR1XS
IST-MES1 M2naU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PXRWlEPTB;Mz65OFAzQSEQvF2= NWXiSYpjW0GQR1XS
NH-12 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHjSZNWUUN3ME2zMlk1OTh5IN88US=> NXXlO2s4W0GQR1XS
JVM-2 M33FSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\OOnM6UUN3ME2zMlk1PzV{IN88US=> NV\xSlJmW0GQR1XS
EW-16 M1fnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTNwOUW1O|ch|ryP M{HSVnNCVkeHUh?=
NCI-H441 MonES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELj[4hKSzVyPUOuPVcxOTRizszN NI\4XWxUSU6JRWK=
RCC10RGB NX35WHI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPmTWM2OD12LkCxNlQ3KM7:TR?= M4Hp[HNCVkeHUh?=
TCCSUP MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfpOWhVUUN3ME20MlEyODVizszN NHS3SnNUSU6JRWK=
HL-60 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETPPXVKSzVyPUSuNVIzPDFizszN MoHWV2FPT0WU
EW-11 NITTbFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;1RWlEPTB;ND6xN|I3OSEQvF2= NXz1Z5E3W0GQR1XS
KARPAS-299 M4[3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGry[3dKSzVyPUSuN|ExOTNizszN MmDxV2FPT0WU
SNU-C2B M1;rXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTRwM{S2PFYh|ryP MoHTV2FPT0WU
LU-139 NIrmc45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[3TWM2OD12LkO3NlQ4KM7:TR?= M1:0dXNCVkeHUh?=
HCC1937 M4DJXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTRwM{e5PVMh|ryP MXTTRW5ITVJ?
GR-ST MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nMW2lEPTB;ND60N|E5KM7:TR?= MUjTRW5ITVJ?
SK-OV-3 NHnDcG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTRwNE[wOFIh|ryP NYHseVdxW0GQR1XS
A172 NHm1TGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzZRllKSzVyPUSuOVU2OjFizszN Mke4V2FPT0WU
NB10 NGHZNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTRwNUm3PFEh|ryP NF\qUlZUSU6JRWK=
P30-OHK NHzXUI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fEemlEPTB;ND64NVkzQSEQvF2= MkjYV2FPT0WU
KYSE-520 M1L6Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nnR2lEPTB;ND64PFAyQCEQvF2= NH;oTGVUSU6JRWK=
KNS-62 MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTDdVR7UUN3ME20MlkxQDB5IN88US=> M1\aUXNCVkeHUh?=
ES1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT6TWM2OD12Lkm2NFM2KM7:TR?= NFjabYVUSU6JRWK=
KOSC-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvhTWM2OD12Lkm5PVU6KM7:TR?= NUnDeWljW0GQR1XS
TE-9 NEC1SYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK5cXR[UUN3ME21MlAyPTJ3IN88US=> MnnSV2FPT0WU
NCI-H1838 MoP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TYVGlEPTB;NT6wNlA4PiEQvF2= MmrBV2FPT0WU
KP-N-YN NFzHclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrlTWM2OD13LkGyOVkyKM7:TR?= NGH1SGRUSU6JRWK=
ALL-PO MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;XWYZKSzVyPUWuNlI2QDdizszN MlXrV2FPT0WU
NOMO-1 MlfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jYXWlEPTB;NT6yN|E4PiEQvF2= NX3oSnFpW0GQR1XS
CGTH-W-1 NHH2e5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e4WWlEPTB;NT6zPFU5PCEQvF2= M3GxWHNCVkeHUh?=
ATN-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvzdFFKSzVyPUWuOFEyQDRizszN NHHtO41USU6JRWK=
AGS M1jsOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HORWlEPTB;NT60PVYyQCEQvF2= NVPvR4VTW0GQR1XS
SW13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPaTWM2OD13LkWzNlY2KM7:TR?= MYDTRW5ITVJ?
SW1990 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTVwNkKyPFUh|ryP NWjjTFdQW0GQR1XS
BFTC-905 Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X2fmlEPTB;NT62OVg4QCEQvF2= Mly5V2FPT0WU
RMG-I M2iyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTVwNkW5OFIh|ryP NF;ZOpFUSU6JRWK=
HD-MY-Z MlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m4NGlEPTB;NT62PFU5OSEQvF2= MV;TRW5ITVJ?
HCC1187 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XtR2lEPTB;NT63NVA{OiEQvF2= NIj6eWhUSU6JRWK=
HCC2998 M{ftZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTVwN{G4O|ch|ryP NILWWZFUSU6JRWK=
RT-112 NGj0SnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnuxTWM2OD13LkmwNlQ2KM7:TR?= Mn;wV2FPT0WU
CAKI-1 M4joZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXibG4xUUN3ME22MlAxQTh3IN88US=> NYG0enpXW0GQR1XS
HDLM-2 NIDNTGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr1SVA6UUN3ME22MlAyPDh7IN88US=> NYfzZo5LW0GQR1XS
TE-10 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml33TWM2OD14LkC0PFM{KM7:TR?= MWDTRW5ITVJ?
KE-37 M{P1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTZwMEeyOVgh|ryP NY\mXVlNW0GQR1XS
RCM-1 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jIcmlEPTB;Nj6wO|cyQSEQvF2= MojCV2FPT0WU
Mewo MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTZwMUG0PFch|ryP M1vZbnNCVkeHUh?=
L-428 NIfPc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\aXJU3UUN3ME22MlE5ODN5IN88US=> NHvZdXpUSU6JRWK=
8-MG-BA NFjMXnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW4dZpKSzVyPU[uNVk{PzlizszN NX7PUGlDW0GQR1XS
SK-MEL-28 NVTIdmE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jrNmlEPTB;Nj6yNFk3PyEQvF2= NHXBRnlUSU6JRWK=
VA-ES-BJ MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjRSnRKSzVyPU[uN|A1PjJizszN MV3TRW5ITVJ?
CAL-120 NEnZfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTZwNEWxOlIh|ryP MWDTRW5ITVJ?
GAMG M1H0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH5TWM2OD14LkWwOlIh|ryP NGXKSHNUSU6JRWK=
MSTO-221H MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTZwNUGxO{DPxE1? NF7uTJlUSU6JRWK=
GCT MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzUcXZKSzVyPU[uOVM{QDdizszN MlHEV2FPT0WU
SH-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjWS2h3UUN3ME22MlU5QDR2IN88US=> NXXsNYdRW0GQR1XS
Calu-3 M{X5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq2R4xpUUN3ME22MlY2PTZ6IN88US=> MoXyV2FPT0WU
SK-HEP-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTZwN{G3OVMh|ryP MVHTRW5ITVJ?
PFSK-1 NGmxbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonsTWM2OD14LkezOFc5KM7:TR?= M1XqS3NCVkeHUh?=
NB12 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTZwN{i0NFQh|ryP NV:xTWl4W0GQR1XS
A388 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3JN2lKSzVyPU[uPFk2OiEQvF2= M1X0OnNCVkeHUh?=
KLE M3W2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\UTWM2OD14Lkm2OVE3KM7:TR?= NYLNV|Y4W0GQR1XS
TE-11 NGnJTGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W3TWlEPTB;Nz6wOFk3PyEQvF2= MmqzV2FPT0WU
NCI-H2405 Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\kN2lKSzVyPUeuNFg{QTNizszN M3noTHNCVkeHUh?=
OVCAR-4 M2LaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:5NJlJUUN3ME23MlE2OzVizszN NH\jOW5USU6JRWK=
KP-N-YS NVrTW5FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTBT|RKSzVyPUeuNVgyPCEQvF2= NIjle5ZUSU6JRWK=
NOS-1 NXvvVXFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fO[2lEPTB;Nz6yOVgzQCEQvF2= NVTnXGlHW0GQR1XS
DMS-114 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\1ZmlEPTB;Nz6yPVY{OSEQvF2= NIO4[HRUSU6JRWK=
NCI-H2030 M1;vcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3F[Ix{UUN3ME23MlM{Pjl6IN88US=> M17UfnNCVkeHUh?=
HEL M4TCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITVWZFKSzVyPUeuN|c2OjFizszN MkOyV2FPT0WU
CAL-62 M2fYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfGTWM2OD15LkO5PFY3KM7:TR?= NVvXXWk1W0GQR1XS
COLO-668 NWjOT2RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTdwNEO5Olch|ryP NYPJNYJGW0GQR1XS
SKG-IIIa MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLYTWM2OD15LkS1N|gyKM7:TR?= MlrxV2FPT0WU
HCC1419 M3vncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi1eVFkUUN3ME23MlQ3QDN|IN88US=> M{\td3NCVkeHUh?=
OS-RC-2 NGnJclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\NVGlEPTB;Nz60PVg6PCEQvF2= MnvDV2FPT0WU
COLO-829 MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;pW2hKSzVyPUeuOlY1PjNizszN M4faNnNCVkeHUh?=
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AM-38 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRThwMU[yPEDPxE1? Ml;uV2FPT0WU
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D-392MG NGTp[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7tN4JKSzVyPUiuOlYzOTRizszN MWfTRW5ITVJ?
A673 NYTNTXNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3e0SWlEPTB;OD62O|YyOSEQvF2= MnTmV2FPT0WU
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NCI-H1792 NEmyR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRThwOEi5NFMh|ryP MY\TRW5ITVJ?
LS-1034 NHf1UohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3znfGlEPTB;OD65OFY2OiEQvF2= NUj4Xpg6W0GQR1XS
D-566MG NU\W[IkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljNTWM2OD17LkCxPFEh|ryP NEXzZlBUSU6JRWK=
NCI-H226 NWfnd25WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTlwMEmg{txO MoT4V2FPT0WU
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NCI-H2228 NGfNeVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDvTWM2OD17LkGxNFgyKM7:TR?= MYjTRW5ITVJ?
RPMI-8226 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnCTWM2OD17LkGxN|A1KM7:TR?= NIHKO|BUSU6JRWK=
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Capan-2 M2DPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj0TWM2OD17LkSwNVA6KM7:TR?= MVjTRW5ITVJ?
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KP-4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm0ZlFIUUN3ME25MlQ5QDN6IN88US=> Ml\3V2FPT0WU
A101D MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTlwNUG3NVkh|ryP NY[0NFdDW0GQR1XS
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SW837 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYntXppvUUN3ME25Mlg1QDJizszN MXPTRW5ITVJ?
OCI-AML2 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDZRmVKSzVyPUmuPFY6PiEQvF2= MlzNV2FPT0WU
NCI-H1355 M2TaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXzTWM2OD17Lkm0NFg5KM7:TR?= NWjqeWtZW0GQR1XS
NCI-H2342 NHq1[mJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n4VGlEPTB;MUCuNFE2PSEQvF2= NYTrdY5[W0GQR1XS
A204 Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFyLkC0OlYh|ryP M3TQdXNCVkeHUh?=
CAL-51 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;FeYp7UUN3ME2xNE4xQDd5IN88US=> MmHoV2FPT0WU
HCE-4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXrVmdxUUN3ME2xNE4yOTJ{IN88US=> NFfW[5lUSU6JRWK=
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A2058 NGfhfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;3WWlEPTB;MUCuOVQ6OSEQvF2= NEKwVmxUSU6JRWK=
SW962 MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnZcmN[UUN3ME2xNE43OjB2IN88US=> NVvxV2lZW0GQR1XS
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HCC38 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;SSnpUUUN3ME2xNE46PzF4IN88US=> NHXQUItUSU6JRWK=
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NCI-H1299 NE[yT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz2UWpqUUN3ME2xNU43PjR5IN88US=> M1rrdXNCVkeHUh?=
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NCI-H1993 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfv[ZV[UUN3ME2xN{41Ojh3IN88US=> M1PqeXNCVkeHUh?=
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TGBC1TKB MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrhTG9PUUN3ME2xOE43PjF3IN88US=> M1zLVXNCVkeHUh?=
NCI-H630 NXHKW2JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Lb5ZnUUN3ME2xOE46PDZ5IN88US=> NWHXWGRbW0GQR1XS
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NCI-H1755 MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[3OWlEPTB;MUSuPVk2OyEQvF2= MmrqV2FPT0WU
MOLT-4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF3LkC0PVch|ryP MUDTRW5ITVJ?
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NCI-H23 NV3QXHp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnsTWM2OD1zNT64OFM5KM7:TR?= MmS0V2FPT0WU
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GP5d MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYruWpBiUUN3ME2xOk4zOTh5IN88US=> MXTTRW5ITVJ?
BHT-101 NHm1ZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTF4LkK0N|kh|ryP Ml[3V2FPT0WU
M059J MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfJdnhKSzVyPUG2MlI5PCEQvF2= MVvTRW5ITVJ?
D-283MED MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF4LkSyNFkh|ryP NXnEO4JpW0GQR1XS
BEN NGPyNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPqVZJKSzVyPUG2MlUyPTVizszN MoPGV2FPT0WU
LB373-MEL-D M4XDdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn2OJJKSzVyPUG2MlczOzJizszN MW\TRW5ITVJ?
MEL-HO M3XUS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\kZ49VUUN3ME2xOk45QDV2IN88US=> NUTVdGwyW0GQR1XS
GI-ME-N M2LySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPsVXl3UUN3ME2xOk46ODN{IN88US=> M360SHNCVkeHUh?=
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MZ2-MEL M4rZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7DTWM2OD1zNz6xN|Mh|ryP M2K5VnNCVkeHUh?=
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NCI-H1581 NIrq[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHGTWM2OD1zNz60OFEyKM7:TR?= MYrTRW5ITVJ?
NCI-H747 NGGzTVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TTRmlEPTB;MUeuOVI6PyEQvF2= MV;TRW5ITVJ?
SW1783 NIS2VWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;wT2lEPTB;MUeuOlQyPSEQvF2= NEnJfodUSU6JRWK=
Calu-6 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLuS4xvUUN3ME2xO{43Pzh{IN88US=> NHL4UmVUSU6JRWK=
SF268 NXPXbpJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MliwTWM2OD1zNz62PVY6KM7:TR?= NFu4TGxUSU6JRWK=
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D-502MG MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfuOpp{UUN3ME2xO{46QDB6IN88US=> MV\TRW5ITVJ?
HLE M1mxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yyRmlEPTB;MUiuN|E1QCEQvF2= M32xUHNCVkeHUh?=
SW982 M3nBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vJU2lEPTB;MUiuOFA4PSEQvF2= MXXTRW5ITVJ?
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NCI-H1563 NGD6PYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLGWnZwUUN3ME2xPE44OTJ2IN88US=> M33LZnNCVkeHUh?=
MFE-280 NGPKflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTsWGlKSzVyPUG4MlczQTNizszN MmizV2FPT0WU
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NB14 Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmzUWZKSzVyPUO4MlQ2PDRizszN NFK5e3JUSU6JRWK=
D-423MG NWX0TW12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\neYU2UUN3ME2zPE41QDZ7IN88US=> NYnyd244W0GQR1XS
NCI-H510A MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULUbJc2UUN3ME2zPE43PDVzIN88US=> M3PDOnNCVkeHUh?=
NMC-G1 M3fifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTN6LkeyNlIh|ryP Ml3sV2FPT0WU
SW948 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKyOWJ[UUN3ME2zPE45QTR7IN88US=> NWD1bYs6W0GQR1XS
MFM-223 NIj0dnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq2TWM2OD1|OD65OFMyKM7:TR?= MWLTRW5ITVJ?
PAN1 NIr6UWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHs[YVFUUN3ME2zPE46QTF7IN88US=> NGnOVm1USU6JRWK=
MZ7-mel M13ER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrKTWM2OD1|OT6xNVk6KM7:TR?= NWrhTGJXW0GQR1XS
COLO-679 M3\3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF6wRoNKSzVyPUO5Mlk4ODhizszN MYfTRW5ITVJ?
SW872 M2jsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvTTWM2OD12MD6yNFMyKM7:TR?= M2\SNnNCVkeHUh?=
HT-1197 MoDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTRyLkK4Olkh|ryP MoTMV2FPT0WU
ES6 NYTYcHMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnVdXlKSzVyPUSwMlQ2PTJizszN Mln4V2FPT0WU
SNU-387 NGPJc4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITQcnRKSzVyPUSwMlgzOzhizszN NI\kR4lUSU6JRWK=
T47D NF74dolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRzLkCxPVIh|ryP NEG3NndUSU6JRWK=
G-402 NIDkVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvXbHhKUUN3ME20NU4xQDB7IN88US=> M3q1TXNCVkeHUh?=
MZ1-PC M2HsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTRzLkixJO69VQ>? NIXyWY1USU6JRWK=
SW1417 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13ZTmlEPTB;NEKuN|A{KM7:TR?= MXfTRW5ITVJ?
RERF-LC-MS MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nic2lEPTB;NEKuOVA5PyEQvF2= M{WzU3NCVkeHUh?=
SF539 NVPMOJlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfDRplsUUN3ME20Nk42PTJ7IN88US=> MYTTRW5ITVJ?
ESS-1 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTR|LkW1OVgh|ryP Ml\OV2FPT0WU
RO82-W-1 NHjPXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzQ[HhZUUN3ME20N{43OTV|IN88US=> NWrBd5JYW0GQR1XS
S-117 NI\CR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjs[2lkUUN3ME20N{43QTV6IN88US=> MV3TRW5ITVJ?
SW756 NEXM[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjlTWM2OD12Mz64NlQzKM7:TR?= M3;JO3NCVkeHUh?=
CP66-MEL M4rxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR3LkexOFMh|ryP MX7TRW5ITVJ?
H-EMC-SS NYP5SowxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[zOmlEPTB;NEWuO|Y6OyEQvF2= M1HsVXNCVkeHUh?=
NCI-H2052 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HYOGlEPTB;NEWuPVAzPyEQvF2= NFXTeJRUSU6JRWK=
SW684 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33LNGlEPTB;NEeuNFA5OSEQvF2= MoLUV2FPT0WU
HCC1569 NG\wO|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjRVHhKSzVyPUS3MlE3PThizszN NXfaN2lzW0GQR1XS
KGN MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;sfHhKSzVyPUS3MlM{OTFizszN MnvvV2FPT0WU
LCLC-103H MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L1RmlEPTB;NEeuOFQxPCEQvF2= MUXTRW5ITVJ?
SW780 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTR5Lk[zOVEh|ryP M2LzTHNCVkeHUh?=
NCI-H1703 M4HYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13Sd2lEPTB;NEiuN|M2OiEQvF2= M1;ac3NCVkeHUh?=
HCC1395 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTR6Lke0N|Ih|ryP Mon5V2FPT0WU

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 順序で溶剤を入れること:
1% CMC Na
30mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co., Ltd. September 8, 2016 Phase 1
NCT02856893 Not yet recruiting NSCLC European Organisation for Research and Treatment of Cancer - EORTC|AstraZeneca March 2017 Phase 2
NCT02976116 Recruiting NSCLC Hutchison Medipharma Limited December 2016 Phase 2
NCT02951637 Not yet recruiting Lung Adenocarcinoma Shanghai Chest Hospital|Ruijin Hospital|Changhai Hospital December 2016 Phase 2
NCT02930954 Not yet recruiting Non-small-cell Lung Cancer Caicun Zhou|Tongji University November 2016 Phase 2
NCT02929693 Enrolling by invitation Cancer Shanghai University of Traditional Chinese Medicine|Shanghai Chest Hospital|Shanghai Pulmonary Hospital, Shanghai, China October 2016 Phase 3

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID