Inulin

製品コード：S2609

Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.

CAS No. 9005-80-5

サイズ	価格(税別)	在庫状況
10mg	JPY 13600	国内在庫あり
50mg	JPY 21800	国内在庫あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

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関連化合物ライブラリー	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ Express-Pick Library	もっと見る

生物活性

製品説明	Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.

In Vitro
In vitro	Inulin causes (20 g/d and 40 g/d) a significant increase in bifidobacterial counts in feces.^[1] Inulin exerts a preferential stimulatory effect on numbers of the health-promoting genus Bifidobacterium, whilst maintaining populations of potential pathogens (Escherichia coli, Clostridium) at relatively low levels. ^[2] Inulin combined with Bifidobacterium results in more potent inhibition of aberrant crypt foci (ACF) than administration of the two separately, achieving 80% inhibition of small ACF. ^[3] Inulin is made by a set of linear chains of fructose molecules, with a degree of polymerization (DP) ranging between 3 and 65, it can be fractionated into a slowly fermentable long-chain fraction (DP ranging from 10 to 65, average 25) or in a rapidly fermentable fraction made of oligofructose (DP ranging from 3 to 8, average 4). ^[4] Long-chain inulin combined with short-chain oligofructose results in larger numbers of caecal, colonic and faecal bacteria of the Clostridium coccoides-Eubacterium rectale cluster than Control in rats, whereas OF alone does not affect this bacterial group in caecum, colon or faeces. ^[5]

In Vivo
In Vivo	Inulin results in an increase in caecal wt and beta-glucosidase activity and a decrease in caecal pH were observed in rats given inulin-containing diets (with or without B. longum). ^[3]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試験 (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05254340	Active not recruiting	Healthy	Indiana University\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	August 1 2021	Not Applicable
NCT03983434	Active not recruiting	IBS - Irritable Bowel Syndrome	Indiana University\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	August 13 2019	Not Applicable

参考
[1] Roberfroid MB, et al. J Nutr, 1998, 128(1), 11-19. [2] Wang X, et al. J Appl Bacteriol, 1993, 75(4), 373-380. [3] Rowland IR, et al. Carcinogenesis, 1998, 19(2), 281-285. [4] Femia AP, et al. Carcinogenesis, 2002, 23(11), 1953-1960. [5] Kleessen B, et al. Br J Nutr, 2001, 86(2), 291-300. + 展開

参考

+ 展開

化学情報

分子量		化学式	C_6nH_10n+2O_5n+1
CAS No.	9005-80-5	SDF	Download Inulin SDFをダウンロードする
Smiles	OCC1OC(OC2(CO)OC(CO)C(O)C2O)C(O)C(O)C1O
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1个月-20°Cin solvent

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量 mg/kg 動物平均体重 g 投与体積（動物毎）μL 動物数匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

* 必須

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C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):