NU7441 (KU-57788)

製品コードS2638

NU7441 (KU-57788)化学構造

分子量(MW):413.49

NU7441 (KU-57788)は一種の高度有効的で、選択性的なDNA-PK阻害剤で、無細胞試験でIC50値が14 nMになって、PI3Kも抑制して、このIC50値が5μMになります。

サイズ 価格(税別) 在庫  
JPY 11620.00 あり
JPY 19920.00 あり
JPY 61420.00 あり
JPY 161020.00 あり

カスタマーフィードバック(5)

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

  • Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

    Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

製品安全説明書

DNA-PK阻害剤の選択性比較

生物活性

製品説明 NU7441 (KU-57788)は一種の高度有効的で、選択性的なDNA-PK阻害剤で、無細胞試験でIC50値が14 nMになって、PI3Kも抑制して、このIC50値が5μMになります。
ターゲット
DNA-PK [1]
(Cell-free assay)
14 nM
体外試験

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 NVLjdoZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LrcmlEPTB;MD6wNlE1OyEQvF2= NGD0ZWFUSU6JRWK=
A172 M{HNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHNTWM2OD1yLkG1N|E3KM7:TR?= MUHTRW5ITVJ?
NCI-H526 MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e3cmlEPTB;MD6yPFQxPyEQvF2= M32we3NCVkeHUh?=
HDLM-2 Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NECxZ2hKSzVyPUCuN|I{PDVizszN MVzTRW5ITVJ?
HuO-3N1 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7GPJlpUUN3ME2wMlQ3PjN4IN88US=> NWTtbI85W0GQR1XS
NCI-SNU-1 NX\CXpN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIruUZdKSzVyPUCuOlA6QTRizszN MXPTRW5ITVJ?
SK-N-AS NFu2dplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPlZXNKSzVyPUCuOlIzOTZizszN MVvTRW5ITVJ?
LoVo M{fWWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwOE[3OFkh|ryP M4HSWHNCVkeHUh?=
LAMA-84 MoDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\wV4xJUUN3ME2wMlk5QDN|IN88US=> NEjucYlUSU6JRWK=
CTB-1 M1[wd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPiTWM2OD1zLkGxOVQ3KM7:TR?= Mlr5V2FPT0WU
KP-N-YS M1SyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwMUSyN|Eh|ryP M1HtdHNCVkeHUh?=
HH Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHS0VppKSzVyPUGuNVgxQTNizszN NYeySoNVW0GQR1XS
CHL-1 MmDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHEVFBGUUN3ME2xMlIyOzZ6IN88US=> MUTTRW5ITVJ?
NB7 NX[xd4p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwMkS3OFUh|ryP M3PDNXNCVkeHUh?=
HL-60 NWj5NGtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXrUVc5UUN3ME2xMlM5OTlizszN M{ewfHNCVkeHUh?=
639-V M2m0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX4em9lUUN3ME2xMlQ1OTJ6IN88US=> MV3TRW5ITVJ?
NCI-H1793 M4P3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwNEW4OEDPxE1? MliwV2FPT0WU
NEC8 Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrYemd3UUN3ME2xMlU2OzVizszN NGDBfVNUSU6JRWK=
PA-1 M2\0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Toc2lEPTB;MT61PFI6PCEQvF2= M4fpPXNCVkeHUh?=
D-423MG NIraVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFwNkmzOlEh|ryP NILJPVNUSU6JRWK=
NCI-H292 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonETWM2OD1zLke0NFE{KM7:TR?= Ml3SV2FPT0WU
SK-MEL-1 MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwN{m0O|kh|ryP MUPTRW5ITVJ?
LB2241-RCC MoPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPxbnJKSzVyPUKuNVQyPDZizszN NV\nNG1vW0GQR1XS
SK-MEL-3 M{PnUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJwMU[0PUDPxE1? MkXzV2FPT0WU
MHH-PREB-1 NGDzOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHETWM2OD1{LkG2OlA6KM7:TR?= MnK5V2FPT0WU
BFTC-905 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7DTWM2OD1{LkG2Olg4KM7:TR?= MXnTRW5ITVJ?
Ramos-2G6-4C10 M1[4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJwMUm5NFkh|ryP NFT0eG1USU6JRWK=
G-361 NUXKRVNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJwMkG2PEDPxE1? MXPTRW5ITVJ?
MOLT-4 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvEcGU1UUN3ME2yMlIyQDh6IN88US=> MXnTRW5ITVJ?
DEL NHTxXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor1TWM2OD1{LkO1OVY1KM7:TR?= MmHrV2FPT0WU
MV-4-11 M2q4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwM{ezPUDPxE1? M{W2ZnNCVkeHUh?=
SK-NEP-1 NF[5cFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKxPFJKSzVyPUKuN|g4QDNizszN NEnpfYlUSU6JRWK=
RS4-11 M3ezR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TsNGlEPTB;Mj61OlAzOyEQvF2= NHjLOYRUSU6JRWK=
HuH-7 NXnJeoZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17uTGlEPTB;Mj61OlcxOiEQvF2= M4GydXNCVkeHUh?=
A101D MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTQO3NKSzVyPUKuOlE{OzhizszN MljnV2FPT0WU
KG-1 NWS2NJA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rGNmlEPTB;Mj62O|kzPCEQvF2= MnS5V2FPT0WU
KALS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe2NJNmUUN3ME2yMlY6PjN|IN88US=> M2ryPXNCVkeHUh?=
VMRC-RCZ MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7GXpdRUUN3ME2yMlc4OzJ6IN88US=> NFXReINUSU6JRWK=
SK-UT-1 M13YPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITCVlBKSzVyPUOuNVU{OSEQvF2= MnjSV2FPT0WU
SW962 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrwTWM2OD1|LkKwN|UzKM7:TR?= M4C4TnNCVkeHUh?=
DBTRG-05MG NWH1[WM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPRTWM2OD1|LkK4NFg2KM7:TR?= NIPGbFlUSU6JRWK=
PANC-08-13 NYf0TW5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTNwNEGyO|gh|ryP M2DVNnNCVkeHUh?=
QIMR-WIL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXezVlV[UUN3ME2zMlQyOzRzIN88US=> Mm\5V2FPT0WU
SK-MEL-30 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfzZmhsUUN3ME2zMlQzPTl6IN88US=> M2G4dXNCVkeHUh?=
697 NWHtVnBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\yTWM2OD1|LkS0PVk{KM7:TR?= Mo\HV2FPT0WU
NY M2jnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TRZWlEPTB;Mz60OVAzOiEQvF2= NXTWUo5ZW0GQR1XS
ES7 NFfhZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrGbWF1UUN3ME2zMlQ3PzJ7IN88US=> Ml\sV2FPT0WU
JVM-3 NXmwNFVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi1[41KSzVyPUOuOFgxPzdizszN MU\TRW5ITVJ?
U031 NV3h[mFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LBcmlEPTB;Mz61PVM3QCEQvF2= MkTXV2FPT0WU
BHT-101 M3jYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3STWM2OD1|LkW5PVg2KM7:TR?= MWrTRW5ITVJ?
8305C M{HwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfEU2lHUUN3ME2zMlYyPzN4IN88US=> M3XlZXNCVkeHUh?=
MG-63 NXnwWZhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknhTWM2OD1|Lk[yOlc3KM7:TR?= MXrTRW5ITVJ?
NOS-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7HTWM2OD1|Lk[1N|EzKM7:TR?= MXPTRW5ITVJ?
YH-13 NYTi[3h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFq3R2RKSzVyPUOuPFcyQDlizszN MYPTRW5ITVJ?
LXF-289 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvUd4hKSzVyPUOuPVExPDFizszN Mnz3V2FPT0WU
GOTO NXfOeIpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHsTVlKUUN3ME2zMlkyPDlizszN M{O2bnNCVkeHUh?=
EKVX NGnKfZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3HTWM2OD12LkKyOVI1KM7:TR?= NGq3VmNUSU6JRWK=
CAL-51 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTRwMkS4OVQh|ryP M{jkXXNCVkeHUh?=
AN3-CA MlG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfCTWM2OD12LkK1PFE{KM7:TR?= NGXkWJpUSU6JRWK=
IA-LM NVS5OmVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfMTWM2OD12LkK3PVM2KM7:TR?= NFTK[|NUSU6JRWK=
KU-19-19 M17NXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\XTWM2OD12LkOyPVIyKM7:TR?= MkDxV2FPT0WU
A704 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTRwNEC4PFgh|ryP NIXQcIhUSU6JRWK=
RH-18 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj1bYdKSzVyPUSuOFQ6PTNizszN M{PrWHNCVkeHUh?=
IST-MEL1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjqOXV4UUN3ME20MlU5OjZ|IN88US=> Mn[5V2FPT0WU
LU-134-A MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoWwTWM2OD12LkW5Olg2KM7:TR?= MljsV2FPT0WU
SF126 NIj0e|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TwXGlEPTB;ND62NFcyPSEQvF2= MmPhV2FPT0WU
EFO-27 NHzuOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTRwNk[1NlUh|ryP MmLNV2FPT0WU
SN12C NHfqeoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTHeVhUUUN3ME20MlcyQDl6IN88US=> MWTTRW5ITVJ?
L-363 NFzSZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL4eoo{UUN3ME20Mlc4OTF4IN88US=> NHKxWWpUSU6JRWK=
MEL-HO MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfiTWM2OD12Lke3PVg6KM7:TR?= NWLHd2U1W0GQR1XS
TYK-nu MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTRwOECxNlgh|ryP MXPTRW5ITVJ?
MDA-MB-415 Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3RTWM2OD13LkCwN|E1KM7:TR?= NVrnZZk2W0GQR1XS
HCC70 NVrBbplqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTVwMEO5N|kh|ryP MoPYV2FPT0WU
IGROV-1 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PXe2lEPTB;NT6yOVI6OiEQvF2= MlfLV2FPT0WU
NCI-H1355 NInWPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjaNFBqUUN3ME21MlI6PiEQvF2= MYrTRW5ITVJ?
23132-87 M2L1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTVwM{KwNlQh|ryP M3XjcHNCVkeHUh?=
NB69 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXSTWM2OD13LkOyOFIh|ryP M4jqbnNCVkeHUh?=
HSC-2 Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTVwNEG3O|Mh|ryP MkjSV2FPT0WU
KYSE-410 MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK3PZJzUUN3ME21MlQ4PjN4IN88US=> NX2xR3lLW0GQR1XS
GCIY NXXibYlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:0TWM2OD13LkWxN|c5KM7:TR?= MYjTRW5ITVJ?
A427 NEHOSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTVwNUO2OlEh|ryP MWfTRW5ITVJ?
ChaGo-K-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDKWm9KSzVyPUWuOVY2QTlizszN MWjTRW5ITVJ?
PFSK-1 NESzPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvzTWM2OD13Lk[yNVk1KM7:TR?= NVPzUG9FW0GQR1XS
MLMA MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7rbFhoUUN3ME21Mlg{PjB4IN88US=> M{ex[nNCVkeHUh?=
RVH-421 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTZwMEezN|gh|ryP NHLnPHZUSU6JRWK=
LB1047-RCC Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nhWmlEPTB;Nj6xO|UzOiEQvF2= NEXVfnNUSU6JRWK=
MHH-NB-11 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnuT4xCUUN3ME22MlMzPzJzIN88US=> NIfz[lFUSU6JRWK=
J-RT3-T3-5 NHzOSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3xWJBKSzVyPU[uOlMzQTFizszN NHzQfpdUSU6JRWK=
UM-UC-3 NWr3eXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XwTWlEPTB;Nj62OFM{PCEQvF2= NX;0d5lZW0GQR1XS
IST-SL1 M3XBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TrZ2lEPTB;Nj62PVM3QSEQvF2= MVjTRW5ITVJ?
NB14 NWC3cFR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\QS4JlUUN3ME22Mlc6PzZzIN88US=> M{C4eHNCVkeHUh?=
NBsusSR MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHOTWM2OD14LkiyOVAzKM7:TR?= M4TIZXNCVkeHUh?=
D-263MG NVvtbHdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn2yTWM2OD14LkmxNFY5KM7:TR?= M2fiNXNCVkeHUh?=
NCI-H2347 NX\Nb3pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm3bIZ4UUN3ME22Mlk{OjF|IN88US=> NVTtdYtSW0GQR1XS
ES8 MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF6xd5JKSzVyPU[uPVc2QDhizszN M4O1UXNCVkeHUh?=
786-0 NEXVO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli3TWM2OD15LkC5O|g3KM7:TR?= NH3EUFRUSU6JRWK=
EPLC-272H NInweVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P0cWlEPTB;Nz6xOlI1PiEQvF2= NEDj[YdUSU6JRWK=
CAPAN-1 M3qzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi5OIpKSzVyPUeuNlQ{PTlizszN M{H5SHNCVkeHUh?=
NCI-H82 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PEc2lEPTB;Nz6yOlY2QSEQvF2= NV6zfohTW0GQR1XS
G-402 NHXPeXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTdwM{CwOVEh|ryP Ml;NV2FPT0WU
SW982 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\5TWM2OD15LkOwNlA{KM7:TR?= NUm2W4tmW0GQR1XS
OVCAR-4 NW\ye3g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXSOWRKSzVyPUeuN|E{OjhizszN MWHTRW5ITVJ?
KARPAS-299 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTdwM{K2NlIh|ryP NIXFNFNUSU6JRWK=
MIA-PaCa-2 M1G2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnre2tLUUN3ME23MlM3QDJ|IN88US=> NVj4fW9{W0GQR1XS
AU565 NHG5cHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLIVXluUUN3ME23MlU6QDN|IN88US=> MonGV2FPT0WU
GAMG NETwcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX1W5VKSzVyPUeuOlQyOzFizszN MULTRW5ITVJ?
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FADU MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\NT4J2UUN3ME24MlA{PjV2IN88US=> MVrTRW5ITVJ?
NCI-H28 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfDe2pKSzVyPUiuNVY6PjJizszN MVvTRW5ITVJ?
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CAL-72 M1z6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjpeXNQUUN3ME2xNE45ODl2IN88US=> MnK4V2FPT0WU
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NCI-H650 NEf0bWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzjTWM2OD1zMT64PVYyKM7:TR?= MoLrV2FPT0WU
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BALL-1 NIT1TZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInZc2tKSzVyPUGyMlI3PjJizszN MVTTRW5ITVJ?
GT3TKB NXL6XlFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TjOGlEPTB;MUKuN|A4PCEQvF2= NXjpRWh5W0GQR1XS
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SKG-IIIa Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:xdHZKSzVyPUGzMlA2PTRizszN NESzfIZUSU6JRWK=
Becker MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq4TWM2OD1zMz6wOVgh|ryP MVnTRW5ITVJ?
ES5 NH7TXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF|LkGzOVYh|ryP MYnTRW5ITVJ?
NCI-H2030 NH7mN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfPTWM2OD1zMz6yNFYzKM7:TR?= M2TVS3NCVkeHUh?=
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CP50-MEL-B M2DrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF|Lk[yN|Ih|ryP M1[4fHNCVkeHUh?=
NCI-H1092 MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXpPXQ3UUN3ME2xN{44PDd3IN88US=> MoG4V2FPT0WU
8-MG-BA NGj5ZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHGT45KSzVyPUGzMlc2OTNizszN MnnJV2FPT0WU
CAL-27 NVXoNnRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrEWVVKSzVyPUG0MlA4OjdizszN NUjTfINHW0GQR1XS
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BFTC-909 NVLifFJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zDUGlEPTB;MUSuOVA2PSEQvF2= MmTDV2FPT0WU
D-566MG Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPxUZZNUUN3ME2xOE44PzB4IN88US=> NEXrZ5JUSU6JRWK=
MZ7-mel NGjMeXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;tXIgxUUN3ME2xOU4yODZ5IN88US=> M4L4[HNCVkeHUh?=
TE-5 M{fDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF3LkKzN|Mh|ryP MnrCV2FPT0WU
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DMS-114 M2LwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLtTWM2OD1zNT6zNlkyKM7:TR?= M4\ZUXNCVkeHUh?=
ME-180 NUXTWVlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu0PYpYUUN3ME2xOU41Pzh|IN88US=> M2\XZnNCVkeHUh?=
MS-1 MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF3LkW2NlMh|ryP M1HSOXNCVkeHUh?=
NUGC-3 NIHUS|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L6b2lEPTB;MUWuOlI1PSEQvF2= Mnf0V2FPT0WU
GB-1 M1jGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\2TWM2OD1zNT62OFM4KM7:TR?= NVPmTJFKW0GQR1XS
LOXIMVI M2PCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr5TWM2OD1zNT64PVE6KM7:TR?= NVHDRWk4W0GQR1XS
NCI-H1304 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPCR3Y6UUN3ME2xOU45QTJ6IN88US=> MlriV2FPT0WU
KURAMOCHI M{HEWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3DTWM2OD1zNT65O|Eh|ryP MkS2V2FPT0WU
SW1783 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTF4LkC5PVMh|ryP NH3ZO4NUSU6JRWK=
EGI-1 NH71OHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\KOHR1UUN3ME2xOk42OzZ3IN88US=> MoXHV2FPT0WU
KGN NHTLWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jZO2lEPTB;MU[uOVU5PiEQvF2= M4XtZnNCVkeHUh?=
PANC-03-27 M{XiNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF4Lke2OlIh|ryP MULTRW5ITVJ?
RH-1 M3\Xcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4juUmlEPTB;MU[uPFI2KM7:TR?= MkjuV2FPT0WU
HT-1376 NYGwRZl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;PWGlEPTB;MU[uPFQ1PiEQvF2= MkjxV2FPT0WU
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TI-73 M1r2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTF4Lkm0NFgh|ryP NGi4XY9USU6JRWK=
TK10 NGLUZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn4UpJKSzVyPUG3MlAxPzlizszN Mlu0V2FPT0WU
SW684 NHTzSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULiR5VWUUN3ME2xO{4xOTV2IN88US=> NXu5RZNTW0GQR1XS
RPMI-8866 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF5LkC2PVkh|ryP M3q0e3NCVkeHUh?=
LNCaP-Clone-FGC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rYRWlEPTB;MUeuOVIxOSEQvF2= NFLURZFUSU6JRWK=
NCI-H2291 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHZTWM2OD1zOD60N|Q2KM7:TR?= M4LrVXNCVkeHUh?=
T47D Ml\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF6LkS4PEDPxE1? MWfTRW5ITVJ?
A204 M3nNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITKSXNKSzVyPUG4MlU1PTJizszN MnTVV2FPT0WU
HT-144 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTF6Lke0Nlch|ryP NHjRWGRUSU6JRWK=
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HCC1806 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TxemlEPTB;MUmuNVU6OSEQvF2= NHficY9USU6JRWK=
NCI-H596 NHWySo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzHTWM2OD1zOT62N|kyKM7:TR?= M4PDNXNCVkeHUh?=
K-562 NH60eYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\4RoRsUUN3ME2xPU45QTJ4IN88US=> M1HLU3NCVkeHUh?=
D-336MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\HV2lEPTB;MUmuPVMzOiEQvF2= M1;3T3NCVkeHUh?=
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EW-13 MneyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJyLkW0OFMh|ryP MnjTV2FPT0WU
Hs-578-T M17pT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\wTWM2OD1{MD61OVg{KM7:TR?= MlrZV2FPT0WU
SJSA-1 MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vuXGlEPTB;MkCuOVY5QCEQvF2= MULTRW5ITVJ?
RCC10RGB M3fkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f3PGlEPTB;MkCuOlcyQSEQvF2= M1LtSXNCVkeHUh?=
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NCI-H1048 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X4eWlEPTB;MkGuNlI2QCEQvF2= MonaV2FPT0WU
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BE-13 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G0b2lEPTB;MkGuOlEyOyEQvF2= MoTLV2FPT0WU
KINGS-1 NH;YTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zVVWlEPTB;MkGuOlMyPiEQvF2= MWLTRW5ITVJ?
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NCI-H2452 M4\aPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zXfWlEPTB;MkGuPFY1PyEQvF2= NGmwW4JUSU6JRWK=
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D-542MG NYe4WIpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PaU2lEPTB;MkGuPVA3QSEQvF2= NIfifnpUSU6JRWK=
NCI-H630 NVi4VlVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7EfoNrUUN3ME2yNk4xOjl4IN88US=> NUmxR|FsW0GQR1XS
TGBC11TKB M2H1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJ{LkC0PUDPxE1? MknLV2FPT0WU
BCPAP Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfEdWdPUUN3ME2yNk43OTFizszN MoDtV2FPT0WU
HLE M{Owb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJ{Lk[5O{DPxE1? Ml:3V2FPT0WU
NCI-H727 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnZfXRKSzVyPUKyMlc{PSEQvF2= NVHhVW9QW0GQR1XS
RD NF\vcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDne|ZKSzVyPUKyMlc2OThizszN NFjOU3hUSU6JRWK=
NCI-H522 NHO1TolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rIdmlEPTB;MkKuPFQ{OSEQvF2= NXrZXVlQW0GQR1XS
CGTH-W-1 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13BVmlEPTB;MkOuNFY1OSEQvF2= MVTTRW5ITVJ?
SK-LU-1 NHPtR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfUTWM2OD1{Mz60Olg{KM7:TR?= NEfSfVBUSU6JRWK=
BB65-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\WTWM2OD1{Mz63PFY{KM7:TR?= NHLPbGlUSU6JRWK=
HSC-3 MlWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\oWmlEPTB;MkOuPFUzPyEQvF2= MnzTV2FPT0WU
SK-MES-1 MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLGTWM2OD1{ND6wNVYyKM7:TR?= MnzEV2FPT0WU
DB NXi0TG1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnrSIFKSzVyPUK0MlExOjhizszN M4n3R3NCVkeHUh?=
HO-1-N-1 Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJ2LkOwPVMh|ryP M4XvXHNCVkeHUh?=
MKN1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXLfZRKSzVyPUK0MlY5KM7:TR?= MWTTRW5ITVJ?
MN-60 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\RTWM2OD1{ND64OVE6KM7:TR?= MYDTRW5ITVJ?
8505C NYHJeHM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHYTWM2OD1{NT6xPFQ2KM7:TR?= MYDTRW5ITVJ?
COLO-320-HSR MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;KTWM2OD1{NT6yNlA5KM7:TR?= NHjxb5RUSU6JRWK=
BB30-HNC NV:ydmhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTt[nZKSzVyPUK1MlI1QDNizszN M33HdHNCVkeHUh?=
KM12 NHTvTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ3LkW4NFch|ryP MWnTRW5ITVJ?
NB13 NFTTWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXObYxKSzVyPUK1MlU5QThizszN MVjTRW5ITVJ?
HCC2998 NXfz[JhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfBb4hKSzVyPUK2MlAzQDNizszN M4flcXNCVkeHUh?=
U-118-MG M2ew[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r5ZWlEPTB;Mk[uNFgxQCEQvF2= MUnTRW5ITVJ?
NB10 NWXISmRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXKV4lKSzVyPUK2MlI{PCEQvF2= NVzic2RqW0GQR1XS
SK-LMS-1 NH:4bI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli1TWM2OD1{Nz6wO|A1KM7:TR?= Ml\GV2FPT0WU
SW1573 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ToUmlEPTB;MkeuNVEh|ryP NX;nXYhsW0GQR1XS
LB373-MEL-D MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW5bJBKSzVyPUK3MlEzQTRizszN MVrTRW5ITVJ?
DK-MG MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJ5LkG4NVch|ryP MnPOV2FPT0WU
RMG-I NUW5d|ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJ5LkKwNlkh|ryP MXXTRW5ITVJ?
SW1088 NYD0[m5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDufXFwUUN3ME2yO{42ODR{IN88US=> MUHTRW5ITVJ?
SK-OV-3 M33qXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvrTWVqUUN3ME2yO{44PTl|IN88US=> NUfO[40zW0GQR1XS
KP-N-YN MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rGeWlEPTB;MkeuPFA1OyEQvF2= NGnq[GlUSU6JRWK=
RPMI-7951 MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJ6LkK0OVYh|ryP M3\ufHNCVkeHUh?=
CaR-1 NX32OnhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTsTWM2OD1{OD61OVgzKM7:TR?= MX3TRW5ITVJ?
MKN7 M{KyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3wU3lKSzVyPUK4MlU6PjRizszN M1HtNnNCVkeHUh?=
CHP-212 NVvMTpFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fvbWlEPTB;MkiuO|QxOSEQvF2= NWfLUIlbW0GQR1XS
KYSE-450 M{jxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS2TWM2OD1{OD64NFkyKM7:TR?= Mn;LV2FPT0WU
RXF393 M1TGPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXNOYVKSzVyPUK5MlI6ODZizszN NHLPTJdUSU6JRWK=
P30-OHK MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O3eGlEPTB;MkmuN|A1QCEQvF2= NYqxZlk1W0GQR1XS
Ca9-22 NFTjVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nFUGlEPTB;MkmuOFI6QSEQvF2= M2HTcnNCVkeHUh?=
RT-112 NXLaW5lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy3TWc2UUN3ME2yPU41PjFzIN88US=> M1y0SnNCVkeHUh?=
ES1 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX0SnNJUUN3ME2yPU45PTR2IN88US=> M1P2eXNCVkeHUh?=
HCE-4 M2\TdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\3W41wUUN3ME2yPU45Pzh4IN88US=> NELaUWlUSU6JRWK=
AM-38 NUTmTIt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjkVWxKSzVyPUOwMlA3ODZizszN MV;TRW5ITVJ?
AsPC-1 NYfLeVM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTyTWM2OD1|MD64NFU{KM7:TR?= Mlr3V2FPT0WU
TE-9 NYH3VolzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3wTWM2OD1|MD64O|M4KM7:TR?= MV;TRW5ITVJ?
HuP-T4 MlqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTNyLkm2N|gh|ryP M4XVSnNCVkeHUh?=
LB2518-MEL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTNzLkC3OFQh|ryP MnfhV2FPT0WU
NCI-H1703 NIjzOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NImyW3JKSzVyPUOxMlA6ODVizszN Mle2V2FPT0WU
NCI-H2228 NX7meHJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTNzLkS2OVEh|ryP MYTTRW5ITVJ?
SCC-4 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNzLkmxPFEh|ryP MoDwV2FPT0WU
KNS-81-FD MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzvPFFYUUN3ME2zNk4xOTJ6IN88US=> MkjCV2FPT0WU
NTERA-S-cl-D1 NWrFfIUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjXc2doUUN3ME2zNk4xPzN7IN88US=> Mn\mV2FPT0WU
Daoy M37FSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLXRlBKSzVyPUOyMlA5OzhizszN NXrleYxZW0GQR1XS
ES4 NGj3NmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7x[VRKSzVyPUOyMlM6OjJizszN NE[zU21USU6JRWK=
MHH-ES-1 NID2SJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPjT2hXUUN3ME2zNk41QDd{IN88US=> M1qzc3NCVkeHUh?=
C-33-A M3HWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPLTWM2OD1|Mj63O|I5KM7:TR?= MkDQV2FPT0WU
BHY MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTN{Lkm0PVUh|ryP MoPqV2FPT0WU
Detroit562 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK1e5hKSzVyPUOzMlY3PTdizszN M{PzeXNCVkeHUh?=
EW-1 M3zVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Hhb2lEPTB;M{OuPVMzOiEQvF2= NGS5cYlUSU6JRWK=
NCI-H1395 NULpZ284T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHRXWFpUUN3ME2zOE4xPzl7IN88US=> MWrTRW5ITVJ?
KM-H2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHqWoR1UUN3ME2zOk41PzR|IN88US=> NYO0[Jg6W0GQR1XS
NCI-H520 M4DUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrmR2pKSzVyPUO2Mlc2PDFizszN NYfWWI84W0GQR1XS
D-392MG NHrEdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXpWJlbUUN3ME2zO{4{OzR2IN88US=> NYnnR3dUW0GQR1XS
NOMO-1 NVPsbVl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTN5LkiwPFkh|ryP NYnoWm9tW0GQR1XS
TE-6 MoTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvvTWM2OD1|OD6xNlQh|ryP NX64WWNWW0GQR1XS
HT-3 NEWydHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e4V2lEPTB;M{iuOFQ{PiEQvF2= MUjTRW5ITVJ?
RPMI-8226 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnWZZYyUUN3ME2zPE46PTF7IN88US=> M2TxVnNCVkeHUh?=
U251 M2nZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{T3XWlEPTB;M{muNFEzPCEQvF2= MoDyV2FPT0WU
GCT MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDOWY1jUUN3ME2zPU4yQDV{IN88US=> M{jTcHNCVkeHUh?=
A431 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnscmxlUUN3ME2zPU4yQDl2IN88US=> MoThV2FPT0WU
TE-12 M1TEZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTN7LkK0OFgh|ryP M4DocnNCVkeHUh?=
HMV-II MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorTTWM2OD1|OT61NFQ4KM7:TR?= MlToV2FPT0WU
IST-MES1 NUDFco82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PQOWlEPTB;NECuNVUxOiEQvF2= NF;2PFVUSU6JRWK=
SW13 NXriWpZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETkWnZKSzVyPUSwMlUyQSEQvF2= MVXTRW5ITVJ?
SF295 NF\4SJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfNTWM2OD12MD64NFY3KM7:TR?= MV7TRW5ITVJ?
MDA-MB-157 NFOwcHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Ht[mlEPTB;NECuPVQ3OiEQvF2= NYPj[Io3W0GQR1XS
TE-1 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnpdWhDUUN3ME20NU45PzF2IN88US=> NXTaTod7W0GQR1XS
HuCCT1 NHPCSXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXvTWM2OD12Mj61Nlg6KM7:TR?= NI\KPWpUSU6JRWK=
KYSE-510 M4eyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTR|LkG3OVQh|ryP Mn70V2FPT0WU
NCI-H358 NFPyS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTycoNKSzVyPUS0MlA{ODRizszN MmHYV2FPT0WU
SW900 NHPFdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLyWmFlUUN3ME20OE4xPzV6IN88US=> MXrTRW5ITVJ?
CAS-1 MnfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETtU2hKSzVyPUS0MlA6QTFizszN NH:zclFUSU6JRWK=
TE-8 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP2VY1YUUN3ME20OE42PjV6IN88US=> MlPqV2FPT0WU
P12-ICHIKAWA MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnpWVlKSzVyPUS0MlYyOTJizszN M3\Ec3NCVkeHUh?=
YKG-1 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\SbGNQUUN3ME20OE44QDFizszN MVrTRW5ITVJ?
SNU-C2B MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nM[GlEPTB;NESuO|kxOyEQvF2= MmXhV2FPT0WU
LCLC-103H NESzOVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrt[nVKSzVyPUS0Mlg4ODNizszN MXfTRW5ITVJ?
U-87-MG NUjhVoZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTVNWdKSzVyPUS1MlExOjJizszN MYXTRW5ITVJ?
HAL-01 NVHKfGRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K5UWlEPTB;NEWuNVM4QSEQvF2= NIjSOWJUSU6JRWK=
OVCAR-8 NGnPWHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LGTmlEPTB;NEWuN|U3PCEQvF2= M3;OTHNCVkeHUh?=
KYSE-150 M3jsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR5LkGwOVIh|ryP MYLTRW5ITVJ?
OE33 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTR5LkG0Nlkh|ryP MlnWV2FPT0WU
CAL-62 NXrCUoFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PVdmlEPTB;NEeuOFA3QCEQvF2= M1zIRXNCVkeHUh?=
TCCSUP MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\YfmlEPTB;NEeuOlI3PCEQvF2= NFjOXWtUSU6JRWK=
H4 NHriPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPVfpRGUUN3ME20O{43PjJzIN88US=> M{nVT3NCVkeHUh?=
CP66-MEL M1;PeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR6LkC3NFQh|ryP M1XEVXNCVkeHUh?=
SNB75 M{jvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHxSXd[UUN3ME20PE4yQDd2IN88US=> NHvUWI9USU6JRWK=
Mo-T Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW5VZp1UUN3ME20PE4zPzlizszN MVnTRW5ITVJ?
BT-549 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:3fmlEPTB;NEiuN|czQSEQvF2= NFn0cG5USU6JRWK=
IGR-1 NYn6bGs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTR6Lk[2OFUh|ryP Ml;RV2FPT0WU
NCI-H1299 NYTXSpZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTTTWM2OD12OD63NlQ5KM7:TR?= MWfTRW5ITVJ?
ALL-PO M1PxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nSfGlEPTB;NEmuPVI3QCEQvF2= NXSxcFBNW0GQR1XS

多くの細胞株試験データを見る場合、クリックしてください

体内試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

お薦めの試験操作(参考用のみ)

細胞試験: [2]
+ 展開
  • 細胞株: SW620, LoVo, V3-YAC and V3 cells
  • 濃度: 0.5 μM or 1 μM
  • 反応時間: 17 hours
  • 実験の流れ: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (参考用のみ)
動物試験:[2]
+ 展開
  • 動物モデル: Female rude mice bearing SW620 xenografts
  • 製剤: Sterile 0.9% sodium chloride solution
  • 投薬量: 10 mg/kg
  • 投与方法: Intraperitoneally administrated
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 4 mg/mL (9.67 mM) warming
Water Insoluble
Ethanol Insoluble
体内 順序で溶剤を入れること:
4% DMSO+30% PEG 300+5% Tween 80+ddH2O
1mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • 回答:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

DNA-PK信号経路図

DNA-PK Inhibitors with Unique Features

相関DNA-PK製品

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID