Sarilumab (anti-IL-6Rα)

製品コードA2011 別名: SAR153191, REGN88

製品コード：A2011 純度：98.05%

Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

サイズ	価格(税別)	在庫状況
1mg	JPY 44500	国内在庫あり
1mg*5	JPY 146500	お問い合わせ
5mg	JPY 146500	国内在庫あり
1mg*25	JPY 445500	お問い合わせ

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

文献中Selleckの製品使用例（4）

質量管理及び製品安全説明書

現在のバッチを見る： A201101 純度： 98.05% タンパク質濃度： 5.0 mg/ml 内毒素： ≤1 EU/mg

98.05

IL Receptor阻害剤の選択性比較

生物活性

製品説明

Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

同型

Human IgG1

Targets

IL-6R (human) ^[1]	IL-6R (monkey) ^[1]
61.9 pM(Kd)	71.9 pM(Kd)

In Vitro
In Vitro	Sarilumab can reverse IL-6 enhanced colony formation in HCC cells under sorafenib or regorafenib treatment.^[1]
細胞実験	Cells were treated with drugs for 36 h. The soluble form of IL-6Rα in cell culture supernatants was measured with a human IL-6Rα ELISA kit according to the manufacturer’s instructions. Plates were measured on a microplate reader at a wavelength of 450 nm.

In Vivo
In Vivo	Sarilumab has been shown in preclinical studies to inhibit IL-6 signalling in a dose-dependent manner^[2].

参考
[1] Dai Z, et al. Cancer Lett. 2022 Jan 1;524:161-171. [2] Huizinga TW, et al. Ann Rheum Dis. 2014, 73(9):1626-34.

参考

製品説明

CAS No.	1189541-98-7
Formulation	PBS buffer, pH 7.2
Isotype	Human IgG1
Source	CHO cells
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping	Shipped under low temperature conditions
Sterility	5.0 mg/ml

技術サポート

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Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

* 必須

よくある質問（FAQ）

質問：1：
How to store the antibody?

回答：
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.